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The map label for this gene is 148359614

Identifier: 148359614

GI number: 148359614

Start: 2400200

End: 2401147

Strand: Reverse

Name: 148359614

Synonym: LPC_1526

Alternate gene names: NA

Gene position: 2401147-2400200 (Counterclockwise)

Preceding gene: 148359615

Following gene: 148359613

Centisome position: 67.14

GC content: 37.55

Gene sequence:

>948_bases
ATGCATTGGTTTGCTCAGGCACCATCTAATATCGCTTTGATCAAATATATGGGTAAAAAGGATGAAAATTCCAATTTACC
TGATAATTCTTCTCTATCTTACACCTTGAGTAATTTATTAAGTTCCGTGAAATTAGAGAAATTGCCGACTAAAAAAGACA
TTTGGGAGCCACTTAGTATTCCTGGAGCACCAGAATTTAACCTGTCAGTTGAAGCGCAAAAACGGTTTATTGATCATTTA
GTACGATTGAAAGAGTATTTTGGATATGTCGGTGGGTTTTTAATTCAATCCAGTAATAATTTTCCTCATAGTAGCGGTTT
GGCGAGTTCTGCCTCCAGCTTTGCTGCCTTGACAAAGTGTGCATCAATTGCATTAAGTGATCTAACTCAAAAACCTTTGC
CTTCTATTGATGAGCAAGCACAACTGAGTCGATTAGGTTCAGGCTCATCATGCCGTTCTTTTTATGCACCATGGGCGTTA
TGGACCGGCGATAAAGTATCTGCAATCGATTTGCCTTATAAAGATCTATTACACCAAGTCATAGTAATTAGCAGTCAGGA
AAAAGAAATACCATCAAGGGTAGCGCATAAGCTGGTTAAAACAAGTCCTTTTTATGAAACGCGAAGCGAAAGGGCCGAGG
CAAATTTGAAGTTGTTACTGAACGCTTTTGAAAACAAAGATTGGACGAGCATATACCAAATTTGCTGGCATGAATTTCTC
GACATGCATCAATTATTTAAAACCTGTGAAAAACCATTTTCTTACATTACAGATAATACTTTGCATATATTGAGCGTTAT
TGAAAAATTTTGGAACGAGAAAGGTGACGGCCCCGTAGTTACTATGGATGCTGGCCCTAATGTTCATTTGCTTTATAGAT
CAGATCAAACAGATCTCGCACGACAATTTAAATCGGATCATTTGGTAGGAAACTATGATGTTTTATGA

Upstream 100 bases:

>100_bases
ATTGGATAATTCAGGATAAATTACCAGTTCGTTTTCAACTACAATTACATAAAATTTTATGGAATGATGCACCTGGTCAT
TGACCTCAAGGAGACTAACT

Downstream 100 bases:

>100_bases
TTTTGAAACCACCACTTTCGGCAAGTGGATTTTAGCAGGTGAACACGCGGTAGTAAGGGGACATGAAGCTTTAGTATTTC
CTATTAAAGAAAGGCAATTA

Product: mevalonate diphosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MHWFAQAPSNIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKDIWEPLSIPGAPEFNLSVEAQKRFIDHL
VRLKEYFGYVGGFLIQSSNNFPHSSGLASSASSFAALTKCASIALSDLTQKPLPSIDEQAQLSRLGSGSSCRSFYAPWAL
WTGDKVSAIDLPYKDLLHQVIVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQICWHEFL
DMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYRSDQTDLARQFKSDHLVGNYDVL

Sequences:

>Translated_315_residues
MHWFAQAPSNIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKDIWEPLSIPGAPEFNLSVEAQKRFIDHL
VRLKEYFGYVGGFLIQSSNNFPHSSGLASSASSFAALTKCASIALSDLTQKPLPSIDEQAQLSRLGSGSSCRSFYAPWAL
WTGDKVSAIDLPYKDLLHQVIVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQICWHEFL
DMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYRSDQTDLARQFKSDHLVGNYDVL
>Mature_315_residues
MHWFAQAPSNIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKDIWEPLSIPGAPEFNLSVEAQKRFIDHL
VRLKEYFGYVGGFLIQSSNNFPHSSGLASSASSFAALTKCASIALSDLTQKPLPSIDEQAQLSRLGSGSSCRSFYAPWAL
WTGDKVSAIDLPYKDLLHQVIVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQICWHEFL
DMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYRSDQTDLARQFKSDHLVGNYDVL

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=326, Percent_Identity=29.7546012269939, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537201, Length=330, Percent_Identity=23.3333333333333, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324371, Length=317, Percent_Identity=29.9684542586751, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI28571205, Length=307, Percent_Identity=29.6416938110749, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 35538; Mature: 35538

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHWFAQAPSNIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKDIWEPLSI
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCC
PGAPEFNLSVEAQKRFIDHLVRLKEYFGYVGGFLIQSSNNFPHSSGLASSASSFAALTKC
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHH
ASIALSDLTQKPLPSIDEQAQLSRLGSGSSCRSFYAPWALWTGDKVSAIDLPYKDLLHQV
HHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHCCEEEECCCCCEEECCCHHHHHHHH
IVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQICWHEFL
HHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYRSDQTDLA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCHHHHH
RQFKSDHLVGNYDVL
HHHHCCCCCCCCCCC
>Mature Secondary Structure
MHWFAQAPSNIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKDIWEPLSI
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCC
PGAPEFNLSVEAQKRFIDHLVRLKEYFGYVGGFLIQSSNNFPHSSGLASSASSFAALTKC
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHH
ASIALSDLTQKPLPSIDEQAQLSRLGSGSSCRSFYAPWALWTGDKVSAIDLPYKDLLHQV
HHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHCCEEEECCCCCEEECCCHHHHHHHH
IVISSQEKEIPSRVAHKLVKTSPFYETRSERAEANLKLLLNAFENKDWTSIYQICWHEFL
HHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DMHQLFKTCEKPFSYITDNTLHILSVIEKFWNEKGDGPVVTMDAGPNVHLLYRSDQTDLA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCHHHHH
RQFKSDHLVGNYDVL
HHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA