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The map label for this gene is odp2 [H]

Identifier: 148359094

GI number: 148359094

Start: 1790308

End: 1791420

Strand: Direct

Name: odp2 [H]

Synonym: LPC_0982

Alternate gene names: 148359094

Gene position: 1790308-1791420 (Clockwise)

Preceding gene: 148359093

Following gene: 148359095

Centisome position: 50.06

GC content: 40.52

Gene sequence:

>1113_bases
ATGAATATTTTTAATCTACCCGATTTAGGTGAAGGTTTACCTGACGCTGAAATTCATGAATGGTTTGTTAAGGAAGGCGA
CACAGTTAAAGCAGATCAACCTTTAGTTTCTATGGAAACGGCAAAAGCAGTTGTTGACGTACCCTGCCCTCAATCAGGCA
CTATCGCAAAACTTTATGGCAAACCAGGTGACGTTATCAAAACAGGTGAGCCTCTTGTAGCGTTTGTTTCAACTACCGAA
AAACCTGCAGATAAAGGCACAGTTGTTGGTAATCTGGAGGAAAGTACTGATGTGTCAGAAGATAATTTTATTATTGGAAG
TCAGCGTTCTTCTCACCGCGTTAAGACAACACCTGCTGTAAGAATGTTAGCAAAAAAATTAGGAGTTGATTTAAGCTCTT
TAAAAGGTAGTGGTGACAATGGTGTTATTACTCGAGAAGATGTTCAAAATCAGGCCAATATCAATTCACAACCACCTGCC
GGGTTTGAGCCCTTGCGAGGTGTTAGGCGAGCCATGCTTAATAGCATGGTACAATCTCATGCAGAAATAGTTCCAGTCAG
TATTTTTGATGAAGCAGATATCCATATTTGGAAACCCAACACAGACATTACTGTTCGTTTAATCCGGGCTATTATCCATG
CGTCAAAAAAGGAACCTGCTCTTAATGCCTGGTTTGATACCAAACATGCCGCACGTAGATGTTTTAAAGAAGTGCATCTT
GGCATTGCCATGGACAATGAGGAAGGTTTATTTGTTCCTGTTATCCATGATGCAGAAAAATATTCCGACAGTGAATTAAG
AAAAATAATTGATGAATTCAAAGAATCGGTTCGTAATCGGGCGGTTAGTGCAGACAAGCTAAAAGGGGCGACAATTACGC
TGTCTAATTTTGGAAAATTTTCAGGACGTTTTGCCAGTCCAATAATTGTTCCTCCAATGGTAGCGATTTTAGCGGTTGGA
AGACTTTATAAAGCTGCCGTAATTAATGATGAGGATAAAATTGAAGCCCACAAAATGCTTCCTTTATCCTTGAGCTTTGA
TCATAGGGCCATTACCGGAGGCGAGGCCACTCGATTCTTAGGTGCCGTTATTGAATCTTTGCAACAAGCATGA

Upstream 100 bases:

>100_bases
CGGGGTATGATACGGTTATGCCTTATTTCCAACTTGAAAAACAGTACATACCTAGCATTGCACGTATTAAAAACACTGTT
ATGAGTATAATGGAGTAATA

Downstream 100 bases:

>100_bases
TTTTAATTTATGTTGGGCTTCGTAAATAACGAGGCCTAACAACAAACAATATTACTACAACTATCTGTCTTTTCTATATA
AAATTAACTGCGAAAAATTT

Product: branched-chain alpha-keto acid dehydrogenase subunit E2

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MNIFNLPDLGEGLPDAEIHEWFVKEGDTVKADQPLVSMETAKAVVDVPCPQSGTIAKLYGKPGDVIKTGEPLVAFVSTTE
KPADKGTVVGNLEESTDVSEDNFIIGSQRSSHRVKTTPAVRMLAKKLGVDLSSLKGSGDNGVITREDVQNQANINSQPPA
GFEPLRGVRRAMLNSMVQSHAEIVPVSIFDEADIHIWKPNTDITVRLIRAIIHASKKEPALNAWFDTKHAARRCFKEVHL
GIAMDNEEGLFVPVIHDAEKYSDSELRKIIDEFKESVRNRAVSADKLKGATITLSNFGKFSGRFASPIIVPPMVAILAVG
RLYKAAVINDEDKIEAHKMLPLSLSFDHRAITGGEATRFLGAVIESLQQA

Sequences:

>Translated_370_residues
MNIFNLPDLGEGLPDAEIHEWFVKEGDTVKADQPLVSMETAKAVVDVPCPQSGTIAKLYGKPGDVIKTGEPLVAFVSTTE
KPADKGTVVGNLEESTDVSEDNFIIGSQRSSHRVKTTPAVRMLAKKLGVDLSSLKGSGDNGVITREDVQNQANINSQPPA
GFEPLRGVRRAMLNSMVQSHAEIVPVSIFDEADIHIWKPNTDITVRLIRAIIHASKKEPALNAWFDTKHAARRCFKEVHL
GIAMDNEEGLFVPVIHDAEKYSDSELRKIIDEFKESVRNRAVSADKLKGATITLSNFGKFSGRFASPIIVPPMVAILAVG
RLYKAAVINDEDKIEAHKMLPLSLSFDHRAITGGEATRFLGAVIESLQQA
>Mature_370_residues
MNIFNLPDLGEGLPDAEIHEWFVKEGDTVKADQPLVSMETAKAVVDVPCPQSGTIAKLYGKPGDVIKTGEPLVAFVSTTE
KPADKGTVVGNLEESTDVSEDNFIIGSQRSSHRVKTTPAVRMLAKKLGVDLSSLKGSGDNGVITREDVQNQANINSQPPA
GFEPLRGVRRAMLNSMVQSHAEIVPVSIFDEADIHIWKPNTDITVRLIRAIIHASKKEPALNAWFDTKHAARRCFKEVHL
GIAMDNEEGLFVPVIHDAEKYSDSELRKIIDEFKESVRNRAVSADKLKGATITLSNFGKFSGRFASPIIVPPMVAILAVG
RLYKAAVINDEDKIEAHKMLPLSLSFDHRAITGGEATRFLGAVIESLQQA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI110671329, Length=406, Percent_Identity=29.3103448275862, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI19923748, Length=156, Percent_Identity=32.6923076923077, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI31711992, Length=425, Percent_Identity=23.5294117647059, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI203098753, Length=437, Percent_Identity=21.2814645308924, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI203098816, Length=437, Percent_Identity=21.2814645308924, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1786305, Length=416, Percent_Identity=26.9230769230769, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786946, Length=406, Percent_Identity=24.8768472906404, Blast_Score=118, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17537937, Length=398, Percent_Identity=26.8844221105528, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI25146366, Length=154, Percent_Identity=30.5194805194805, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560088, Length=429, Percent_Identity=23.3100233100233, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320352, Length=395, Percent_Identity=25.3164556962025, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324258, Length=166, Percent_Identity=28.9156626506024, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859875, Length=407, Percent_Identity=28.5012285012285, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24582497, Length=158, Percent_Identity=31.6455696202532, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI20129315, Length=158, Percent_Identity=31.6455696202532, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24645909, Length=153, Percent_Identity=30.718954248366, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 912 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 40366; Mature: 40366

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFNLPDLGEGLPDAEIHEWFVKEGDTVKADQPLVSMETAKAVVDVPCPQSGTIAKLYG
CCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHEEECCCCCCCCEEEECC
KPGDVIKTGEPLVAFVSTTEKPADKGTVVGNLEESTDVSEDNFIIGSQRSSHRVKTTPAV
CCCCEEECCCCEEEEEECCCCCCCCCCEEECCHHCCCCCCCCEEEECCCCCCCEECCHHH
RMLAKKLGVDLSSLKGSGDNGVITREDVQNQANINSQPPAGFEPLRGVRRAMLNSMVQSH
HHHHHHHCCCHHHHCCCCCCCCEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AEIVPVSIFDEADIHIWKPNTDITVRLIRAIIHASKKEPALNAWFDTKHAARRCFKEVHL
HCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHC
GIAMDNEEGLFVPVIHDAEKYSDSELRKIIDEFKESVRNRAVSADKLKGATITLSNFGKF
CEEEECCCCEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEECCCCCC
SGRFASPIIVPPMVAILAVGRLYKAAVINDEDKIEAHKMLPLSLSFDHRAITGGEATRFL
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEEECCCCCEECCCHHHHHH
GAVIESLQQA
HHHHHHHHCC
>Mature Secondary Structure
MNIFNLPDLGEGLPDAEIHEWFVKEGDTVKADQPLVSMETAKAVVDVPCPQSGTIAKLYG
CCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHEEECCCCCCCCEEEECC
KPGDVIKTGEPLVAFVSTTEKPADKGTVVGNLEESTDVSEDNFIIGSQRSSHRVKTTPAV
CCCCEEECCCCEEEEEECCCCCCCCCCEEECCHHCCCCCCCCEEEECCCCCCCEECCHHH
RMLAKKLGVDLSSLKGSGDNGVITREDVQNQANINSQPPAGFEPLRGVRRAMLNSMVQSH
HHHHHHHCCCHHHHCCCCCCCCEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AEIVPVSIFDEADIHIWKPNTDITVRLIRAIIHASKKEPALNAWFDTKHAARRCFKEVHL
HCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHC
GIAMDNEEGLFVPVIHDAEKYSDSELRKIIDEFKESVRNRAVSADKLKGATITLSNFGKF
CEEEECCCCEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEECCCCCC
SGRFASPIIVPPMVAILAVGRLYKAAVINDEDKIEAHKMLPLSLSFDHRAITGGEATRFL
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEEECCCCCEECCCHHHHHH
GAVIESLQQA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA