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The map label for this gene is 148359800

Identifier: 148359800

GI number: 148359800

Start: 2674737

End: 2676095

Strand: Reverse

Name: 148359800

Synonym: LPC_1725

Alternate gene names: NA

Gene position: 2676095-2674737 (Counterclockwise)

Preceding gene: 148359801

Following gene: 148359799

Centisome position: 74.83

GC content: 39.81

Gene sequence:

>1359_bases
ATGAAATTGTCTTTTTTAGGTGCTACCAGTACGGTTACCGGTTCTAAGTACCTGGTAGAATCAAATAATAAAAAGATTTT
GGTAGATTGTGGACTTTTCCAAGGGTTAAAAGAATTGAGACTAAGAAACTGGTCACCCCTGCCTGTGTCTCCAGAATCGA
TAGATGCCGTTGTTTTGACCCATGCACATATTGATCATAGTGGTTATTTGCCATTATTGGTGAAACAGGGATTTAAGGGG
CGCATCTATGCAACAGCTGCAACAACCGATTTATGTTCTATCTTGCTGCCTGATAGCGGTTTTTTGCACGAGGAAGATGC
TAGAAGAGCAAATAAATATGGGTACAGCAAGCACCATCCGGCTTTACCTTTGTATACTCAGGAAGATGCAAATAATACCT
TAAAGTATTTTGAATCAGTAGAATATGACACCCCTTATCCTTTAATGGAGGATTGTGAAATCAGTTGGCATAGGGCAGGG
CATATATTAGGGTCTGCATTTATTCAATTTCAAACAAAGCAAATCAAGTTATTATTTAGTGGTGATATTGGAAGACTCAA
TGATCCTGTTATGAAGCCTTCCGAGTTAATGAAATCTACCGATTATTTGGTGATTGAATCAACTTATGGGAATCGCTTGC
ATGATAAAACCGATCCTTTAGCGTTTATAGCCAACATAGTCAATACGACTTGTAAAAGAGGTGGTACAGTGCTAATTCCT
GCTTTTGCAGTCGGTAGGGCACAAACTATGTTGTATTATTTGTATATTTTAAAACAAAAAAAATTAATTCCTGATGTTCC
TGTCTATCTGGATAGCCCTATGGCTATTGATGCCACTGAATTATTATTAAAACATCATAACGAACATCGCTTAAGTGCAG
AGGAGTGTCGAGCCGTCTGCCAAATAGCGACTTATGTCCATACCCCAAATGAATCCATGGCAGTGGATTGGGGGCGCGAA
TCTAAAATTATTATTTCTGCAAGTGGCATGATGACAGGGGGCAGGGTTTTGCATCATTTGAAGGTATATGCTCCTGATCC
TGCAAGTACTATCCTTTTGACCGGATTCCAGGCTGCTGGAACGAGAGGTGAAAAAATGTTAAATCATGAGCCGTCCATTA
AAATCCATGGCGATGATTATCCAGTCAGGGCTCAGGTAGCTATGTTAACCAATGCCTCTGCTCACGCAGATTATGAGGAA
ATACTAGTTTGGCTAAAGCATTTTGAGAAAGCCCCAAAGGAAGTTTTTATTACCCATGGCGAGCCTCAAGCGGCATTAGG
GTTAAAGGGACATATTGAAGCGGAGCTAGGATGGAATTGCAAGATACCTAACTATCTTGAAAAAGTAAATTTGGATTAA

Upstream 100 bases:

>100_bases
AAGATTTACAATTTCAAACTTCAAATGACTTTAAAATAAATTGGCAATAGGTCGTGTTATTCATTACAGTACTGAGAATG
ACATACAACAAGGTATTATT

Downstream 100 bases:

>100_bases
CGAATCCCCAAAATAATATTCGATTTAATATTCTGAACAAGAGCTACAGAGACTCGGAAAATAGGAAACAATCATTCATA
TTCCAGTTTTTTCGCAATAT

Product: metallo-beta-lactamase superfamily transporter protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKLSFLGATSTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLTHAHIDHSGYLPLLVKQGFKG
RIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAG
HILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVCQIATYVHTPNESMAVDWGRE
SKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAGTRGEKMLNHEPSIKIHGDDYPVRAQVAMLTNASAHADYEE
ILVWLKHFEKAPKEVFITHGEPQAALGLKGHIEAELGWNCKIPNYLEKVNLD

Sequences:

>Translated_452_residues
MKLSFLGATSTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLTHAHIDHSGYLPLLVKQGFKG
RIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAG
HILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVCQIATYVHTPNESMAVDWGRE
SKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAGTRGEKMLNHEPSIKIHGDDYPVRAQVAMLTNASAHADYEE
ILVWLKHFEKAPKEVFITHGEPQAALGLKGHIEAELGWNCKIPNYLEKVNLD
>Mature_452_residues
MKLSFLGATSTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLTHAHIDHSGYLPLLVKQGFKG
RIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAG
HILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVCQIATYVHTPNESMAVDWGRE
SKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAGTRGEKMLNHEPSIKIHGDDYPVRAQVAMLTNASAHADYEE
ILVWLKHFEKAPKEVFITHGEPQAALGLKGHIEAELGWNCKIPNYLEKVNLD

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=434, Percent_Identity=27.8801843317972, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI33300633, Length=463, Percent_Identity=26.5658747300216, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI32566029, Length=444, Percent_Identity=27.7027027027027, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI32564696, Length=447, Percent_Identity=26.6219239373602, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323307, Length=450, Percent_Identity=25.1111111111111, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24648013, Length=462, Percent_Identity=27.0562770562771, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI21358523, Length=464, Percent_Identity=25.8620689655172, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 50483; Mature: 50483

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSFLGATSTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLT
CEEEEECCCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
HAHIDHSGYLPLLVKQGFKGRIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHP
EEEECCCCCCHHHCCCCCCCEEEEEECHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCCC
ALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAGHILGSAFIQFQTKQIKLLFS
CCCEEECCCCCHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHEEEEEEEEEEEEE
GDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
CCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVC
EHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHH
QIATYVHTPNESMAVDWGRESKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAG
HHHHEEECCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEECCHHCC
TRGEKMLNHEPSIKIHGDDYPVRAQVAMLTNASAHADYEEILVWLKHFEKAPKEVFITHG
CCCHHHHCCCCCEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECC
EPQAALGLKGHIEAELGWNCKIPNYLEKVNLD
CCCEECCCCCEEEEECCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MKLSFLGATSTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLT
CEEEEECCCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
HAHIDHSGYLPLLVKQGFKGRIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHP
EEEECCCCCCHHHCCCCCCCEEEEEECHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCCC
ALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAGHILGSAFIQFQTKQIKLLFS
CCCEEECCCCCHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHEEEEEEEEEEEEE
GDIGRLNDPVMKPSELMKSTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
CCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVC
EHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHH
QIATYVHTPNESMAVDWGRESKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAG
HHHHEEECCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEECCHHCC
TRGEKMLNHEPSIKIHGDDYPVRAQVAMLTNASAHADYEEILVWLKHFEKAPKEVFITHG
CCCHHHHCCCCCEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECC
EPQAALGLKGHIEAELGWNCKIPNYLEKVNLD
CCCEECCCCCEEEEECCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA