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The map label for this gene is hisC [H]

Identifier: 148359569

GI number: 148359569

Start: 2352324

End: 2353433

Strand: Direct

Name: hisC [H]

Synonym: LPC_1481

Alternate gene names: 148359569

Gene position: 2352324-2353433 (Clockwise)

Preceding gene: 148359564

Following gene: 148359570

Centisome position: 65.77

GC content: 36.31

Gene sequence:

>1110_bases
ATGTCTATTGATTTTCAACAATTACCTCATGCCGGGATACGTTCTTTAATTCCTTATGTACCAGGTAAATCCATCGAAGA
ATTGGCAAAAGAAAAGGGAATAACTGATATTATCAAGCTGGCTAGTAATGAAAACCCATTGGGATGCAGCCCATTAGCCC
TTTCCGTCATTCAGACTATGTCATCGCATTACATAGCAACCTACCCATCGCCCTGGAACCATCCTTTAATGTCCAAACTT
GCAAGTTACTTAAAAGTAAAACCTGAGCAATTGTTTCTAAGCAATGGGTCTGATTACCTGTTTAATATTTTATTAAATTG
TTTCGCTCTTCATACCGACAGACATATCCTTACTCATGATTACGCTTTTAGCACTTATGCCATCCAAGCCAATTCCCTGC
AAATACCAATAAATAGTGTGCCTATTGGCCACAACTGGGAGGTTAATATCACTGATATCGTTAATGCTTGCAATGAACAA
ACAGGAATTATTTTTATAGCTAACCCAAATAATCCAACTGGGGTGCTAATCCAACAAGAGGAAATTAAATATTTATTGGA
ACAAATTCCGAAAAGTACTTTGTTAGTTTTAGATGAAGCCTATTATGAATTTGCTGCTAGCCAATTGACTGTCAATAGTT
TGGATTGGCTTGAAGAACATCCTAATTTGGTTGTTACTCGTACGTTTTCAAAAATCTATGGTATGGCAGGTTTGCGTTTA
GGTTATGCTATTGCCAACCCATCCATTATTAATATTTTAAAACGAGTACAATTGCCATTTATAGTCAATCAAGTTGCTCT
TGCAGCAGCCTATGCTGCCATCGATGATGATGACTTCATCCAGTCTAGCCTCAAAATGAATAATGAAGGGATGTCGCAGC
TACAGGCGGGCTTTAATGAATTAAACATAAAATACTTACCCTCTTCCTGTAATTTCCTTACTTTTGACTGCGAAGAGGAT
AGTATGGCTCTTTATAATTATCTATTGGATAATGGCATAATAGTAAGGCCTCTACATGCTTATAAGATGAATAATTTCAT
CAGGGTTACTATTGGCACCAAAGAACAAAATTCCAGATTTCTAACAGCACTGAAAAATTTTTATTTGTAA

Upstream 100 bases:

>100_bases
TCAATATAACGATTTATAAATTCTAAAAAATAAATTCATTCGTGACAGCTGGCATATGCTTAGGTAATATAAAAACATTT
TTCTGTCTAGGAATAGAGTT

Downstream 100 bases:

>100_bases
CTCTTTTTAAATTAAAAATAAAATTAAGGAATCAAAATGACTAGTGATTTAAGTAGTAAGCATTGTGAATCTTGTGAGGG
AATTGGTGCTGCGCTCAACT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLALSVIQTMSSHYIATYPSPWNHPLMSKL
ASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDRHILTHDYAFSTYAIQANSLQIPINSVPIGHNWEVNITDIVNACNEQ
TGIIFIANPNNPTGVLIQQEEIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYGMAGLRL
GYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMSQLQAGFNELNIKYLPSSCNFLTFDCEED
SMALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTKEQNSRFLTALKNFYL

Sequences:

>Translated_369_residues
MSIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLALSVIQTMSSHYIATYPSPWNHPLMSKL
ASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDRHILTHDYAFSTYAIQANSLQIPINSVPIGHNWEVNITDIVNACNEQ
TGIIFIANPNNPTGVLIQQEEIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYGMAGLRL
GYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMSQLQAGFNELNIKYLPSSCNFLTFDCEED
SMALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTKEQNSRFLTALKNFYL
>Mature_368_residues
SIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLALSVIQTMSSHYIATYPSPWNHPLMSKLA
SYLKVKPEQLFLSNGSDYLFNILLNCFALHTDRHILTHDYAFSTYAIQANSLQIPINSVPIGHNWEVNITDIVNACNEQT
GIIFIANPNNPTGVLIQQEEIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYGMAGLRLG
YAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMSQLQAGFNELNIKYLPSSCNFLTFDCEEDS
MALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTKEQNSRFLTALKNFYL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=375, Percent_Identity=27.4666666666667, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322075, Length=395, Percent_Identity=23.7974683544304, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41464; Mature: 41333

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLALSVIQTM
CCCCHHHCCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
SSHYIATYPSPWNHPLMSKLASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDRHILTHD
HCCEEEECCCCCCCHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHCCCCEEEEEC
YAFSTYAIQANSLQIPINSVPIGHNWEVNITDIVNACNEQTGIIFIANPNNPTGVLIQQE
CEEEEEEEEECCEEEECCCCCCCCCCEEEHHHHHHCCCCCCCEEEEECCCCCCEEEEEHH
EIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYGMAGLRL
HHHHHHHHCCCCEEEEEHHHHHHHHHHHEEEHHHHHHHHCCCEEEEEEHHHHHCCHHHHE
GYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMSQLQAGFNE
EHEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHCCHHH
LNIKYLPSSCNFLTFDCEEDSMALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTKEQNSRF
CEEEECCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEEHHEECCCEEEEEECCCCCCHHH
LTALKNFYL
HHHHHHHCC
>Mature Secondary Structure 
SIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLALSVIQTM
CCCHHHCCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
SSHYIATYPSPWNHPLMSKLASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDRHILTHD
HCCEEEECCCCCCCHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHCCCCEEEEEC
YAFSTYAIQANSLQIPINSVPIGHNWEVNITDIVNACNEQTGIIFIANPNNPTGVLIQQE
CEEEEEEEEECCEEEECCCCCCCCCCEEEHHHHHHCCCCCCCEEEEECCCCCCEEEEEHH
EIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYGMAGLRL
HHHHHHHHCCCCEEEEEHHHHHHHHHHHEEEHHHHHHHHCCCEEEEEEHHHHHCCHHHHE
GYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMSQLQAGFNE
EHEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHCCHHH
LNIKYLPSSCNFLTFDCEEDSMALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTKEQNSRF
CEEEECCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEEHHEECCCEEEEEECCCCCCHHH
LTALKNFYL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA