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The map label for this gene is dnaA

Identifier: 148358140

GI number: 148358140

Start: 655

End: 2013

Strand: Direct

Name: dnaA

Synonym: LPC_0001

Alternate gene names: 148358140

Gene position: 655-2013 (Clockwise)

Preceding gene: NA

Following gene: 148358141

Centisome position: 0.02

GC content: 37.53

Gene sequence:

>1359_bases
GTGTCAACTACTGCTTGGCAAAAATGTTTAGGTTTGTTGCAAGATGAATTTTCTGCTCAGCAATTTAATACTTGGTTGCG
CCCTTTACAAGCTTACATGGACGAGCAGCGTTTAATCTTATTAGCGCCTAATCGTTTCGTTGTTGATTGGGTTAGAAAAC
ATTTTTTTTCTCGTATTGAAGAGTTGATTAAACAGTTCTCCGGCGATGACATCAAAGCTATTTCTATTGAAGTAGGTAGT
AAGCCTGTCGAAGCTGTTGATACGCCTGCTGAAACAATTGTCACTTCATCTAGTACAGCACCTCTAAAATCCGCTCCTAA
AAAAGCAGTTGACTATAAAAGCAGTCACTTAAATAAAAAATTTGTTTTTGACAGCTTTGTCGAAGGAAATTCAAATCAAC
TGGCGAGAGCTGCGTCCATGCAGGTAGCCGAGCGCCCTGGGGATGCTTATAATCCCTTATTTATTTATGGGGGAGTGGGC
TTAGGTAAAACACATCTCATGCATGCCATTGGTAATAGTATTTTAAAGAATAATCCTGAGGCTAAAGTATTGTATTTGCA
TTCAGAACGTTTTGTTGCAGATATGGTTAAAGCATTGCAAACAAATTCTATTAATGAATTTAAACGATTTTATCGTTCTT
TAAATGCTTTACTTATAGATGATATTCAGTTTTTTGCGGGGAAGGACAGGTCACAAGAGGAATTTTTTCATACTTTTAAC
GCCTTACTGGAAGGACAACAGCAAATCATTTTGACCAGTGATCGATATCCTAAGGAAATAGAAGGGATGGAAGAGCGTTT
AAAATCTCGATTTGGTTGGGGATTGACTGTAGCAGTGGAGCCTCCAGAGTTAGAAACGCGCGTCGCAATCTTAATTAGTA
AAGCTGAGCAATCTAATATTGAATTGCCTTATGAAGTAGCCTTTTTTATAGCCAAACGTATACGTTCGAATGTCAGAGAA
CTTGAAGGTGCCTTGCGTCGAGTTATAGCCAATGCTCACTTTACTGGTAAGCCGATAACTATTGAATTTGTACATGAAGC
ATTACGTGATCTTCTAGCTTTACAAGATAAGTTAGTTACTATAGAAAATATCCAAAAAACGGTAGCTGAATATTATAAAG
TAAAGGTCGCTGATTTACTTTCAAAACGCAGAAGCCGGTCTATTGCAAGACCAAGGCAAATGGCAATGGCTTTGAGTAAA
GAATTGACTAATCATAGTTTACCTGAAATCGGTGATCATTTCGGTGGTAAGGATCATACGACAGTCATACATGCCTGTCG
GAAGGTTAAAGAATTAATCCAGGATGATAGCGATTTTGCTGAAGATTATAAAAATTTAATGCGAATATTATCTTCTTGA

Upstream 100 bases:

>100_bases
TGTCTTGCTGATCGGGTACTTTCAATGGCAATATTTAATACTGTGGATAGATAGTTTTAAGTATTCTTTTACCACCCTTG
TTTAAATTAGGAGTTATTTT

Downstream 100 bases:

>100_bases
TACGGAGTCTATCTTGTTTGAGCTAACCATTAAAAAAGAAGATCTGCTTACTCCATTGCTTACTGTTTCCGGAGCCGTAG
ATAAGAAGCAGTCTTTGGCT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSTTAWQKCLGLLQDEFSAQQFNTWLRPLQAYMDEQRLILLAPNRFVVDWVRKHFFSRIEELIKQFSGDDIKAISIEVGS
KPVEAVDTPAETIVTSSSTAPLKSAPKKAVDYKSSHLNKKFVFDSFVEGNSNQLARAASMQVAERPGDAYNPLFIYGGVG
LGKTHLMHAIGNSILKNNPEAKVLYLHSERFVADMVKALQTNSINEFKRFYRSLNALLIDDIQFFAGKDRSQEEFFHTFN
ALLEGQQQIILTSDRYPKEIEGMEERLKSRFGWGLTVAVEPPELETRVAILISKAEQSNIELPYEVAFFIAKRIRSNVRE
LEGALRRVIANAHFTGKPITIEFVHEALRDLLALQDKLVTIENIQKTVAEYYKVKVADLLSKRRSRSIARPRQMAMALSK
ELTNHSLPEIGDHFGGKDHTTVIHACRKVKELIQDDSDFAEDYKNLMRILSS

Sequences:

>Translated_452_residues
MSTTAWQKCLGLLQDEFSAQQFNTWLRPLQAYMDEQRLILLAPNRFVVDWVRKHFFSRIEELIKQFSGDDIKAISIEVGS
KPVEAVDTPAETIVTSSSTAPLKSAPKKAVDYKSSHLNKKFVFDSFVEGNSNQLARAASMQVAERPGDAYNPLFIYGGVG
LGKTHLMHAIGNSILKNNPEAKVLYLHSERFVADMVKALQTNSINEFKRFYRSLNALLIDDIQFFAGKDRSQEEFFHTFN
ALLEGQQQIILTSDRYPKEIEGMEERLKSRFGWGLTVAVEPPELETRVAILISKAEQSNIELPYEVAFFIAKRIRSNVRE
LEGALRRVIANAHFTGKPITIEFVHEALRDLLALQDKLVTIENIQKTVAEYYKVKVADLLSKRRSRSIARPRQMAMALSK
ELTNHSLPEIGDHFGGKDHTTVIHACRKVKELIQDDSDFAEDYKNLMRILSS
>Mature_451_residues
STTAWQKCLGLLQDEFSAQQFNTWLRPLQAYMDEQRLILLAPNRFVVDWVRKHFFSRIEELIKQFSGDDIKAISIEVGSK
PVEAVDTPAETIVTSSSTAPLKSAPKKAVDYKSSHLNKKFVFDSFVEGNSNQLARAASMQVAERPGDAYNPLFIYGGVGL
GKTHLMHAIGNSILKNNPEAKVLYLHSERFVADMVKALQTNSINEFKRFYRSLNALLIDDIQFFAGKDRSQEEFFHTFNA
LLEGQQQIILTSDRYPKEIEGMEERLKSRFGWGLTVAVEPPELETRVAILISKAEQSNIELPYEVAFFIAKRIRSNVREL
EGALRRVIANAHFTGKPITIEFVHEALRDLLALQDKLVTIENIQKTVAEYYKVKVADLLSKRRSRSIARPRQMAMALSKE
LTNHSLPEIGDHFGGKDHTTVIHACRKVKELIQDDSDFAEDYKNLMRILSS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=470, Percent_Identity=66.8085106382979, Blast_Score=648, Evalue=0.0,
Organism=Escherichia coli, GI226510964, Length=236, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_LEGPA (Q5X990)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_122353.1
- ProteinModelPortal:   Q5X990
- STRING:   Q5X990
- GeneID:   3118365
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp0001
- LegioList:   lpp0001
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- BioCyc:   LPNE297246:LPP0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51380; Mature: 51249

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTAWQKCLGLLQDEFSAQQFNTWLRPLQAYMDEQRLILLAPNRFVVDWVRKHFFSRIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHH
ELIKQFSGDDIKAISIEVGSKPVEAVDTPAETIVTSSSTAPLKSAPKKAVDYKSSHLNKK
HHHHHHCCCCEEEEEEEECCCCCHHHCCCHHHHEECCCCCCCHHCCHHHHCCHHHHCCHH
FVFDSFVEGNSNQLARAASMQVAERPGDAYNPLFIYGGVGLGKTHLMHAIGNSILKNNPE
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC
AKVLYLHSERFVADMVKALQTNSINEFKRFYRSLNALLIDDIQFFAGKDRSQEEFFHTFN
CEEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ALLEGQQQIILTSDRYPKEIEGMEERLKSRFGWGLTVAVEPPELETRVAILISKAEQSNI
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHEEEHHCCCCC
ELPYEVAFFIAKRIRSNVRELEGALRRVIANAHFTGKPITIEFVHEALRDLLALQDKLVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IENIQKTVAEYYKVKVADLLSKRRSRSIARPRQMAMALSKELTNHSLPEIGDHFGGKDHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHH
TVIHACRKVKELIQDDSDFAEDYKNLMRILSS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STTAWQKCLGLLQDEFSAQQFNTWLRPLQAYMDEQRLILLAPNRFVVDWVRKHFFSRIE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHH
ELIKQFSGDDIKAISIEVGSKPVEAVDTPAETIVTSSSTAPLKSAPKKAVDYKSSHLNKK
HHHHHHCCCCEEEEEEEECCCCCHHHCCCHHHHEECCCCCCCHHCCHHHHCCHHHHCCHH
FVFDSFVEGNSNQLARAASMQVAERPGDAYNPLFIYGGVGLGKTHLMHAIGNSILKNNPE
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC
AKVLYLHSERFVADMVKALQTNSINEFKRFYRSLNALLIDDIQFFAGKDRSQEEFFHTFN
CEEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ALLEGQQQIILTSDRYPKEIEGMEERLKSRFGWGLTVAVEPPELETRVAILISKAEQSNI
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHEEEHHCCCCC
ELPYEVAFFIAKRIRSNVRELEGALRRVIANAHFTGKPITIEFVHEALRDLLALQDKLVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IENIQKTVAEYYKVKVADLLSKRRSRSIARPRQMAMALSKELTNHSLPEIGDHFGGKDHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHH
TVIHACRKVKELIQDDSDFAEDYKNLMRILSS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA