| Definition | Acidiphilium cryptum JF-5 chromosome, complete genome. |
|---|---|
| Accession | NC_009484 |
| Length | 3,389,227 |
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The map label for this gene is cobT [H]
Identifier: 148260707
GI number: 148260707
Start: 1892569
End: 1894437
Strand: Reverse
Name: cobT [H]
Synonym: Acry_1711
Alternate gene names: 148260707
Gene position: 1894437-1892569 (Counterclockwise)
Preceding gene: 148260708
Following gene: 148260698
Centisome position: 55.9
GC content: 72.23
Gene sequence:
>1869_bases ATGCCGGCCGAACCCTCCCGCAGCGAGGAATTCAAGCGCGCCACCGCCGGCGCCGTCCGCGCCATCGCCGGGTCGGACGA GGTGCAGGTCGCCTACCAGCCGGGGGCGGCGGGCCTCGCCGGCAAGCGCGCCCGCCTGCCGGCGCCGACGCGCGCCCTGC CGCCGGCCGAGGTCGCCAGGCTGCGCGGCATCGCCGATGCGATGGCGCTGCGCCTGCGCCATCACGACGACGCCATCCAC GCCGCCCGCGCCCCCGTCGCCCGCGACGCCCGCGATGCCTACGACGCGCTGGAACAGGCCCGCGTCGAGATCGTCGGCGC CGCCCACATGCAGGGTGTCGCCGCCAATCTCCAGCGCAAGCTGAACGAGGACGCCGAGGCCGAGGGGCTCGACCGGATGA GCCGCGCCGAGCAGCTCTCCACCGCCCAGGCGCTCGGCCTGCTCGCCCGCGAGCGCATGGACCCGGCCTCGATCCCCGCC GCCGCCCGCCACATCCTCGATCTCTGGCGCGAGACCCTGACCGGCGATGCCGACCGGGCGCTGGACGATCTCGCCGCCGA GCGCGCCGACCAGGACGCCTTCGCCCGCGCCGCCCGCCGCCTGCTCGCGGTGATGGACCTCGCCGAGGCCGAAGCCGAGT CCGAGGAAGGCGAGGACAGCGAGGAACAGGGCGAGCAGGGCGAACAGTCCCTCTCGCAGGACAATTCCGGCGAGGGCGAG ACCCAGACCCGCGAGGACGACCAGGACCTGCTTTCCGAGGCCCCCGACTCCCTCGAATCCGAAGCCTCCGACGCCGAGGC CGACGAGGAGACCGACGACGATTCCGCCGCCGCGCCGGACGAGGCGCCCGCCGGCCCGCAGCAGCGCCGCAAGCCGGTGG AAGATGAAACCGGTGCCGCCTACCACGCCTATACCCGCGCCTTCGACGAGGAAATCGGCGCCGAGCAGCTCTGCGATCCC GAGGAACTCGCCCGCCTGCGCCAGCAGCTCGACCAGCAGCTCCAGCATCTCCACGGCGTGGTCTCCAAGCTCGCCAACCG GCTGCAGCGCCGCCTGCTCGCCCAGCAGCAGCGCGCCTGGGATTTCGACCTGGAGGAAGGCCTGCTCGATGTCGGCCGCC TCGCCCGCGTCGTCGCCGACCCGCTGCTGCCGCTCTCCTTCAAGCGCGAGCGCGAGATGGAATTCCGCGACACGGTGGTG ACCCTGCTGATCGACAATTCCGGCTCGATGCGCGGCCGGCCGATCTCGGTCGCCGCCATGTGCAGCGACATCCTGGCCCG CACGCTGGAGCGCTGCGCGGTGAAGGTGGAAATCCTCGGCTTCACCACCCGCGCCTGGAAGGGCGGGCAGAGCCGCGAGA AATGGGTGGCGGACGGCAAGCCGCGCAATCCCGGCCGGCTGAACGACCTCCGCCACATCGTCTACAAGGGGGCGGACGAA CCCTGGCGCCGCGCCCGCCGCAATCTCGGCCTGATGCTGCGCGAGGGGCTGCTCAAGGAAAACATCGACGGCGAGGCCCT GGCCTGGGCCTATCGCCGCCTCTGCGCCCGGCCCGAGCACCGCCGCATCCTGATGGTCATCTCCGATGGCGCGCCGGTCG ACGATTCCACCCTCTCGGTCAACCAGGGCAGCTATCTCGAACGCCATCTGCGCGACGTGATCCGCGACATCGAAAGCCGC GACTTCGTCGAGCTGGTCGCCATCGGCATCGGCCACGACGTCACGCGCTACTACCGCCGCGCCGTCACCCTGGTCGATGC CGAGGAACTCGGCGGCACGATGATGAAGAAACTCGCCGAACTCTTCGACCAGGACGCCGCCGAAAGCTGGGCCCGCGCCG CCGCCCTCCGCGCCCCGCTGGTCGCCTGA
Upstream 100 bases:
>100_bases ACAAGTGCGACGAGGCCGAGCGCGCCACCGTGGCCGAATACTACCAGCGCTGCTTCAACGCGGAGGTTGAAACCGGCGTG CATCCCCGCCGCGGCGCCTG
Downstream 100 bases:
>100_bases GGGCAGCGCCCGCGCCTCAATCCGCCGAGGTGAGCCGGAACTCGATCCGCCGGTTCTGCGCGAGGTCCTGCGGCGTATTG CCCGTGGCGATCGGGTGATC
