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The map label for this gene is cyaA [H]

Identifier: 148359020

GI number: 148359020

Start: 1711571

End: 1712896

Strand: Direct

Name: cyaA [H]

Synonym: LPC_0906

Alternate gene names: 148359020

Gene position: 1711571-1712896 (Clockwise)

Preceding gene: 148359019

Following gene: 148359021

Centisome position: 47.86

GC content: 37.41

Gene sequence:

>1326_bases
ATGAGCGCATTGTACTATAATCTTAATAACCACTATGTCTTTCATTTTATTTATTCACCTGAGAAAAGAGCCAATCGTGA
TAACAATCCTGAGAAAATTATGAAGAAACCTTTGGATACTACTGAGCAGAATCGCATTGCTGCGCTATACGAATTGAAAA
TTCTGGATACACCAGCAGATGAAAGATTTGATCGAATTATCCGACTCACTTCGGGTTACTTATCTGTTCCTATTGCTTTT
ATTTCTTTTATTGATTCTAAACACCAATGGTTCAAATCCAGCTGTGGCATAGGTCTTAACAAAATATCCCGGAATGATTC
ATTTTGCCACTACACTATTCAGCAAAATAAACCGATGATTATTCCTGATGCCTTGTTGGATGAGCGATTTTGTAATAATC
CTTATGTGACTAATTCACCAAATATTCGTTTTTACGCAGGATTTCCGTTATCAACATTTGATGGTTTTAACGTAGGAACA
CTATGCGCAATAGATAAAAAACCACGTAATTTAGATGAGACTGAAATTCAAATTTTAAAAGATTTGGCAACTTTGGCAGA
AGATCAAGTCAACCTGCTGGATATTTCGCTTCTTGAGAAGACTGTACGAGAAAAAAATATTTCTCTGACAAAAGCAAAGA
AAGAACTCGAAATGCGTAATAATTTTATTCGTAAAGTATTTGGCAGCTTTATGTCTGACGAGATTGTTGCAGCGCTTCTT
GAATCAAAATCAAAGTTAAAATTAGGGGGGGAGGAGCGCAAAATTACAATTTTGTTTAGCGACTTAAGAAATTTTACTAC
TCTGTCGGAGCATTTTCCTGCGGATAAAATTGTCGCTGCACTTAATAATCATTATGGAAAAATGGTTGATGTCATAGAAA
AATACAATGGTACTGTTGATTCCTTTATTGGTGACGCCATTATGGTGGTATTTGGAGCACCACACTCCGGAGGAGATGAC
GCATACAGAGCGATAGCCTGTGCATTAGAGATGCAGGCGACCATGCAAGAGGTGAACACAATAAATCGCAACAGCAGTTT
ACCCGAATTGGCAATGGGCATAGGGATTAATACAGGTTATGCTATTGTAGGTAACATTGGTTCTCAGAAACGTATGCAAT
ACAGCGCGATTGGTTCTCCGGTTAATCTGGCATCACGTATCCAAGAGCTGACTTTGGGGGGGCAAATTTTAATTTCTGAG
GCAACTTACCAGGAAGTTAATCATTCGCTTGAGTTAAATGGGCATCTCAGAGTAAAAGTTAAGGGAGTTGCTGCTCCTAT
CACTATTTATGATGTAATCGGTTTGAATAAAAAATCAGATTCATAG

Upstream 100 bases:

>100_bases
ATCCCCTCCATAACAAGCGTTAGCCACATACAAGTAACTCATCAACTTTATTTCCATTGCTGAATACAATTAACTTATTC
GTTGTTTTAAGCCAATTAAT

Downstream 100 bases:

>100_bases
AAGTAATAATATCACTCTTTAAAATCATGGGATCAAGAAATTGCTTAAATTACCAATCTCAATGGTATTATGATTGAAAT
AAGCAGCCTAAGGGATAGAT

Product: fused adenylate cyclase/two component hybrid sensor/regulator

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSALYYNLNNHYVFHFIYSPEKRANRDNNPEKIMKKPLDTTEQNRIAALYELKILDTPADERFDRIIRLTSGYLSVPIAF
ISFIDSKHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMIIPDALLDERFCNNPYVTNSPNIRFYAGFPLSTFDGFNVGT
LCAIDKKPRNLDETEIQILKDLATLAEDQVNLLDISLLEKTVREKNISLTKAKKELEMRNNFIRKVFGSFMSDEIVAALL
ESKSKLKLGGEERKITILFSDLRNFTTLSEHFPADKIVAALNNHYGKMVDVIEKYNGTVDSFIGDAIMVVFGAPHSGGDD
AYRAIACALEMQATMQEVNTINRNSSLPELAMGIGINTGYAIVGNIGSQKRMQYSAIGSPVNLASRIQELTLGGQILISE
ATYQEVNHSLELNGHLRVKVKGVAAPITIYDVIGLNKKSDS

Sequences:

>Translated_441_residues
MSALYYNLNNHYVFHFIYSPEKRANRDNNPEKIMKKPLDTTEQNRIAALYELKILDTPADERFDRIIRLTSGYLSVPIAF
ISFIDSKHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMIIPDALLDERFCNNPYVTNSPNIRFYAGFPLSTFDGFNVGT
LCAIDKKPRNLDETEIQILKDLATLAEDQVNLLDISLLEKTVREKNISLTKAKKELEMRNNFIRKVFGSFMSDEIVAALL
ESKSKLKLGGEERKITILFSDLRNFTTLSEHFPADKIVAALNNHYGKMVDVIEKYNGTVDSFIGDAIMVVFGAPHSGGDD
AYRAIACALEMQATMQEVNTINRNSSLPELAMGIGINTGYAIVGNIGSQKRMQYSAIGSPVNLASRIQELTLGGQILISE
ATYQEVNHSLELNGHLRVKVKGVAAPITIYDVIGLNKKSDS
>Mature_440_residues
SALYYNLNNHYVFHFIYSPEKRANRDNNPEKIMKKPLDTTEQNRIAALYELKILDTPADERFDRIIRLTSGYLSVPIAFI
SFIDSKHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMIIPDALLDERFCNNPYVTNSPNIRFYAGFPLSTFDGFNVGTL
CAIDKKPRNLDETEIQILKDLATLAEDQVNLLDISLLEKTVREKNISLTKAKKELEMRNNFIRKVFGSFMSDEIVAALLE
SKSKLKLGGEERKITILFSDLRNFTTLSEHFPADKIVAALNNHYGKMVDVIEKYNGTVDSFIGDAIMVVFGAPHSGGDDA
YRAIACALEMQATMQEVNTINRNSSLPELAMGIGINTGYAIVGNIGSQKRMQYSAIGSPVNLASRIQELTLGGQILISEA
TYQEVNHSLELNGHLRVKVKGVAAPITIYDVIGLNKKSDS

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI50959205, Length=159, Percent_Identity=27.6729559748428, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI148536830, Length=148, Percent_Identity=27.7027027027027, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4557255, Length=167, Percent_Identity=28.7425149700599, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551720, Length=281, Percent_Identity=26.6903914590747, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71989822, Length=180, Percent_Identity=32.7777777777778, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71989805, Length=180, Percent_Identity=32.7777777777778, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193206632, Length=194, Percent_Identity=30.9278350515464, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212645052, Length=260, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561802, Length=248, Percent_Identity=28.6290322580645, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71995305, Length=237, Percent_Identity=29.1139240506329, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17534655, Length=295, Percent_Identity=26.1016949152542, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561800, Length=255, Percent_Identity=27.0588235294118, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71995893, Length=233, Percent_Identity=23.6051502145923, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71995895, Length=233, Percent_Identity=23.6051502145923, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17534659, Length=237, Percent_Identity=28.6919831223629, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193207841, Length=300, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI221330468, Length=259, Percent_Identity=28.957528957529, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221330470, Length=259, Percent_Identity=28.957528957529, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI62484298, Length=170, Percent_Identity=30, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI62484477, Length=170, Percent_Identity=30, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI116008008, Length=171, Percent_Identity=29.8245614035088, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574512, Length=151, Percent_Identity=34.4370860927152, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161076872, Length=151, Percent_Identity=34.4370860927152, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583978, Length=153, Percent_Identity=30.0653594771242, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161078020, Length=245, Percent_Identity=27.3469387755102, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583976, Length=153, Percent_Identity=28.1045751633987, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585694, Length=184, Percent_Identity=24.4565217391304, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 49411; Mature: 49280

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALYYNLNNHYVFHFIYSPEKRANRDNNPEKIMKKPLDTTEQNRIAALYELKILDTPAD
CCEEEEECCCEEEEEEEECCHHHCCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEECCCCH
ERFDRIIRLTSGYLSVPIAFISFIDSKHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEECCCCEE
IPDALLDERFCNNPYVTNSPNIRFYAGFPLSTFDGFNVGTLCAIDKKPRNLDETEIQILK
CCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
DLATLAEDQVNLLDISLLEKTVREKNISLTKAKKELEMRNNFIRKVFGSFMSDEIVAALL
HHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESKSKLKLGGEERKITILFSDLRNFTTLSEHFPADKIVAALNNHYGKMVDVIEKYNGTVD
HCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
SFIGDAIMVVFGAPHSGGDDAYRAIACALEMQATMQEVNTINRNSSLPELAMGIGINTGY
HHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCE
AIVGNIGSQKRMQYSAIGSPVNLASRIQELTLGGQILISEATYQEVNHSLELNGHLRVKV
EEEECCCCCHHEEHHHCCCCHHHHHHHHHHCCCCEEEEECHHHHHCCCEEEECCEEEEEE
KGVAAPITIYDVIGLNKKSDS
ECEECCEEEEEEECCCCCCCC
>Mature Secondary Structure 
SALYYNLNNHYVFHFIYSPEKRANRDNNPEKIMKKPLDTTEQNRIAALYELKILDTPAD
CEEEEECCCEEEEEEEECCHHHCCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEECCCCH
ERFDRIIRLTSGYLSVPIAFISFIDSKHQWFKSSCGIGLNKISRNDSFCHYTIQQNKPMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEECCCCEE
IPDALLDERFCNNPYVTNSPNIRFYAGFPLSTFDGFNVGTLCAIDKKPRNLDETEIQILK
CCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
DLATLAEDQVNLLDISLLEKTVREKNISLTKAKKELEMRNNFIRKVFGSFMSDEIVAALL
HHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESKSKLKLGGEERKITILFSDLRNFTTLSEHFPADKIVAALNNHYGKMVDVIEKYNGTVD
HCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
SFIGDAIMVVFGAPHSGGDDAYRAIACALEMQATMQEVNTINRNSSLPELAMGIGINTGY
HHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCE
AIVGNIGSQKRMQYSAIGSPVNLASRIQELTLGGQILISEATYQEVNHSLELNGHLRVKV
EEEECCCCCHHEEHHHCCCCHHHHHHHHHHCCCCEEEEECHHHHHCCCEEEECCEEEEEE
KGVAAPITIYDVIGLNKKSDS
ECEECCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]