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The map label for this gene is dnaX [H]

Identifier: 148260992

GI number: 148260992

Start: 2191834

End: 2193678

Strand: Reverse

Name: dnaX [H]

Synonym: Acry_2000

Alternate gene names: 148260992

Gene position: 2193678-2191834 (Counterclockwise)

Preceding gene: 148260996

Following gene: 148260991

Centisome position: 64.73

GC content: 70.73

Gene sequence:

>1845_bases
ATGGCCGGTCTGTTCGACGACGACGAGACGGACGATCAGCCTAGGTCCGAGCCGCCGCCGCCGGGACCGTCGCTGTTCGG
CGACGACGAATTGCCCGAGGCCGCCGCCCCGGTCCATGCCGAGTCCTACCGCGTCCTCGCCCGCAAATACCGCCCGACCA
CCTTCGACGACCTAATCGGCCAGGACGGGCTGGTCCGCACCCTGCGCAACGCCTTCGCGATGAACCGCATCGCCCACGCC
TTCATGCTCACCGGCGTGCGCGGTGTGGGCAAGACGACGACGGCGCGGATTCTCGCCCGCGCGCTGAACTGCACCGGGGC
GGACGGGCAGGGCGGTCCCACGCCCGATCCCTGCGGCGTGTGCGATAATTGCGTGGCGATCCTCGCCGACCGCCACCCCG
ACGTGGTGGAGATGGACGCGGCCTCGAACACCGGGGTCGACGACGTGCGCGAGATCATCGAGGCGACGCGCTTCCGCCCG
ATGATCGCCCGCACCAAGGTGTTCATCGTCGACGAGGTCCACATGCTCTCGCGCAACGCGTTCAACGCGCTGCTCAAGAC
GCTGGAGGAACCGCCGCCGCACGTGAAATTCGTGTTCGCCACCACGGAAATCCGCAAGGTGCCGATCACCGTGCTCTCGC
GCTGCCAGCGTTTCGACCTCAAGCGCGTGCCGGTCGATGTGCTGGCCGCGCATTTTGCCCGCATCGCGGAGAAGGAGGCG
GTCGCGGTCGAAGGTGGCGCGCTCGACGCCGTCGCGCGCGCCGCCGACGGGTCGGTGCGCGACGGGCTCTCCCTGCTCGA
CCAGGCGATCGCCCGGGCCGATGAGGGGGCACCGGTCACGGCCGAACTGGTGGCCGATATGCTCGGCCTGGCCGATCGCG
GCATGGTCTTCGATCTGCTGGAGGCCGTCGCCGCCGGCGATCCCGCCGGTGCGCTCGGCGTGATGGACCGCGCGCATGAA
GCCGGCGCCGATCCGGTATTGGTGATGCAGGATCTGCTCGGCCTCGCCCATACGCTCTCGCGCCTGAAGGCGATCCCGGC
CCTGGCCGAGGGCAGCGAATTGCCCGAGCTCGACCGCGCCCGCGGCGCGCCGCTGGCCGCGCGGCTTTCGGTGCCGTTTC
TCGGCCGCCTCTGGCAGATGCTGCTCAAGGGCGTCGCCGAGGTGGAGCAGGCGACCGACCGGCGCGCCGCCGCCGACATG
ATCCTGATCCGCCTCTGCTACGTGTCCGACCTGCCGCCACCCGGCGAACTGGTTCGGCGCCTGTCTGGCGAGGGGACGGT
GGCCCGCGGCAATGCCGTGCCCGCGTCCGCGCCCGGCCCGGCCCCAAGGGCGGTGGTGAACGGCGCCCCGGTCGCGCCGG
CCGAGACCGCCCCGGCAACGGCCCCGCGCCTTGCCCGGTTCGAGGACGTGATTGCCCTGGCCGGCGAGAAGCGGGACGCC
TTGCTCTATGCCCATCTCCGCCACGATGCCCGGCTGGTGCGGTTCGCGCCGCCGGTGATCGAACTGAACCTTACCCCCGA
GGCGCCTCGCGATCTTTCGTCCCGCCTCGCCAGGTTTCTCGAGGCGGAAACCGGACGGCGATGGACCATCGCCCTATCCC
GCGCCGCCGGCGCACCGAGCATGGTCGAGGCCGAAACCACGGCACGCGAGACGGCGCGCAACGAGGCACTCGACCATCCG
CTGGTCAGGGCCATCTTCGAGACGTTTCCTGGGGCGAAGATCGCGAGCGTCGAGGTCGACGCGCCGCCCGCCCTTGCGGA
GCCGCCCGTGATGGATGATGACCGCTTCGACGATGTCCCGCCGATTTCCGACGACGACATCGCCGATGCCATGGAGATCG
ACTGA

Upstream 100 bases:

>100_bases
AACCCGGTCAGGGCCGGAAGGCAGCAGCCGCAACGAGTTTCCGCACGGGTCGCGGTTCCGGTCTCCCACCTCTCAATCCA
GCCCAGCTCATCGGAGGCGC

Downstream 100 bases:

>100_bases
TGAAGAACCTCGCCGGCCTGATGAAGCAGGCCCAGCAGATGCAGCAGAACATGCAGGAGATGCAGACGCGTCTCGAAGCC
ATGGAGATCCGGGGCGAGGC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 613

Protein sequence:

>614_residues
MAGLFDDDETDDQPRSEPPPPGPSLFGDDELPEAAAPVHAESYRVLARKYRPTTFDDLIGQDGLVRTLRNAFAMNRIAHA
FMLTGVRGVGKTTTARILARALNCTGADGQGGPTPDPCGVCDNCVAILADRHPDVVEMDAASNTGVDDVREIIEATRFRP
MIARTKVFIVDEVHMLSRNAFNALLKTLEEPPPHVKFVFATTEIRKVPITVLSRCQRFDLKRVPVDVLAAHFARIAEKEA
VAVEGGALDAVARAADGSVRDGLSLLDQAIARADEGAPVTAELVADMLGLADRGMVFDLLEAVAAGDPAGALGVMDRAHE
AGADPVLVMQDLLGLAHTLSRLKAIPALAEGSELPELDRARGAPLAARLSVPFLGRLWQMLLKGVAEVEQATDRRAAADM
ILIRLCYVSDLPPPGELVRRLSGEGTVARGNAVPASAPGPAPRAVVNGAPVAPAETAPATAPRLARFEDVIALAGEKRDA
LLYAHLRHDARLVRFAPPVIELNLTPEAPRDLSSRLARFLEAETGRRWTIALSRAAGAPSMVEAETTARETARNEALDHP
LVRAIFETFPGAKIASVEVDAPPALAEPPVMDDDRFDDVPPISDDDIADAMEID

Sequences:

>Translated_614_residues
MAGLFDDDETDDQPRSEPPPPGPSLFGDDELPEAAAPVHAESYRVLARKYRPTTFDDLIGQDGLVRTLRNAFAMNRIAHA
FMLTGVRGVGKTTTARILARALNCTGADGQGGPTPDPCGVCDNCVAILADRHPDVVEMDAASNTGVDDVREIIEATRFRP
MIARTKVFIVDEVHMLSRNAFNALLKTLEEPPPHVKFVFATTEIRKVPITVLSRCQRFDLKRVPVDVLAAHFARIAEKEA
VAVEGGALDAVARAADGSVRDGLSLLDQAIARADEGAPVTAELVADMLGLADRGMVFDLLEAVAAGDPAGALGVMDRAHE
AGADPVLVMQDLLGLAHTLSRLKAIPALAEGSELPELDRARGAPLAARLSVPFLGRLWQMLLKGVAEVEQATDRRAAADM
ILIRLCYVSDLPPPGELVRRLSGEGTVARGNAVPASAPGPAPRAVVNGAPVAPAETAPATAPRLARFEDVIALAGEKRDA
LLYAHLRHDARLVRFAPPVIELNLTPEAPRDLSSRLARFLEAETGRRWTIALSRAAGAPSMVEAETTARETARNEALDHP
LVRAIFETFPGAKIASVEVDAPPALAEPPVMDDDRFDDVPPISDDDIADAMEID
>Mature_613_residues
AGLFDDDETDDQPRSEPPPPGPSLFGDDELPEAAAPVHAESYRVLARKYRPTTFDDLIGQDGLVRTLRNAFAMNRIAHAF
MLTGVRGVGKTTTARILARALNCTGADGQGGPTPDPCGVCDNCVAILADRHPDVVEMDAASNTGVDDVREIIEATRFRPM
IARTKVFIVDEVHMLSRNAFNALLKTLEEPPPHVKFVFATTEIRKVPITVLSRCQRFDLKRVPVDVLAAHFARIAEKEAV
AVEGGALDAVARAADGSVRDGLSLLDQAIARADEGAPVTAELVADMLGLADRGMVFDLLEAVAAGDPAGALGVMDRAHEA
GADPVLVMQDLLGLAHTLSRLKAIPALAEGSELPELDRARGAPLAARLSVPFLGRLWQMLLKGVAEVEQATDRRAAADMI
LIRLCYVSDLPPPGELVRRLSGEGTVARGNAVPASAPGPAPRAVVNGAPVAPAETAPATAPRLARFEDVIALAGEKRDAL
LYAHLRHDARLVRFAPPVIELNLTPEAPRDLSSRLARFLEAETGRRWTIALSRAAGAPSMVEAETTARETARNEALDHPL
VRAIFETFPGAKIASVEVDAPPALAEPPVMDDDRFDDVPPISDDDIADAMEID

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=374, Percent_Identity=42.2459893048128, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1787341, Length=149, Percent_Identity=34.2281879194631, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554730, Length=230, Percent_Identity=25.2173913043478, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17541988, Length=237, Percent_Identity=27.8481012658228, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=275, Percent_Identity=23.6363636363636, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324478, Length=227, Percent_Identity=23.7885462555066, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17647857, Length=281, Percent_Identity=25.2669039145907, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859927, Length=272, Percent_Identity=24.2647058823529, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65536; Mature: 65405

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLFDDDETDDQPRSEPPPPGPSLFGDDELPEAAAPVHAESYRVLARKYRPTTFDDLIG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCHHHHHC
QDGLVRTLRNAFAMNRIAHAFMLTGVRGVGKTTTARILARALNCTGADGQGGPTPDPCGV
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
CDNCVAILADRHPDVVEMDAASNTGVDDVREIIEATRFRPMIARTKVFIVDEVHMLSRNA
HHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHCCHHHHHCEEEEEHHHHHHHHHH
FNALLKTLEEPPPHVKFVFATTEIRKVPITVLSRCQRFDLKRVPVDVLAAHFARIAEKEA
HHHHHHHHCCCCCCEEEEEEECHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VAVEGGALDAVARAADGSVRDGLSLLDQAIARADEGAPVTAELVADMLGLADRGMVFDLL
EEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHH
EAVAAGDPAGALGVMDRAHEAGADPVLVMQDLLGLAHTLSRLKAIPALAEGSELPELDRA
HHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RGAPLAARLSVPFLGRLWQMLLKGVAEVEQATDRRAAADMILIRLCYVSDLPPPGELVRR
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LSGEGTVARGNAVPASAPGPAPRAVVNGAPVAPAETAPATAPRLARFEDVIALAGEKRDA
HCCCCCEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
LLYAHLRHDARLVRFAPPVIELNLTPEAPRDLSSRLARFLEAETGRRWTIALSRAAGAPS
EEEEEHHCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
MVEAETTARETARNEALDHPLVRAIFETFPGAKIASVEVDAPPALAEPPVMDDDRFDDVP
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
PISDDDIADAMEID
CCCCCCCCHHHCCC
>Mature Secondary Structure 
AGLFDDDETDDQPRSEPPPPGPSLFGDDELPEAAAPVHAESYRVLARKYRPTTFDDLIG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCHHHHHC
QDGLVRTLRNAFAMNRIAHAFMLTGVRGVGKTTTARILARALNCTGADGQGGPTPDPCGV
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
CDNCVAILADRHPDVVEMDAASNTGVDDVREIIEATRFRPMIARTKVFIVDEVHMLSRNA
HHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHCCHHHHHCEEEEEHHHHHHHHHH
FNALLKTLEEPPPHVKFVFATTEIRKVPITVLSRCQRFDLKRVPVDVLAAHFARIAEKEA
HHHHHHHHCCCCCCEEEEEEECHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VAVEGGALDAVARAADGSVRDGLSLLDQAIARADEGAPVTAELVADMLGLADRGMVFDLL
EEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHH
EAVAAGDPAGALGVMDRAHEAGADPVLVMQDLLGLAHTLSRLKAIPALAEGSELPELDRA
HHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RGAPLAARLSVPFLGRLWQMLLKGVAEVEQATDRRAAADMILIRLCYVSDLPPPGELVRR
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LSGEGTVARGNAVPASAPGPAPRAVVNGAPVAPAETAPATAPRLARFEDVIALAGEKRDA
HCCCCCEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
LLYAHLRHDARLVRFAPPVIELNLTPEAPRDLSSRLARFLEAETGRRWTIALSRAAGAPS
EEEEEHHCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
MVEAETTARETARNEALDHPLVRAIFETFPGAKIASVEVDAPPALAEPPVMDDDRFDDVP
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
PISDDDIADAMEID
CCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]