Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 148359073

GI number: 148359073

Start: 1770932

End: 1771357

Strand: Direct

Name: folK [H]

Synonym: LPC_0960

Alternate gene names: 148359073

Gene position: 1770932-1771357 (Clockwise)

Preceding gene: 148359072

Following gene: 148359074

Centisome position: 49.52

GC content: 35.92

Gene sequence:

>426_bases
ATGAATGTTTGCTATCTGAGCTTGGGATCGAATCAAAAAAATCCTGAGCGCCAAATAAGACAAGCCATTAAAGAAATCAA
ACAGATTCCATCAACATGCCTTATCAAGGCGTCTCGCTTATATTGGAATAAGGCCTGGGGCTTTGAAAATCAACAGGAAT
TTTGTAATGTCGTTATAGAGATACAAACTACTCTGTTACCCCATAAGCTCCTTAAGTGGTGCCAGAAAATAGAAAACAGG
CACAAGCGAGTCAGGAGAAAGTTTTGGGGGCCAAGAACATTAGATATTGATATCATTTTATATGGCTATAGATTAATTCG
CACAAAAAACTTAATCGTTCCACATCCTTGTTTCCATTTACGAGATTTTGTTCTTGTTCCTCTAAGAGAATTAAACTCTA
ATTTAAAAATACCAAATTACACATAG

Upstream 100 bases:

>100_bases
TTCAAGAGGTCGATGATGTTGAAAAAAATAACATGGTAACCCAATTGGCTGCAACAACGCCCGGGCGGCCTAAAAAACGT
CGTAAACGGAAAATAGCAAA

Downstream 100 bases:

>100_bases
ATATCATAATCTACTACACTATAACTTAATGATTCTATTTAAAATGAGGTTAACATGTATACAAATATTTTATTTGCCAC
AGATTTGTTAAATGAACATA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKASRLYWNKAWGFENQQEFCNVVIEIQTTLLPHKLLKWCQKIENR
HKRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHLRDFVLVPLRELNSNLKIPNYT

Sequences:

>Translated_141_residues
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKASRLYWNKAWGFENQQEFCNVVIEIQTTLLPHKLLKWCQKIENR
HKRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHLRDFVLVPLRELNSNLKIPNYT
>Mature_141_residues
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKASRLYWNKAWGFENQQEFCNVVIEIQTTLLPHKLLKWCQKIENR
HKRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHLRDFVLVPLRELNSNLKIPNYT

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=140, Percent_Identity=37.8571428571429, Blast_Score=109, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=34.5588235294118, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 16914; Mature: 16914

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKASRLYWNKAWGFENQQEFCNVVIE
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IQTTLLPHKLLKWCQKIENRHKRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHEEHHHHHHCCCCCCCCCHHHH
RDFVLVPLRELNSNLKIPNYT
HHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKASRLYWNKAWGFENQQEFCNVVIE
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IQTTLLPHKLLKWCQKIENRHKRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHEEHHHHHHCCCCCCCCCHHHH
RDFVLVPLRELNSNLKIPNYT
HHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]