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The map label for this gene is hemF [H]

Identifier: 148358802

GI number: 148358802

Start: 1466570

End: 1467505

Strand: Reverse

Name: hemF [H]

Synonym: LPC_0684

Alternate gene names: 148358802

Gene position: 1467505-1466570 (Counterclockwise)

Preceding gene: 148358817

Following gene: 148358798

Centisome position: 41.03

GC content: 41.35

Gene sequence:

>936_bases
ATGCCAATCTCGAAGACACTTCCTTATAATGCGATAGAGCAAATTAAATCTTATCTGCTCCAACTCCAAAATACAATTTG
TGTCTCACTGGAGTCAATTGATGGCAAAACCAGATTCCATGAGGATTCCTGGCAGCGAGCTGCTGGAGGTGGAGGAAAAA
CAAGAATAATGGCGAATGGGAATGTCTTTGAAAAAGCCGGCGTCAATTTCTCACATGTTTCAGGGGAACAATTACCAGCA
TCAGCCAGTGCACATAGAGAAGAATTGGCAGGAAGGCATTTCAGCGCATTAGGTGTATCTCTGGTCATTCATCCTCAAAA
CCCCTATGTGCCAACAACACATGCCAATGTTCGATTTTTTGTCGCTGAAAAGGAAGATTCGGAACCAGTCTGGTGGTTTG
GTGGAGGATTTGATTTAACTCCTTATTATGGATTTGTTGAAGACTGTGAGCATTGGCATCAAACGGCATTAAATGCCTGT
TTACCTTTTGGAGAAACGATTTACCCAAAATTCAAGCGTTGGTGCGATGATTATTTTTTTATTAAGCACAGAAATGAAGC
ACGTGGAATTGGCGGTTTATTTTTTGATGATTACAATGAAATCAGCTTTGATCACAGCTTTGAACTCATGCGTAGCATAG
GCGATCATTTTATTCTGGCTTATGAACCCATAGTGGCTCGCCGTAAAGACATCCCTTTTGGCAACAGGGAAAAAGCATTT
CAGAATTACCGCAGAGGCCGTTATGCGGAGTTCAATTTAGTCTATGATCGAGGCACTTTATTTGGTCTGCAATCTGGCGG
AAGGACTGAGTCTATATTGATGTCCCTGCCTCCCATTGTTCATTGGGAATACAATTGGCATCCTGAAAAAGGCAGTGATG
AAGAAAAGTTATACACAGATTTTTTACCTGCAAAAGATTGGTTGAAAAAGGAGTAA

Upstream 100 bases:

>100_bases
GATAAAAAAATCCTATTTAAACAAAGCAAACATTGTGCCAATATCCAAAAAATGAGAAAATGAAACATCCAAGCGCTAAT
TCCCTATGCGGAGTCTCATC

Downstream 100 bases:

>100_bases
AACACCAAACTCAAAAATAAATGATGGCTTTCTCCCCTTACCTGAAAATTTCGAGGAGCCAGTATACATGCAGTAAATGA
GCACCGCGAAACGTTTACAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSGEQLPA
SASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQTALNAC
LPFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAF
QNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTDFLPAKDWLKKE

Sequences:

>Translated_311_residues
MPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSGEQLPA
SASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQTALNAC
LPFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAF
QNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTDFLPAKDWLKKE
>Mature_310_residues
PISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSGEQLPAS
ASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQTALNACL
PFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAFQ
NYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTDFLPAKDWLKKE

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=310, Percent_Identity=43.8709677419355, Blast_Score=269, Evalue=3e-72,
Organism=Escherichia coli, GI1788777, Length=295, Percent_Identity=65.0847457627119, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320249, Length=316, Percent_Identity=44.9367088607595, Blast_Score=270, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17864388, Length=307, Percent_Identity=47.2312703583062, Blast_Score=278, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 35821; Mature: 35689

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANG
CCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECC
NVFEKAGVNFSHVSGEQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFF
CEEHHCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCEEEE
VAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQTALNACLPFGETIYPKFKRWCDDYFF
EEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEE
IKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAF
EEECCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEECHHHHHCCCCCCCCHHHHH
QNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTD
HHHHCCCEEEEEEEEECCEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCCCHHHHHHH
FLPAKDWLKKE
CCCCHHHHCCC
>Mature Secondary Structure 
PISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANG
CCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECC
NVFEKAGVNFSHVSGEQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFF
CEEHHCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCEEEE
VAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQTALNACLPFGETIYPKFKRWCDDYFF
EEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEE
IKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAF
EEECCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEECHHHHHCCCCCCCCHHHHH
QNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTD
HHHHCCCEEEEEEEEECCEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCCCHHHHHHH
FLPAKDWLKKE
CCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA