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The map label for this gene is icaR

Identifier: 148269098

GI number: 148269098

Start: 2861714

End: 2862274

Strand: Reverse

Name: icaR

Synonym: SaurJH9_2689

Alternate gene names: 148269098

Gene position: 2862274-2861714 (Counterclockwise)

Preceding gene: 148269103

Following gene: 148269097

Centisome position: 98.47

GC content: 27.63

Gene sequence:

>561_bases
TTGAAGGATAAGATTATTGATAACGCAATAACCTTATTTTCAGAGAAGGGGTATGACGGTACAACACTTGATGATATAGC
TAAAAGTGTAAATATAAAGAAAGCGAGTTTATATTACCATTTTGACTCGAAAAAAAGTATTTACGAACAAAGTGTTAAAT
GCTGTTTTGATTACCTTAATAATATTATTATGATGAATCAAAATAAATCGAACTATTCAATTGATGCTTTATATCAATTC
TTATTTGAGTTTATTTTCGACATCGAAGAAAGGTATATTAGAATGTACGTTCAATTATCTAATACGCCTGAGGAATTTTC
TGGAAATATTTACGGACAAATACAAGATTTAAATCAATCATTAAGTAAAGAGATAGCAAAATTCTATGATGAATCAAAGA
TAAAGATGACAAAAGAAGACTTTCAGAATTTAATATTGCTGTTTCTTGAAAGTTGGTATTTGAAAGCATCCTTTTCGCAA
AAATTTGGAGCAGTGGAAGAAAGTAAAAGTCAATTCAAAGATGAAGTGTATTCGCTACTAAATATATTTTTGAAGAAATA
A

Upstream 100 bases:

>100_bases
TGCAATAGATTGTTGTTATAATTAAACGGAAATATTTGTAATTGCAACTTAATTTTCCTGTAACATAGTGTGATTAATTT
TCAGTAGGGGGTTATAAAAA

Downstream 100 bases:

>100_bases
TTTTTGTTACTAGTTTGTAATAATTAACTTACTTTTGTAAAAAAAGACATGAGATTATTTTTTTAAATCTATATAAAGTT
GACAATACAAATCGATATTG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Intercellular adhesion protein R

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYSIDALYQF
LFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQ
KFGAVEESKSQFKDEVYSLLNIFLKK

Sequences:

>Translated_186_residues
MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYSIDALYQF
LFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQ
KFGAVEESKSQFKDEVYSLLNIFLKK
>Mature_186_residues
MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYSIDALYQF
LFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQ
KFGAVEESKSQFKDEVYSLLNIFLKK

Specific function: Represses transcription of the icaADBC operon necessary for biofilm production

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ICAR_STAA8 (Q9RQQ0)

Other databases:

- EMBL:   AF086783
- EMBL:   CP000253
- PIR:   A99975
- RefSeq:   YP_501450.1
- ProteinModelPortal:   Q9RQQ0
- SMR:   Q9RQQ0
- STRING:   Q9RQQ0
- EnsemblBacteria:   EBSTAT00000029049
- GeneID:   3921483
- GenomeReviews:   CP000253_GR
- KEGG:   sao:SAOUHSC_03001
- eggNOG:   COG1309
- GeneTree:   EBGT00050000024441
- HOGENOM:   HBG693015
- OMA:   DANDIEI
- ProtClustDB:   CLSK886141
- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647
- Gene3D:   G3DSA:1.10.357.10
- PRINTS:   PR00455

Pfam domain/function: PF00440 TetR_N; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 21987; Mature: 21987

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01081 HTH_TETR_1; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLN
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHC
NIIMMNQNKSNYSIDALYQFLFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQS
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
LSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLL
HHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NIFLKK
HHHHCC
>Mature Secondary Structure
MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLN
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHC
NIIMMNQNKSNYSIDALYQFLFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQS
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
LSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLL
HHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NIFLKK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10496925