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The map label for this gene is hisG

Identifier: 148269112

GI number: 148269112

Start: 2874796

End: 2875410

Strand: Reverse

Name: hisG

Synonym: SaurJH9_2703

Alternate gene names: 148269112

Gene position: 2875410-2874796 (Counterclockwise)

Preceding gene: 148269113

Following gene: 148269111

Centisome position: 98.92

GC content: 33.66

Gene sequence:

>615_bases
ATGTTAAGAATCGCCATAGCCAAAGGACGTCTAATGGATAGTTTAATTAACTATTTAGATGTAATTGAATATACGACATT
ATCAGAAACATTAAAAAATAGAGAACGCCAATTATTATTAAGTGTAGATAATATTGAATGCATTTTAGTAAAAGGAAGTG
ACGTGCCAATCTATGTGGAACAAGGAATGGCCGACATAGGCATTGTTGGTAGCGACATATTAGATGAGCGCCAATATAAT
GTTAATAATTTGTTGAATATGCCTTTTGGAGCATGTCATTTTGCGGTTGCAGCGAAACCTGAAACGACCAATTATCGTAA
AATCGCAACGAGTTATGTTCATACTGCTGAAACATATTTTAAATCAAAAGGTATTGATGTCGAATTGATTAAATTGAATG
GTTCTGTTGAATTAGCTTGTGTCGTAGATATGGTAGACGGAATTGTCGACATCGTTCAAACAGGTACTACGCTAAAAGCG
AACGGACTGGTTGAAAAGCAACATATTAGTGATATCAATGCAAGATTAATAACTAATAAAGCAGCTTATTTTAAAAAATC
ACAATTAATAGAGCAATTTATTCGCTCTTTGGAGGTGTCTATTGCCAATGCTTAA

Upstream 100 bases:

>100_bases
TTGCTGAAAATGAATCTCGAGTTTTAACAGGTGGTTATTACAAAGGAAGCATCGAAGGGTTTGGATTAGGATTAACACTT
TAAGTAAGGGAGTATGCACA

Downstream 100 bases:

>100_bases
TGCACAACAATTTTTAAATCAATTTTCATTAGAAGCACCATTAGATGAGTCATTGTATCCAATTATTCGCGATATTTGTC
AGGAAGTTAAAGTTCATGGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLRIAIAKGRLMDSLINYLDVIEYTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGMADIGIVGSDILDERQYN
VNNLLNMPFGACHFAVAAKPETTNYRKIATSYVHTAETYFKSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLKA
NGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA

Sequences:

>Translated_204_residues
MLRIAIAKGRLMDSLINYLDVIEYTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGMADIGIVGSDILDERQYN
VNNLLNMPFGACHFAVAAKPETTNYRKIATSYVHTAETYFKSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLKA
NGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA
>Mature_204_residues
MLRIAIAKGRLMDSLINYLDVIEYTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGMADIGIVGSDILDERQYN
VNNLLNMPFGACHFAVAAKPETTNYRKIATSYVHTAETYFKSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLKA
NGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=214, Percent_Identity=33.6448598130841, Blast_Score=92, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=196, Percent_Identity=30.1020408163265, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_STAA1 (A7X770)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001443253.1
- ProteinModelPortal:   A7X770
- SMR:   A7X770
- STRING:   A7X770
- EnsemblBacteria:   EBSTAT00000004395
- GeneID:   5561090
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2663
- eggNOG:   COG0040
- GeneTree:   EBGT00050000025545
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK13584
- BioCyc:   SAUR418127:SAHV_2663-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 22643; Mature: 22643

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAIAKGRLMDSLINYLDVIEYTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVE
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEEEECCCCEEEEE
QGMADIGIVGSDILDERQYNVNNLLNMPFGACHFAVAAKPETTNYRKIATSYVHTAETYF
CCCCCCCCCCHHHHHCCCCCHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLKANGLVEKQHISDINARLITNK
HCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHCCCEEEECCCEEHHHHCCCHHEEEECH
AAYFKKSQLIEQFIRSLEVSIANA
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRIAIAKGRLMDSLINYLDVIEYTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVE
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEEEECCCCEEEEE
QGMADIGIVGSDILDERQYNVNNLLNMPFGACHFAVAAKPETTNYRKIATSYVHTAETYF
CCCCCCCCCCHHHHHCCCCCHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLKANGLVEKQHISDINARLITNK
HCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHCCCEEEECCCEEHHHHCCCHHEEEECH
AAYFKKSQLIEQFIRSLEVSIANA
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA