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The map label for this gene is gcvT [H]

Identifier: 148358276

GI number: 148358276

Start: 144108

End: 145190

Strand: Reverse

Name: gcvT [H]

Synonym: LPC_0138

Alternate gene names: 148358276

Gene position: 145190-144108 (Counterclockwise)

Preceding gene: 148358278

Following gene: 148358275

Centisome position: 4.06

GC content: 44.69

Gene sequence:

>1083_bases
ATGACTGCTAAAACTCCTCTTCACACTACGCACTTAGCATGTGGTGCCAAAATGGTGGATTTCCATGGTTGGGATATGCC
TCTTCATTATGGATCTCAGTTAAACGAACATCATGCTGTCAGAAACGATGCTGGCATGTTTGATGTCTCACATATGACCA
TCGTTGATATTTTAGGCGCCGGTGGCCGTCAATTTCTGCGCAAACTGCTAACCAACGATGTCGATCAAATTACTCATAAT
GGAAAAGCCCTATACAGCTGTATGTGTAATGAACACGGCGGAATTATAGATGACCTGATTGTATATCAACGCGCTTCCGA
TAATTACCGAGTGGTACTTAATTCGGCAACCAGGCAAAATGATGTGGCCTGGATTCGAGCAAAAAGTGAAGGATTTGCTG
TTGGCTTGCAAGAAAGGCGCGAATTATCAATGCTCGCTGTACAAGGTCCAAATGCCATAGCGAAAACATTGAGTATTCTT
GCACCCGCCCATGTAGATGCCGTTTCAACTCTTACCCCTTTCGAATGCGTTGATGTAGATCACTGGTTTTTTGCTCGCAC
CGGCTATACGGGGGAAGATGGCCTTGAAATCATTGTCCCTAATGAATTTATTACTCAACTCTGGAATGATCTCCTGAATG
CTGGAGTAACGCCATGTGGATTAGGGGCCAGAGATACCCTGAGATTAGAGGCAGGAATGCTTCTTTACGGCCAGGATATG
GATGAAACAACAACCCCACTGGAATCTGGTTTGGCCTGGACAGTAAAGTGGGAGCCGGAAGATAGAGGATTTATCGGAAT
GGGCGCTTTGGTTTCTCAAAAGCAACAAGGAATTAAACGTAAAATGGTCGGTTTAACCTTGTTGGACAAAGGCATTATGC
GTCATGGCCAAAAGGTTATTATTGAAGGCTGTCCCGATGGAATTATCACAAGTGGCAGTTATTCTCCTACCCTGCAACAA
TCTATAGCTTTGGCACGAGTTCCCGTGGAAACAGGGGAACAAGTACTTGTTGACATACGCGGAAAGTTAATCCCGGCAAA
AGTAGGGAAGCCTCGCTTTATCAAACAAGGAAAACCTGTTTAA

Upstream 100 bases:

>100_bases
CAGGGAGAGGATCATGCAAAAAAAATCAAATTGGAAACCTCGCAAAATTAATCCCAACAGGTATAATCACATCCAATAAG
TGATAAAAAAAGGAAATGCA

Downstream 100 bases:

>100_bases
ATTTTAGTAATATTAATATTAAGGATATACAAAATGAATGATTTGAAATTCACAACAACCCATGAATGGCTGCGAGAAGA
TGAGGAAGAGGTCACAGTAG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGAGGRQFLRKLLTNDVDQITHN
GKALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQNDVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSIL
APAHVDAVSTLTPFECVDVDHWFFARTGYTGEDGLEIIVPNEFITQLWNDLLNAGVTPCGLGARDTLRLEAGMLLYGQDM
DETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVIIEGCPDGIITSGSYSPTLQQ
SIALARVPVETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV

Sequences:

>Translated_360_residues
MTAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGAGGRQFLRKLLTNDVDQITHN
GKALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQNDVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSIL
APAHVDAVSTLTPFECVDVDHWFFARTGYTGEDGLEIIVPNEFITQLWNDLLNAGVTPCGLGARDTLRLEAGMLLYGQDM
DETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVIIEGCPDGIITSGSYSPTLQQ
SIALARVPVETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV
>Mature_359_residues
TAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGAGGRQFLRKLLTNDVDQITHNG
KALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQNDVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSILA
PAHVDAVSTLTPFECVDVDHWFFARTGYTGEDGLEIIVPNEFITQLWNDLLNAGVTPCGLGARDTLRLEAGMLLYGQDMD
ETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVIIEGCPDGIITSGSYSPTLQQS
IALARVPVETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=368, Percent_Identity=37.5, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI257796258, Length=353, Percent_Identity=37.3937677053824, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI257796254, Length=363, Percent_Identity=33.8842975206612, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI257796256, Length=314, Percent_Identity=36.3057324840764, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24797151, Length=328, Percent_Identity=30.7926829268293, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI197927446, Length=349, Percent_Identity=25.214899713467, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI21361378, Length=349, Percent_Identity=25.214899713467, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI194306651, Length=392, Percent_Identity=23.9795918367347, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789272, Length=364, Percent_Identity=55.4945054945055, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17560118, Length=370, Percent_Identity=35.1351351351351, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71994052, Length=344, Percent_Identity=25.8720930232558, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994045, Length=344, Percent_Identity=25.8720930232558, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320222, Length=378, Percent_Identity=33.8624338624339, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129441, Length=372, Percent_Identity=35.752688172043, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI28571104, Length=277, Percent_Identity=28.158844765343, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20130091, Length=406, Percent_Identity=25.1231527093596, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39484; Mature: 39353

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGA
CCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHCCCCCEEEECHHHEEHHHCC
GGRQFLRKLLTNDVDQITHNGKALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQN
CHHHHHHHHHHCCHHHHHCCCCEEEEEHHCCCCCHHHHHHHEEECCCCEEEEEECCCCCC
DVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSILAPAHVDAVSTLTPFECVDVD
CEEEEEECCCCEEECHHHHCCEEEEEECCCHHHHHHHHHHCCCHHHHHHCCCCCEEECCC
HWFFARTGYTGEDGLEIIVPNEFITQLWNDLLNAGVTPCGLGARDTLRLEAGMLLYGQDM
CEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEECCC
DETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVI
CCCCCHHHCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IEGCPDGIITSGSYSPTLQQSIALARVPVETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV
EECCCCCEEECCCCCHHHHHHHHHEECCCCCCCEEEEEECCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGA
CCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHCCCCCEEEECHHHEEHHHCC
GGRQFLRKLLTNDVDQITHNGKALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQN
CHHHHHHHHHHCCHHHHHCCCCEEEEEHHCCCCCHHHHHHHEEECCCCEEEEEECCCCCC
DVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSILAPAHVDAVSTLTPFECVDVD
CEEEEEECCCCEEECHHHHCCEEEEEECCCHHHHHHHHHHCCCHHHHHHCCCCCEEECCC
HWFFARTGYTGEDGLEIIVPNEFITQLWNDLLNAGVTPCGLGARDTLRLEAGMLLYGQDM
CEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEECCC
DETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVI
CCCCCHHHCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IEGCPDGIITSGSYSPTLQQSIALARVPVETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV
EECCCCCEEECCCCCHHHHHHHHHEECCCCCCCEEEEEECCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA