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The map label for this gene is pyrD [H]

Identifier: 148260954

GI number: 148260954

Start: 2151015

End: 2152079

Strand: Reverse

Name: pyrD [H]

Synonym: Acry_1961

Alternate gene names: 148260954

Gene position: 2152079-2151015 (Counterclockwise)

Preceding gene: 148260955

Following gene: 148260953

Centisome position: 63.5

GC content: 73.9

Gene sequence:

>1065_bases
ATGCCCGTCGCTGATCTGGCGACGGCCGCGCTGCGCCTTCTCGAACCGGAGACGGCGCACAACGCCGCCATTGCGGCGCT
GCGCCTCGGCCTCGCCGGAAGGCAGCGTGTTCCCGCCGATCCGCGCCTCGCCATGCCGGCCTTCGGACGGACCATCGCCC
TGCCGATCGGCCTCGCCGCCGGGTTCGACAAGAACGCCGCCGCCCTCGCCGGCCTGTCCCGCCTCGGCTTCGGCTTCGTC
GAGGCCGGCACCGTCACCCGCCGGCCGCAGCCGGGCAATCCGAAGCCCCGCCTGTTCCGCCTCGAGGATGACGGCGCGCT
GATCAACCGCATGGGCTTCAACAATCTCGGGATCGAGGGTTTCGCCGCCCGCCTTGCCAGGGCTGACCGCGCGCTCACGG
CGCTCGGCGCCAATCTCGGCATCAACAAGGAGGGCGCCGATCCGCTGGCCGACTACCCCGCCCTGGTCGCCGCGGTCGCC
CCGCATGCCGACTACGTCGCGATCAACGTCTCTTCGCCGAACACGCCTGGCCTGCGCGACCTGCAGGCCGCCGACCGTCT
GGCCGCGATCCTCGACGCGATCCGCGCCGCCGTGCCCAACGCGCCGCCGCTCTTCGTCAAGCTGGCCCCCGATCTCGACG
AGGCGGCGCTGCCCGAGCTGGTCGACATGGCGATCGGCCGCGCGGTGGCCGGGCTGATCGTCAGCAACACCACGCTCGCC
CGGCCCGAGAGCCTGCGCGGCGCGGCGCGCGGCGAGGCCGGCGGCCTGTCCGGCGCGCCGCTGTTCAACCGGTCGACGCG
CATGCTCGCCCGCGTCCGCCTGCTCGCCGGCGACCGGCTTCTGCTGATCGGCGTCGGCGGCGTGGCGACGCCGGAACAGG
CCCTCGCCAAGTTCCGCGCCGGCGCCAGCCTCGTGCAGGTCTATACCGCCTTCGTCTATCAGGGGCCGTCATTGCTGCCC
CGCCTCGCCGCCGGCCTGTCCGCCCTGCTCGACCAGTACGGCGCCGCCACCCTCGCCGAGCTCGTCGGCCGCGATGCCGA
CCGCCTCGCGGAGATCGCTCCATGA

Upstream 100 bases:

>100_bases
CCGACGGTGTCGCGCCCGATCACGTCTCGCTCGGCGCCTCGGCGCCGCTGCACGCGGTACCGCCGCCCGCAACACCCGAG
ATCGTGGTCTTCGCGAAGTA

Downstream 100 bases:

>100_bases
CCGCCGATACGATGAGCGTCGAAACCCTCGCCCATGATCACGACGGCTTCATCGTCGATCTCTGGGGCGTGGTGCATGAC
GGCGTGCGCCCCTATCCCGG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPVADLATAALRLLEPETAHNAAIAALRLGLAGRQRVPADPRLAMPAFGRTIALPIGLAAGFDKNAAALAGLSRLGFGFV
EAGTVTRRPQPGNPKPRLFRLEDDGALINRMGFNNLGIEGFAARLARADRALTALGANLGINKEGADPLADYPALVAAVA
PHADYVAINVSSPNTPGLRDLQAADRLAAILDAIRAAVPNAPPLFVKLAPDLDEAALPELVDMAIGRAVAGLIVSNTTLA
RPESLRGAARGEAGGLSGAPLFNRSTRMLARVRLLAGDRLLLIGVGGVATPEQALAKFRAGASLVQVYTAFVYQGPSLLP
RLAAGLSALLDQYGAATLAELVGRDADRLAEIAP

Sequences:

>Translated_354_residues
MPVADLATAALRLLEPETAHNAAIAALRLGLAGRQRVPADPRLAMPAFGRTIALPIGLAAGFDKNAAALAGLSRLGFGFV
EAGTVTRRPQPGNPKPRLFRLEDDGALINRMGFNNLGIEGFAARLARADRALTALGANLGINKEGADPLADYPALVAAVA
PHADYVAINVSSPNTPGLRDLQAADRLAAILDAIRAAVPNAPPLFVKLAPDLDEAALPELVDMAIGRAVAGLIVSNTTLA
RPESLRGAARGEAGGLSGAPLFNRSTRMLARVRLLAGDRLLLIGVGGVATPEQALAKFRAGASLVQVYTAFVYQGPSLLP
RLAAGLSALLDQYGAATLAELVGRDADRLAEIAP
>Mature_353_residues
PVADLATAALRLLEPETAHNAAIAALRLGLAGRQRVPADPRLAMPAFGRTIALPIGLAAGFDKNAAALAGLSRLGFGFVE
AGTVTRRPQPGNPKPRLFRLEDDGALINRMGFNNLGIEGFAARLARADRALTALGANLGINKEGADPLADYPALVAAVAP
HADYVAINVSSPNTPGLRDLQAADRLAAILDAIRAAVPNAPPLFVKLAPDLDEAALPELVDMAIGRAVAGLIVSNTTLAR
PESLRGAARGEAGGLSGAPLFNRSTRMLARVRLLAGDRLLLIGVGGVATPEQALAKFRAGASLVQVYTAFVYQGPSLLPR
LAAGLSALLDQYGAATLAELVGRDADRLAEIAP

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=350, Percent_Identity=43.4285714285714, Blast_Score=257, Evalue=9e-69,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=42.2619047619048, Blast_Score=228, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17509475, Length=349, Percent_Identity=40.6876790830946, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI281361352, Length=348, Percent_Identity=44.2528735632184, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI17137316, Length=348, Percent_Identity=44.2528735632184, Blast_Score=271, Evalue=6e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36515; Mature: 36383

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVADLATAALRLLEPETAHNAAIAALRLGLAGRQRVPADPRLAMPAFGRTIALPIGLAA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHC
GFDKNAAALAGLSRLGFGFVEAGTVTRRPQPGNPKPRLFRLEDDGALINRMGFNNLGIEG
CCCCCHHHHHHHHHHCCCCEECCCEECCCCCCCCCCEEEEECCCCCCHHHCCCCCCCHHH
FAARLARADRALTALGANLGINKEGADPLADYPALVAAVAPHADYVAINVSSPNTPGLRD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHH
LQAADRLAAILDAIRAAVPNAPPLFVKLAPDLDEAALPELVDMAIGRAVAGLIVSNTTLA
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPESLRGAARGEAGGLSGAPLFNRSTRMLARVRLLAGDRLLLIGVGGVATPEQALAKFRA
CCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHC
GASLVQVYTAFVYQGPSLLPRLAAGLSALLDQYGAATLAELVGRDADRLAEIAP
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure 
PVADLATAALRLLEPETAHNAAIAALRLGLAGRQRVPADPRLAMPAFGRTIALPIGLAA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHC
GFDKNAAALAGLSRLGFGFVEAGTVTRRPQPGNPKPRLFRLEDDGALINRMGFNNLGIEG
CCCCCHHHHHHHHHHCCCCEECCCEECCCCCCCCCCEEEEECCCCCCHHHCCCCCCCHHH
FAARLARADRALTALGANLGINKEGADPLADYPALVAAVAPHADYVAINVSSPNTPGLRD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHH
LQAADRLAAILDAIRAAVPNAPPLFVKLAPDLDEAALPELVDMAIGRAVAGLIVSNTTLA
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPESLRGAARGEAGGLSGAPLFNRSTRMLARVRLLAGDRLLLIGVGGVATPEQALAKFRA
CCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHC
GASLVQVYTAFVYQGPSLLPRLAAGLSALLDQYGAATLAELVGRDADRLAEIAP
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA