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The map label for this gene is gcdH [H]

Identifier: 148358690

GI number: 148358690

Start: 3084495

End: 3085643

Strand: Reverse

Name: gcdH [H]

Synonym: LPC_0567

Alternate gene names: 148358690

Gene position: 3085643-3084495 (Counterclockwise)

Preceding gene: 148358689

Following gene: 148358691

Centisome position: 86.28

GC content: 42.73

Gene sequence:

>1149_bases
TTGTTGTTTCTTGATGAACAATTACATGATGACGAGCGCATGATACGAGATAGTGTGTCTCGTTTTGTTAGCAATGACGT
AATACCTTTGATGGCTGAATCTTATGAACATGCCCATTTTCCAAAAGAGTTGATAAAAAAATCTGCTGATCTGGGTTTGT
TGGGCTTAACTTTACCTGCGGAATATGGGGGTGCAGAAGCTTCTTATGTTGCCTATGGTTTAGTATGCCAGGAATTGGAG
CGAGGTGATAGCGGTTTGCGCAGCTTTGTTTCTGTGCAAAGTTCTTTGTGTATGTATCCTATTTTTAAATTTGGCAGTGA
AGAGCAAAAAAAACGCTACCTGCCAGAGATGGCTGCGGGGAATATTATAGGTTGCTTTGGATTAACTGAGCCAGACTCAG
GATCTGACCCGGCCAGCATGCGTACTCATGCCAAAAAAATTGAAGGTGGCTGGGTTTTGAATGGTGCTAAAATGTGGATC
ACCAATGCCCCTATCGCAGACATAGCGATAGTGTGGGCAAAAACAGAGGCGGGAATTCGTGGTTTTATTGTCGATACAAA
ATCTGAAGGCATGAGTTGTCCTGAAATTAAGTTAAAGATGTCTTTACGAGCCTCCATTACCGGGGAGCTGGTCTTTGATA
ATGTTTTTGTTCCAGACGAGAATTTATTGCCAAAAAGTGAAAAAGGGCTTGGAGCTGCGTTAAGTTGCTTGAGCCAGGCG
CGTTATGGTATCGCATGGGGCGCAATGGGCGCTGCCATGGCTTGCTTTGATATCGCTCGGAATTATTTGCTGGAACGCAA
GCAGTTTGCCAAACCTTTGGCCTCGTTTCAGTTGATTCAAAAAGATTTGGCTGATATGTATACAGAAATTATTAAAGCAC
AATGCCTTAATTTGCAGATTGGGCGTTTAAAGGATCAGCATCGTGAGACACCGACTATGATTTCTCTGGCTAAGGGTAAT
GCGTGCCGTGAAGCATTGAAAATTGCGAGAAAATGTAGGAATCTAATGGGCGGGAATGGAATTAGTCTTGAGTATCATGT
CATTCGGCATATGCTGAATCTGGAGTCGGTCTTTACTTATGAAGGTACCGATAATGTGCATACTTTGGTCTTGGGAAGAC
ATATAACGGGAATTAATGCTTTTGGTTAA

Upstream 100 bases:

>100_bases
TTAGGAACTGCTTGGCAGTATTTATTGCCAAGTCAGGAAAGTATTATAGACGCGGTAATCGCATTACAGTCAGATAAAAG
GGAGAAGGAAAGTGGACGAC

Downstream 100 bases:

>100_bases
GGATTTTTCTGCTTTTATCGAGTTAGTTCTGAATACCACAAGATAACTATTCTTAATCAGTAATGATTACGGTTCAAGTT
CCTTTTTCTTATGGAAAGAG

Product: glutaryl CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLTLPAEYGGAEASYVAYGLVCQELE
RGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEMAAGNIIGCFGLTEPDSGSDPASMRTHAKKIEGGWVLNGAKMWI
TNAPIADIAIVWAKTEAGIRGFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCLSQA
RYGIAWGAMGAAMACFDIARNYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLNLQIGRLKDQHRETPTMISLAKGN
ACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESVFTYEGTDNVHTLVLGRHITGINAFG

Sequences:

>Translated_382_residues
MLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLTLPAEYGGAEASYVAYGLVCQELE
RGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEMAAGNIIGCFGLTEPDSGSDPASMRTHAKKIEGGWVLNGAKMWI
TNAPIADIAIVWAKTEAGIRGFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCLSQA
RYGIAWGAMGAAMACFDIARNYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLNLQIGRLKDQHRETPTMISLAKGN
ACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESVFTYEGTDNVHTLVLGRHITGINAFG
>Mature_382_residues
MLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLTLPAEYGGAEASYVAYGLVCQELE
RGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEMAAGNIIGCFGLTEPDSGSDPASMRTHAKKIEGGWVLNGAKMWI
TNAPIADIAIVWAKTEAGIRGFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCLSQA
RYGIAWGAMGAAMACFDIARNYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLNLQIGRLKDQHRETPTMISLAKGN
ACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESVFTYEGTDNVHTLVLGRHITGINAFG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=383, Percent_Identity=53.2637075718016, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=52.6170798898072, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=33.509234828496, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=34.1333333333333, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=31.2, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=32.4483775811209, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=30.6878306878307, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=30.6878306878307, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=31.2, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=28.6096256684492, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI76496475, Length=405, Percent_Identity=29.1358024691358, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI4557235, Length=405, Percent_Identity=29.1358024691358, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI21361497, Length=360, Percent_Identity=29.7222222222222, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI38505218, Length=343, Percent_Identity=27.1137026239067, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI48976061, Length=398, Percent_Identity=23.8693467336683, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI211971008, Length=398, Percent_Identity=23.8693467336683, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786223, Length=377, Percent_Identity=24.9336870026525, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=26.3020833333333, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87081702, Length=276, Percent_Identity=26.8115942028986, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=48.3028720626632, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=34.6049046321526, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17538396, Length=383, Percent_Identity=31.8537859007833, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=31.4814814814815, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=30.0268096514745, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=30.5263157894737, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=30.5039787798408, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=280, Percent_Identity=35.3571428571429, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71990804, Length=261, Percent_Identity=35.2490421455939, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=367, Percent_Identity=29.4277929155313, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17533517, Length=381, Percent_Identity=25.9842519685039, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985192, Length=283, Percent_Identity=31.095406360424, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=33.7662337662338, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17551932, Length=351, Percent_Identity=25.0712250712251, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17505929, Length=352, Percent_Identity=24.7159090909091, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=381, Percent_Identity=26.246719160105, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=27.8008298755187, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19920834, Length=385, Percent_Identity=53.7662337662338, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=35.0267379679144, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=33.2439678284182, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=32.8125, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=31.7460317460317, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=29.7587131367292, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI281363737, Length=350, Percent_Identity=30.8571428571429, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42140; Mature: 42140

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLTLPA
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCC
EYGGAEASYVAYGLVCQELERGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEMAAG
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCC
NIIGCFGLTEPDSGSDPASMRTHAKKIEGGWVLNGAKMWITNAPIADIAIVWAKTEAGIR
CEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEECCEEEEECCCHHHEEEEEEECCCCCE
GFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCLSQA
EEEEECCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
RYGIAWGAMGAAMACFDIARNYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLNLQI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
GRLKDQHRETPTMISLAKGNACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESVFTY
HHCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHEEEE
EGTDNVHTLVLGRHITGINAFG
CCCCCEEEEEEECEECCCCCCC
>Mature Secondary Structure
MLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLTLPA
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCC
EYGGAEASYVAYGLVCQELERGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEMAAG
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCC
NIIGCFGLTEPDSGSDPASMRTHAKKIEGGWVLNGAKMWITNAPIADIAIVWAKTEAGIR
CEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEECCEEEEECCCHHHEEEEEEECCCCCE
GFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCLSQA
EEEEECCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
RYGIAWGAMGAAMACFDIARNYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLNLQI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
GRLKDQHRETPTMISLAKGNACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESVFTY
HHCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHEEEE
EGTDNVHTLVLGRHITGINAFG
CCCCCEEEEEEECEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]