Click here to switch to the map view.

The map label for this gene is pepQ [H]

Identifier: 148284935

GI number: 148284935

Start: 1671105

End: 1672877

Strand: Direct

Name: pepQ [H]

Synonym: OTBS_1718

Alternate gene names: 148284935

Gene position: 1671105-1672877 (Clockwise)

Preceding gene: 148284934

Following gene: 148284937

Centisome position: 78.56

GC content: 30.23

Gene sequence:

>1773_bases
ATGAAGCATAATGAACAAAGGTTGAAGCAATTAAGGCAAAAATTTTTAGAATTTGGTATCAGTGGATACATTATTCCTTC
CAGTAATGAATATCAAAGTGAATGTGCTCCGAAATATGCTAGAAGATTGGAGTATATTACCGGATTTTCTGGATCATATG
GAATAGCCATAATTACATTAAATAAAGCTATATTATTTACTGATGGTAGATATTTAATTCAAGCAAGTAACCAAGTTGAT
TTGGAGCAATTTCAAATTATAAATATCAAAGATATTTTGACAACAGATTGGTGTAGTATTATTTCAAGTGATACAGATAT
GATTATAGGTTATGATCCTTATCTTTTAAACTTACACTCAATTACCTACTTTCAGAAGTTAAAATTAAAGACTATATCAC
CAAATTTAATTGACTTGATCTGGAATAACCAGCCTTCTAAACCATCGACTAATGCTTGGATTTACTCAATAGACTATGCA
GGACAAACAATTCAGGATAAAATTTCTAAGTTATTTATTGAGCTTAAAAATAAAAATGTTGATGGATATTTTATTACTGA
TTCTACATCAATATGCTGGTTGCTTAATATTAGGGCATATGATACCGAATTTACACCTTTAATGCTATCATACGCTTACC
TAGATTGCAAGGATCAATCAGTGTATCTTTTTACAAATTTAGAACGTTTGAATCAATCAGTAAAGCAACACCTTAATCAA
GGATATCAAACTATTAAATTATATTCAGAAACTGATATTAATGTTATATTGAAGCATATTACAAATAAAATTCTTGTTAG
TGAAAGCTGTCCTATAGGCTTTTTATCACCAATTAAAAATAAGCAAATTGTTAAGCAGCAACATGATTTGTGTTCAACAA
TGAAAGCTTGTAAAAATCAAGTTGAAATTGCTGCCGCTAAGCAATGCCATATCAATGATGCAGTAGCAGTATGCGAATTT
TTTGCTTGGTTAGATGATATAGTTACTCAACATAAGCTTGAATCAATAAATATTACTGAATATAGTTTAAGCGAAATGCT
TACTAGCTTTCGTAAAAAACAGCCAAATTATATTTGTAATAGCTTTGATAGCATATGTGGCTTTAATGAAAATAGTGCTA
TTATACATTATCAACCAACAAATCAATCTGCAAAGTTAATCAAAGGTGATGGAATTCTATTAGTAGATTCTGGAGGACAA
TATCTCGGTGGTACTACTGATATTACTCGTACAATAGTAATTGGACAAGCAACTCCGTTACAAAAGGAGAGATATACTTT
GATTCTAAAAGGACATATATCTTTACTAAACAGTGTTTTCCCTTGTGGAACAGTAGGAAGTAATCTAGATGTTATTGCTA
GAAGAAATTTATGGCATCATGGCCTTGATTATCCTCATGGTACTGGACATGGAGTTAGTAATTGTCTTAGTGTTCACGAA
GGTCCTCAATCTATTGGGCAATATAATAACGATGTAGCATTAGCTGAAGGTATGATACTTTCAAATGAACCAGGGTACTA
TGAAGAAGGTAAGTATGGTATTAGAATAGAAAATCTTATGTTTGTTAAAAATTCAAAATATGAAGGATTTTTAGAATTTG
AGACTTTAACGCTTGTTCCATATTGTAGTGATCTTATTTTAACCTCACTACTAACTAACGAAGAAAAAGAATATATTCAT
CATTATTGTCAAAGAATAAACGATCAAGTGAAGCTACTTCTTAGTGATAAAGCAAAACTTTGGATTGAAAAGCACATAAG
TATGAATATTTGA

Upstream 100 bases:

>100_bases
AGGTAACAAAGCTGGAAACAAGCTACAGAAAGCTCAGCAACTAGGAATTAAAATTATTAATGAAGAAGAATGGATTAAAA
TGGTTAATGAATAATGAATT

Downstream 100 bases:

>100_bases
AAATCATGGTTTAACTAAATATTAGGCAGTGTTAACAAACATCTAACCTTATAATAAAAGCATAAGTTGGATAAATTGAT
ACATCATAGAGTAGCAAGAA

Product: aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITLNKAILFTDGRYLIQASNQVD
LEQFQIINIKDILTTDWCSIISSDTDMIIGYDPYLLNLHSITYFQKLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYA
GQTIQDKISKLFIELKNKNVDGYFITDSTSICWLLNIRAYDTEFTPLMLSYAYLDCKDQSVYLFTNLERLNQSVKQHLNQ
GYQTIKLYSETDINVILKHITNKILVSESCPIGFLSPIKNKQIVKQQHDLCSTMKACKNQVEIAAAKQCHINDAVAVCEF
FAWLDDIVTQHKLESINITEYSLSEMLTSFRKKQPNYICNSFDSICGFNENSAIIHYQPTNQSAKLIKGDGILLVDSGGQ
YLGGTTDITRTIVIGQATPLQKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
GPQSIGQYNNDVALAEGMILSNEPGYYEEGKYGIRIENLMFVKNSKYEGFLEFETLTLVPYCSDLILTSLLTNEEKEYIH
HYCQRINDQVKLLLSDKAKLWIEKHISMNI

Sequences:

>Translated_590_residues
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITLNKAILFTDGRYLIQASNQVD
LEQFQIINIKDILTTDWCSIISSDTDMIIGYDPYLLNLHSITYFQKLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYA
GQTIQDKISKLFIELKNKNVDGYFITDSTSICWLLNIRAYDTEFTPLMLSYAYLDCKDQSVYLFTNLERLNQSVKQHLNQ
GYQTIKLYSETDINVILKHITNKILVSESCPIGFLSPIKNKQIVKQQHDLCSTMKACKNQVEIAAAKQCHINDAVAVCEF
FAWLDDIVTQHKLESINITEYSLSEMLTSFRKKQPNYICNSFDSICGFNENSAIIHYQPTNQSAKLIKGDGILLVDSGGQ
YLGGTTDITRTIVIGQATPLQKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
GPQSIGQYNNDVALAEGMILSNEPGYYEEGKYGIRIENLMFVKNSKYEGFLEFETLTLVPYCSDLILTSLLTNEEKEYIH
HYCQRINDQVKLLLSDKAKLWIEKHISMNI
>Mature_590_residues
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITLNKAILFTDGRYLIQASNQVD
LEQFQIINIKDILTTDWCSIISSDTDMIIGYDPYLLNLHSITYFQKLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYA
GQTIQDKISKLFIELKNKNVDGYFITDSTSICWLLNIRAYDTEFTPLMLSYAYLDCKDQSVYLFTNLERLNQSVKQHLNQ
GYQTIKLYSETDINVILKHITNKILVSESCPIGFLSPIKNKQIVKQQHDLCSTMKACKNQVEIAAAKQCHINDAVAVCEF
FAWLDDIVTQHKLESINITEYSLSEMLTSFRKKQPNYICNSFDSICGFNENSAIIHYQPTNQSAKLIKGDGILLVDSGGQ
YLGGTTDITRTIVIGQATPLQKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
GPQSIGQYNNDVALAEGMILSNEPGYYEEGKYGIRIENLMFVKNSKYEGFLEFETLTLVPYCSDLILTSLLTNEEKEYIH
HYCQRINDQVKLLLSDKAKLWIEKHISMNI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=598, Percent_Identity=35.9531772575251, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI93141226, Length=613, Percent_Identity=33.605220228385, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI264681565, Length=598, Percent_Identity=34.6153846153846, Blast_Score=319, Evalue=4e-87,
Organism=Escherichia coli, GI1788728, Length=199, Percent_Identity=26.1306532663317, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17509539, Length=585, Percent_Identity=32.4786324786325, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI25149105, Length=589, Percent_Identity=28.5229202037351, Blast_Score=232, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6322999, Length=629, Percent_Identity=34.8171701112878, Blast_Score=331, Evalue=2e-91,
Organism=Drosophila melanogaster, GI17137632, Length=623, Percent_Identity=33.5473515248796, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI161078230, Length=603, Percent_Identity=28.3582089552239, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI21357287, Length=603, Percent_Identity=28.3582089552239, Blast_Score=249, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 67215; Mature: 67215

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITL
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
NKAILFTDGRYLIQASNQVDLEQFQIINIKDILTTDWCSIISSDTDMIIGYDPYLLNLHS
CEEEEEECCEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEECCCEEEEEHH
ITYFQKLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYAGQTIQDKISKLFIELKNKNV
HHEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHEECCCC
DGYFITDSTSICWLLNIRAYDTEFTPLMLSYAYLDCKDQSVYLFTNLERLNQSVKQHLNQ
CEEEEECCCCEEEEEEEEEECCCCCHHHEEEEEEECCCCCEEEEECHHHHHHHHHHHHHC
GYQTIKLYSETDINVILKHITNKILVSESCPIGFLSPIKNKQIVKQQHDLCSTMKACKNQ
CCEEEEEECCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VEIAAAKQCHINDAVAVCEFFAWLDDIVTQHKLESINITEYSLSEMLTSFRKKQPNYICN
HEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHH
SFDSICGFNENSAIIHYQPTNQSAKLIKGDGILLVDSGGQYLGGTTDITRTIVIGQATPL
CHHHHCCCCCCCEEEEEECCCCCCEEEECCCEEEECCCCCCCCCCCCCEEEEEEECCCCC
QKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
CCCCEEEEEEEHHHHHHHHCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCHHHHHHHCC
GPQSIGQYNNDVALAEGMILSNEPGYYEEGKYGIRIENLMFVKNSKYEGFLEFETLTLVP
CHHHHHCCCCCEEEECCEEECCCCCCCCCCCEEEEEEEEEEEECCCCCCEEEEEEEEECH
YCSDLILTSLLTNEEKEYIHHYCQRINDQVKLLLSDKAKLWIEKHISMNI
HHHHHHHHHHHCCCHHHHHHHHHHHHCHHEEEEECCCHHEEEEECCCCCC
>Mature Secondary Structure
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITL
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
NKAILFTDGRYLIQASNQVDLEQFQIINIKDILTTDWCSIISSDTDMIIGYDPYLLNLHS
CEEEEEECCEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEECCCEEEEEHH
ITYFQKLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYAGQTIQDKISKLFIELKNKNV
HHEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHEECCCC
DGYFITDSTSICWLLNIRAYDTEFTPLMLSYAYLDCKDQSVYLFTNLERLNQSVKQHLNQ
CEEEEECCCCEEEEEEEEEECCCCCHHHEEEEEEECCCCCEEEEECHHHHHHHHHHHHHC
GYQTIKLYSETDINVILKHITNKILVSESCPIGFLSPIKNKQIVKQQHDLCSTMKACKNQ
CCEEEEEECCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VEIAAAKQCHINDAVAVCEFFAWLDDIVTQHKLESINITEYSLSEMLTSFRKKQPNYICN
HEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHH
SFDSICGFNENSAIIHYQPTNQSAKLIKGDGILLVDSGGQYLGGTTDITRTIVIGQATPL
CHHHHCCCCCCCEEEEEECCCCCCEEEECCCEEEECCCCCCCCCCCCCEEEEEEECCCCC
QKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
CCCCEEEEEEEHHHHHHHHCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCHHHHHHHCC
GPQSIGQYNNDVALAEGMILSNEPGYYEEGKYGIRIENLMFVKNSKYEGFLEFETLTLVP
CHHHHHCCCCCEEEECCEEECCCCCCCCCCCEEEEEEEEEEEECCCCCCEEEEEEEEECH
YCSDLILTSLLTNEEKEYIHHYCQRINDQVKLLLSDKAKLWIEKHISMNI
HHHHHHHHHHHCCCHHHHHHHHHHHHCHHEEEEECCCHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]