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The map label for this gene is fabG [C]

Identifier: 148359033

GI number: 148359033

Start: 1724125

End: 1724826

Strand: Reverse

Name: fabG [C]

Synonym: LPC_0919

Alternate gene names: 148359033

Gene position: 1724826-1724125 (Counterclockwise)

Preceding gene: 148359034

Following gene: 148359032

Centisome position: 48.23

GC content: 36.04

Gene sequence:

>702_bases
TTGCAAAAAGTTAAAAGATCAATTATTTTGATTTTACAAGCCACGGATAGAGAATTTAAATTGAAGACTCTCGTCATAAC
AGGAATCAGTAGAGGGATAGGCCTGGAAATTGCTAGAATTTTCCTTGACAAAGACTGGACGGTTATTGGTACTTCCACCA
GCGGATATTCTCCTATAAAACATAAAAACCTGCGCACATACAAGTTAGACCTAGCCATTTCGGAGCACATCGATGCATTT
GCAAAAAATTTACCTAAAATTGATGTACTGATTAATAATGCCGCCGTGTTGCTTGAAGAGTGGAATGAAGAAAAAATTAA
TATGTCCTTATTGAAAAAAACCTTTGCAATTAACCTGTTTGGTACAGTTGAGTTAACTGAAAAATGTATCCCCAAGTTCA
ATGATGGTGCACAAATCATTAATATCTCTTCAGGGTGGGGAGCATTTAGTTCCAATAATTCCCCCTTTCAACCACATTAT
AAAATGTCAAAAGTCAGTTTGAATATGTATACTAAATTGCTTGCAGAGAGACTTCCCCAAATAACTGTATCCAGTTTTGA
TCCAGGTTGGGTTAAAACAAACATGGGAACACAAAATGCAAAAAAACTTCCCAGTGAAACGGCACTGGAAATCTATGAGC
TGATTAGTATGAAGAAAAAAAGCGGCTATTTTTGGTTTAATGGAAAACCTAGGGATTGGTAG

Upstream 100 bases:

>100_bases
AGGTAAAAAACGTTTTTTAGGAGGGAATTTAGATAAACTAAATGATTGAATTATAAATATTTTTTAACAAAGAGATTGAG
TTTTTTTGTGAGTCCTGTTT

Downstream 100 bases:

>100_bases
CTAGTTAAATTTCAGTTATTCTCAACTATAAAATAAAGAATCAAAGGAGTGACAAACGTGAGTTTCGATTTTATAAAATC
AATATGGATTGCAGCTCTTA

Product: short chain dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: Short Chain Dehydrogenase; Oxidoreductase Short Chain Dehydrogenase/Reductase Family; Dehydrogenase; Short-Chain Dehydrogenase/Reductase; Short Chain Oxidoreductase; Short-Chain Dehydrogenase; Short Chain Dehydrogenase/Reductase Family Oxidoreductase; Short-Chain Dehydrogenase/Reductase Sdr; Short Chain Dehydrogenase Family Protein; Short-Chain Dehydrogenase/Reductase Family Protein; 3-Ketoacyl-(Acyl-Carrier-Protein) Reductase; Oxidoreductase; Short-Chain Type Dehydrogenase; 3-Oxoacyl-[Acyl-Carrier Protein] Reductase; Short-Chain Dehydrogenase/Reductase Superfamily Protein; Oxidoreductase Protein; 3-Oxoacyl-[Acyl-Carrier-Protein] Reductase; Carbonyl Reductase; Short-Chain Dehydrogenase Oxidoreductase; 2-Hydroxycyclohexanecarboxyl-CoA Dehydrogenase; CsgA Protein; C-Signal Protein; C-Factor Protein; NADPH-Dependent Carbonyl Reductase; KR Domain Superfamily; Short Chain Dehydrogenase/Oxidoreductase; Dehydrogenase Protein; Short-Chain Dehydrogenase/Reductase Family Oxidoreductase; SDR Family Dehydrogenase/Reductase; Short-Chain Alcohol Dehydrogenase; Retinol Dehydrogenase; Short-Chain Alcohol Dehydrogenase-Like Protein; Cis-2 3-Dihydrobiphenyl-2 3-Diol Dehydrogenase; Short-Chain Dehydrogenase/Reductase SDR Family; Estradiol; Short-Chain Dehydrogenase/Reductase Superfamily; 20-Beta-Hydroxysteroid Dehydrogenase; Oxidoreductase Short-Chain Dehydrogenase/Reductase Family; Short-Chain Alcohol Dehydrogenase Like Protein; Short-Chain Dehydrogenase Family Protein; Oxidoreductase Short Chain Dehydrogenase/Reductase; Gluconate 5-Dehydrogenase; Short Chanin Dehydrogenase/ Reductase; Oxidoreductase Short-Chain Dehydrogenase; 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MQKVKRSIILILQATDREFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAF
AKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLFGTVELTEKCIPKFNDGAQIINISSGWGAFSSNNSPFQPHY
KMSKVSLNMYTKLLAERLPQITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW

Sequences:

>Translated_233_residues
MQKVKRSIILILQATDREFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAF
AKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLFGTVELTEKCIPKFNDGAQIINISSGWGAFSSNNSPFQPHY
KMSKVSLNMYTKLLAERLPQITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW
>Mature_233_residues
MQKVKRSIILILQATDREFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAF
AKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLFGTVELTEKCIPKFNDGAQIINISSGWGAFSSNNSPFQPHY
KMSKVSLNMYTKLLAERLPQITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI17558994, Length=244, Percent_Identity=28.2786885245902, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559962, Length=212, Percent_Identity=31.1320754716981, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17559964, Length=210, Percent_Identity=32.3809523809524, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17558990, Length=211, Percent_Identity=27.4881516587678, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI72001658, Length=211, Percent_Identity=29.3838862559242, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=233, Percent_Identity=27.4678111587983, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193207563, Length=243, Percent_Identity=25.5144032921811, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558992, Length=246, Percent_Identity=27.2357723577236, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=233, Percent_Identity=27.0386266094421, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=236, Percent_Identity=27.5423728813559, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532177, Length=213, Percent_Identity=30.9859154929577, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=238, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558996, Length=240, Percent_Identity=28.3333333333333, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322226, Length=195, Percent_Identity=29.7435897435897, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640547, Length=251, Percent_Identity=28.2868525896414, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24643142, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26449; Mature: 26449

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVKRSIILILQATDREFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIK
CCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCCCCCC
HKNLRTYKLDLAISEHIDAFAKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLF
CCCCEEEEEEEEHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHEEEEE
GTVELTEKCIPKFNDGAQIINISSGWGAFSSNNSPFQPHYKMSKVSLNMYTKLLAERLPQ
EEEEEHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
ITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW
EEEECCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure
MQKVKRSIILILQATDREFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIK
CCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCCCCCC
HKNLRTYKLDLAISEHIDAFAKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLF
CCCCEEEEEEEEHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHEEEEE
GTVELTEKCIPKFNDGAQIINISSGWGAFSSNNSPFQPHYKMSKVSLNMYTKLLAERLPQ
EEEEEHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
ITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW
EEEECCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA