| Definition | Legionella pneumophila str. Corby chromosome, complete genome. |
|---|---|
| Accession | NC_009494 |
| Length | 3,576,470 |
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The map label for this gene is gmk [H]
Identifier: 148359582
GI number: 148359582
Start: 2365120
End: 2365749
Strand: Reverse
Name: gmk [H]
Synonym: LPC_1494
Alternate gene names: 148359582
Gene position: 2365749-2365120 (Counterclockwise)
Preceding gene: 148359583
Following gene: 148359581
Centisome position: 66.15
GC content: 38.41
Gene sequence:
>630_bases ATGGCTAGTGATAATTCAGGAAATTTATATATTGTTGCAGCACCCTCCGGAGGAGGAAAAACAAGTTTGGTGAAAAAACT CATTGAAATGGTGGGTGAGATTGAAGTATCGGTTTCTCATACGACCAGACCTATGAGGCCTGGAGAAAAAGAAGGGGTGG ATTATTTTTTCATTGATGAGGAACAATTTATTTCTATGGTGAATGAGGGGGCGTTTATTGAGCATGCCAAAGTATTTAAC CATTGGTATGGTACCTCAGTTGTTCAAATTAACAAACGGTTACAATTTGGAATTGACGTCGTTCTCGATATTGATTGGCA AGGAGCGGAGCAAATTAGACACGCTTATCCGGATGCAGTGAGTGTATTTATCATTCCTCCTTCTTTAGACGCATTAAATG AACGCTTGATGAACAGGCGACAAGATAAAGATCATGTGATTAGTGAGAGAATGACCAAAGCACAGGATGAACTTGGCCAT TATCCTGAATTTGATTATCTGATTGTTAATGATGATTTTGAAAAGGCGGCAATGGAATTACAGTCGATAGTAATTGCCAA TAGGCTTCGAATTGAAAAACAAGTAAATAAACAAGCCAAATTGCTTTCTTTCCTCTTGTCATCGCAGTAA
Upstream 100 bases:
>100_bases GCTCAAAATCAGATTCAGCAGAGTTAACTTTATGTGCTGTTGAAATGAAAGTATTGATTGAGCAGATGCGCGAACAAATT CAGAATTTTGAGTAAATGAT
Downstream 100 bases:
>100_bases AATAAAAGATTTGAGCTAGTATCTGTTCTAATAACCTGGAGGTGGATTTTATGGCACGAGTAACAGTTGAAGATTGTTTA GAACATGTTAAAAACCGGTT
Product: guanylate kinase
Products: NA
Alternate protein names: GMP kinase [H]
Number of amino acids: Translated: 209; Mature: 208
Protein sequence:
>209_residues MASDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDEEQFISMVNEGAFIEHAKVFN HWYGTSVVQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAVSVFIIPPSLDALNERLMNRRQDKDHVISERMTKAQDELGH YPEFDYLIVNDDFEKAAMELQSIVIANRLRIEKQVNKQAKLLSFLLSSQ
Sequences:
>Translated_209_residues MASDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDEEQFISMVNEGAFIEHAKVFN HWYGTSVVQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAVSVFIIPPSLDALNERLMNRRQDKDHVISERMTKAQDELGH YPEFDYLIVNDDFEKAAMELQSIVIANRLRIEKQVNKQAKLLSFLLSSQ >Mature_208_residues ASDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDEEQFISMVNEGAFIEHAKVFNH WYGTSVVQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAVSVFIIPPSLDALNERLMNRRQDKDHVISERMTKAQDELGHY PEFDYLIVNDDFEKAAMELQSIVIANRLRIEKQVNKQAKLLSFLLSSQ
Specific function: Essential for recycling GMP and indirectly, cGMP [H]
COG id: COG0194
COG function: function code F; Guanylate kinase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 guanylate kinase-like domain [H]
Homologues:
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=36.5714285714286, Blast_Score=115, Evalue=3e-26, Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=36.5714285714286, Blast_Score=115, Evalue=3e-26, Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=36.5714285714286, Blast_Score=115, Evalue=3e-26, Organism=Homo sapiens, GI38570142, Length=189, Percent_Identity=30.1587301587302, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI119943108, Length=151, Percent_Identity=30.4635761589404, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI261862237, Length=151, Percent_Identity=30.4635761589404, Blast_Score=73, Evalue=1e-13, Organism=Homo sapiens, GI119943106, Length=151, Percent_Identity=30.4635761589404, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI111154074, Length=173, Percent_Identity=30.635838150289, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI52630447, Length=200, Percent_Identity=29.5, Blast_Score=71, Evalue=6e-13, Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=24.8677248677249, Blast_Score=69, Evalue=2e-12, Organism=Homo sapiens, GI148539578, Length=153, Percent_Identity=32.0261437908497, Blast_Score=67, Evalue=9e-12, Organism=Homo sapiens, GI148539628, Length=153, Percent_Identity=32.0261437908497, Blast_Score=67, Evalue=9e-12, Organism=Homo sapiens, GI21361598, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=9e-12, Organism=Homo sapiens, GI218156340, Length=141, Percent_Identity=32.6241134751773, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI218156338, Length=141, Percent_Identity=32.6241134751773, Blast_Score=65, Evalue=6e-11, Organism=Homo sapiens, GI91199538, Length=141, Percent_Identity=32.6241134751773, Blast_Score=64, Evalue=7e-11, Organism=Homo sapiens, GI218156270, Length=141, Percent_Identity=32.6241134751773, Blast_Score=64, Evalue=7e-11, Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=50.7389162561576, Blast_Score=213, Evalue=5e-57, Organism=Caenorhabditis elegans, GI193203132, Length=175, Percent_Identity=35.4285714285714, Blast_Score=107, Evalue=4e-24, Organism=Caenorhabditis elegans, GI17508835, Length=175, Percent_Identity=35.4285714285714, Blast_Score=106, Evalue=7e-24, Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=27.0718232044199, Blast_Score=64, Evalue=5e-11, Organism=Caenorhabditis elegans, GI71988041, Length=150, Percent_Identity=26.6666666666667, Blast_Score=64, Evalue=8e-11, Organism=Caenorhabditis elegans, GI71988048, Length=150, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=37.7049180327869, Blast_Score=120, Evalue=1e-28, Organism=Drosophila melanogaster, GI21356141, Length=188, Percent_Identity=33.5106382978723, Blast_Score=102, Evalue=2e-22, Organism=Drosophila melanogaster, GI85724806, Length=174, Percent_Identity=30.4597701149425, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI45554481, Length=174, Percent_Identity=30.4597701149425, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI24640542, Length=188, Percent_Identity=30.3191489361702, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI161077626, Length=188, Percent_Identity=30.3191489361702, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI45554489, Length=188, Percent_Identity=30.3191489361702, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI116007136, Length=174, Percent_Identity=30.4597701149425, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI221330166, Length=125, Percent_Identity=32.8, Blast_Score=72, Evalue=2e-13, Organism=Drosophila melanogaster, GI221330162, Length=125, Percent_Identity=32.8, Blast_Score=72, Evalue=2e-13, Organism=Drosophila melanogaster, GI221330164, Length=125, Percent_Identity=32.8, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI45554813, Length=153, Percent_Identity=32.6797385620915, Blast_Score=70, Evalue=8e-13, Organism=Drosophila melanogaster, GI161077754, Length=153, Percent_Identity=32.6797385620915, Blast_Score=70, Evalue=9e-13, Organism=Drosophila melanogaster, GI45554791, Length=153, Percent_Identity=32.6797385620915, Blast_Score=70, Evalue=9e-13, Organism=Drosophila melanogaster, GI24641280, Length=153, Percent_Identity=32.6797385620915, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI161077752, Length=153, Percent_Identity=32.6797385620915, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI281360700, Length=153, Percent_Identity=32.6797385620915, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24641282, Length=153, Percent_Identity=32.6797385620915, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI45554818, Length=153, Percent_Identity=32.6797385620915, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI45554804, Length=153, Percent_Identity=32.6797385620915, Blast_Score=70, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR008144 - InterPro: IPR008145 - InterPro: IPR020590 - InterPro: IPR017665 [H]
Pfam domain/function: PF00625 Guanylate_kin [H]
EC number: =2.7.4.8 [H]
Molecular weight: Translated: 23729; Mature: 23598
Theoretical pI: Translated: 4.97; Mature: 4.97
Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 3.3 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MASDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDE CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEECH EQFISMVNEGAFIEHAKVFNHWYGTSVVQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAV HHHHHHHHCCCHHHHHHHHHHHCCCHHEEEHHHHHCCEEEEEEECCCCHHHHHHHCCCEE SVFIIPPSLDALNERLMNRRQDKDHVISERMTKAQDELGHYPEFDYLIVNDDFEKAAMEL EEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHH QSIVIANRLRIEKQVNKQAKLLSFLLSSQ HHHHHHHHHHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure ASDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDE CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEECH EQFISMVNEGAFIEHAKVFNHWYGTSVVQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAV HHHHHHHHCCCHHHHHHHHHHHCCCHHEEEHHHHHCCEEEEEEECCCCHHHHHHHCCCEE SVFIIPPSLDALNERLMNRRQDKDHVISERMTKAQDELGHYPEFDYLIVNDDFEKAAMEL EEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHH QSIVIANRLRIEKQVNKQAKLLSFLLSSQ HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA