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The map label for this gene is icd [H]

Identifier: 148261021

GI number: 148261021

Start: 2223909

End: 2225372

Strand: Reverse

Name: icd [H]

Synonym: Acry_2029

Alternate gene names: 148261021

Gene position: 2225372-2223909 (Counterclockwise)

Preceding gene: 148261023

Following gene: 148261019

Centisome position: 65.66

GC content: 66.46

Gene sequence:

>1464_bases
ATGATCGCAACCTCGCCCGCCCTCGCCAAGACCCTTGTCACCGCCCTGCCGGGCGATGGGATCGGCCCCGAAGTCTTCGA
GGCGACGCGCCGCATCTTCGAGGCCGCCGAAGCGCCGGTCGAGTGGGAGGTTGCCGAAGCCGGCGCCGCCGTGTTCAGGA
AGGGCATCGCCTCCGGCGCGCCGCGCGAAACCCTCGATTCCATCGCGCGCAACCGCATCGCCCTCAAGGGGCCGCTGGAA
ACGCCGGTCGGCTACGGCAACAAGTCGGCCAACGTCACCCTGCGCAAGCATTTCGAGCTCTATGCCAATATCCGCCCGGT
CCGCGAGCTGCCCGGGGTGAAGACGCCGTTCACCGGGCGCGGGATCGACATGGTCATCGTCCGCGAGAACGTGGAGGACG
TCTATGCCGGCATCGAGCACATGCAGACTCCGGATGTCGCCCAGTGCCTCAAGCTGATGACGCGGCCGGGCTGCGAGCGC
ATCATCCGCGCCGCCTTCGGCCTTGCCCAGGCGGAGGACCGCCGGAAGCTGACCTGTGCCACCAAGGCGAACATCATGAA
GCTCACCGAGGGCATGATGAAGCGCGTCTTCGAGGAAGTCGGTCCCGATTATCCGGATATCGCGCAGGATCACATCATCA
TCGACAACTGCGCCCATCAGCTCGTCATCGCCCCCGAGCAGTTCGACGTGATCGTGACCTCGAACATGAATGGCGACATC
ATTTCCGACCTCGCCGCCGGGCTGGTCGGTGGCCTCGGCATCGCGCCATCCTCCAATCTCGGCGATCACGCGGCGATTTT
CGAGGCGGTGCACGGCTCGGCGCCGGCCATCGCCGGCAAGGGGCTCGCCAACCCGACCGCGCTGCTGTCCGCCGCGATCA
TGATGCTCCGCCATATCGGCGCCTTCGAGACGGCCGAGACGATCGAGCAGGCGCTGTTCATCACCCTCGCCGAGGGGGAG
AACCTGACCGGCGACCTCTCGCCGCGCGGCCATGGCGTCGGCACCGACAAGTTCGTCGGCCAGGTCATCGAGAATCTCGG
CCGCACGAGCAATCTCCCGTCGCGCGCCTACCGGCCGCTCGAGCTCAAGGCGTGGCCCGACCGCACCGCCCATACGGAGC
CCGCAAGCCGCGAACTGATTGGCGTCGACATCTTTCTGGAAAGCAGCCTTTCCGCGGCCGAGCTGGGCGCCTCCCTCACC
GCCATTGCCGAGGGCAGTGCGCTCCGCCTCGACTCGATCTCGAATCGCGGCGTCCAGGTCTGGCCGGCGACCGGCGGCAG
GACCTTCCTCGTCGACCATTTCGATTGCCGCTTCATGCTCAATGAACCCGCGGCCGGAAACGGGCCGCAGGGCATTTCCG
ACCTCGTGAAGGCGATCGGACAGAAGCATTCCTGGATGCATGTCGAGAAGCTGCAACGGTTCGATGGCAAGGACGCCTTC
GAACGGCCCCAGGGCGAAAGCTGA

Upstream 100 bases:

>100_bases
CCCGGCATTCCGTCGGGGCTGCCATTTGTTGCGCTGCGGTAGCATCGGCGGACCGGCAGGCGTATACGCGCAATCACAAC
CAGACCATGGGGGATCAACG

Downstream 100 bases:

>100_bases
TCGGCGCTATTTGAAGATGCGCTGGCGGACGAAGCGTCGTGCCGCCAGCCAGCCGCACAGCGAGGCGAGACCGGAAACCA
CACCACCCCAGACAATGTCG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MIATSPALAKTLVTALPGDGIGPEVFEATRRIFEAAEAPVEWEVAEAGAAVFRKGIASGAPRETLDSIARNRIALKGPLE
TPVGYGNKSANVTLRKHFELYANIRPVRELPGVKTPFTGRGIDMVIVRENVEDVYAGIEHMQTPDVAQCLKLMTRPGCER
IIRAAFGLAQAEDRRKLTCATKANIMKLTEGMMKRVFEEVGPDYPDIAQDHIIIDNCAHQLVIAPEQFDVIVTSNMNGDI
ISDLAAGLVGGLGIAPSSNLGDHAAIFEAVHGSAPAIAGKGLANPTALLSAAIMMLRHIGAFETAETIEQALFITLAEGE
NLTGDLSPRGHGVGTDKFVGQVIENLGRTSNLPSRAYRPLELKAWPDRTAHTEPASRELIGVDIFLESSLSAAELGASLT
AIAEGSALRLDSISNRGVQVWPATGGRTFLVDHFDCRFMLNEPAAGNGPQGISDLVKAIGQKHSWMHVEKLQRFDGKDAF
ERPQGES

Sequences:

>Translated_487_residues
MIATSPALAKTLVTALPGDGIGPEVFEATRRIFEAAEAPVEWEVAEAGAAVFRKGIASGAPRETLDSIARNRIALKGPLE
TPVGYGNKSANVTLRKHFELYANIRPVRELPGVKTPFTGRGIDMVIVRENVEDVYAGIEHMQTPDVAQCLKLMTRPGCER
IIRAAFGLAQAEDRRKLTCATKANIMKLTEGMMKRVFEEVGPDYPDIAQDHIIIDNCAHQLVIAPEQFDVIVTSNMNGDI
ISDLAAGLVGGLGIAPSSNLGDHAAIFEAVHGSAPAIAGKGLANPTALLSAAIMMLRHIGAFETAETIEQALFITLAEGE
NLTGDLSPRGHGVGTDKFVGQVIENLGRTSNLPSRAYRPLELKAWPDRTAHTEPASRELIGVDIFLESSLSAAELGASLT
AIAEGSALRLDSISNRGVQVWPATGGRTFLVDHFDCRFMLNEPAAGNGPQGISDLVKAIGQKHSWMHVEKLQRFDGKDAF
ERPQGES
>Mature_487_residues
MIATSPALAKTLVTALPGDGIGPEVFEATRRIFEAAEAPVEWEVAEAGAAVFRKGIASGAPRETLDSIARNRIALKGPLE
TPVGYGNKSANVTLRKHFELYANIRPVRELPGVKTPFTGRGIDMVIVRENVEDVYAGIEHMQTPDVAQCLKLMTRPGCER
IIRAAFGLAQAEDRRKLTCATKANIMKLTEGMMKRVFEEVGPDYPDIAQDHIIIDNCAHQLVIAPEQFDVIVTSNMNGDI
ISDLAAGLVGGLGIAPSSNLGDHAAIFEAVHGSAPAIAGKGLANPTALLSAAIMMLRHIGAFETAETIEQALFITLAEGE
NLTGDLSPRGHGVGTDKFVGQVIENLGRTSNLPSRAYRPLELKAWPDRTAHTEPASRELIGVDIFLESSLSAAELGASLT
AIAEGSALRLDSISNRGVQVWPATGGRTFLVDHFDCRFMLNEPAAGNGPQGISDLVKAIGQKHSWMHVEKLQRFDGKDAF
ERPQGES

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=315, Percent_Identity=46.6666666666667, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI28178821, Length=338, Percent_Identity=39.3491124260355, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI4758582, Length=322, Percent_Identity=40.0621118012422, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI28178838, Length=313, Percent_Identity=40.2555910543131, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI28178816, Length=291, Percent_Identity=41.5807560137457, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI28178819, Length=203, Percent_Identity=42.8571428571429, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1787381, Length=353, Percent_Identity=36.8271954674221, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788101, Length=316, Percent_Identity=36.0759493670886, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI87081683, Length=355, Percent_Identity=32.3943661971831, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71986051, Length=318, Percent_Identity=44.9685534591195, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI17505779, Length=316, Percent_Identity=41.4556962025316, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI25144293, Length=355, Percent_Identity=40.2816901408451, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17550882, Length=344, Percent_Identity=38.0813953488372, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324709, Length=346, Percent_Identity=43.3526011560694, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6324291, Length=339, Percent_Identity=40.117994100295, Blast_Score=249, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6322097, Length=365, Percent_Identity=35.0684931506849, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319830, Length=342, Percent_Identity=32.1637426900585, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24643270, Length=317, Percent_Identity=47.0031545741325, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24643268, Length=317, Percent_Identity=47.0031545741325, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24661184, Length=341, Percent_Identity=41.3489736070381, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI161078635, Length=340, Percent_Identity=38.5294117647059, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161078633, Length=340, Percent_Identity=38.5294117647059, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24650122, Length=340, Percent_Identity=38.5294117647059, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161078637, Length=340, Percent_Identity=38.5294117647059, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161078639, Length=337, Percent_Identity=38.2789317507418, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI281362242, Length=344, Percent_Identity=38.953488372093, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24648872, Length=344, Percent_Identity=38.953488372093, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI20130355, Length=345, Percent_Identity=29.8550724637681, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI45550436, Length=284, Percent_Identity=22.887323943662, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 52191; Mature: 52191

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIATSPALAKTLVTALPGDGIGPEVFEATRRIFEAAEAPVEWEVAEAGAAVFRKGIASGA
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCC
PRETLDSIARNRIALKGPLETPVGYGNKSANVTLRKHFELYANIRPVRELPGVKTPFTGR
CHHHHHHHHHCCEEEECCCCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHCCCCCCCCCCC
GIDMVIVRENVEDVYAGIEHMQTPDVAQCLKLMTRPGCERIIRAAFGLAQAEDRRKLTCA
CEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEHH
TKANIMKLTEGMMKRVFEEVGPDYPDIAQDHIIIDNCAHQLVIAPEQFDVIVTSNMNGDI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCCEEEEEECCCCCHH
ISDLAAGLVGGLGIAPSSNLGDHAAIFEAVHGSAPAIAGKGLANPTALLSAAIMMLRHIG
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
AFETAETIEQALFITLAEGENLTGDLSPRGHGVGTDKFVGQVIENLGRTSNLPSRAYRPL
CHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHCCCCE
ELKAWPDRTAHTEPASRELIGVDIFLESSLSAAELGASLTAIAEGSALRLDSISNRGVQV
EEECCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHCCHHEEECCCCEEEECCCCCCCEEE
WPATGGRTFLVDHFDCRFMLNEPAAGNGPQGISDLVKAIGQKHSWMHVEKLQRFDGKDAF
EECCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCHH
ERPQGES
CCCCCCC
>Mature Secondary Structure
MIATSPALAKTLVTALPGDGIGPEVFEATRRIFEAAEAPVEWEVAEAGAAVFRKGIASGA
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCC
PRETLDSIARNRIALKGPLETPVGYGNKSANVTLRKHFELYANIRPVRELPGVKTPFTGR
CHHHHHHHHHCCEEEECCCCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHCCCCCCCCCCC
GIDMVIVRENVEDVYAGIEHMQTPDVAQCLKLMTRPGCERIIRAAFGLAQAEDRRKLTCA
CEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEHH
TKANIMKLTEGMMKRVFEEVGPDYPDIAQDHIIIDNCAHQLVIAPEQFDVIVTSNMNGDI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCCEEEEEECCCCCHH
ISDLAAGLVGGLGIAPSSNLGDHAAIFEAVHGSAPAIAGKGLANPTALLSAAIMMLRHIG
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
AFETAETIEQALFITLAEGENLTGDLSPRGHGVGTDKFVGQVIENLGRTSNLPSRAYRPL
CHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHCCCCE
ELKAWPDRTAHTEPASRELIGVDIFLESSLSAAELGASLTAIAEGSALRLDSISNRGVQV
EEECCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHCCHHEEECCCCEEEECCCCCCCEEE
WPATGGRTFLVDHFDCRFMLNEPAAGNGPQGISDLVKAIGQKHSWMHVEKLQRFDGKDAF
EECCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCHH
ERPQGES
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1539996 [H]