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The map label for this gene is hemF [H]

Identifier: 148284093

GI number: 148284093

Start: 179019

End: 179864

Strand: Direct

Name: hemF [H]

Synonym: OTBS_0188

Alternate gene names: 148284093

Gene position: 179019-179864 (Clockwise)

Preceding gene: 148284092

Following gene: 148284094

Centisome position: 8.42

GC content: 32.15

Gene sequence:

>846_bases
TTGAGATTTATGATTGAATATCAGGAAAAATGTTATCAATGGTTTAAAGAACTACGAGATGAGCTTATCAAAACCTTTGA
ACTAATAGAACAGCATTACGCAAGTAACAAAAAAGTTAAAGTAGCTAAATTTATTCAGAGTCAGTGGAGCAGAGCTGGTG
GTGGTGGTGGAGAAATGTCGATAATGCGAGGTAATGTATTTGCTAAGGTTGGAGTTAATATTTCAAAAGTTTATGGAGAT
GTACCAATAGCATTATGTGATATCATACCTTGCGCTAATTATGGTTCTAATTTTTTTGCTACAGGTATTTCAGTAGTAGC
GCATATGAAATCTCCTCTAGTTCCAGCTGTGCATTTCAATACCAGATATTTACAAACTAACAACTATTGGTTTGGAGGTG
GAAGTGATTTAACACCATTATATCCGGATAAGCTTGAGACTAAAAAATTTCATCAGGCTTTTCAACTAGTATGTGATAAA
TATAACCCATCATATTATGAAAAATTTAAAGCGGCGTGCGATAATTATTTTTATTTGCCTCATAGAAAAGAGTTTAGAGG
AGTTGGAGGAATATTTTATGATTATCTAAATAGCAAAAACTTTGATACGGATTTTAATTTTACTAAGAATATTGGAGAAG
CTTTTTTAGCTATTTATCCTGATATTGTAAAAAGCAAAATGTTTTTGCCATGGAGCAATAGCCAATATGAAGCTCTACTA
GTTAAACGCGGAAGATATGTGGAATTTAATTTATTATATGATAGAGGTACTAAATTTGGATTAATGACTGATGGTAACAT
TGATGCTATATTAATGTCACTTCCACCTGAAGTAAAGTGGCCATAA

Upstream 100 bases:

>100_bases
AACATAAGGCGTGGTCATTGGAAGCACTAATTTTCAACCTCTTTCATTTTAACTATTCAAAAGCTATGGTATATAAAAAC
TCAAATACAGTAAGCTAAGT

Downstream 100 bases:

>100_bases
ATTATTATAACAAATTAAAAACAAAGAATATAAAGTATAGTATTTACTAATATTATGAAAATGAAATAATATAATGTAGT
ATAAAAATTAAGCTATCACT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MRFMIEYQEKCYQWFKELRDELIKTFELIEQHYASNKKVKVAKFIQSQWSRAGGGGGEMSIMRGNVFAKVGVNISKVYGD
VPIALCDIIPCANYGSNFFATGISVVAHMKSPLVPAVHFNTRYLQTNNYWFGGGSDLTPLYPDKLETKKFHQAFQLVCDK
YNPSYYEKFKAACDNYFYLPHRKEFRGVGGIFYDYLNSKNFDTDFNFTKNIGEAFLAIYPDIVKSKMFLPWSNSQYEALL
VKRGRYVEFNLLYDRGTKFGLMTDGNIDAILMSLPPEVKWP

Sequences:

>Translated_281_residues
MRFMIEYQEKCYQWFKELRDELIKTFELIEQHYASNKKVKVAKFIQSQWSRAGGGGGEMSIMRGNVFAKVGVNISKVYGD
VPIALCDIIPCANYGSNFFATGISVVAHMKSPLVPAVHFNTRYLQTNNYWFGGGSDLTPLYPDKLETKKFHQAFQLVCDK
YNPSYYEKFKAACDNYFYLPHRKEFRGVGGIFYDYLNSKNFDTDFNFTKNIGEAFLAIYPDIVKSKMFLPWSNSQYEALL
VKRGRYVEFNLLYDRGTKFGLMTDGNIDAILMSLPPEVKWP
>Mature_281_residues
MRFMIEYQEKCYQWFKELRDELIKTFELIEQHYASNKKVKVAKFIQSQWSRAGGGGGEMSIMRGNVFAKVGVNISKVYGD
VPIALCDIIPCANYGSNFFATGISVVAHMKSPLVPAVHFNTRYLQTNNYWFGGGSDLTPLYPDKLETKKFHQAFQLVCDK
YNPSYYEKFKAACDNYFYLPHRKEFRGVGGIFYDYLNSKNFDTDFNFTKNIGEAFLAIYPDIVKSKMFLPWSNSQYEALL
VKRGRYVEFNLLYDRGTKFGLMTDGNIDAILMSLPPEVKWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=254, Percent_Identity=40.1574803149606, Blast_Score=189, Evalue=2e-48,
Organism=Escherichia coli, GI1788777, Length=249, Percent_Identity=39.7590361445783, Blast_Score=197, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6320249, Length=271, Percent_Identity=39.4833948339483, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17864388, Length=254, Percent_Identity=42.9133858267717, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 32476; Mature: 32476

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFMIEYQEKCYQWFKELRDELIKTFELIEQHYASNKKVKVAKFIQSQWSRAGGGGGEMS
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEE
IMRGNVFAKVGVNISKVYGDVPIALCDIIPCANYGSNFFATGISVVAHMKSPLVPAVHFN
EEECCEEEEECCCHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC
TRYLQTNNYWFGGGSDLTPLYPDKLETKKFHQAFQLVCDKYNPSYYEKFKAACDNYFYLP
EEEEEECCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECC
HRKEFRGVGGIFYDYLNSKNFDTDFNFTKNIGEAFLAIYPDIVKSKMFLPWSNSQYEALL
CCHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEECCCCCCCCEEEE
VKRGRYVEFNLLYDRGTKFGLMTDGNIDAILMSLPPEVKWP
EECCCEEEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MRFMIEYQEKCYQWFKELRDELIKTFELIEQHYASNKKVKVAKFIQSQWSRAGGGGGEMS
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEE
IMRGNVFAKVGVNISKVYGDVPIALCDIIPCANYGSNFFATGISVVAHMKSPLVPAVHFN
EEECCEEEEECCCHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC
TRYLQTNNYWFGGGSDLTPLYPDKLETKKFHQAFQLVCDKYNPSYYEKFKAACDNYFYLP
EEEEEECCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECC
HRKEFRGVGGIFYDYLNSKNFDTDFNFTKNIGEAFLAIYPDIVKSKMFLPWSNSQYEALL
CCHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEECCCCCCCCEEEE
VKRGRYVEFNLLYDRGTKFGLMTDGNIDAILMSLPPEVKWP
EECCCEEEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA