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The map label for this gene is pcoA [H]

Identifier: 148260136

GI number: 148260136

Start: 1261415

End: 1262929

Strand: Reverse

Name: pcoA [H]

Synonym: Acry_1132

Alternate gene names: 148260136

Gene position: 1262929-1261415 (Counterclockwise)

Preceding gene: 148260137

Following gene: 148260133

Centisome position: 37.26

GC content: 68.32

Gene sequence:

>1515_bases
ATGTCCTCCCGCCTGACACGTCGCCTTCTTCTTGCCGCCGCCGGTTCCGCCGGTGCCGTTCCATGGGTTTCCGCGCAGGC
CGGTCAGGCCCCTGCCGCGGCCGCGGGCGGGCATCGCCTGCTGGCTGGCACCCGCACCCTCGAGGTGAACGGCCGCGCGG
CCCGGGTCTTCCGTCTCACCGCTGATAGCGGGCAAGCCGGGCTGTTCCTCGCACCGGGAGAGCGCTTCCGCGTCGATCTG
ACCAACACGCTCGACGAGCACACGATCATCCACTGGCACGGCCAGCTGCCGCCCTGGACCCAGGATGGCTTCCCCTGGCC
GCAGACGCCGCCGCTGGCGCCAGGCGCGACCCGAAGCTACGACTACGCGCCGATCCCCGGCACCTACTGGATGCATTCGC
ATGACGGCCTGCAGGAGCAGAGCCTGATGACGGCGCCGCTGATCGTCCGCACCGCCGCCGAGATGCGCGAGGACCGGCAG
GACATCGTGCTGATGCTGCACGATTTCAGCTTCAGGACGCCGGACGACCTTCTGGCCGGCCTGACGGGGGCGAAGCCTTC
CGCCGTCCACGATATGGTCCGCCATGCCGAGAATGTCGCGGCGCCGGCCATGAACATGCATGGCATGGCCTCCGGCGGCA
TGGCGTCGATGTCCTCGGGCGACATGGGGCAGGGGCACTCCATGGGCGGCATGACCATGGATGTGAACGATATCGACTAC
GACGCCTTCCTCGCCAACGACCGCACGCTCGCCGATCCCGAGGTGGTGCGCGTCGGGCGCAGCGGGCGCGTGCACCTGCG
CATCATCAACGGCTCGTCCTCCAGCCAGTTCTGGATCGATCTCGGGACCCTCAAAGGCAGGATCGTCGCCGTCGACGGTC
ATCCGGTTCACCCGGTCGCCGGCGCCCGCTTTCCGCTCGCCATCGCCCAGCGGATGGACATCCTCGTCGACCTGCCGCCC
TCCGGCGCCTTTCCCATCCTCGCGCGTCTCGAAGCCTCGCGTCGCCGCACGGGCATCGTCCTGGCAACGCCGGGTGCGCG
CATCCCCACGATCGCCGAAACGGGGCACGACAGGACGCCGCCGCTCGACAATGCGCTGGAAATGCGTCTCGCCGCGGCCC
AGCCGCTGAGGCCGCGCAAGCCCGACCTCGTGCACCGCATCGACCTGTCCGGATCGATGAAACCCTATCGCTGGGCGCTG
AACGGCGACTACTGGCCGCATGTCACGCCGCTCATGCTCGAAGCCGGGCAGCGCGTGGAAATCGAGCTGGTCAATCGCTC
TTCCATGGCGCATCCTATGCATCTTCACGGGCATGCCTTCCAGGTCATCGGCATCAACGGCAAGACGGTGAACGGCGCGG
TCCGGGATACGGTTCTGGTCACCCCCCGGCACGGCCGCGTGCGGATCGCCTTCGATGCGGACAATCCCGGCCGCTGGGCC
TTCCACTGCCATAACCTCTACCACATGGCGACCGGCATGATGACCGAGTTCCGCTATCGCGGGATCGCGGTCTGA

Upstream 100 bases:

>100_bases
GCACCATCTGCCCGAGCAAATTTCGCGTTGACCTTCCCACGATGGAAGGCCCCATATCGCTCCCGCCACCGAACGCCGAT
CCCAGCCAGGAATATCGCCA

Downstream 100 bases:

>100_bases
CGCAGGGGCCAGGCCGGAACTTCAGGACCGCGCCGCGGGGAGATGATGCCGCGAACAGTCCGTCGCGCACAGCGCGGCAT
CGGTCTCGATCTGCAGGGTG

Product: multicopper oxidase, type 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSSRLTRRLLLAAAGSAGAVPWVSAQAGQAPAAAAGGHRLLAGTRTLEVNGRAARVFRLTADSGQAGLFLAPGERFRVDL
TNTLDEHTIIHWHGQLPPWTQDGFPWPQTPPLAPGATRSYDYAPIPGTYWMHSHDGLQEQSLMTAPLIVRTAAEMREDRQ
DIVLMLHDFSFRTPDDLLAGLTGAKPSAVHDMVRHAENVAAPAMNMHGMASGGMASMSSGDMGQGHSMGGMTMDVNDIDY
DAFLANDRTLADPEVVRVGRSGRVHLRIINGSSSSQFWIDLGTLKGRIVAVDGHPVHPVAGARFPLAIAQRMDILVDLPP
SGAFPILARLEASRRRTGIVLATPGARIPTIAETGHDRTPPLDNALEMRLAAAQPLRPRKPDLVHRIDLSGSMKPYRWAL
NGDYWPHVTPLMLEAGQRVEIELVNRSSMAHPMHLHGHAFQVIGINGKTVNGAVRDTVLVTPRHGRVRIAFDADNPGRWA
FHCHNLYHMATGMMTEFRYRGIAV

