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The map label for this gene is sdhA [H]

Identifier: 148284921

GI number: 148284921

Start: 1651291

End: 1653078

Strand: Direct

Name: sdhA [H]

Synonym: OTBS_1698

Alternate gene names: 148284921

Gene position: 1651291-1653078 (Clockwise)

Preceding gene: 148284920

Following gene: 148284922

Centisome position: 77.63

GC content: 37.19

Gene sequence:

>1788_bases
GTGAAGGCTTATAAAATTATAAATCATGAATTTGATGTTGTAGTAGTTGGAGCTGGTGGAGCAGGACTAAGGGCTATAGT
TGGTATGGCTGAAGCTGGTCTCCGTGCTGCTTGTATTACCAAATTGTTTCCTACTCGTAGTCATACTGTTGCAGCTCAAG
GTGGTATTAGTGCTGCACTAGGTAATATACAACCAGATAAATGGCAATGGCATGCTTATGATACTATTAAGGGATCGGAT
TGGCTTGGAGATCAAGATGCAATTGCTTATATGTGCAGAGAAGCCCCAGCTGCTATTATTGAATTAGAGCATTATGGAGT
TCCATTTTCACGTACAGCAGATGGAAAAATTTATCAAAGACATTTTGGAGGTATGACAACTGAGTTTGGAGATGGTGCAG
CTGCTATGCGAACCTGCGCAGCAGCTGATAGAACTGGTCATGCTATGTTACATACTTTATATCAGCAAGCGTTGAAACAT
AAAGCTAAATTTTTCATTGAGTATATAGCTCTTGATTTAATTATGGATAATGGAGCTTGTAATGGGATAGTCGCTTGGAA
CCTTGACGATGGTACTATTCATTGCTTTAGATCACATATAGTAGTCTTAGCAACTGGAGGGTATGGAAGAGCTTATTTTT
CAGCAACATCAGCTCACAGTTGTACTGGTGATGGAAATGCTATGTGCGCTAGAGCTGGCATAGCTTTACAAGATATGGAA
TTTGTTCAATTTCATCCTACAGGAATTTATGGCGCAGGATGTTTAATCACTGAAGGAGCCAGAGGAGAAGGTGGGTACTT
AGTTAACTCAGAAGGTGAGCGTTTCATGGAAAGATACGCCCCATCAGCCAAAGATCTTGCTTCACGAGATGTAGTTGCCA
GGGCCATGACTATGGAAATCAATGCTGGCCGCGGGGTAGGTATATATAAAGATCATATATTTTTGCATTTAAATCATCTT
GATAGCAAAACGATACAGCAAAGGTTACCTGGAATATCTGAAACTGCAATGATCTTTGCTGGAGTTGATGTTACAAAGCA
GCCTATACCAGTAATTCCAACTGTACATTATAATATGGGTGGTATACCAACCAATTATCATGGCCAAGTAGTAACTAAAA
CAGAAAATGGTGATATGGAAATAGTACCTGGATTAATGGCTATTGGAGAAGCTGCTTGCGTATCAGTTCATGGGGCTAAT
AGACTAGGATCTAACTCTCTACTTGATCTAATAATCTTTGGTCGAGCTGCAGCCAATAAAGCAAAAGAAATTATTACTAC
ATCAACAAAACATCAACCATTAGGCAATAACATTTTTGATGCTATTATAGAAAGATTTGACCAAACAAGGTTTTTAAATG
GTAATATGCCAATTGCTGAGTTAAGATTAACTATGCAACGTGCTATGCAAAACTATGCTGGAGTATTTCGTAGCTATGAT
AAGTTAACAGAAGGTATGAAAATAATAAAACAAAATTTTAATTCTAGAACAGATATTAAATTAACAGATCATTCACTAAT
TTGGAACACTGATTTAGTTGAGGCAATTGAATTACAAAATTTATTATATCAAGCTGCAATAACTATGTTTTGTGCTGCTA
ATCGTCAAGAAAGCCGAGGAGCCCATGCTCGAGAAGATTATCCTAATAGAGATGATGATAATTGGCTCAAACATACATTA
GCCACAATTGATGAAGAAGGAAACGTAGATATAGATTATAGAGACGTAGTATTAGATCCAAAAAATGATGAAATGATGTC
TATAGTTCCTAAAAAGCGAGTATATTAA

Upstream 100 bases:

>100_bases
TAGTAACAAGTTAAGTTAATACACCAATAAAAGAAATACAGACTTTAAATAGTATATGATGTTTGCAAAATTTGATGTTA
ATTTAATTTTAAAATAAATT

Downstream 100 bases:

>100_bases
CTAGTGATTAGCAAGTAATAAATGAGTCATGCAAATGGTAGAATTTAGATTACCACCAAATTCAAAAGTTAAAGTAGGTA
AGCGCTATGTTGCTAAAGAC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAEAGLRAACITKLFPTRSHTVAAQGGISAALGNIQPDKWQWHAYDTIKGSD
WLGDQDAIAYMCREAPAAIIELEHYGVPFSRTADGKIYQRHFGGMTTEFGDGAAAMRTCAAADRTGHAMLHTLYQQALKH
KAKFFIEYIALDLIMDNGACNGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEINAGRGVGIYKDHIFLHLNHL
DSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMGGIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGAN
RLGSNSLLDLIIFGRAAANKAKEIITTSTKHQPLGNNIFDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRGAHAREDYPNRDDDNWLKHTL
ATIDEEGNVDIDYRDVVLDPKNDEMMSIVPKKRVY

Sequences:

>Translated_595_residues
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAEAGLRAACITKLFPTRSHTVAAQGGISAALGNIQPDKWQWHAYDTIKGSD
WLGDQDAIAYMCREAPAAIIELEHYGVPFSRTADGKIYQRHFGGMTTEFGDGAAAMRTCAAADRTGHAMLHTLYQQALKH
KAKFFIEYIALDLIMDNGACNGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEINAGRGVGIYKDHIFLHLNHL
DSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMGGIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGAN
RLGSNSLLDLIIFGRAAANKAKEIITTSTKHQPLGNNIFDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRGAHAREDYPNRDDDNWLKHTL
ATIDEEGNVDIDYRDVVLDPKNDEMMSIVPKKRVY
>Mature_595_residues
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAEAGLRAACITKLFPTRSHTVAAQGGISAALGNIQPDKWQWHAYDTIKGSD
WLGDQDAIAYMCREAPAAIIELEHYGVPFSRTADGKIYQRHFGGMTTEFGDGAAAMRTCAAADRTGHAMLHTLYQQALKH
KAKFFIEYIALDLIMDNGACNGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEINAGRGVGIYKDHIFLHLNHL
DSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMGGIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGAN
RLGSNSLLDLIIFGRAAANKAKEIITTSTKHQPLGNNIFDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRGAHAREDYPNRDDDNWLKHTL
ATIDEEGNVDIDYRDVVLDPKNDEMMSIVPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=605, Percent_Identity=59.3388429752066, Blast_Score=718, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=594, Percent_Identity=52.020202020202, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=39.8613518197574, Blast_Score=384, Evalue=1e-107,
Organism=Escherichia coli, GI1788928, Length=577, Percent_Identity=31.5424610051993, Blast_Score=226, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17550100, Length=613, Percent_Identity=61.5008156606852, Blast_Score=741, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=620, Percent_Identity=58.8709677419355, Blast_Score=696, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=64.321608040201, Blast_Score=785, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=599, Percent_Identity=63.2721202003339, Blast_Score=770, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=612, Percent_Identity=59.1503267973856, Blast_Score=739, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=612, Percent_Identity=59.1503267973856, Blast_Score=739, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=612, Percent_Identity=59.1503267973856, Blast_Score=739, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=612, Percent_Identity=55.2287581699346, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65319; Mature: 65319

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAEAGLRAACITKLFPTRSHTVAAQGGISAAL
CCCEEEECCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCHHHH
GNIQPDKWQWHAYDTIKGSDWLGDQDAIAYMCREAPAAIIELEHYGVPFSRTADGKIYQR
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHH
HFGGMTTEFGDGAAAMRTCAAADRTGHAMLHTLYQQALKHKAKFFIEYIALDLIMDNGAC
HCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
NGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
CCEEEEECCCCEEEEEECCEEEEEECCCCEEEEECCCCCCCCCCCCCEEEECCCEEECCE
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEI
EEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHEEEEEE
NAGRGVGIYKDHIFLHLNHLDSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMG
CCCCCCCEEECEEEEEEECCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
GIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGANRLGSNSLLDLIIFGRAAANK
CCCCCCCCEEEEEECCCCEEEECHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCHHHHH
AKEIITTSTKHQPLGNNIFDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRG
HHHHHHHHHHHCCCCCCCEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AHAREDYPNRDDDNWLKHTLATIDEEGNVDIDYRDVVLDPKNDEMMSIVPKKRVY
CCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCC
>Mature Secondary Structure
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAEAGLRAACITKLFPTRSHTVAAQGGISAAL
CCCEEEECCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCHHHH
GNIQPDKWQWHAYDTIKGSDWLGDQDAIAYMCREAPAAIIELEHYGVPFSRTADGKIYQR
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHH
HFGGMTTEFGDGAAAMRTCAAADRTGHAMLHTLYQQALKHKAKFFIEYIALDLIMDNGAC
HCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
NGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
CCEEEEECCCCEEEEEECCEEEEEECCCCEEEEECCCCCCCCCCCCCEEEECCCEEECCE
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEI
EEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHEEEEEE
NAGRGVGIYKDHIFLHLNHLDSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMG
CCCCCCCEEECEEEEEEECCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
GIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGANRLGSNSLLDLIIFGRAAANK
CCCCCCCCEEEEEECCCCEEEECHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCHHHHH
AKEIITTSTKHQPLGNNIFDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRG
HHHHHHHHHHHCCCCCCCEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AHAREDYPNRDDDNWLKHTLATIDEEGNVDIDYRDVVLDPKNDEMMSIVPKKRVY
CCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA