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The map label for this gene is aaeA [H]

Identifier: 148358468

GI number: 148358468

Start: 357994

End: 358986

Strand: Direct

Name: aaeA [H]

Synonym: LPC_0334

Alternate gene names: 148358468

Gene position: 357994-358986 (Clockwise)

Preceding gene: 148358467

Following gene: 148358469

Centisome position: 10.01

GC content: 38.57

Gene sequence:

>993_bases
ATGAGTGACAAACCCAAAGCTGGATTCCCTGTAATTATTTTATTATGCGTGTTTCTATTCATTCTGATTTATCATTACTC
GTATTTATTTCCTTTTACAAACAATGCATTTGTTGTTGCGAATGTTCGTCCAGTTGCTGCCAATGTAAAAGGTTATATCA
CCAATATTTATGTTAAAAATGAACAGGAAGTAAAAAAAGGCCAACCATTATTTACCGTATTCAAAGCCCCCTATGAATTG
GCCTACAGGAAAGCTGTGAGCGATGTTCAAGAGGCGAAAGCCCAATTATTGTTATTCAATAAACAAGTTGAGAAAACGAA
ATATCTGCTGCAAGCACAAAAAGAGCTTTATGAAAAATTCCGCTTTGATTATGAGCATAATCATTCTGCCTTGCGTGATC
ACGCAGTTTCTAAGCTGACCGTCAATACGATGTTAAAAGAAAAAAATGCGGCACTAAGCAAATTAAAAGCATTGGAAAAA
GAGTTGGAGGTCAACCAGCAACAAGTCATTGTGCAAAAAAAGAAAATTGACTCTTTAATTGCGGTGATGAAGAATGCCAA
AATCGATTTGGATGAAACCACAGTTTATGCCAAACAAAATGGGGCAGTTCAGGATATGTTTGTTGCATTGGGAACCCCCA
TCAAAACCCGAAAACCAGTCTTTGCCATAGCGGATACCGATACTTTGTTTATCCAGGCTAATTTCAACGAAACGGATTTA
AGAAGGGTACAGCCAGGGGATAAAGTCTCTATTTTCCCGAGAATGTATTTTGGATCTAAAATTTATCATGGAGTGATTCT
TTCCAGAAACTGGGCTGCAAGCCGCCTGGAAACCCATCGGGCAACGCAAATACAAATTGTTCGCAATAGCGAAAGCAACT
GGTTTTTATTACCTCAACGCCTGCCAGTACAAATTCAAATAACAGACTATGACCCGGTGCATTACCCGTTAAGTATAGGC
GCTAGCGCCTATGTGTATATCCATACTCATTAA

Upstream 100 bases:

>100_bases
TATTAATTTACGATGTTTATGATATCAGGTTGAATGAGATGTAAAGACTCATTCCAATATCTTGGGAAGGGTTCAATAGA
AATGAGGATGAAAAAGACAC

Downstream 100 bases:

>100_bases
AATTATGGAAGGTGTTGAAATCAAGAGTGCAATATATTCTGTTTTTTTCTATTTCCAGGGTTAATTTTTAGCTGGTAATT
TGACTGTGAGCATTTTTTAG

Product: multidrug resistance secretion protein

Products: NA

Alternate protein names: pHBA efflux pump protein A [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSDKPKAGFPVIILLCVFLFILIYHYSYLFPFTNNAFVVANVRPVAANVKGYITNIYVKNEQEVKKGQPLFTVFKAPYEL
AYRKAVSDVQEAKAQLLLFNKQVEKTKYLLQAQKELYEKFRFDYEHNHSALRDHAVSKLTVNTMLKEKNAALSKLKALEK
ELEVNQQQVIVQKKKIDSLIAVMKNAKIDLDETTVYAKQNGAVQDMFVALGTPIKTRKPVFAIADTDTLFIQANFNETDL
RRVQPGDKVSIFPRMYFGSKIYHGVILSRNWAASRLETHRATQIQIVRNSESNWFLLPQRLPVQIQITDYDPVHYPLSIG
ASAYVYIHTH

Sequences:

>Translated_330_residues
MSDKPKAGFPVIILLCVFLFILIYHYSYLFPFTNNAFVVANVRPVAANVKGYITNIYVKNEQEVKKGQPLFTVFKAPYEL
AYRKAVSDVQEAKAQLLLFNKQVEKTKYLLQAQKELYEKFRFDYEHNHSALRDHAVSKLTVNTMLKEKNAALSKLKALEK
ELEVNQQQVIVQKKKIDSLIAVMKNAKIDLDETTVYAKQNGAVQDMFVALGTPIKTRKPVFAIADTDTLFIQANFNETDL
RRVQPGDKVSIFPRMYFGSKIYHGVILSRNWAASRLETHRATQIQIVRNSESNWFLLPQRLPVQIQITDYDPVHYPLSIG
ASAYVYIHTH
>Mature_329_residues
SDKPKAGFPVIILLCVFLFILIYHYSYLFPFTNNAFVVANVRPVAANVKGYITNIYVKNEQEVKKGQPLFTVFKAPYELA
YRKAVSDVQEAKAQLLLFNKQVEKTKYLLQAQKELYEKFRFDYEHNHSALRDHAVSKLTVNTMLKEKNAALSKLKALEKE
LEVNQQQVIVQKKKIDSLIAVMKNAKIDLDETTVYAKQNGAVQDMFVALGTPIKTRKPVFAIADTDTLFIQANFNETDLR
RVQPGDKVSIFPRMYFGSKIYHGVILSRNWAASRLETHRATQIQIVRNSESNWFLLPQRLPVQIQITDYDPVHYPLSIGA
SAYVYIHTH

Specific function: The Emr Locus Confers Resistance To Substances Of High Hydrophobicity. Emra Probably Participate In A Transport System To Extrude Toxins And Drugs From The Cell. [C]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=334, Percent_Identity=23.9520958083832, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788711, Length=338, Percent_Identity=25.7396449704142, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790519, Length=311, Percent_Identity=25.4019292604502, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022871
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37907; Mature: 37776

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKPKAGFPVIILLCVFLFILIYHYSYLFPFTNNAFVVANVRPVAANVKGYITNIYVKN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCEEECCCCEEEEEEEEEC
EQEVKKGQPLFTVFKAPYELAYRKAVSDVQEAKAQLLLFNKQVEKTKYLLQAQKELYEKF
HHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHH
RFDYEHNHSALRDHAVSKLTVNTMLKEKNAALSKLKALEKELEVNQQQVIVQKKKIDSLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AVMKNAKIDLDETTVYAKQNGAVQDMFVALGTPIKTRKPVFAIADTDTLFIQANFNETDL
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCHHHH
RRVQPGDKVSIFPRMYFGSKIYHGVILSRNWAASRLETHRATQIQIVRNSESNWFLLPQR
HHCCCCCCEEEEEEHHHCCHHHEEEEEECCCHHHHHHHCCCEEEEEEEECCCCEEEECCC
LPVQIQITDYDPVHYPLSIGASAYVYIHTH
CCEEEEEECCCCCCCEEECCCEEEEEEEEC
>Mature Secondary Structure 
SDKPKAGFPVIILLCVFLFILIYHYSYLFPFTNNAFVVANVRPVAANVKGYITNIYVKN
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCEEECCCCEEEEEEEEEC
EQEVKKGQPLFTVFKAPYELAYRKAVSDVQEAKAQLLLFNKQVEKTKYLLQAQKELYEKF
HHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHH
RFDYEHNHSALRDHAVSKLTVNTMLKEKNAALSKLKALEKELEVNQQQVIVQKKKIDSLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AVMKNAKIDLDETTVYAKQNGAVQDMFVALGTPIKTRKPVFAIADTDTLFIQANFNETDL
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCHHHH
RRVQPGDKVSIFPRMYFGSKIYHGVILSRNWAASRLETHRATQIQIVRNSESNWFLLPQR
HHCCCCCCEEEEEEHHHCCHHHEEEEEECCCHHHHHHHCCCEEEEEEEECCCCEEEECCC
LPVQIQITDYDPVHYPLSIGASAYVYIHTH
CCEEEEEECCCCCCCEEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA