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The map label for this gene is adk

Identifier: 148260918

GI number: 148260918

Start: 2121387

End: 2122061

Strand: Reverse

Name: adk

Synonym: Acry_1925

Alternate gene names: 148260918

Gene position: 2122061-2121387 (Counterclockwise)

Preceding gene: 148260919

Following gene: 148260917

Centisome position: 62.61

GC content: 67.11

Gene sequence:

>675_bases
ATGAACATCATTCTTTTGGGACCACCCGGTGCCGGCAAGGGCACCCAGGCCAAGATCCTGCAGGATCGTTACGGTGTTGC
CCAGATCGCGACCGGCGACATGCTGCGGGCCGAGGTGAAGGCGGGCACCGAGCTGGGCCGCGCGGCGAAGGCGGTGATGG
AGTCGGGCGCGCTGGTTTCGGACGAGATCATCATCGGCATGCTGCGCAACCGCCTGTCCCAGCCGGACTGCCGCAACGGC
TTCATCCTCGACGGTTTTCCGCGCACGGTGCCGCAGGCCGAGGCGCTGGACACGATGCTCGCCGAGCAGAAATTCGATCT
CGACGCCGTCATCCTGCTCAAGGTCGACGAGGCGGTGCTGGTCGAGCGCATTTCCGGCCGCTTCACCTGTGCGCATTGCG
GCGCCGGCTATCACGACAAGTTCCACCCGACCGGCGTCCCCGGCGTGTGCGACAAATGCGGCAGCCATGATTTCGTCCGC
CGGCCGGACGACAAGGCCGAGGTCGTGAAGGACCGCCTGGTCGCCTACAATGCGCAGACCGCGCCGATCCTGCCCTATTA
CGAGCAGAAGGGCCGACTTCACGTCGTCGACGGGATGGCCGCGATGGATCAGGTGACGGCCGAGATCGAGGGCGCGCTGC
GCCGCGCCGGGGTCGCCGCGCCGGCAACGGCATGA

Upstream 100 bases:

>100_bases
TATCTGTTACGATGGACACGGTAGCGCAGATCCAGTCGCACCTTCTGGCACACCAGTATGAAGGCCTGATCCGAAAAGGC
CGAGGGAGAACACGCGGTCG

Downstream 100 bases:

>100_bases
ACGGCCCCGATCACGCAAATTTGATCAAGGTCGATTGACTCTGACCGGGTCGGGCTTTAGACAACCAGTCTTGCGGCGCT
CCCTGGCGGGGCGCCGCACT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNIILLGPPGAGKGTQAKILQDRYGVAQIATGDMLRAEVKAGTELGRAAKAVMESGALVSDEIIIGMLRNRLSQPDCRNG
FILDGFPRTVPQAEALDTMLAEQKFDLDAVILLKVDEAVLVERISGRFTCAHCGAGYHDKFHPTGVPGVCDKCGSHDFVR
RPDDKAEVVKDRLVAYNAQTAPILPYYEQKGRLHVVDGMAAMDQVTAEIEGALRRAGVAAPATA

Sequences:

>Translated_224_residues
MNIILLGPPGAGKGTQAKILQDRYGVAQIATGDMLRAEVKAGTELGRAAKAVMESGALVSDEIIIGMLRNRLSQPDCRNG
FILDGFPRTVPQAEALDTMLAEQKFDLDAVILLKVDEAVLVERISGRFTCAHCGAGYHDKFHPTGVPGVCDKCGSHDFVR
RPDDKAEVVKDRLVAYNAQTAPILPYYEQKGRLHVVDGMAAMDQVTAEIEGALRRAGVAAPATA
>Mature_224_residues
MNIILLGPPGAGKGTQAKILQDRYGVAQIATGDMLRAEVKAGTELGRAAKAVMESGALVSDEIIIGMLRNRLSQPDCRNG
FILDGFPRTVPQAEALDTMLAEQKFDLDAVILLKVDEAVLVERISGRFTCAHCGAGYHDKFHPTGVPGVCDKCGSHDFVR
RPDDKAEVVKDRLVAYNAQTAPILPYYEQKGRLHVVDGMAAMDQVTAEIEGALRRAGVAAPATA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=45.0704225352113, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=45.0704225352113, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=36.6834170854271, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=36.5482233502538, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=36.5482233502538, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=36.5482233502538, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=36.5482233502538, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI4502011, Length=210, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI7706497, Length=220, Percent_Identity=25.9090909090909, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI28144899, Length=209, Percent_Identity=26.7942583732057, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI28144897, Length=209, Percent_Identity=26.7942583732057, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI22749187, Length=180, Percent_Identity=27.2222222222222, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=46.3302752293578, Blast_Score=197, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17552384, Length=207, Percent_Identity=43.9613526570048, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17567503, Length=216, Percent_Identity=30.5555555555556, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=209, Percent_Identity=28.2296650717703, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=208, Percent_Identity=27.8846153846154, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=225, Percent_Identity=28, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=214, Percent_Identity=47.6635514018692, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=201, Percent_Identity=36.81592039801, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=215, Percent_Identity=27.906976744186, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI22026816, Length=215, Percent_Identity=46.5116279069767, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=37.9487179487179, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=37.9487179487179, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI221459597, Length=209, Percent_Identity=27.7511961722488, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356893, Length=209, Percent_Identity=27.7511961722488, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17647141, Length=189, Percent_Identity=29.6296296296296, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24663208, Length=189, Percent_Identity=29.6296296296296, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ACICJ (A5FZU4)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001235045.1
- ProteinModelPortal:   A5FZU4
- SMR:   A5FZU4
- STRING:   A5FZU4
- GeneID:   5160512
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_1925
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- BioCyc:   ACRY349163:ACRY_1925-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23999; Mature: 23999

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILLGPPGAGKGTQAKILQDRYGVAQIATGDMLRAEVKAGTELGRAAKAVMESGALVS
CEEEEECCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHCHHHHHHHHHHHHCCCCCH
DEIIIGMLRNRLSQPDCRNGFILDGFPRTVPQAEALDTMLAEQKFDLDAVILLKVDEAVL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHH
VERISGRFTCAHCGAGYHDKFHPTGVPGVCDKCGSHDFVRRPDDKAEVVKDRLVAYNAQT
HHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCC
APILPYYEQKGRLHVVDGMAAMDQVTAEIEGALRRAGVAAPATA
CCCCCHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNIILLGPPGAGKGTQAKILQDRYGVAQIATGDMLRAEVKAGTELGRAAKAVMESGALVS
CEEEEECCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHCHHHHHHHHHHHHCCCCCH
DEIIIGMLRNRLSQPDCRNGFILDGFPRTVPQAEALDTMLAEQKFDLDAVILLKVDEAVL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHH
VERISGRFTCAHCGAGYHDKFHPTGVPGVCDKCGSHDFVRRPDDKAEVVKDRLVAYNAQT
HHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCC
APILPYYEQKGRLHVVDGMAAMDQVTAEIEGALRRAGVAAPATA
CCCCCHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA