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The map label for this gene is pepA [H]

Identifier: 148358631

GI number: 148358631

Start: 3151648

End: 3153012

Strand: Reverse

Name: pepA [H]

Synonym: LPC_0507

Alternate gene names: 148358631

Gene position: 3153012-3151648 (Counterclockwise)

Preceding gene: 148358630

Following gene: 148358632

Centisome position: 88.16

GC content: 42.71

Gene sequence:

>1365_bases
ATGCAAGCAGAAGTATTTTACAAAAGTTGCGGCGATAGGATAGTTCCTGTCCATCTCATTTCTCAATCGCAATGGGACGA
AGGAATTGAAAATCTAACCCCCATGGAGCGAAATTGTTTTTCTGTACGTCAGTTTAAGGGCAAATTAGGCGATTATTGTT
TTATTCCCAATGCGGATGGCGTGATTGAAAAAGCTTTTATTGGATCGGGAATTGGCAATCAGGAAAGTGCTTTGGCCAAT
GCCGCACTTTTATTGCCTCCAGGGAACTATCAATTGCAAGATAAGTTAAGTCGTGAGTCTGGCGTAGTTTGGGGATTAGC
GCAATATCGATTTGATGAGTATAAAAAATACGAGTTACAGCCTCGAGTTTTAATTGTTGAGGCAAATGATATGGATTATA
TTTTATCCTTGGCGAATTCTTTATTTCTCGTGCGGGATCTCATTAACACGCCAACCTGCGATATGGGGCCAGAATCGTTA
GCTCATGTTGTCGAAGAATTGGCTAAAACACACAAGGCTTACTTTAAGCAATGGATTGGAGAGGAATTGATAAAGGATAA
TTTTCCTGCCATTCATGCGGTTGGAAGAGCTTCTGCTTTAGCGCCTCGCTTATTATCTTTGCATTGGGGAAATGAGAAAC
ATCCACGCGTAACTTTGATTGGAAAGGGTGTTTGTTTTGATAGTGGCGGGCTTGATATCAAACCTTCATCAGGCATGCGT
TTGATGAAAAAAGATATGGGCGGTGCCGCACACGTCATAGGTTTAGCCCAGTGGATAATGGTTCAGCGTTTGCCAATTCG
ATTACAGGTATTAATCCCCGCTGTTGAAAACGCCATTGGTCCGAATGCTTTTAGGCCAGGAGATGTTTTAACCATGCGCA
ATGGATTAACCGTAGAAATAGAAAACACTGATGCAGAGGGTCGATTGATTCTGGCAGATGCTTTGGTTAAGGCTTGTGAA
GAAAAACCCGATTTGATCATTGATTTTGCTACTTTAACAGGTGCTGCTCGTGTCGCTGTCGGAACTGAAATTGCAGCCAT
GTTTTCTAATCATGATCAACTGGCTCAGGATATAGTAGCGGCATCTAATAAAGTCTCAGACCCCGTCTGGCGGTTGCCTT
TATTTTCACCATACGAAGAGTTATTGAATTCGAATATTGCAGACATGAGCAATTCCAGTTCTTCGTCCTATGCTGGGGCT
ATTACTGCCGGCTTATTTCTACAACGATTTGTGGCAAAATCAATACCATGGGTTCATTTTGATATCATGGCCTGGAATAC
TGCAAGTAAGCCAGGAAAGCCCGAAGGTGGTGAAGCAATGGGCTTGCGAGCGGTTGCCGAGTATTTATTACAGACTTACG
GATAG

Upstream 100 bases:

>100_bases
TTGGCTCATGTGTTCGTCACCGTAGTCATCTATTTATTAGTTTTAGGTATAATAGGGCTTAGACCTAACCACTTTCGTGG
CCAGATAAAGGATTAAAAAG

Downstream 100 bases:

>100_bases
AATTTTCAGTTGGGAGTTAGTTATGTTTGTGACTTTTAGTTGTGATGCATATGAGAACCTTACTTATTTTGAAAATGTGG
CAAAACAATTATTGTTGTTA

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFIPNADGVIEKAFIGSGIGNQESALAN
AALLLPPGNYQLQDKLSRESGVVWGLAQYRFDEYKKYELQPRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESL
AHVVEELAKTHKAYFKQWIGEELIKDNFPAIHAVGRASALAPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEIENTDAEGRLILADALVKACE
EKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVAASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGA
ITAGLFLQRFVAKSIPWVHFDIMAWNTASKPGKPEGGEAMGLRAVAEYLLQTYG

Sequences:

>Translated_454_residues
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFIPNADGVIEKAFIGSGIGNQESALAN
AALLLPPGNYQLQDKLSRESGVVWGLAQYRFDEYKKYELQPRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESL
AHVVEELAKTHKAYFKQWIGEELIKDNFPAIHAVGRASALAPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEIENTDAEGRLILADALVKACE
EKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVAASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGA
ITAGLFLQRFVAKSIPWVHFDIMAWNTASKPGKPEGGEAMGLRAVAEYLLQTYG
>Mature_454_residues
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFIPNADGVIEKAFIGSGIGNQESALAN
AALLLPPGNYQLQDKLSRESGVVWGLAQYRFDEYKKYELQPRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESL
AHVVEELAKTHKAYFKQWIGEELIKDNFPAIHAVGRASALAPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEIENTDAEGRLILADALVKACE
EKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVAASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGA
ITAGLFLQRFVAKSIPWVHFDIMAWNTASKPGKPEGGEAMGLRAVAEYLLQTYG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=374, Percent_Identity=34.4919786096257, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI47155554, Length=306, Percent_Identity=34.3137254901961, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI87082123, Length=349, Percent_Identity=38.10888252149, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1790710, Length=365, Percent_Identity=38.3561643835616, Blast_Score=210, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17556903, Length=345, Percent_Identity=33.6231884057971, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=179, Percent_Identity=35.195530726257, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357381, Length=302, Percent_Identity=34.1059602649007, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI221379063, Length=302, Percent_Identity=34.1059602649007, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI221379062, Length=302, Percent_Identity=34.1059602649007, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI21355725, Length=328, Percent_Identity=32.6219512195122, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24661038, Length=294, Percent_Identity=34.6938775510204, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI161077148, Length=332, Percent_Identity=29.5180722891566, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI20130057, Length=332, Percent_Identity=29.5180722891566, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24662227, Length=298, Percent_Identity=27.5167785234899, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI20129969, Length=342, Percent_Identity=26.6081871345029, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI19922386, Length=344, Percent_Identity=27.0348837209302, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355645, Length=331, Percent_Identity=25.0755287009063, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24662223, Length=331, Percent_Identity=25.0755287009063, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129963, Length=384, Percent_Identity=26.3020833333333, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646701, Length=173, Percent_Identity=35.8381502890173, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646703, Length=173, Percent_Identity=35.8381502890173, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358201, Length=173, Percent_Identity=35.8381502890173, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49792; Mature: 49792

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFIPNADG
CCCCEEHHHCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCC
VIEKAFIGSGIGNQESALANAALLLPPGNYQLQDKLSRESGVVWGLAQYRFDEYKKYELQ
HHHHHHHCCCCCCCHHHHHCEEEEECCCCCHHHHHHCCCCCCEEEHHHHHHHHHHHEECC
PRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESLAHVVEELAKTHKAYFKQWIG
CEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EELIKDNFPAIHAVGRASALAPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
HHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCEEECCCCCEECCCCCCH
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEI
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCCCCCCCCEEEECCCEEEEE
ENTDAEGRLILADALVKACEEKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVA
ECCCCCCCEEHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGAITAGLFLQRFVAKSIPWVHF
HCCCCCCCEEECCCCCHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
DIMAWNTASKPGKPEGGEAMGLRAVAEYLLQTYG
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQAEVFYKSCGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFIPNADG
CCCCEEHHHCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCC
VIEKAFIGSGIGNQESALANAALLLPPGNYQLQDKLSRESGVVWGLAQYRFDEYKKYELQ
HHHHHHHCCCCCCCHHHHHCEEEEECCCCCHHHHHHCCCCCCEEEHHHHHHHHHHHEECC
PRVLIVEANDMDYILSLANSLFLVRDLINTPTCDMGPESLAHVVEELAKTHKAYFKQWIG
CEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EELIKDNFPAIHAVGRASALAPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
HHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCEEECCCCCEECCCCCCH
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEI
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCCCCCCCCEEEECCCEEEEE
ENTDAEGRLILADALVKACEEKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVA
ECCCCCCCEEHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ASNKVSDPVWRLPLFSPYEELLNSNIADMSNSSSSSYAGAITAGLFLQRFVAKSIPWVHF
HCCCCCCCEEECCCCCHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
DIMAWNTASKPGKPEGGEAMGLRAVAEYLLQTYG
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA