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The map label for this gene is fabF [H]

Identifier: 148284221

GI number: 148284221

Start: 365120

End: 366391

Strand: Direct

Name: fabF [H]

Synonym: OTBS_0383

Alternate gene names: 148284221

Gene position: 365120-366391 (Clockwise)

Preceding gene: 148284220

Following gene: 148284235

Centisome position: 17.17

GC content: 34.04

Gene sequence:

>1272_bases
ATGGCTAACAGGCGAGTAGTTATTACTGGAATAGGCATGGTAACTCCTTTAGGTGTCAATGCTAAAAGCTCATGGGAAAA
TCTTATAAAATGCAAAAGTGGCATTACACGAATTCATAGATTTGACACTTCTAATCTAAAGTGTAAAATTGCTGGTCTAG
TCTTACATGATAGTACACTAAAAATTTATAGCATTAGAGGGCATGAATTACTAGTTGACTCAACAGATAAAAAAAAAGAC
ATTTTCATTCAATATGGAATTATTGCTGCTCAAGAAGCTATAGAAGATAGTGGAATTGATCTTAATAATAATGAAAAAAT
AAAAGAAAATACAGGAGTCATTATTGGAACTGGCCTTGGAGGAATTCAAGCAACAGCCGATAATGTGATCAATCTCTATA
TTAATAATAAAATAAGTACTTATTTTATTCCATCAATCCTATCAAATTTGATATCAGGACATATTTCTATAATGTATGGC
TTTCGAGGGCCAAATCAATCAGTTAACTCAGCATGCGCTACAGGAGCACATGCAATCACTGATGCAGCACGTATGATAAA
ATGCAATGAAGCCAATGTTATGATTGCAGGAGGCGCAGAAGCAGCTATCACAGATATTAGCATGGCTGGATTTAACGCAA
TTAAAGCTTTAAGCACAAAATATAACGATAATCCAAAAGCCGCTTGTAGACCCTGGGACAAAGATCGTAACGGTTTTATA
ATGTCTGAAGGAGCAGGAGTAGTAGTTCTAGAGGAGCTAGAACATGCCAAAAAGCGCAGAGCAAAAATATATGCCGAATT
GACTGGATATGGACTAAGCAGCGATGCATATCATATTACCTCACCACACCCAGAAGGAATAGGTAGCAAAATAGCAATGT
TAAAAGCAATTAAAACTTCTAAAATTCATATTGGAGATATTAATTATATTAATGCTCATGCTCCCTCTACAGAAAAGGGA
GACTTAATAGAATTAAAAGCCATTAAAAACCTCATTCTAAAAGAAAATTCTAAAGTTGCTATTTCATCAACTAAATCTTC
TACAGGTCATTTACTTGGTGCTAGCGGCAGCGTTGAAATAATATTTTCAGCTCTAGCATTACAAAATCAAGTTATACCAG
CAACATTAAATCTTGATAATCCTATAGAAGAAGCTAAAGATATTAACTTAGTACCAAATATACCTCAAGAATGCAAAATA
AATCATATACTTAGCAACTCGTTTGGCTTTGGCAGTACTAATGTTAGTATAGTACTAACAAAATTTGCCTAA

Upstream 100 bases:

>100_bases
TAACAAAATAAAATTTAATTTTAAAATTAAATTTCTTAAACCATCTAAAGGCTTATAAACATTATTTAACCTAACAAAAT
TTCAACTTAAGTAAATATCA

Downstream 100 bases:

>100_bases
AATTAACTCATAAAACTTACGCTATAATACTAACTGTTCAAAATGAGAAATATAATAAACATTCTGAACTATAGATTAAG
ATAATGCAATATAAGAAAAA

Product: 3-oxoacyl-[acyl carrier protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MANRRVVITGIGMVTPLGVNAKSSWENLIKCKSGITRIHRFDTSNLKCKIAGLVLHDSTLKIYSIRGHELLVDSTDKKKD
IFIQYGIIAAQEAIEDSGIDLNNNEKIKENTGVIIGTGLGGIQATADNVINLYINNKISTYFIPSILSNLISGHISIMYG
FRGPNQSVNSACATGAHAITDAARMIKCNEANVMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFI
MSEGAGVVVLEELEHAKKRRAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTSKIHIGDINYINAHAPSTEKG
DLIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEIIFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKI
NHILSNSFGFGSTNVSIVLTKFA

Sequences:

>Translated_423_residues
MANRRVVITGIGMVTPLGVNAKSSWENLIKCKSGITRIHRFDTSNLKCKIAGLVLHDSTLKIYSIRGHELLVDSTDKKKD
IFIQYGIIAAQEAIEDSGIDLNNNEKIKENTGVIIGTGLGGIQATADNVINLYINNKISTYFIPSILSNLISGHISIMYG
FRGPNQSVNSACATGAHAITDAARMIKCNEANVMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFI
MSEGAGVVVLEELEHAKKRRAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTSKIHIGDINYINAHAPSTEKG
DLIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEIIFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKI
NHILSNSFGFGSTNVSIVLTKFA
>Mature_422_residues
ANRRVVITGIGMVTPLGVNAKSSWENLIKCKSGITRIHRFDTSNLKCKIAGLVLHDSTLKIYSIRGHELLVDSTDKKKDI
FIQYGIIAAQEAIEDSGIDLNNNEKIKENTGVIIGTGLGGIQATADNVINLYINNKISTYFIPSILSNLISGHISIMYGF
RGPNQSVNSACATGAHAITDAARMIKCNEANVMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFIM
SEGAGVVVLEELEHAKKRRAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTSKIHIGDINYINAHAPSTEKGD
LIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEIIFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKIN
HILSNSFGFGSTNVSIVLTKFA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=423, Percent_Identity=44.9172576832151, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=48.6486486486487, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI41872631, Length=427, Percent_Identity=25.2927400468384, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1787337, Length=424, Percent_Identity=46.2264150943396, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1788663, Length=430, Percent_Identity=33.7209302325581, Blast_Score=224, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71983541, Length=428, Percent_Identity=35.2803738317757, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=41.5730337078652, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI212642053, Length=340, Percent_Identity=25.8823529411765, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=276, Percent_Identity=26.0869565217391, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=38.7892376681614, Blast_Score=280, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24644341, Length=429, Percent_Identity=40.7925407925408, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI19920632, Length=345, Percent_Identity=24.9275362318841, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221330659, Length=357, Percent_Identity=24.3697478991597, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581345, Length=338, Percent_Identity=23.6686390532544, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45410; Mature: 45279

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRRVVITGIGMVTPLGVNAKSSWENLIKCKSGITRIHRFDTSNLKCKIAGLVLHDSTL
CCCCEEEEEECCEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEEEECCEE
KIYSIRGHELLVDSTDKKKDIFIQYGIIAAQEAIEDSGIDLNNNEKIKENTGVIIGTGLG
EEEEECCCEEEEECCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCEECCCCEEEECCCC
GIQATADNVINLYINNKISTYFIPSILSNLISGHISIMYGFRGPNQSVNSACATGAHAIT
CCEECCCCEEEEEECCCCCEEEHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHCCCHHHH
DAARMIKCNEANVMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFI
HHHHEEEECCCCEEEECCCCEEEEEEEHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
MSEGAGVVVLEELEHAKKRRAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTS
EECCCCEEEEHHHHHHHHHHHEEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHHHCCC
KIHIGDINYINAHAPSTEKGDLIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEI
EEEECCCEEEECCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHH
IFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKINHILSNSFGFGSTNVSIVLT
HHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCCCHHCEEEEEECCCCCCCCCCEEEEEE
KFA
ECC
>Mature Secondary Structure 
ANRRVVITGIGMVTPLGVNAKSSWENLIKCKSGITRIHRFDTSNLKCKIAGLVLHDSTL
CCCEEEEEECCEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEEEECCEE
KIYSIRGHELLVDSTDKKKDIFIQYGIIAAQEAIEDSGIDLNNNEKIKENTGVIIGTGLG
EEEEECCCEEEEECCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCEECCCCEEEECCCC
GIQATADNVINLYINNKISTYFIPSILSNLISGHISIMYGFRGPNQSVNSACATGAHAIT
CCEECCCCEEEEEECCCCCEEEHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHCCCHHHH
DAARMIKCNEANVMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFI
HHHHEEEECCCCEEEECCCCEEEEEEEHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
MSEGAGVVVLEELEHAKKRRAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTS
EECCCCEEEEHHHHHHHHHHHEEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHHHCCC
KIHIGDINYINAHAPSTEKGDLIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEI
EEEECCCEEEECCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHH
IFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKINHILSNSFGFGSTNVSIVLT
HHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCCCHHCEEEEEECCCCCCCCCCEEEEEE
KFA
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]