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The map label for this gene is ispA [C]

Identifier: 148260202

GI number: 148260202

Start: 1335010

End: 1335915

Strand: Reverse

Name: ispA [C]

Synonym: Acry_1198

Alternate gene names: 148260202

Gene position: 1335915-1335010 (Counterclockwise)

Preceding gene: 148260203

Following gene: 148260201

Centisome position: 39.42

GC content: 70.42

Gene sequence:

>906_bases
ATGACCGCCACCGAGTCCGACGCCGCTCTCGCCGCTGCCCTCAGGGACGCGGCTGCCCTGATCGAGACCGAACTCGACGT
GCTGCTGCCCCTGCCCGAGGGTGAGGAGCGCCCGCTGGTCGAGGCGATGCGCTACGCCGTGCTCGGCGGCGGCAAGCGGA
TGCGCGGCTTCCTCGTGATCGAGACGGCACGGCTGTTTTCGGTCAACATCACCTGCGCCGTGCGCGTTGCCGCCGCGGTC
GAGATGCTGCACGCCTATTCGCTGGTGCATGACGACCTGCCGGCGATGGATGATGACGATCTGCGCCGCGGCAAGCCGTC
CTGCCACAAGGCCTTCGACGAGGCGACCGCGATCCTGGCCGGCGATGCGCTGCAAACCCGCGCCTTCGAGGTGCTGGCCG
AGCCGGACACCCATTCCGATCCCGAGGTGCGCTGCGAACTGGTGCTGGCCCTCGCGGCCGCCTCCGGCGCGCGCGGCATG
GTCGGCGGCCAGATGATCGACATCGTCTCGGAAGGCCGGCAGCTCGAACCGCCGGTGATCACCCGCCTGCAGGCGCTCAA
GACCGGGCGGCTGATCCAGTTCAGCGCCGAGGCCGGTGCCATTCTCGGTCGCGCGCCGGGGCCGCAGCGGCACCATATCG
CCGGCTACGGGCGGGATCTCGGCGCCGCCTTCCAGATTGCCGACGACATTCTCGACGAGGAGGGCTCGGATGCCAGCCTC
GGCAAGACCGCCGGCAAGGACGCTGCCCAGGGCAAGGCGACGATGGTCGCGGTGATGGGGATCGAGCGCGCGCGCACCCA
TGCGGCGCATCTCGCGAGCCAGGCCGCCGCCTATCTCGACAGTTTCGGCGCGAAGGCGGATCTGCTTCGCGCGCTGGCCG
CCTTCACGGTCAACCGCCGGAACTGA

Upstream 100 bases:

>100_bases
GTCTGAAGCAGCATTGCGAGGCGCGGCTGGCCGAGGCGGAGAGCCGCGTGCAGTCGATCGTCGCCCGCGCCGACGGCTCC
CTTGCCCTGAAGGACGACCA

Downstream 100 bases:

>100_bases
CCGGCGGACGATGCGGATCGTCATCGCCAGCCGGATCCTGAACGAGGAGGACATCGTCGAGGCCTTCGTGCGGCACAACG
CGAGCTTCGCGGCGCACATG

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTATESDAALAAALRDAAALIETELDVLLPLPEGEERPLVEAMRYAVLGGGKRMRGFLVIETARLFSVNITCAVRVAAAV
EMLHAYSLVHDDLPAMDDDDLRRGKPSCHKAFDEATAILAGDALQTRAFEVLAEPDTHSDPEVRCELVLALAAASGARGM
VGGQMIDIVSEGRQLEPPVITRLQALKTGRLIQFSAEAGAILGRAPGPQRHHIAGYGRDLGAAFQIADDILDEEGSDASL
GKTAGKDAAQGKATMVAVMGIERARTHAAHLASQAAAYLDSFGAKADLLRALAAFTVNRRN

Sequences:

>Translated_301_residues
MTATESDAALAAALRDAAALIETELDVLLPLPEGEERPLVEAMRYAVLGGGKRMRGFLVIETARLFSVNITCAVRVAAAV
EMLHAYSLVHDDLPAMDDDDLRRGKPSCHKAFDEATAILAGDALQTRAFEVLAEPDTHSDPEVRCELVLALAAASGARGM
VGGQMIDIVSEGRQLEPPVITRLQALKTGRLIQFSAEAGAILGRAPGPQRHHIAGYGRDLGAAFQIADDILDEEGSDASL
GKTAGKDAAQGKATMVAVMGIERARTHAAHLASQAAAYLDSFGAKADLLRALAAFTVNRRN
>Mature_300_residues
TATESDAALAAALRDAAALIETELDVLLPLPEGEERPLVEAMRYAVLGGGKRMRGFLVIETARLFSVNITCAVRVAAAVE
MLHAYSLVHDDLPAMDDDDLRRGKPSCHKAFDEATAILAGDALQTRAFEVLAEPDTHSDPEVRCELVLALAAASGARGMV
GGQMIDIVSEGRQLEPPVITRLQALKTGRLIQFSAEAGAILGRAPGPQRHHIAGYGRDLGAAFQIADDILDEEGSDASLG
KTAGKDAAQGKATMVAVMGIERARTHAAHLASQAAAYLDSFGAKADLLRALAAFTVNRRN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=225, Percent_Identity=31.1111111111111, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786623, Length=283, Percent_Identity=44.8763250883392, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1789578, Length=216, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17505681, Length=190, Percent_Identity=30.5263157894737, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651612, Length=249, Percent_Identity=26.9076305220884, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31773; Mature: 31641

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATESDAALAAALRDAAALIETELDVLLPLPEGEERPLVEAMRYAVLGGGKRMRGFLVI
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEE
ETARLFSVNITCAVRVAAAVEMLHAYSLVHDDLPAMDDDDLRRGKPSCHKAFDEATAILA
EEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHC
GDALQTRAFEVLAEPDTHSDPEVRCELVLALAAASGARGMVGGQMIDIVSEGRQLEPPVI
CCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHH
TRLQALKTGRLIQFSAEAGAILGRAPGPQRHHIAGYGRDLGAAFQIADDILDEEGSDASL
HHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
GKTAGKDAAQGKATMVAVMGIERARTHAAHLASQAAAYLDSFGAKADLLRALAAFTVNRR
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
N
C
>Mature Secondary Structure 
TATESDAALAAALRDAAALIETELDVLLPLPEGEERPLVEAMRYAVLGGGKRMRGFLVI
CCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEE
ETARLFSVNITCAVRVAAAVEMLHAYSLVHDDLPAMDDDDLRRGKPSCHKAFDEATAILA
EEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHC
GDALQTRAFEVLAEPDTHSDPEVRCELVLALAAASGARGMVGGQMIDIVSEGRQLEPPVI
CCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHH
TRLQALKTGRLIQFSAEAGAILGRAPGPQRHHIAGYGRDLGAAFQIADDILDEEGSDASL
HHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
GKTAGKDAAQGKATMVAVMGIERARTHAAHLASQAAAYLDSFGAKADLLRALAAFTVNRR
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]