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The map label for this gene is xapA [H]

Identifier: 148358965

GI number: 148358965

Start: 1649134

End: 1649973

Strand: Reverse

Name: xapA [H]

Synonym: LPC_0850

Alternate gene names: 148358965

Gene position: 1649973-1649134 (Counterclockwise)

Preceding gene: 148358966

Following gene: 148358964

Centisome position: 46.13

GC content: 38.93

Gene sequence:

>840_bases
ATGACGACTTCAATATCCACTATCAGTTACCCACATTTAGCAGCAGAATATATTCAAAAAACATGTCCATCATTTAAACC
AAAAGTGGGTGTAGTATTAGGCTCAGGGTTAGGTCAATTTGCCGAAGAGTTAGAAGATACAGTTGCTATTGAATACGAAA
AACTCCCAGGATTTCCCAGAACTACAGTACAGGGGCATGGAGGAAAATTAATTTTAGGATATTATGGATCTACTGCGGTT
ATTTGCTTACAAGGCAGAGCCCATACTTACGAAAGCATGGAAAATCATGAAGCAGTAAAAACCTATGTAAGAACTTTAAA
GCTATTAGGTTGCCAGTATTTTATAGCAACAAATGCTTCTGGTTCACTTAAAGAAGAAGTTGGACCGGGTGAATTAATGC
TAATTACCGATCACATCAATTTTCAACCCGGAAATCCCCTGGTTGGTCCAAATGATGATGAGTTTGGACCCAGGTTTTAT
CCTTTAGATAATGCTTATGACATTACCATGCGTAATGCATTATTGGATATTGCTCAAAGACATTCGATTAAACTACACCA
GGGGGTTTATATCTCTGTCTTGGGACCAAACTATGAAACAGCTGCTGAAATTCGTGCCTTTAAATTGCTGGGAGCTGATG
CAGTGGGGATGTCAACTGTTCCTGAAGTTTTAGTCGCCAATCATTGTGGCTTGCGTGTCGCTGTCATTGCAACCATAACA
AATTATGCAACTGGCCTTGCAAAAACCAGTCATAGCCATGAATCCGTTGTCAAAATGGCTTCTAGTGCCGCTGAAAAACT
TAATACTTTGATTAAACAGTATATTTTGGAATTATCGTGA

Upstream 100 bases:

>100_bases
CATGGTACATCTCTGTAATAAAGAAACAATATTTCATAGTATTACAATAAATGAATTACTACCCTTGGCTTTTGATTTTA
ACCCTTAATCGGACGATTTT

Downstream 100 bases:

>100_bases
GTTTGGATAAGCATTTTAATGATGTCTTGGACAAGCTCCTGTCAAACCAGGATATTATATCTATTTCGAATGCTCAGTTG
ATGCATTGCATTGATTTGAC

Product: purine nucleoside phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTTSISTISYPHLAAEYIQKTCPSFKPKVGVVLGSGLGQFAEELEDTVAIEYEKLPGFPRTTVQGHGGKLILGYYGSTAV
ICLQGRAHTYESMENHEAVKTYVRTLKLLGCQYFIATNASGSLKEEVGPGELMLITDHINFQPGNPLVGPNDDEFGPRFY
PLDNAYDITMRNALLDIAQRHSIKLHQGVYISVLGPNYETAAEIRAFKLLGADAVGMSTVPEVLVANHCGLRVAVIATIT
NYATGLAKTSHSHESVVKMASSAAEKLNTLIKQYILELS

Sequences:

>Translated_279_residues
MTTSISTISYPHLAAEYIQKTCPSFKPKVGVVLGSGLGQFAEELEDTVAIEYEKLPGFPRTTVQGHGGKLILGYYGSTAV
ICLQGRAHTYESMENHEAVKTYVRTLKLLGCQYFIATNASGSLKEEVGPGELMLITDHINFQPGNPLVGPNDDEFGPRFY
PLDNAYDITMRNALLDIAQRHSIKLHQGVYISVLGPNYETAAEIRAFKLLGADAVGMSTVPEVLVANHCGLRVAVIATIT
NYATGLAKTSHSHESVVKMASSAAEKLNTLIKQYILELS
>Mature_278_residues
TTSISTISYPHLAAEYIQKTCPSFKPKVGVVLGSGLGQFAEELEDTVAIEYEKLPGFPRTTVQGHGGKLILGYYGSTAVI
CLQGRAHTYESMENHEAVKTYVRTLKLLGCQYFIATNASGSLKEEVGPGELMLITDHINFQPGNPLVGPNDDEFGPRFYP
LDNAYDITMRNALLDIAQRHSIKLHQGVYISVLGPNYETAAEIRAFKLLGADAVGMSTVPEVLVANHCGLRVAVIATITN
YATGLAKTSHSHESVVKMASSAAEKLNTLIKQYILELS

Specific function: The nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the nucleoside molecule, with the formation of the corresponding free bases and pentose-1-phosphate. This protein can degrade all purine nucleosides except ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI157168362, Length=255, Percent_Identity=43.1372549019608, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI47132622, Length=226, Percent_Identity=30.5309734513274, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1788746, Length=269, Percent_Identity=45.3531598513011, Blast_Score=257, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17541190, Length=260, Percent_Identity=40.7692307692308, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71980569, Length=255, Percent_Identity=26.2745098039216, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323238, Length=272, Percent_Identity=38.9705882352941, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI45552887, Length=273, Percent_Identity=39.1941391941392, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI45552885, Length=273, Percent_Identity=39.1941391941392, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24656090, Length=273, Percent_Identity=39.1941391941392, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24656093, Length=273, Percent_Identity=39.1941391941392, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24762376, Length=227, Percent_Identity=33.0396475770925, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20130079, Length=222, Percent_Identity=26.5765765765766, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221459247, Length=196, Percent_Identity=25, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011268
- InterPro:   IPR000845
- InterPro:   IPR010943
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 30278; Mature: 30147

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSISTISYPHLAAEYIQKTCPSFKPKVGVVLGSGLGQFAEELEDTVAIEYEKLPGFPR
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHEEEEHHHCCCCCC
TTVQGHGGKLILGYYGSTAVICLQGRAHTYESMENHEAVKTYVRTLKLLGCQYFIATNAS
CEECCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
GSLKEEVGPGELMLITDHINFQPGNPLVGPNDDEFGPRFYPLDNAYDITMRNALLDIAQR
CCHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHH
HSIKLHQGVYISVLGPNYETAAEIRAFKLLGADAVGMSTVPEVLVANHCGLRVAVIATIT
CCEEEECCEEEEEECCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEHHHHHH
NYATGLAKTSHSHESVVKMASSAAEKLNTLIKQYILELS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTSISTISYPHLAAEYIQKTCPSFKPKVGVVLGSGLGQFAEELEDTVAIEYEKLPGFPR
CCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHEEEEHHHCCCCCC
TTVQGHGGKLILGYYGSTAVICLQGRAHTYESMENHEAVKTYVRTLKLLGCQYFIATNAS
CEECCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
GSLKEEVGPGELMLITDHINFQPGNPLVGPNDDEFGPRFYPLDNAYDITMRNALLDIAQR
CCHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHH
HSIKLHQGVYISVLGPNYETAAEIRAFKLLGADAVGMSTVPEVLVANHCGLRVAVIATIT
CCEEEECCEEEEEECCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEHHHHHH
NYATGLAKTSHSHESVVKMASSAAEKLNTLIKQYILELS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7559336; 9205837; 9278503 [H]