Product: cobalt chelatase, pCobT subunit
Products: NA
Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobT [H]
Number of amino acids: Translated: 622; Mature: 621
Protein sequence:
>622_residues MPAEPSRSEEFKRATAGAVRAIAGSDEVQVAYQPGAAGLAGKRARLPAPTRALPPAEVARLRGIADAMALRLRHHDDAIH AARAPVARDARDAYDALEQARVEIVGAAHMQGVAANLQRKLNEDAEAEGLDRMSRAEQLSTAQALGLLARERMDPASIPA AARHILDLWRETLTGDADRALDDLAAERADQDAFARAARRLLAVMDLAEAEAESEEGEDSEEQGEQGEQSLSQDNSGEGE TQTREDDQDLLSEAPDSLESEASDAEADEETDDDSAAAPDEAPAGPQQRRKPVEDETGAAYHAYTRAFDEEIGAEQLCDP EELARLRQQLDQQLQHLHGVVSKLANRLQRRLLAQQQRAWDFDLEEGLLDVGRLARVVADPLLPLSFKREREMEFRDTVV TLLIDNSGSMRGRPISVAAMCSDILARTLERCAVKVEILGFTTRAWKGGQSREKWVADGKPRNPGRLNDLRHIVYKGADE PWRRARRNLGLMLREGLLKENIDGEALAWAYRRLCARPEHRRILMVISDGAPVDDSTLSVNQGSYLERHLRDVIRDIESR DFVELVAIGIGHDVTRYYRRAVTLVDAEELGGTMMKKLAELFDQDAAESWARAAALRAPLVA
Sequences:
>Translated_622_residues MPAEPSRSEEFKRATAGAVRAIAGSDEVQVAYQPGAAGLAGKRARLPAPTRALPPAEVARLRGIADAMALRLRHHDDAIH AARAPVARDARDAYDALEQARVEIVGAAHMQGVAANLQRKLNEDAEAEGLDRMSRAEQLSTAQALGLLARERMDPASIPA AARHILDLWRETLTGDADRALDDLAAERADQDAFARAARRLLAVMDLAEAEAESEEGEDSEEQGEQGEQSLSQDNSGEGE TQTREDDQDLLSEAPDSLESEASDAEADEETDDDSAAAPDEAPAGPQQRRKPVEDETGAAYHAYTRAFDEEIGAEQLCDP EELARLRQQLDQQLQHLHGVVSKLANRLQRRLLAQQQRAWDFDLEEGLLDVGRLARVVADPLLPLSFKREREMEFRDTVV TLLIDNSGSMRGRPISVAAMCSDILARTLERCAVKVEILGFTTRAWKGGQSREKWVADGKPRNPGRLNDLRHIVYKGADE PWRRARRNLGLMLREGLLKENIDGEALAWAYRRLCARPEHRRILMVISDGAPVDDSTLSVNQGSYLERHLRDVIRDIESR DFVELVAIGIGHDVTRYYRRAVTLVDAEELGGTMMKKLAELFDQDAAESWARAAALRAPLVA >Mature_621_residues PAEPSRSEEFKRATAGAVRAIAGSDEVQVAYQPGAAGLAGKRARLPAPTRALPPAEVARLRGIADAMALRLRHHDDAIHA ARAPVARDARDAYDALEQARVEIVGAAHMQGVAANLQRKLNEDAEAEGLDRMSRAEQLSTAQALGLLARERMDPASIPAA ARHILDLWRETLTGDADRALDDLAAERADQDAFARAARRLLAVMDLAEAEAESEEGEDSEEQGEQGEQSLSQDNSGEGET QTREDDQDLLSEAPDSLESEASDAEADEETDDDSAAAPDEAPAGPQQRRKPVEDETGAAYHAYTRAFDEEIGAEQLCDPE ELARLRQQLDQQLQHLHGVVSKLANRLQRRLLAQQQRAWDFDLEEGLLDVGRLARVVADPLLPLSFKREREMEFRDTVVT LLIDNSGSMRGRPISVAAMCSDILARTLERCAVKVEILGFTTRAWKGGQSREKWVADGKPRNPGRLNDLRHIVYKGADEP WRRARRNLGLMLREGLLKENIDGEALAWAYRRLCARPEHRRILMVISDGAPVDDSTLSVNQGSYLERHLRDVIRDIESRD FVELVAIGIGHDVTRYYRRAVTLVDAEELGGTMMKKLAELFDQDAAESWARAAALRAPLVA
Specific function: Catalyzes cobalt insertion in the corrin ring [H]
COG id: COG4547
COG function: function code H; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase)
Gene ontology:
Cell location: Cytoplasm (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Contains 1 VWFA domain [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006538 - InterPro: IPR002035 [H]
Pfam domain/function: PF06213 CobT [H]
EC number: =6.6.1.2 [H]
Molecular weight: Translated: 68666; Mature: 68535
Theoretical pI: Translated: 4.67; Mature: 4.67
Prosite motif: PS50234 VWFA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPAEPSRSEEFKRATAGAVRAIAGSDEVQVAYQPGAAGLAGKRARLPAPTRALPPAEVAR CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH LRGIADAMALRLRHHDDAIHAARAPVARDARDAYDALEQARVEIVGAAHMQGVAANLQRK HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LNEDAEAEGLDRMSRAEQLSTAQALGLLARERMDPASIPAAARHILDLWRETLTGDADRA HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHH LDDLAAERADQDAFARAARRLLAVMDLAEAEAESEEGEDSEEQGEQGEQSLSQDNSGEGE HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCC TQTREDDQDLLSEAPDSLESEASDAEADEETDDDSAAAPDEAPAGPQQRRKPVEDETGAA CCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCH YHAYTRAFDEEIGAEQLCDPEELARLRQQLDQQLQHLHGVVSKLANRLQRRLLAQQQRAW HHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC DFDLEEGLLDVGRLARVVADPLLPLSFKREREMEFRDTVVTLLIDNSGSMRGRPISVAAM CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHH CSDILARTLERCAVKVEILGFTTRAWKGGQSREKWVADGKPRNPGRLNDLRHIVYKGADE HHHHHHHHHHHHHEEHHEEEEEHHHCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCC PWRRARRNLGLMLREGLLKENIDGEALAWAYRRLCARPEHRRILMVISDGAPVDDSTLSV HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEC NQGSYLERHLRDVIRDIESRDFVELVAIGIGHDVTRYYRRAVTLVDAEELGGTMMKKLAE CCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHH LFDQDAAESWARAAALRAPLVA HHHHHHHHHHHHHHHHHCCCCC >Mature Secondary Structure PAEPSRSEEFKRATAGAVRAIAGSDEVQVAYQPGAAGLAGKRARLPAPTRALPPAEVAR CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH LRGIADAMALRLRHHDDAIHAARAPVARDARDAYDALEQARVEIVGAAHMQGVAANLQRK HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LNEDAEAEGLDRMSRAEQLSTAQALGLLARERMDPASIPAAARHILDLWRETLTGDADRA HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHH LDDLAAERADQDAFARAARRLLAVMDLAEAEAESEEGEDSEEQGEQGEQSLSQDNSGEGE HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCC TQTREDDQDLLSEAPDSLESEASDAEADEETDDDSAAAPDEAPAGPQQRRKPVEDETGAA CCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCH YHAYTRAFDEEIGAEQLCDPEELARLRQQLDQQLQHLHGVVSKLANRLQRRLLAQQQRAW HHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC DFDLEEGLLDVGRLARVVADPLLPLSFKREREMEFRDTVVTLLIDNSGSMRGRPISVAAM CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHH CSDILARTLERCAVKVEILGFTTRAWKGGQSREKWVADGKPRNPGRLNDLRHIVYKGADE HHHHHHHHHHHHHEEHHEEEEEHHHCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCC PWRRARRNLGLMLREGLLKENIDGEALAWAYRRLCARPEHRRILMVISDGAPVDDSTLSV HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEC NQGSYLERHLRDVIRDIESRDFVELVAIGIGHDVTRYYRRAVTLVDAEELGGTMMKKLAE CCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHH LFDQDAAESWARAAALRAPLVA HHHHHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1917840 [H]