Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 148359000

GI number: 148359000

Start: 1686915

End: 1688291

Strand: Reverse

Name: bioA [H]

Synonym: LPC_0885

Alternate gene names: 148359000

Gene position: 1688291-1686915 (Counterclockwise)

Preceding gene: 148359010

Following gene: 148358999

Centisome position: 47.21

GC content: 38.71

Gene sequence:

>1377_bases
ATGATAAAGTCGCGCCTATACTTGTCAACCAAAATTTTTAAAATGGTAAACACAGATCAACTTATTGCAAAAGACTTAAA
GCACATTTGGCATCCTTGTTCACAAATGAAAGATTTCGAAACATTCCCCCCTATCGTTGTCAACAAAGCACAAGGTAGCT
ATCTCTATACCAATAAGGGCCCCGTGATTGATGCAATTTCCAGTTGGTGGTGCAAATCATTAGGGCATGGTCATCCAGCA
GTGATAGCTGCTATCAAGAACCAACTGGACTGTTTTGAGCATGTGATTAGTGCCAATACAACTCATCCTGCTGCAGTGGA
ATTAGCTGAAAAATTAAGCGAAATTACAGGAAAACAGCATGTGTTTTTTGCCAGTGATGGTTCCAGTGCTGTTGAAATTG
CCATGAAATTAGCTATTCATGCTTCACAAATAAAAGGGCACAAAAATAAAAACCAATTCATTGCCTTAAAAAATGGCTAC
CACGGAGAAACTATTGGCACCATGAGTGTCAGTGATTTGGGACTCTATAAGGCTCCCTATGCATCGTTTGGCGTGCAATG
CCATTACATCGATGATATTCCCTATGTCTCAGGCTTTAAGGATCCCTTATGGACAGATTGCGATGCTTATTGGAATAAAG
TCGTACAACAATTGAATAAAATTTGCGATAAAGTTTGTGCGATACTTCTGGAGCCTATCATTCAGGGTGCTGGAGGTATG
CTATGTTACAGTGCAGATTTTCTCTCGAAAATCTCGTCATGGGCTAAGGAAAAAGGCATTTATTTAATTGCTGATGAGAT
TATGACTGGTATAGGCAGAACTGGAGAATGGCTAGCCTGTGATCATGCAAGGGTACAACCTGATCTGATTTGTCTATCTA
AAGGATTAACTTCCGGCTCAATACCATTTAGCTGTGTCATGATTGACAGTACCTTATTTGATCTTTTTTATGATGATTAC
CATACAGGGAAATCTTTTTTGCACTCACATACCTATAGCGGTAATCCACTTGCTATAGTCGCTGCTTTAGCAACTATTAA
AACAATAGAACAAGATAATTTACTGATGCATAGTCAGGAACTTGGTAAAATCATGTTTTCCTATCTGCAGGATATAGCAA
GGGACAGTAGAAAACTTGTAAATGTTCGTGGTGTTGGAGCAGTTGTTGCAGCTGACCTCATAGAGGGCAGCCAAGCAAGA
ATTGGATTTAAAATTTATCAGGAAGCAATAAAACAAGGCGCACTGATTCGCCCAATTGGAAATACTCTCTATTGGTTACC
ACCTCTTAACACAGATAAAAAAATTATTGGGAAATTAGCAGAAATCACATTAAACTCTATAGAAGAAGCCTATAACAAAG
CTCAAGGATATGAGTAA

Upstream 100 bases:

>100_bases
AATCATTAAATGGTTGTTGATAAATTGCTTCAATATCAGAAATTGACCACTGTTTATTTTCTTCAGACACGGCTACCCCC
TTTAATTCAGAATAGTGAAC

Downstream 100 bases:

>100_bases
GGTTATTCACAAATTATCTTTATTTCTTTTTAAAAAATTTAAAATCATATGGATTCTCTTAACTATTGGTATCCTGATTT
CAGCTTTTTACGCTAATTGG

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MIKSRLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSLGHGHPA
VIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGKQHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGY
HGETIGTMSVSDLGLYKAPYASFGVQCHYIDDIPYVSGFKDPLWTDCDAYWNKVVQQLNKICDKVCAILLEPIIQGAGGM
LCYSADFLSKISSWAKEKGIYLIADEIMTGIGRTGEWLACDHARVQPDLICLSKGLTSGSIPFSCVMIDSTLFDLFYDDY
HTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADLIEGSQAR
IGFKIYQEAIKQGALIRPIGNTLYWLPPLNTDKKIIGKLAEITLNSIEEAYNKAQGYE

Sequences:

>Translated_458_residues
MIKSRLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSLGHGHPA
VIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGKQHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGY
HGETIGTMSVSDLGLYKAPYASFGVQCHYIDDIPYVSGFKDPLWTDCDAYWNKVVQQLNKICDKVCAILLEPIIQGAGGM
LCYSADFLSKISSWAKEKGIYLIADEIMTGIGRTGEWLACDHARVQPDLICLSKGLTSGSIPFSCVMIDSTLFDLFYDDY
HTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADLIEGSQAR
IGFKIYQEAIKQGALIRPIGNTLYWLPPLNTDKKIIGKLAEITLNSIEEAYNKAQGYE
>Mature_458_residues
MIKSRLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSLGHGHPA
VIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGKQHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGY
HGETIGTMSVSDLGLYKAPYASFGVQCHYIDDIPYVSGFKDPLWTDCDAYWNKVVQQLNKICDKVCAILLEPIIQGAGGM
LCYSADFLSKISSWAKEKGIYLIADEIMTGIGRTGEWLACDHARVQPDLICLSKGLTSGSIPFSCVMIDSTLFDLFYDDY
HTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADLIEGSQAR
IGFKIYQEAIKQGALIRPIGNTLYWLPPLNTDKKIIGKLAEITLNSIEEAYNKAQGYE

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=420, Percent_Identity=28.0952380952381, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI13994255, Length=378, Percent_Identity=26.7195767195767, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI24119277, Length=439, Percent_Identity=26.6514806378132, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI284507298, Length=304, Percent_Identity=29.9342105263158, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI37574042, Length=449, Percent_Identity=24.2761692650334, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226442709, Length=401, Percent_Identity=23.6907730673317, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI226442705, Length=449, Percent_Identity=23.8307349665924, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1786991, Length=425, Percent_Identity=34.3529411764706, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI145693181, Length=373, Percent_Identity=31.0991957104558, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789016, Length=419, Percent_Identity=28.6396181384248, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789759, Length=381, Percent_Identity=29.1338582677165, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787560, Length=382, Percent_Identity=30.6282722513089, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=28.5353535353535, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786349, Length=360, Percent_Identity=25.8333333333333, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=410, Percent_Identity=25.3658536585366, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=27.1689497716895, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=393, Percent_Identity=27.2264631043257, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=321, Percent_Identity=26.1682242990654, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=394, Percent_Identity=23.0964467005076, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=484, Percent_Identity=29.7520661157025, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323470, Length=416, Percent_Identity=29.0865384615385, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=420, Percent_Identity=24.2857142857143, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=26.6968325791855, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21357415, Length=407, Percent_Identity=25.3071253071253, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574759, Length=420, Percent_Identity=26.6666666666667, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21356575, Length=392, Percent_Identity=26.0204081632653, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281366494, Length=382, Percent_Identity=23.0366492146597, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667139, Length=382, Percent_Identity=23.0366492146597, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667143, Length=382, Percent_Identity=23.0366492146597, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50663; Mature: 50663

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSRLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKG
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCC
PVIDAISSWWCKSLGHGHPAVIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGKQH
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCE
VFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGYHGETIGTMSVSDLGLYKAPY
EEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEECEEHHHCCCCCCCC
ASFGVQCHYIDDIPYVSGFKDPLWTDCDAYWNKVVQQLNKICDKVCAILLEPIIQGAGGM
HHHCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LCYSADFLSKISSWAKEKGIYLIADEIMTGIGRTGEWLACDHARVQPDLICLSKGLTSGS
EEECHHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCEEEECCCCCCCHHHHHHCCCCCCC
IPFSCVMIDSTLFDLFYDDYHTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQE
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
LGKIMFSYLQDIARDSRKLVNVRGVGAVVAADLIEGSQARIGFKIYQEAIKQGALIRPIG
HHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECC
NTLYWLPPLNTDKKIIGKLAEITLNSIEEAYNKAQGYE
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKSRLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKG
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCC
PVIDAISSWWCKSLGHGHPAVIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGKQH
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCE
VFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGYHGETIGTMSVSDLGLYKAPY
EEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEECEEHHHCCCCCCCC
ASFGVQCHYIDDIPYVSGFKDPLWTDCDAYWNKVVQQLNKICDKVCAILLEPIIQGAGGM
HHHCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LCYSADFLSKISSWAKEKGIYLIADEIMTGIGRTGEWLACDHARVQPDLICLSKGLTSGS
EEECHHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCEEEECCCCCCCHHHHHHCCCCCCC
IPFSCVMIDSTLFDLFYDDYHTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQE
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
LGKIMFSYLQDIARDSRKLVNVRGVGAVVAADLIEGSQARIGFKIYQEAIKQGALIRPIG
HHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECC
NTLYWLPPLNTDKKIIGKLAEITLNSIEEAYNKAQGYE
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]