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The map label for this gene is mutT [H]

Identifier: 148358994

GI number: 148358994

Start: 1681796

End: 1682200

Strand: Direct

Name: mutT [H]

Synonym: LPC_0879

Alternate gene names: 148358994

Gene position: 1681796-1682200 (Clockwise)

Preceding gene: 148358993

Following gene: 148358995

Centisome position: 47.02

GC content: 36.79

Gene sequence:

>405_bases
GTGAAAGTAGCAGTTGCTATCATTATCGATGAAAAACAACGTATACTAATTACCCAACGTCCTTTTCATGTCGCACATGG
AGGATTTTGGGAGTTTCCTGGCGGAAAATTGGAGCCTCATGAATCCCCAGAGGATGCTTTGGTTCGGGAGATTAGGGAGG
AGTTAGGTATAATTGTAAATGAATATCGTTTTCTGGGGTATGTCGATTATGACTATCCAGATAAACACATACAATTAATA
ATTTTTATGGTGACTCGTTTTACAGGCAACCCTTTATGTCAGGAAGGACAGCTCAATATGAAGTGGGTAAAAAAAGAGGA
ATTAGATATTAATGATTTCCCTAAAGCAAATCATGCGATTTTCGATTTAATTGACATCCCTGAACTTCAATATCAAGTTT
TATAA

Upstream 100 bases:

>100_bases
AAACGCAAACTTTTAGACGACAAGAAAAGAAAATTGGCCGTAATGATCCTTGCCCCTGTGGCTCAGGTAAAAAATATAAA
GCCTGTCATGGAAGCCTTGT

Downstream 100 bases:

>100_bases
ATGTGCGAATAATCTAAAGTTTGAAGCTAGGACATCATATTTAATTGCTAAGCACAAAATAAACTCCCTGTTTAGATGAT
GTTTTAACAGATCAGTTGTC

Product: mutator MutT protein

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MKVAVAIIIDEKQRILITQRPFHVAHGGFWEFPGGKLEPHESPEDALVREIREELGIIVNEYRFLGYVDYDYPDKHIQLI
IFMVTRFTGNPLCQEGQLNMKWVKKEELDINDFPKANHAIFDLIDIPELQYQVL

Sequences:

>Translated_134_residues
MKVAVAIIIDEKQRILITQRPFHVAHGGFWEFPGGKLEPHESPEDALVREIREELGIIVNEYRFLGYVDYDYPDKHIQLI
IFMVTRFTGNPLCQEGQLNMKWVKKEELDINDFPKANHAIFDLIDIPELQYQVL
>Mature_134_residues
MKVAVAIIIDEKQRILITQRPFHVAHGGFWEFPGGKLEPHESPEDALVREIREELGIIVNEYRFLGYVDYDYPDKHIQLI
IFMVTRFTGNPLCQEGQLNMKWVKKEELDINDFPKANHAIFDLIDIPELQYQVL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=120, Percent_Identity=39.1666666666667, Blast_Score=94, Evalue=3e-21,
Organism=Escherichia coli, GI1788056, Length=103, Percent_Identity=39.8058252427184, Blast_Score=70, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 15708; Mature: 15708

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAVAIIIDEKQRILITQRPFHVAHGGFWEFPGGKLEPHESPEDALVREIREELGIIVN
CEEEEEEEECCCCEEEEEECCEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCEEEE
EYRFLGYVDYDYPDKHIQLIIFMVTRFTGNPLCQEGQLNMKWVKKEELDINDFPKANHAI
CEEEEEEECCCCCCHHHEEHEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEE
FDLIDIPELQYQVL
EEEECCCCCEEEEC
>Mature Secondary Structure
MKVAVAIIIDEKQRILITQRPFHVAHGGFWEFPGGKLEPHESPEDALVREIREELGIIVN
CEEEEEEEECCCCEEEEEECCEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCEEEE
EYRFLGYVDYDYPDKHIQLIIFMVTRFTGNPLCQEGQLNMKWVKKEELDINDFPKANHAI
CEEEEEEECCCCCCHHHEEHEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEE
FDLIDIPELQYQVL
EEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8244038 [H]