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The map label for this gene is mltD [H]

Identifier: 148358835

GI number: 148358835

Start: 1500512

End: 1501951

Strand: Reverse

Name: mltD [H]

Synonym: LPC_0718

Alternate gene names: 148358835

Gene position: 1501951-1500512 (Counterclockwise)

Preceding gene: 148358836

Following gene: 148358834

Centisome position: 42.0

GC content: 37.92

Gene sequence:

>1440_bases
TTGAATTGTAATTTATTGATTATAAAAAGATTTTTTTCATTCATCCTTATTTTTATTGGTATTTCTAACCCGGCAATTTC
TGGCACAGCTCCAGATGTATGGGATGTATTACGTAGTGAATTTACCTTAAGCCATGAAGTAACTCGCCCAGAAGTGCAAG
AACAAATCAGATGGCTAATTTCTCATCCTAGTTATATCAACAAAGTAAGTAGCCAATCTGAACCTTACATTTACCACGTG
TTAGGTGAGATAAAGAAAAGAAAACTGCCCGGAGAATTGGCGCTACTCCCCATGATAGAAAGTGCATATGATCCTTTTGC
CTATTCAGGAGCAGGCGCTGCTGGTATATGGCAACTCATGCCTCGAACTGGAAGCGATCTTGGATTAAAGCAAGACTGGT
GGTTTGATGGAAGACGCAGCATTGGCCCTTCAACTGATGCCGCATTAAATTACCTCGTCTATCTAAATAAATATTTTAGT
GGTAACTGGATTTTAGCTATTGCCGCTTATGACTCTGGAGAAGGAACCATTTCACGGGCGCTCAAATCAACCGCACGTAA
CGGGCGCAAGGTGCAATTCTGGAATCTGCCAGTTCCCAGAGAAACCAAGGTATATATCCCACGTTTATTAGCTCTGGCAG
AAATTATTAACAACCCAAAACGGTATAAAATATCACTTCCCAATATTCCCTATCTTCCTTATTTTGAAGAGGTCAATATT
GGTAGTCAAATTGACTTAAATCATGCCGCTAAACTCGCCGGAATCAGTTATAAGGAGTTGATTAAACTAAATCCCGGTTA
TAATCGATGGACAACTGCACCTTATAAGCCATTTAAATTACTAATACCTGCTGAAAAAGTCGAAAGATTTAACTTGAATC
TATCGAATATACCCGAAGATAAGCGCGTAAACTGGACTAAACATCAAGTAAAAAGAGGTGACAGCTTGGATGCTATTGCA
AAGAGATATCACACAACAGTCAATTTGATAAAACAACTCAATCAATTAACCAGCAATAAAGTTCAACTTAATCAATCCCT
ACTCATTCCTAGCAGCAAAAATTCCCCAGTAGTAGCTAAAATACCTCCACAGGAAAAAAAACCTGCTACTAAACAGCTGG
CACCTATGAAAAATGTCCGTATTATTCATATCGTACAAAATAATGATAGCTATCAGAAAATTCAAAAAGCTTATGGGGTT
GCTGCTAAAGAGATACAAAACTGGAATAAATTGACAAATAACGCGCCATTACGTAAAGGCCAGCGACTGGTCATATGGAA
AAGAGTCAAGCAACCTGTTGAGTATATAGTAAAATCAGGGGATAGTTTGAGCGTTATTGCCAAAAAGCACCAAACAAAAG
TGAATACTATTATTAGTTTAAATCCAGGACTTAAAAAATCAATGCCCCTTCGCTTGGGACAAAAAATATTAATTGGCTAG

Upstream 100 bases:

>100_bases
CAAATAAAAGCCCATTTGTACCAAATTAAACCAAAAAGGGTTTAATCCTTCATTAATTTTTAGTAAACTGATTAGCCAAT
CATAATAACAGGTAAGACCA

Downstream 100 bases:

>100_bases
ATTATATGCATTATCGTGATATAAACTAGATAGATTAATGTATCTGTTTGATACAGAAACGTGCTTTTGAGGAATACCAA
GACTACTGGCATGCCGCTAA

Product: membrane bound lytic murein transglycosylase D

Products: 1,6-Anhydrobond In The Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase D; Regulatory protein dniR [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MNCNLLIIKRFFSFILIFIGISNPAISGTAPDVWDVLRSEFTLSHEVTRPEVQEQIRWLISHPSYINKVSSQSEPYIYHV
LGEIKKRKLPGELALLPMIESAYDPFAYSGAGAAGIWQLMPRTGSDLGLKQDWWFDGRRSIGPSTDAALNYLVYLNKYFS
GNWILAIAAYDSGEGTISRALKSTARNGRKVQFWNLPVPRETKVYIPRLLALAEIINNPKRYKISLPNIPYLPYFEEVNI
GSQIDLNHAAKLAGISYKELIKLNPGYNRWTTAPYKPFKLLIPAEKVERFNLNLSNIPEDKRVNWTKHQVKRGDSLDAIA
KRYHTTVNLIKQLNQLTSNKVQLNQSLLIPSSKNSPVVAKIPPQEKKPATKQLAPMKNVRIIHIVQNNDSYQKIQKAYGV
AAKEIQNWNKLTNNAPLRKGQRLVIWKRVKQPVEYIVKSGDSLSVIAKKHQTKVNTIISLNPGLKKSMPLRLGQKILIG

Sequences:

>Translated_479_residues
MNCNLLIIKRFFSFILIFIGISNPAISGTAPDVWDVLRSEFTLSHEVTRPEVQEQIRWLISHPSYINKVSSQSEPYIYHV
LGEIKKRKLPGELALLPMIESAYDPFAYSGAGAAGIWQLMPRTGSDLGLKQDWWFDGRRSIGPSTDAALNYLVYLNKYFS
GNWILAIAAYDSGEGTISRALKSTARNGRKVQFWNLPVPRETKVYIPRLLALAEIINNPKRYKISLPNIPYLPYFEEVNI
GSQIDLNHAAKLAGISYKELIKLNPGYNRWTTAPYKPFKLLIPAEKVERFNLNLSNIPEDKRVNWTKHQVKRGDSLDAIA
KRYHTTVNLIKQLNQLTSNKVQLNQSLLIPSSKNSPVVAKIPPQEKKPATKQLAPMKNVRIIHIVQNNDSYQKIQKAYGV
AAKEIQNWNKLTNNAPLRKGQRLVIWKRVKQPVEYIVKSGDSLSVIAKKHQTKVNTIISLNPGLKKSMPLRLGQKILIG
>Mature_479_residues
MNCNLLIIKRFFSFILIFIGISNPAISGTAPDVWDVLRSEFTLSHEVTRPEVQEQIRWLISHPSYINKVSSQSEPYIYHV
LGEIKKRKLPGELALLPMIESAYDPFAYSGAGAAGIWQLMPRTGSDLGLKQDWWFDGRRSIGPSTDAALNYLVYLNKYFS
GNWILAIAAYDSGEGTISRALKSTARNGRKVQFWNLPVPRETKVYIPRLLALAEIINNPKRYKISLPNIPYLPYFEEVNI
GSQIDLNHAAKLAGISYKELIKLNPGYNRWTTAPYKPFKLLIPAEKVERFNLNLSNIPEDKRVNWTKHQVKRGDSLDAIA
KRYHTTVNLIKQLNQLTSNKVQLNQSLLIPSSKNSPVVAKIPPQEKKPATKQLAPMKNVRIIHIVQNNDSYQKIQKAYGV
AAKEIQNWNKLTNNAPLRKGQRLVIWKRVKQPVEYIVKSGDSLSVIAKKHQTKVNTIISLNPGLKKSMPLRLGQKILIG

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 LysM repeats [H]

Homologues:

Organism=Escherichia coli, GI1786405, Length=408, Percent_Identity=34.0686274509804, Blast_Score=253, Evalue=2e-68,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR010511
- InterPro:   IPR018392
- InterPro:   IPR002482
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01476 LysM; PF06474 MLTD_N; PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 54336; Mature: 54336

Theoretical pI: Translated: 10.58; Mature: 10.58

Prosite motif: PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCNLLIIKRFFSFILIFIGISNPAISGTAPDVWDVLRSEFTLSHEVTRPEVQEQIRWLI
CCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SHPSYINKVSSQSEPYIYHVLGEIKKRKLPGELALLPMIESAYDPFAYSGAGAAGIWQLM
CCCHHHHHHCCCCCCEEEEHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCCCCHHHHHHHC
PRTGSDLGLKQDWWFDGRRSIGPSTDAALNYLVYLNKYFSGNWILAIAAYDSGEGTISRA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCEEEEEEEECCCCHHHHHH
LKSTARNGRKVQFWNLPVPRETKVYIPRLLALAEIINNPKRYKISLPNIPYLPYFEEVNI
HHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHCCC
GSQIDLNHAAKLAGISYKELIKLNPGYNRWTTAPYKPFKLLIPAEKVERFNLNLSNIPED
CCEECCCHHHHHCCCCHHHHEEECCCCCCCCCCCCCCEEEEECHHHHHHCCCCHHCCCCC
KRVNWTKHQVKRGDSLDAIAKRYHTTVNLIKQLNQLTSNKVQLNQSLLIPSSKNSPVVAK
CCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEECCCCCCCCEEEE
IPPQEKKPATKQLAPMKNVRIIHIVQNNDSYQKIQKAYGVAAKEIQNWNKLTNNAPLRKG
CCCCCCCCCHHHHCCCCCCEEEEEEECCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCC
QRLVIWKRVKQPVEYIVKSGDSLSVIAKKHQTKVNTIISLNPGLKKSMPLRLGQKILIG
CEEEEHHHHHHHHHHHHHCCCCEEEHHHHHCCEEEEEEEECCCCCCCCCHHCCCCCCCC
>Mature Secondary Structure
MNCNLLIIKRFFSFILIFIGISNPAISGTAPDVWDVLRSEFTLSHEVTRPEVQEQIRWLI
CCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SHPSYINKVSSQSEPYIYHVLGEIKKRKLPGELALLPMIESAYDPFAYSGAGAAGIWQLM
CCCHHHHHHCCCCCCEEEEHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCCCCHHHHHHHC
PRTGSDLGLKQDWWFDGRRSIGPSTDAALNYLVYLNKYFSGNWILAIAAYDSGEGTISRA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCEEEEEEEECCCCHHHHHH
LKSTARNGRKVQFWNLPVPRETKVYIPRLLALAEIINNPKRYKISLPNIPYLPYFEEVNI
HHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHCCC
GSQIDLNHAAKLAGISYKELIKLNPGYNRWTTAPYKPFKLLIPAEKVERFNLNLSNIPED
CCEECCCHHHHHCCCCHHHHEEECCCCCCCCCCCCCCEEEEECHHHHHHCCCCHHCCCCC
KRVNWTKHQVKRGDSLDAIAKRYHTTVNLIKQLNQLTSNKVQLNQSLLIPSSKNSPVVAK
CCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEECCCCCCCCEEEE
IPPQEKKPATKQLAPMKNVRIIHIVQNNDSYQKIQKAYGVAAKEIQNWNKLTNNAPLRKG
CCCCCCCCCHHHHCCCCCCEEEEEEECCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCC
QRLVIWKRVKQPVEYIVKSGDSLSVIAKKHQTKVNTIISLNPGLKKSMPLRLGQKILIG
CEEEEHHHHHHHHHHHHHCCCCEEEHHHHHCCEEEEEEEECCCCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]