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The map label for this gene is pntAA [H]

Identifier: 148261148

GI number: 148261148

Start: 2380919

End: 2382061

Strand: Reverse

Name: pntAA [H]

Synonym: Acry_2157

Alternate gene names: 148261148

Gene position: 2382061-2380919 (Counterclockwise)

Preceding gene: 148261150

Following gene: 148261147

Centisome position: 70.28

GC content: 70.78

Gene sequence:

>1143_bases
ATGATGCGTCTTGCGGTGTTGAAAGAGCGTCTGCCGGGCGAGACCCGCGTCGCCGCGGTGCCGGATTCGATCAAGAAGCT
GAAGGCCCTCGGGCTCGACGTGGTGATCGAGGCGGGGGCCGGCGAGCGGGCCTCGGTCTCCGACGCGGCGCTGCGCGAGG
CCGGCGCGGAGATCGCGCCGGATGCGGCCTCGGCACTGAAGGGGGCCGGCATCGTGTTCACGGTGCAGCCGCCCGGGGAC
GAGATTCTGGCGCAGATCGAGCGCGGCGCGCTGCTGGTCGGCACGCTCGGCGCGATGGGGAACCAGGAGCGGGTGCAGGC
CTATGCCAAGGCCGGGATCGACGCCTGCTCGATGGAGCTGCTGCCGCGCATCACCCGCGCGCAGTCGATGGACGTGCTGT
CGAGCCAGGCGAATCTCGCCGGCTATCGCGCCGTGATCGAGGCGGCGGAGGCGTTTCCGCGCGGCTTCGCGATGATGATG
ACGGCGGCCGGCACCGTGCCGCCGGCGCGCGTGTTCGTGGTCGGCGCCGGGGTTGCCGGGCTGCAGGCGATCGCCACCGC
CCGCCGGCTCGGCGCCATCGTCTCGGCGACCGACGTGCGGCCGGCGGCGAAGGAGGAGATCAAGTCGCTCGGCGCGACCT
TCGTCGGCGTCGAGGACGAGGAGAGCAAGGCGCAGACCGGCGCCTACGCGAAGGAGATGAGTGCGGAGTTCCGCGCCAAG
CAGGCGGCGCTGATCGCCGAGACGGTGGCGAAGAACGACATCGTCATCTGCACCGCGCTGGTGATGGGGCGCAAGGCGCC
GACCATCGTCACCGCCGACGCGGTGGCGAAGATGCGGATGGGCAGCGTGATCGTCGATATCGCGGCGGATGCCGGCGGCA
ACTGCGAGGCGACGGTGCCGGGCGAGCGGATCGTGACGGAGAACGGCGTGATCGTGCTCGGGCACAGGAACTGGCCGTCG
CGCATCGGCGTCGCCGCCAGCACGCTCTATGCGCGCAACCTCTCGACCTTCCTCACCGGGTTCTGGGACAAGGAGGCCGG
GCGGCCGAAACTGCCCGCCGACGACGATATCGTGAAGGGCGTCCTGCTCACGCGGGATGGCGCCGTCGTTCATCCGAACT
TCCAGCCGCAAGCAGCTGCCTAG

Upstream 100 bases:

>100_bases
CATCTGTGGCATAATTGCTGCTTTGAATGGTGCGGTGCGACACAATATTTCGGACGCCGGGGCGCACGATCGTTGCGCGG
TGTTGAACGAAGGGATGGAT

Downstream 100 bases:

>100_bases
GAGCCACATCATGACCCCTGCACAACTCGCGGACCAGGCCGACGCGCTCGCGCACAAGGCCACCGTGCTGGCGCAGAACG
CCGCCGGCTTCGCCGCCCAG

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MMRLAVLKERLPGETRVAAVPDSIKKLKALGLDVVIEAGAGERASVSDAALREAGAEIAPDAASALKGAGIVFTVQPPGD
EILAQIERGALLVGTLGAMGNQERVQAYAKAGIDACSMELLPRITRAQSMDVLSSQANLAGYRAVIEAAEAFPRGFAMMM
TAAGTVPPARVFVVGAGVAGLQAIATARRLGAIVSATDVRPAAKEEIKSLGATFVGVEDEESKAQTGAYAKEMSAEFRAK
QAALIAETVAKNDIVICTALVMGRKAPTIVTADAVAKMRMGSVIVDIAADAGGNCEATVPGERIVTENGVIVLGHRNWPS
RIGVAASTLYARNLSTFLTGFWDKEAGRPKLPADDDIVKGVLLTRDGAVVHPNFQPQAAA

Sequences:

>Translated_380_residues
MMRLAVLKERLPGETRVAAVPDSIKKLKALGLDVVIEAGAGERASVSDAALREAGAEIAPDAASALKGAGIVFTVQPPGD
EILAQIERGALLVGTLGAMGNQERVQAYAKAGIDACSMELLPRITRAQSMDVLSSQANLAGYRAVIEAAEAFPRGFAMMM
TAAGTVPPARVFVVGAGVAGLQAIATARRLGAIVSATDVRPAAKEEIKSLGATFVGVEDEESKAQTGAYAKEMSAEFRAK
QAALIAETVAKNDIVICTALVMGRKAPTIVTADAVAKMRMGSVIVDIAADAGGNCEATVPGERIVTENGVIVLGHRNWPS
RIGVAASTLYARNLSTFLTGFWDKEAGRPKLPADDDIVKGVLLTRDGAVVHPNFQPQAAA
>Mature_380_residues
MMRLAVLKERLPGETRVAAVPDSIKKLKALGLDVVIEAGAGERASVSDAALREAGAEIAPDAASALKGAGIVFTVQPPGD
EILAQIERGALLVGTLGAMGNQERVQAYAKAGIDACSMELLPRITRAQSMDVLSSQANLAGYRAVIEAAEAFPRGFAMMM
TAAGTVPPARVFVVGAGVAGLQAIATARRLGAIVSATDVRPAAKEEIKSLGATFVGVEDEESKAQTGAYAKEMSAEFRAK
QAALIAETVAKNDIVICTALVMGRKAPTIVTADAVAKMRMGSVIVDIAADAGGNCEATVPGERIVTENGVIVLGHRNWPS
RIGVAASTLYARNLSTFLTGFWDKEAGRPKLPADDDIVKGVLLTRDGAVVHPNFQPQAAA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=389, Percent_Identity=38.560411311054, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI122939153, Length=389, Percent_Identity=38.560411311054, Blast_Score=238, Evalue=5e-63,
Organism=Escherichia coli, GI1787887, Length=371, Percent_Identity=43.6657681940701, Blast_Score=297, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17550456, Length=369, Percent_Identity=40.3794037940379, Blast_Score=265, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39382; Mature: 39382

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRLAVLKERLPGETRVAAVPDSIKKLKALGLDVVIEAGAGERASVSDAALREAGAEIAP
CCHHHHHHHHCCCCCEEEECCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCCCCC
DAASALKGAGIVFTVQPPGDEILAQIERGALLVGTLGAMGNQERVQAYAKAGIDACSMEL
CHHHHHCCCCEEEEECCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHH
LPRITRAQSMDVLSSQANLAGYRAVIEAAEAFPRGFAMMMTAAGTVPPARVFVVGAGVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEECCHHH
LQAIATARRLGAIVSATDVRPAAKEEIKSLGATFVGVEDEESKAQTGAYAKEMSAEFRAK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
QAALIAETVAKNDIVICTALVMGRKAPTIVTADAVAKMRMGSVIVDIAADAGGNCEATVP
HHHHHHHHHCCCCEEEEEHHHHCCCCCEEEEHHHHHHHHHCCEEEEEECCCCCCCEEECC
GERIVTENGVIVLGHRNWPSRIGVAASTLYARNLSTFLTGFWDKEAGRPKLPADDDIVKG
CCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCC
VLLTRDGAVVHPNFQPQAAA
EEEECCCCEECCCCCCCCCC
>Mature Secondary Structure
MMRLAVLKERLPGETRVAAVPDSIKKLKALGLDVVIEAGAGERASVSDAALREAGAEIAP
CCHHHHHHHHCCCCCEEEECCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCCCCC
DAASALKGAGIVFTVQPPGDEILAQIERGALLVGTLGAMGNQERVQAYAKAGIDACSMEL
CHHHHHCCCCEEEEECCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHH
LPRITRAQSMDVLSSQANLAGYRAVIEAAEAFPRGFAMMMTAAGTVPPARVFVVGAGVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEECCHHH
LQAIATARRLGAIVSATDVRPAAKEEIKSLGATFVGVEDEESKAQTGAYAKEMSAEFRAK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
QAALIAETVAKNDIVICTALVMGRKAPTIVTADAVAKMRMGSVIVDIAADAGGNCEATVP
HHHHHHHHHCCCCEEEEEHHHHCCCCCEEEEHHHHHHHHHCCEEEEEECCCCCCCEEECC
GERIVTENGVIVLGHRNWPSRIGVAASTLYARNLSTFLTGFWDKEAGRPKLPADDDIVKG
CCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCC
VLLTRDGAVVHPNFQPQAAA
EEEECCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]