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The map label for this gene is dut [H]

Identifier: 148360060

GI number: 148360060

Start: 2978112

End: 2978570

Strand: Reverse

Name: dut [H]

Synonym: LPC_1991

Alternate gene names: 148360060

Gene position: 2978570-2978112 (Counterclockwise)

Preceding gene: 148360059

Following gene: 148360061

Centisome position: 83.28

GC content: 43.14

Gene sequence:

>459_bases
ATGCATCAAGTTATTCAGTTAAAAATTCTGGATTCAAGGATAGGAGATACCATTCCATTGCCTGCCTATGCCACTGATGG
GTCCGCCGGTCTGGATTTAAGGGTCTGTATCTCGGAGCCTATGCAAGTAGCACCTCAGCAAGCAGTATTGCTGCCCACCG
GCATTGCTATTTATATTGCCGATCCAAAGCTGGCGGCAGTGATTTTACCAAGATCAGGTTTAGGCCATAAAAATGGTATT
GTTTTAGGAAACCTTGTAGGGCTGATTGACTCGGATTATCAAGGAGAATTAAAAATCTCTTGTTGGAACAGGAGCCAGGA
ACATTTTACTGTTAATCCTGGTGATAGAATTGCTCAATTAGTTTTTATCCCGGTTGTACAGGCTTCTTTTGAGGTGGTCA
ATGAATTTACAGAAAGCTCCAGAGGAGAAGGTGGTTTTGGCAGCTCCGGGAGATATTAA

Upstream 100 bases:

>100_bases
AGCTGCCATTAACCCATAAAACACGCCTGGCAGGCCAAATTATTGCAATCCTTGCTGCAAGTCTGCAAAATTAGGCGCAA
TAAAACGATTGAGAATTATT

Downstream 100 bases:

>100_bases
ATGACCTATCAACAAAAGCAAATTCCCCGCTCTGTCTTTCGTGCCTATGACATTAGGGGGATTATCGGTAAAGAACTGGA
TGAGAATTCTTTTTATAGCA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQAVLLPTGIAIYIADPKLAAVILPRSGLGHKNGI
VLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDRIAQLVFIPVVQASFEVVNEFTESSRGEGGFGSSGRY

Sequences:

>Translated_152_residues
MHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQAVLLPTGIAIYIADPKLAAVILPRSGLGHKNGI
VLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDRIAQLVFIPVVQASFEVVNEFTESSRGEGGFGSSGRY
>Mature_152_residues
MHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQAVLLPTGIAIYIADPKLAAVILPRSGLGHKNGI
VLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDRIAQLVFIPVVQASFEVVNEFTESSRGEGGFGSSGRY

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=147, Percent_Identity=32.6530612244898, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4503423, Length=147, Percent_Identity=31.9727891156463, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI70906441, Length=149, Percent_Identity=30.8724832214765, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1790071, Length=147, Percent_Identity=65.9863945578231, Blast_Score=214, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71988561, Length=141, Percent_Identity=36.1702127659575, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319729, Length=84, Percent_Identity=50, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583610, Length=130, Percent_Identity=33.0769230769231, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921126, Length=130, Percent_Identity=33.0769230769231, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16317; Mature: 16317

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQAVLLPTGIAIYIA
CCCEEEEEEECCCCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCEEEEEE
DPKLAAVILPRSGLGHKNGIVLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDRIAQL
CCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCEEEECCHHHHHHH
VFIPVVQASFEVVNEFTESSRGEGGFGSSGRY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQAVLLPTGIAIYIA
CCCEEEEEEECCCCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCEEEEEE
DPKLAAVILPRSGLGHKNGIVLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDRIAQL
CCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCEEEECCHHHHHHH
VFIPVVQASFEVVNEFTESSRGEGGFGSSGRY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA