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The map label for this gene is pepA [H]

Identifier: 148284630

GI number: 148284630

Start: 1117555

End: 1119207

Strand: Direct

Name: pepA [H]

Synonym: OTBS_1135

Alternate gene names: 148284630

Gene position: 1117555-1119207 (Clockwise)

Preceding gene: 148284629

Following gene: 148284631

Centisome position: 52.54

GC content: 31.52

Gene sequence:

>1653_bases
ATGATTATAAATTTTATACAAACAGATAGTCAGAATTTTTTTAATTGCTTAGAAGGAATAAATAAAACAGATGTTACAGA
TATATCCAATAGTCAGTCTATATGTTTATTGATTGGTTCAGATTTAGTGTTAACAGATAGCATGTTACAGCTTGATCAGC
AATGTGGTGGAATTATATCAAAATTTTTGCAACAAAATACGAAGAATAAGCAAATATTTAGTGGCAAGTTTGGTGAAATT
AAATTTTTAACTATTGCTAACGGTGAAGAGATTAAAAATATAATTTTGTTAGGTATTGGCCAAAGTAATCAACTGAAGGA
GTTTCAAATTCAGGAACTAGGAGGAATTATACAAAAATCGATTGCTGCAAATACAATAATGGATGTAATAATTTTGGTGG
ATTATGATATTAGTAATTACAACAGATTTAAAATTGCATCATTGATTGCATCAGGGGCTGAATTAGCATCTTATAAATTT
AAAAAGTATTTCACTAAAAAGAATATTAATAATAATGATAATAAGTTGCAAGAAACTAGCGAAATGCATTTATTTATCAG
CTTAAAAGATGCTAGTGATATTGAGCAGGCTAAAGCTTATTTTAACAATATTTTACAACCAATTAATGAAGGTGTTGTGT
TAGCTAGAAATCTAATCTCAGAACCTCCAAATAAATTATATCCTGCTACTTATGCTCAAAAGATTGAAGAAGAATTTAAG
ATATTAAAAAATGAGTTTGGGGTTGAAGTAAATGTAAAAATTTTAGGCACACAAGAGATGCGTGATTTAAATATGGGAGC
ATTACTTGGAGTTGGGCAAGGATCCCAAAAAGAATCAAAATTAGTATCAATATCTTATTTAGGAGCAGTTAATAAAGATC
AAGCACCATTAGCTTTAGTAGGAAAAGGAGTAACTTTTGATACTGGAGGAATTAGTTTGAAACCATCTGCTGGTATGGAA
GATATGAAATATGATATGGCTGGATCAGCAGCAGTAGTTGGAGCTATAAAAGCTTTAGCGCGTAGAAAGGCAAAAGTAAA
TGTAGTTGGAGTAGTGGCTTTAGTTGAAAATATGCCAGGCAGTAACGCTCAAAGACCTAGTGATGTTGTAACAACAATGT
CAGGTCAAACAGTAGAAGTACTTAATACTGATGCAGAAGGGCGGTTAATACTTGCTGATGCATTATGGTATGTTCAAGAA
GTATTTAAGCCTGAGTCTATTATAGATTTAGCAACTTTAACTGGAGCAATAACTATAGCACTTGGTTATAGTTATGCTGG
ATGTTTTTCTAATAATAATGAATTAGCTCAGAAATTAATTATATCAGGCGAAAAGGTTAATGAAAATTTGTGGCGTATGC
CATTACATAAAGATTATGAAGACATGCTTAAATCTAATATTGCTGATATAGCAAATATTGGCAATGTTCGTGGTGCCGCT
GGTAGCTGTACTGCCGCTAGTTTTTTACAAAAATTTATTCAATTTAAGCAGAATCATGATAGTAGCAAAACTTCTATTCC
ATGGGCTCATTTAGATATAGCTTCTGTTGCTTGGAACAGAAAAGGAGGCAATATTTGTCCTGCAGGAGCAGTAGGATTTG
GAGTTAGATTAATTAACCAGTTTGTAGAAGATAATTATGAATGCATCAAATAA

Upstream 100 bases:

>100_bases
GTTTTATCGTTTCAGTAATGATGTACAGACTTGCAAATCTGTACCATAAACTTTAATATCAAAGAATAATAAATTATTAT
TCTAAATTTAGTGAGTCCAA

Downstream 100 bases:

>100_bases
AGAAATCACATTACCTTACATTTTTGTTATAGGAAATGAAAAAGGTGGTGCAGGTAAGACTACTGTTGCTATGCACTTAA
TTGCTGCTTTGCTTGACAAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MIINFIQTDSQNFFNCLEGINKTDVTDISNSQSICLLIGSDLVLTDSMLQLDQQCGGIISKFLQQNTKNKQIFSGKFGEI
KFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKSIAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKF
KKYFTKKNINNNDNKLQETSEMHLFISLKDASDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
ILKNEFGVEVNVKILGTQEMRDLNMGALLGVGQGSQKESKLVSISYLGAVNKDQAPLALVGKGVTFDTGGISLKPSAGME
DMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPGSNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQE
VFKPESIIDLATLTGAITIALGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYEDMLKSNIADIANIGNVRGAA
GSCTAASFLQKFIQFKQNHDSSKTSIPWAHLDIASVAWNRKGGNICPAGAVGFGVRLINQFVEDNYECIK

Sequences:

>Translated_550_residues
MIINFIQTDSQNFFNCLEGINKTDVTDISNSQSICLLIGSDLVLTDSMLQLDQQCGGIISKFLQQNTKNKQIFSGKFGEI
KFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKSIAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKF
KKYFTKKNINNNDNKLQETSEMHLFISLKDASDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
ILKNEFGVEVNVKILGTQEMRDLNMGALLGVGQGSQKESKLVSISYLGAVNKDQAPLALVGKGVTFDTGGISLKPSAGME
DMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPGSNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQE
VFKPESIIDLATLTGAITIALGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYEDMLKSNIADIANIGNVRGAA
GSCTAASFLQKFIQFKQNHDSSKTSIPWAHLDIASVAWNRKGGNICPAGAVGFGVRLINQFVEDNYECIK
>Mature_550_residues
MIINFIQTDSQNFFNCLEGINKTDVTDISNSQSICLLIGSDLVLTDSMLQLDQQCGGIISKFLQQNTKNKQIFSGKFGEI
KFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKSIAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKF
KKYFTKKNINNNDNKLQETSEMHLFISLKDASDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
ILKNEFGVEVNVKILGTQEMRDLNMGALLGVGQGSQKESKLVSISYLGAVNKDQAPLALVGKGVTFDTGGISLKPSAGME
DMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPGSNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQE
VFKPESIIDLATLTGAITIALGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYEDMLKSNIADIANIGNVRGAA
GSCTAASFLQKFIQFKQNHDSSKTSIPWAHLDIASVAWNRKGGNICPAGAVGFGVRLINQFVEDNYECIK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=398, Percent_Identity=36.4321608040201, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI47155554, Length=339, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1790710, Length=519, Percent_Identity=38.5356454720617, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI87082123, Length=325, Percent_Identity=37.8461538461538, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=316, Percent_Identity=34.1772151898734, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=399, Percent_Identity=27.0676691729323, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24661038, Length=308, Percent_Identity=36.038961038961, Blast_Score=179, Evalue=6e-45,
Organism=Drosophila melanogaster, GI21355725, Length=304, Percent_Identity=35.5263157894737, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI20129969, Length=482, Percent_Identity=28.0082987551867, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI161077148, Length=301, Percent_Identity=33.8870431893688, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20130057, Length=301, Percent_Identity=33.8870431893688, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129963, Length=483, Percent_Identity=28.3643892339545, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24662227, Length=300, Percent_Identity=30.6666666666667, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21355645, Length=472, Percent_Identity=25.8474576271186, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24662223, Length=472, Percent_Identity=25.8474576271186, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI19922386, Length=475, Percent_Identity=26.7368421052632, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI221379063, Length=339, Percent_Identity=31.2684365781711, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221379062, Length=339, Percent_Identity=31.2684365781711, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21357381, Length=339, Percent_Identity=31.2684365781711, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24646701, Length=345, Percent_Identity=26.3768115942029, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646703, Length=345, Percent_Identity=26.3768115942029, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21358201, Length=345, Percent_Identity=26.3768115942029, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 60133; Mature: 60133

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIINFIQTDSQNFFNCLEGINKTDVTDISNSQSICLLIGSDLVLTDSMLQLDQQCGGIIS
CEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
KFLQQNTKNKQIFSGKFGEIKFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKS
HHHHCCCCCCEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
IAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKFKKYFTKKNINNNDNKLQETS
HHHHHHEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHCCC
EMHLFISLKDASDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
CEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ILKNEFGVEVNVKILGTQEMRDLNMGALLGVGQGSQKESKLVSISYLGAVNKDQAPLALV
HHHHHCCCEEEEEEEECHHHHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCEEEE
GKGVTFDTGGISLKPSAGMEDMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPG
ECCEEECCCCEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCEEHEEEEEHHHCCCC
SNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQEVFKPESIIDLATLTGAITIA
CCCCCCCHHHEECCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHEEEEE
LGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYEDMLKSNIADIANIGNVRGAA
ECCCEEEECCCCHHHHHHHHHCCCHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GSCTAASFLQKFIQFKQNHDSSKTSIPWAHLDIASVAWNRKGGNICPAGAVGFGVRLINQ
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHEECCCCCCCCCCCHHHHHHHHHHH
FVEDNYECIK
HHHCCHHHCC
>Mature Secondary Structure
MIINFIQTDSQNFFNCLEGINKTDVTDISNSQSICLLIGSDLVLTDSMLQLDQQCGGIIS
CEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
KFLQQNTKNKQIFSGKFGEIKFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKS
HHHHCCCCCCEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
IAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKFKKYFTKKNINNNDNKLQETS
HHHHHHEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHCCC
EMHLFISLKDASDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
CEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ILKNEFGVEVNVKILGTQEMRDLNMGALLGVGQGSQKESKLVSISYLGAVNKDQAPLALV
HHHHHCCCEEEEEEEECHHHHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCEEEE
GKGVTFDTGGISLKPSAGMEDMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPG
ECCEEECCCCEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCEEHEEEEEHHHCCCC
SNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQEVFKPESIIDLATLTGAITIA
CCCCCCCHHHEECCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHEEEEE
LGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYEDMLKSNIADIANIGNVRGAA
ECCCEEEECCCCHHHHHHHHHCCCHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GSCTAASFLQKFIQFKQNHDSSKTSIPWAHLDIASVAWNRKGGNICPAGAVGFGVRLINQ
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHEECCCCCCCCCCCHHHHHHHHHHH
FVEDNYECIK
HHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA