| Definition | Legionella pneumophila str. Corby chromosome, complete genome. |
|---|---|
| Accession | NC_009494 |
| Length | 3,576,470 |
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The map label for this gene is cypB [H]
Identifier: 148359529
GI number: 148359529
Start: 2307971
End: 2308537
Strand: Direct
Name: cypB [H]
Synonym: LPC_1440
Alternate gene names: 148359529
Gene position: 2307971-2308537 (Clockwise)
Preceding gene: 148359527
Following gene: 148359536
Centisome position: 64.53
GC content: 39.15
Gene sequence:
>567_bases ATGAATAAAATTATTTGTTTACTCAGCAACTTATTGTTAACAATAGGCATCATGTCGGCGCATGCAGAAACTGCAATTAT TAAAACTTCAGAGGGCAACATAACGTGTGAATTATTTACAAAAGAAGCTCCCAATACCGTTGCAAATTTTGTAGGGCTGG CAACTGGAACAAAAGAATTTAAAGACATAAAAACTGGCAAAATGGTTAAACGCCCTTTTTACAATGGCTTAACCTTTCAT CGTGTGATTGCCGGTTTTATGATTCAAGGAGGAGACCCGCTTGGAAATGGGACCGGTGGGCCAGGTTACACATTTGATAA TGAAAATACTAATGCCAGTTTTAACAAACCTGGCGTACTTGCAATGGCTAATGCAGGCCCCAATACGAATGGCAGCCAAT TTTTTATTACCGTTGCGCCAACACCCGAACTACAAGGCAACTACAATGTTTTTGGTCAAGTAATTTCTGGACAAGAAGTT GTTGACAAGATTAGCAAGATGCCTACTGATCCGCAAGATAAGCCAATAACGCCTGTAGTCATTGAAAACATTACCATTCA AAGATAA
Upstream 100 bases:
>100_bases CCTATCTAATTCAGCTGAAACTCTGAGTTTCATTTAAAAACCATTTTAATACGACATAATACTGTTATACTGATCTTAGC CATTCTATGGAGAGCTTATT
Downstream 100 bases:
>100_bases AAGATCAGTGCCTGTGTCAGATTAGGTCTAAACCAATTCATTAAATATATATTAAAACTCGGAACATGGGTACGTAAGAA CTAGATATACCTAATCCCTT
Product: peptidyl-prolyl cis-trans isomerase
Products: NA
Alternate protein names: PPIase B; Cyclophilin ScCypB; Rotamase B; S-cyclophilin [H]
Number of amino acids: Translated: 188; Mature: 188
Protein sequence:
>188_residues MNKIICLLSNLLLTIGIMSAHAETAIIKTSEGNITCELFTKEAPNTVANFVGLATGTKEFKDIKTGKMVKRPFYNGLTFH RVIAGFMIQGGDPLGNGTGGPGYTFDNENTNASFNKPGVLAMANAGPNTNGSQFFITVAPTPELQGNYNVFGQVISGQEV VDKISKMPTDPQDKPITPVVIENITIQR
Sequences:
>Translated_188_residues MNKIICLLSNLLLTIGIMSAHAETAIIKTSEGNITCELFTKEAPNTVANFVGLATGTKEFKDIKTGKMVKRPFYNGLTFH RVIAGFMIQGGDPLGNGTGGPGYTFDNENTNASFNKPGVLAMANAGPNTNGSQFFITVAPTPELQGNYNVFGQVISGQEV VDKISKMPTDPQDKPITPVVIENITIQR >Mature_188_residues MNKIICLLSNLLLTIGIMSAHAETAIIKTSEGNITCELFTKEAPNTVANFVGLATGTKEFKDIKTGKMVKRPFYNGLTFH RVIAGFMIQGGDPLGNGTGGPGYTFDNENTNASFNKPGVLAMANAGPNTNGSQFFITVAPTPELQGNYNVFGQVISGQEV VDKISKMPTDPQDKPITPVVIENITIQR
Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]
COG id: COG0652
COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PPIase cyclophilin-type domain [H]
Homologues:
Organism=Homo sapiens, GI24308049, Length=171, Percent_Identity=46.1988304093567, Blast_Score=140, Evalue=9e-34, Organism=Homo sapiens, GI42560244, Length=164, Percent_Identity=46.9512195121951, Blast_Score=132, Evalue=2e-31, Organism=Homo sapiens, GI7706339, Length=159, Percent_Identity=44.6540880503145, Blast_Score=132, Evalue=2e-31, Organism=Homo sapiens, GI4758950, Length=156, Percent_Identity=46.7948717948718, Blast_Score=125, Evalue=2e-29, Organism=Homo sapiens, GI19557636, Length=169, Percent_Identity=40.2366863905325, Blast_Score=121, Evalue=5e-28, Organism=Homo sapiens, GI6631100, Length=165, Percent_Identity=41.8181818181818, Blast_Score=118, Evalue=3e-27, Organism=Homo sapiens, GI4505991, Length=156, Percent_Identity=47.4358974358974, Blast_Score=117, Evalue=4e-27, Organism=Homo sapiens, GI5454154, Length=158, Percent_Identity=44.3037974683544, Blast_Score=114, Evalue=5e-26, Organism=Homo sapiens, GI4826932, Length=131, Percent_Identity=49.618320610687, Blast_Score=114, Evalue=6e-26, Organism=Homo sapiens, GI64276486, Length=167, Percent_Identity=35.9281437125749, Blast_Score=111, Evalue=3e-25, Organism=Homo sapiens, GI10863927, Length=140, Percent_Identity=45, Blast_Score=109, Evalue=2e-24, Organism=Homo sapiens, GI5031987, Length=137, Percent_Identity=47.4452554744526, Blast_Score=102, Evalue=2e-22, Organism=Homo sapiens, GI310127646, Length=140, Percent_Identity=42.1428571428571, Blast_Score=101, Evalue=3e-22, Organism=Homo sapiens, GI310114371, Length=140, Percent_Identity=42.1428571428571, Blast_Score=101, Evalue=3e-22, Organism=Homo sapiens, GI310119221, Length=140, Percent_Identity=42.1428571428571, Blast_Score=101, Evalue=3e-22, Organism=Homo sapiens, GI310129267, Length=140, Percent_Identity=42.8571428571429, Blast_Score=101, Evalue=4e-22, Organism=Homo sapiens, GI310120620, Length=140, Percent_Identity=42.8571428571429, Blast_Score=101, Evalue=4e-22, Organism=Homo sapiens, GI256017253, Length=135, Percent_Identity=44.4444444444444, Blast_Score=101, Evalue=4e-22, Organism=Homo sapiens, GI221139811, Length=135, Percent_Identity=44.4444444444444, Blast_Score=101, Evalue=4e-22, Organism=Homo sapiens, GI256017251, Length=135, Percent_Identity=44.4444444444444, Blast_Score=101, Evalue=4e-22, Organism=Homo sapiens, GI169163387, Length=137, Percent_Identity=43.0656934306569, Blast_Score=100, Evalue=5e-22, Organism=Homo sapiens, GI169164185, Length=137, Percent_Identity=43.0656934306569, Blast_Score=100, Evalue=6e-22, Organism=Homo sapiens, GI169163623, Length=137, Percent_Identity=43.0656934306569, Blast_Score=100, Evalue=6e-22, Organism=Homo sapiens, GI209417936, Length=137, Percent_Identity=43.0656934306569, Blast_Score=99, Evalue=2e-21, Organism=Homo sapiens, GI30102944, Length=137, Percent_Identity=43.0656934306569, Blast_Score=99, Evalue=2e-21, Organism=Homo sapiens, GI219842199, Length=137, Percent_Identity=43.0656934306569, Blast_Score=99, Evalue=2e-21, Organism=Homo sapiens, GI310110104, Length=140, Percent_Identity=42.1428571428571, Blast_Score=99, Evalue=2e-21, Organism=Homo sapiens, GI178057341, Length=137, Percent_Identity=43.0656934306569, Blast_Score=99, Evalue=3e-21, Organism=Homo sapiens, GI45439316, Length=139, Percent_Identity=43.1654676258993, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI27735045, Length=149, Percent_Identity=38.9261744966443, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI303305009, Length=141, Percent_Identity=42.5531914893617, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI5174637, Length=156, Percent_Identity=40.3846153846154, Blast_Score=95, Evalue=3e-20, Organism=Homo sapiens, GI169214050, Length=137, Percent_Identity=40.8759124087591, Blast_Score=91, Evalue=5e-19, Organism=Homo sapiens, GI239751853, Length=138, Percent_Identity=40.5797101449275, Blast_Score=91, Evalue=6e-19, Organism=Homo sapiens, GI113428306, Length=138, Percent_Identity=40.5797101449275, Blast_Score=91, Evalue=6e-19, Organism=Homo sapiens, GI310132444, Length=140, Percent_Identity=40, Blast_Score=91, Evalue=9e-19, Organism=Homo sapiens, GI310113152, Length=140, Percent_Identity=40, Blast_Score=91, Evalue=9e-19, Organism=Homo sapiens, GI150418007, Length=137, Percent_Identity=43.0656934306569, Blast_Score=90, Evalue=1e-18, Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=35.7575757575758, Blast_Score=84, Evalue=8e-17, Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=35.7575757575758, Blast_Score=84, Evalue=8e-17, Organism=Homo sapiens, GI22547215, Length=165, Percent_Identity=35.7575757575758, Blast_Score=83, Evalue=1e-16, Organism=Homo sapiens, GI310127745, Length=135, Percent_Identity=40.7407407407407, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI310119290, Length=135, Percent_Identity=40.7407407407407, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI310114540, Length=135, Percent_Identity=40.7407407407407, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI289803023, Length=175, Percent_Identity=32, Blast_Score=82, Evalue=3e-16, Organism=Homo sapiens, GI20911035, Length=173, Percent_Identity=29.4797687861272, Blast_Score=76, Evalue=2e-14, Organism=Homo sapiens, GI14277126, Length=88, Percent_Identity=45.4545454545455, Blast_Score=75, Evalue=3e-14, Organism=Escherichia coli, GI1789763, Length=181, Percent_Identity=38.6740331491713, Blast_Score=86, Evalue=1e-18, Organism=Escherichia coli, GI1786736, Length=173, Percent_Identity=36.4161849710983, Blast_Score=80, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17539496, Length=164, Percent_Identity=43.9024390243902, Blast_Score=132, Evalue=1e-31, Organism=Caenorhabditis elegans, GI17551282, Length=155, Percent_Identity=49.0322580645161, Blast_Score=127, Evalue=3e-30, Organism=Caenorhabditis elegans, GI17551284, Length=155, Percent_Identity=49.0322580645161, Blast_Score=127, Evalue=3e-30, Organism=Caenorhabditis elegans, GI17552784, Length=157, Percent_Identity=42.6751592356688, Blast_Score=121, Evalue=3e-28, Organism=Caenorhabditis elegans, GI17506311, Length=169, Percent_Identity=43.7869822485207, Blast_Score=120, Evalue=5e-28, Organism=Caenorhabditis elegans, GI17552780, Length=156, Percent_Identity=45.5128205128205, Blast_Score=116, Evalue=8e-27, Organism=Caenorhabditis elegans, GI17565860, Length=149, Percent_Identity=46.9798657718121, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17506307, Length=154, Percent_Identity=45.4545454545455, Blast_Score=113, Evalue=7e-26, Organism=Caenorhabditis elegans, GI17566266, Length=137, Percent_Identity=47.4452554744526, Blast_Score=109, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17559074, Length=159, Percent_Identity=42.1383647798742, Blast_Score=107, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17532643, Length=154, Percent_Identity=43.5064935064935, Blast_Score=106, Evalue=6e-24, Organism=Caenorhabditis elegans, GI71980594, Length=168, Percent_Identity=34.5238095238095, Blast_Score=106, Evalue=7e-24, Organism=Caenorhabditis elegans, GI17539498, Length=154, Percent_Identity=42.2077922077922, Blast_Score=102, Evalue=8e-23, Organism=Caenorhabditis elegans, GI17552782, Length=156, Percent_Identity=44.8717948717949, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17532641, Length=158, Percent_Identity=37.3417721518987, Blast_Score=99, Evalue=1e-21, Organism=Caenorhabditis elegans, GI71980590, Length=157, Percent_Identity=34.3949044585987, Blast_Score=99, Evalue=1e-21, Organism=Caenorhabditis elegans, GI71997782, Length=134, Percent_Identity=38.8059701492537, Blast_Score=99, Evalue=1e-21, Organism=Caenorhabditis elegans, GI32563659, Length=173, Percent_Identity=28.3236994219653, Blast_Score=80, Evalue=5e-16, Organism=Caenorhabditis elegans, GI115533296, Length=145, Percent_Identity=33.7931034482759, Blast_Score=68, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6323562, Length=180, Percent_Identity=42.2222222222222, Blast_Score=114, Evalue=8e-27, Organism=Saccharomyces cerevisiae, GI6320359, Length=140, Percent_Identity=45.7142857142857, Blast_Score=114, Evalue=9e-27, Organism=Saccharomyces cerevisiae, GI6320510, Length=154, Percent_Identity=44.1558441558442, Blast_Score=111, Evalue=8e-26, Organism=Saccharomyces cerevisiae, GI6323246, Length=162, Percent_Identity=41.9753086419753, Blast_Score=110, Evalue=2e-25, Organism=Saccharomyces cerevisiae, GI6321848, Length=155, Percent_Identity=43.2258064516129, Blast_Score=103, Evalue=2e-23, Organism=Saccharomyces cerevisiae, GI6322492, Length=194, Percent_Identity=34.020618556701, Blast_Score=92, Evalue=6e-20, Organism=Saccharomyces cerevisiae, GI6319914, Length=152, Percent_Identity=35.5263157894737, Blast_Score=69, Evalue=4e-13, Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=43.3734939759036, Blast_Score=139, Evalue=1e-33, Organism=Drosophila melanogaster, GI24650807, Length=156, Percent_Identity=48.0769230769231, Blast_Score=138, Evalue=2e-33, Organism=Drosophila melanogaster, GI20130249, Length=156, Percent_Identity=45.5128205128205, Blast_Score=114, Evalue=4e-26, Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=35.9756097560976, Blast_Score=113, Evalue=9e-26, Organism=Drosophila melanogaster, GI24586038, Length=163, Percent_Identity=42.3312883435583, Blast_Score=112, Evalue=2e-25, Organism=Drosophila melanogaster, GI19922912, Length=169, Percent_Identity=44.3786982248521, Blast_Score=107, Evalue=4e-24, Organism=Drosophila melanogaster, GI21357249, Length=157, Percent_Identity=36.9426751592357, Blast_Score=105, Evalue=2e-23, Organism=Drosophila melanogaster, GI17136360, Length=162, Percent_Identity=38.2716049382716, Blast_Score=104, Evalue=3e-23, Organism=Drosophila melanogaster, GI45549139, Length=137, Percent_Identity=45.2554744525547, Blast_Score=98, Evalue=3e-21, Organism=Drosophila melanogaster, GI24652460, Length=169, Percent_Identity=33.7278106508876, Blast_Score=98, Evalue=4e-21, Organism=Drosophila melanogaster, GI24664125, Length=158, Percent_Identity=41.7721518987342, Blast_Score=96, Evalue=1e-20, Organism=Drosophila melanogaster, GI21357783, Length=158, Percent_Identity=41.7721518987342, Blast_Score=96, Evalue=1e-20, Organism=Drosophila melanogaster, GI17647301, Length=139, Percent_Identity=43.8848920863309, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI24661775, Length=168, Percent_Identity=36.3095238095238, Blast_Score=90, Evalue=8e-19, Organism=Drosophila melanogaster, GI21355237, Length=168, Percent_Identity=36.3095238095238, Blast_Score=90, Evalue=8e-19, Organism=Drosophila melanogaster, GI24661771, Length=168, Percent_Identity=36.3095238095238, Blast_Score=90, Evalue=8e-19, Organism=Drosophila melanogaster, GI21355677, Length=175, Percent_Identity=29.7142857142857, Blast_Score=81, Evalue=5e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015891 - InterPro: IPR020892 - InterPro: IPR002130 [H]
Pfam domain/function: PF00160 Pro_isomerase [H]
EC number: =5.2.1.8 [H]
Molecular weight: Translated: 20138; Mature: 20138
Theoretical pI: Translated: 7.41; Mature: 7.41
Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNKIICLLSNLLLTIGIMSAHAETAIIKTSEGNITCELFTKEAPNTVANFVGLATGTKEF CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHCCCCCHHH KDIKTGKMVKRPFYNGLTFHRVIAGFMIQGGDPLGNGTGGPGYTFDNENTNASFNKPGVL HHCCCCHHHHCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCEECCCCCCCCCCCCCEE AMANAGPNTNGSQFFITVAPTPELQGNYNVFGQVISGQEVVDKISKMPTDPQDKPITPVV EEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCEEE IENITIQR ECCEEECC >Mature Secondary Structure MNKIICLLSNLLLTIGIMSAHAETAIIKTSEGNITCELFTKEAPNTVANFVGLATGTKEF CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHCCCCCHHH KDIKTGKMVKRPFYNGLTFHRVIAGFMIQGGDPLGNGTGGPGYTFDNENTNASFNKPGVL HHCCCCHHHHCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCEECCCCCCCCCCCCCEE AMANAGPNTNGSQFFITVAPTPELQGNYNVFGQVISGQEVVDKISKMPTDPQDKPITPVV EEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCEEE IENITIQR ECCEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9025285 [H]