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The map label for this gene is panB [H]

Identifier: 148358604

GI number: 148358604

Start: 3185301

End: 3186089

Strand: Direct

Name: panB [H]

Synonym: LPC_0478

Alternate gene names: 148358604

Gene position: 3185301-3186089 (Clockwise)

Preceding gene: 148358609

Following gene: 148358603

Centisome position: 89.06

GC content: 41.95

Gene sequence:

>789_bases
ATGAAAATCCATGATTTTAAAAATAAAAAGCAGGAACAAAAGAAAATTTCCATGTTGACCTGTTACGATTACCCTTCAGC
ATGCATAATAGCAAACTCAAATATCCATTGTGTTCTCGTGGGTGATTCCGTAGCTATGGCAGTGCACGGCCATCCTACAA
CCATTATGGCCACTATCGAAATGATGGAATTACATACCCAGGCAGTAGCTCGTGGTTTAGGCAAACAGTTTTTGATTACT
GACTTACCTTTTCTCGGACATAAATCATCTCAAGGTCATACAGTAGAAAACGTAAAAAGGCTGTTACAGGCTGGAGCTCA
AGCAGTTAAAATCGAGGGCGCTGATAAAGACACCTGCCAAACGATTTCCCATTTAGTTAATGCCGGAATCCCTGTTATGG
GTCATATCGGCTTAACTCCCCAATCCATTCATCAATTAGGCGGTTATAAAGTCCAGGGAAAAAACAGCGAACAGGCAGAA
ACTCTATTACAACAGGCAGACGCCCTGGAACAAGCAGGCTGCTTTGCGGTAGTCATTGAATGTGTTCCGCAGGGCTTGGC
AAAAACGATTACCGATTCGTTGGTTATTCCTACTATAGGAATTGGCGCAGGCCCAGGGACTGATGGGCAAGTCCTTGTCT
GGCACGACATGCTGGGTTTACAGACTTCATTTAATCCTAAATTTGTAAAAAAATATTTTAGAGCCAAAGACCATTTTATT
GAAGCCTTAAACAGCTATGTCCAGCAAGTACAACAAATGCATTTCCCAGCTAATGAACATTCTTTCTAG

Upstream 100 bases:

>100_bases
TTATTGACCTTCAGAGGAGGACTTGATCCATGAGACAGGTACCTGTATTACCATCATTCTTATCTATTCCAGGCGCATTC
TCCTATTCAGGGAGAGCGGC

Downstream 100 bases:

>100_bases
GAAAATTATCCATGCAAATTTTTCATAATTTAAATGAGTGGATTCGCTTTAGAAATACCCTGTCCCCTGATTTATCCCTG
GGGTTTGCTCCAACTATGGG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MKIHDFKNKKQEQKKISMLTCYDYPSACIIANSNIHCVLVGDSVAMAVHGHPTTIMATIEMMELHTQAVARGLGKQFLIT
DLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMGHIGLTPQSIHQLGGYKVQGKNSEQAE
TLLQQADALEQAGCFAVVIECVPQGLAKTITDSLVIPTIGIGAGPGTDGQVLVWHDMLGLQTSFNPKFVKKYFRAKDHFI
EALNSYVQQVQQMHFPANEHSF

Sequences:

>Translated_262_residues
MKIHDFKNKKQEQKKISMLTCYDYPSACIIANSNIHCVLVGDSVAMAVHGHPTTIMATIEMMELHTQAVARGLGKQFLIT
DLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMGHIGLTPQSIHQLGGYKVQGKNSEQAE
TLLQQADALEQAGCFAVVIECVPQGLAKTITDSLVIPTIGIGAGPGTDGQVLVWHDMLGLQTSFNPKFVKKYFRAKDHFI
EALNSYVQQVQQMHFPANEHSF
>Mature_262_residues
MKIHDFKNKKQEQKKISMLTCYDYPSACIIANSNIHCVLVGDSVAMAVHGHPTTIMATIEMMELHTQAVARGLGKQFLIT
DLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMGHIGLTPQSIHQLGGYKVQGKNSEQAE
TLLQQADALEQAGCFAVVIECVPQGLAKTITDSLVIPTIGIGAGPGTDGQVLVWHDMLGLQTSFNPKFVKKYFRAKDHFI
EALNSYVQQVQQMHFPANEHSF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=260, Percent_Identity=42.6923076923077, Blast_Score=216, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6319653, Length=268, Percent_Identity=39.5522388059701, Blast_Score=193, Evalue=2e-50,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28568; Mature: 28568

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHDFKNKKQEQKKISMLTCYDYPSACIIANSNIHCVLVGDSVAMAVHGHPTTIMATIE
CCCCCHHHHHHHHHHHHEEEEECCCCEEEEECCCEEEEEECCCEEEEECCCCCCHHHHHH
MMELHTQAVARGLGKQFLITDLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQ
HHHHHHHHHHHHCCCEEHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHH
TISHLVNAGIPVMGHIGLTPQSIHQLGGYKVQGKNSEQAETLLQQADALEQAGCFAVVIE
HHHHHHHCCCCEEEECCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHH
CVPQGLAKTITDSLVIPTIGIGAGPGTDGQVLVWHDMLGLQTSFNPKFVKKYFRAKDHFI
HHHHHHHHHHHHHHECCEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
EALNSYVQQVQQMHFPANEHSF
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKIHDFKNKKQEQKKISMLTCYDYPSACIIANSNIHCVLVGDSVAMAVHGHPTTIMATIE
CCCCCHHHHHHHHHHHHEEEEECCCCEEEEECCCEEEEEECCCEEEEECCCCCCHHHHHH
MMELHTQAVARGLGKQFLITDLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQ
HHHHHHHHHHHHCCCEEHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHH
TISHLVNAGIPVMGHIGLTPQSIHQLGGYKVQGKNSEQAETLLQQADALEQAGCFAVVIE
HHHHHHHCCCCEEEECCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHH
CVPQGLAKTITDSLVIPTIGIGAGPGTDGQVLVWHDMLGLQTSFNPKFVKKYFRAKDHFI
HHHHHHHHHHHHHHECCEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
EALNSYVQQVQQMHFPANEHSF
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA