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The map label for this gene is adhT [H]

Identifier: 148360053

GI number: 148360053

Start: 2986137

End: 2987123

Strand: Direct

Name: adhT [H]

Synonym: LPC_1984

Alternate gene names: 148360053

Gene position: 2986137-2987123 (Clockwise)

Preceding gene: 148360056

Following gene: 148360052

Centisome position: 83.49

GC content: 43.06

Gene sequence:

>987_bases
ATGCATGCCATGATCATGGAAAAGCCTGGATGTGCATTGCAATATCAGGAAGTCAATAAACCAAATCCAAATGAAAATGA
ACTTTTAATTAAAGTATCAGCTTGTGGGATTTGTAGAACTGACTTGCATGTTGTCGATGGTGAGCTGAAAAATCCCAAGA
TTCCCCTTATTCCAGGCCACCAAATTGTAGGAACTGTTGAACAGGTTGGATCCGCTGTGAAGCAATTTGCAATTGGACAG
CGAGTTGGAGTCCCTTGGCTAGGTGGAAGTTGCGGGATCTGTAATTTTTGCACATCTGGCCGAGAAAATTTATGTGATCA
AGCCTGCTTTACTGGATATCAAATAGATGGTGGTTTCGCTGAGTTCTGTGTGGCAAATTACCATTTTTGCTTTCCTATTC
CCGATGGATACCCGGATCATCAGGCAGCACCATTATTTTGTGCGGGTTTAATTGGATATCGTGCCTTGTTAAAGGTTGGT
AATGCAACTCATTTAGGTCTATATGGATTTGGAGCGGCAGCACATATACTAATTCAAGTCGCTTGCCAAAAAGGAATTAA
AATTTATGCGTTTACAAGCCCCGGTGATCAGGAATCTCAAAAATTTGCATACCGATTAGGTGCTGTCTGGGCTGGGGATT
CTACGCAATCACCACCTCATCTTCTTGATGCAGCAATCATTTTTGCACCCGTTGGTGCATTAGTGCCTCAGGCTCTTCGC
AATATTGTAAAAGGAGGTACTGTGGTTTGTGGTGGTATACATATGTCGGATATTCCCAGCTTCCCTTATGAAATACTGTG
GGGTGAACGCGCTGTTTGTTCAATTGCCAATCTAACTCGCAAAGATGGGGAAGAGTTCCTGTCTCTGGCCCCTAAAATCC
CGGTTAAGACAAAAGTTCAAACCTATCCCCTTACCGAAGTTAATCGAGCGCTGGATGATTTAAGACATGGCAGGTATAGA
GGAGCCGGGGTTATTGTTATGAAATAA

Upstream 100 bases:

>100_bases
ATCATTGATGTCAAATATTGTTACTTTTTGAATACATTAAGTAAGTATAACCCACCCTACTATAATTGTAAGATAGAGGA
TAAAAACAGGACCAATACCC

Downstream 100 bases:

>100_bases
AGCTATAATTATCAAAAGCTATTACAACAAACTCAAATCATTGGGGGAAGGACTGATTGATAGCAAGGAATATTCAAATC
ATGAACGCTCTAATGACCAA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MHAMIMEKPGCALQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKIPLIPGHQIVGTVEQVGSAVKQFAIGQ
RVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFAEFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKVG
NATHLGLYGFGAAAHILIQVACQKGIKIYAFTSPGDQESQKFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALR
NIVKGGTVVCGGIHMSDIPSFPYEILWGERAVCSIANLTRKDGEEFLSLAPKIPVKTKVQTYPLTEVNRALDDLRHGRYR
GAGVIVMK

Sequences:

>Translated_328_residues
MHAMIMEKPGCALQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKIPLIPGHQIVGTVEQVGSAVKQFAIGQ
RVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFAEFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKVG
NATHLGLYGFGAAAHILIQVACQKGIKIYAFTSPGDQESQKFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALR
NIVKGGTVVCGGIHMSDIPSFPYEILWGERAVCSIANLTRKDGEEFLSLAPKIPVKTKVQTYPLTEVNRALDDLRHGRYR
GAGVIVMK
>Mature_328_residues
MHAMIMEKPGCALQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKIPLIPGHQIVGTVEQVGSAVKQFAIGQ
RVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFAEFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKVG
NATHLGLYGFGAAAHILIQVACQKGIKIYAFTSPGDQESQKFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALR
NIVKGGTVVCGGIHMSDIPSFPYEILWGERAVCSIANLTRKDGEEFLSLAPKIPVKTKVQTYPLTEVNRALDDLRHGRYR
GAGVIVMK

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=169, Percent_Identity=30.1775147928994, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI262073058, Length=169, Percent_Identity=30.1775147928994, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI156627571, Length=145, Percent_Identity=33.1034482758621, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4501933, Length=179, Percent_Identity=29.608938547486, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI194239676, Length=201, Percent_Identity=27.8606965174129, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI194239674, Length=327, Percent_Identity=24.4648318042813, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI13236495, Length=327, Percent_Identity=24.4648318042813, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081918, Length=319, Percent_Identity=32.6018808777429, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082401, Length=314, Percent_Identity=27.7070063694268, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1786518, Length=337, Percent_Identity=26.7062314540059, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787863, Length=224, Percent_Identity=30.3571428571429, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790045, Length=147, Percent_Identity=35.3741496598639, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI226510992, Length=147, Percent_Identity=34.6938775510204, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788073, Length=159, Percent_Identity=30.8176100628931, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082125, Length=187, Percent_Identity=28.3422459893048, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788075, Length=143, Percent_Identity=28.6713286713287, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=28.3185840707965, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71988145, Length=156, Percent_Identity=37.1794871794872, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=26.6081871345029, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17562876, Length=127, Percent_Identity=35.4330708661417, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=137, Percent_Identity=33.5766423357664, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=200, Percent_Identity=27.5, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=329, Percent_Identity=29.1793313069909, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324486, Length=145, Percent_Identity=41.3793103448276, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6323961, Length=155, Percent_Identity=39.3548387096774, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=157, Percent_Identity=35.6687898089172, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323980, Length=325, Percent_Identity=29.2307692307692, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319949, Length=324, Percent_Identity=28.0864197530864, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=227, Percent_Identity=31.2775330396476, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=354, Percent_Identity=23.4463276836158, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319257, Length=227, Percent_Identity=29.9559471365639, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737895, Length=356, Percent_Identity=24.7191011235955, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35356; Mature: 35356

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAMIMEKPGCALQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKIPLIPGH
CCCEEECCCCCEEEECCCCCCCCCCCEEEEEEECCCEEECCCEEECCCCCCCCCCCCCCH
QIVGTVEQVGSAVKQFAIGQRVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFA
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCHHHHHHHHHHCCEEECCCHH
EFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKVGNATHLGLYGFGAAAHILIQV
HHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
ACQKGIKIYAFTSPGDQESQKFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALR
HHHCCCEEEEECCCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NIVKGGTVVCGGIHMSDIPSFPYEILWGERAVCSIANLTRKDGEEFLSLAPKIPVKTKVQ
HHHCCCCEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCEEE
TYPLTEVNRALDDLRHGRYRGAGVIVMK
ECCHHHHHHHHHHHHCCCCCCCEEEEEC
>Mature Secondary Structure
MHAMIMEKPGCALQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKIPLIPGH
CCCEEECCCCCEEEECCCCCCCCCCCEEEEEEECCCEEECCCEEECCCCCCCCCCCCCCH
QIVGTVEQVGSAVKQFAIGQRVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFA
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCHHHHHHHHHHCCEEECCCHH
EFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKVGNATHLGLYGFGAAAHILIQV
HHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
ACQKGIKIYAFTSPGDQESQKFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALR
HHHCCCEEEEECCCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NIVKGGTVVCGGIHMSDIPSFPYEILWGERAVCSIANLTRKDGEEFLSLAPKIPVKTKVQ
HHHCCCCEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCEEE
TYPLTEVNRALDDLRHGRYRGAGVIVMK
ECCHHHHHHHHHHHHCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]