Sequences:

>Translated_504_residues
MSSRLTRRLLLAAAGSAGAVPWVSAQAGQAPAAAAGGHRLLAGTRTLEVNGRAARVFRLTADSGQAGLFLAPGERFRVDL
TNTLDEHTIIHWHGQLPPWTQDGFPWPQTPPLAPGATRSYDYAPIPGTYWMHSHDGLQEQSLMTAPLIVRTAAEMREDRQ
DIVLMLHDFSFRTPDDLLAGLTGAKPSAVHDMVRHAENVAAPAMNMHGMASGGMASMSSGDMGQGHSMGGMTMDVNDIDY
DAFLANDRTLADPEVVRVGRSGRVHLRIINGSSSSQFWIDLGTLKGRIVAVDGHPVHPVAGARFPLAIAQRMDILVDLPP
SGAFPILARLEASRRRTGIVLATPGARIPTIAETGHDRTPPLDNALEMRLAAAQPLRPRKPDLVHRIDLSGSMKPYRWAL
NGDYWPHVTPLMLEAGQRVEIELVNRSSMAHPMHLHGHAFQVIGINGKTVNGAVRDTVLVTPRHGRVRIAFDADNPGRWA
FHCHNLYHMATGMMTEFRYRGIAV
>Mature_503_residues
SSRLTRRLLLAAAGSAGAVPWVSAQAGQAPAAAAGGHRLLAGTRTLEVNGRAARVFRLTADSGQAGLFLAPGERFRVDLT
NTLDEHTIIHWHGQLPPWTQDGFPWPQTPPLAPGATRSYDYAPIPGTYWMHSHDGLQEQSLMTAPLIVRTAAEMREDRQD
IVLMLHDFSFRTPDDLLAGLTGAKPSAVHDMVRHAENVAAPAMNMHGMASGGMASMSSGDMGQGHSMGGMTMDVNDIDYD
AFLANDRTLADPEVVRVGRSGRVHLRIINGSSSSQFWIDLGTLKGRIVAVDGHPVHPVAGARFPLAIAQRMDILVDLPPS
GAFPILARLEASRRRTGIVLATPGARIPTIAETGHDRTPPLDNALEMRLAAAQPLRPRKPDLVHRIDLSGSMKPYRWALN
GDYWPHVTPLMLEAGQRVEIELVNRSSMAHPMHLHGHAFQVIGINGKTVNGAVRDTVLVTPRHGRVRIAFDADNPGRWAF
HCHNLYHMATGMMTEFRYRGIAV

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323703, Length=490, Percent_Identity=24.0816326530612, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 54855; Mature: 54723

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRLTRRLLLAAAGSAGAVPWVSAQAGQAPAAAAGGHRLLAGTRTLEVNGRAARVFRLT
CCCHHHHHEEEEECCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEEEECCCEEEEEEEE
ADSGQAGLFLAPGERFRVDLTNTLDEHTIIHWHGQLPPWTQDGFPWPQTPPLAPGATRSY
CCCCCCCEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
DYAPIPGTYWMHSHDGLQEQSLMTAPLIVRTAAEMREDRQDIVLMLHDFSFRTPDDLLAG
CCCCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHC
LTGAKPSAVHDMVRHAENVAAPAMNMHGMASGGMASMSSGDMGQGHSMGGMTMDVNDIDY
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
DAFLANDRTLADPEVVRVGRSGRVHLRIINGSSSSQFWIDLGTLKGRIVAVDGHPVHPVA
EEEEECCCCCCCCHHEEECCCCEEEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCCC
GARFPLAIAQRMDILVDLPPSGAFPILARLEASRRRTGIVLATPGARIPTIAETGHDRTP
CCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHCCCCCCC
PLDNALEMRLAAAQPLRPRKPDLVHRIDLSGSMKPYRWALNGDYWPHVTPLMLEAGQRVE
CCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCHHHHCCCCEEE
IELVNRSSMAHPMHLHGHAFQVIGINGKTVNGAVRDTVLVTPRHGRVRIAFDADNPGRWA
EEEECCCCCCCCEEECCCEEEEEECCCCEECCCEEEEEEEECCCCEEEEEEECCCCCCEE
FHCHNLYHMATGMMTEFRYRGIAV
EEECCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSRLTRRLLLAAAGSAGAVPWVSAQAGQAPAAAAGGHRLLAGTRTLEVNGRAARVFRLT
CCHHHHHEEEEECCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEEEECCCEEEEEEEE
ADSGQAGLFLAPGERFRVDLTNTLDEHTIIHWHGQLPPWTQDGFPWPQTPPLAPGATRSY
CCCCCCCEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
DYAPIPGTYWMHSHDGLQEQSLMTAPLIVRTAAEMREDRQDIVLMLHDFSFRTPDDLLAG
CCCCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHC
LTGAKPSAVHDMVRHAENVAAPAMNMHGMASGGMASMSSGDMGQGHSMGGMTMDVNDIDY
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
DAFLANDRTLADPEVVRVGRSGRVHLRIINGSSSSQFWIDLGTLKGRIVAVDGHPVHPVA
EEEEECCCCCCCCHHEEECCCCEEEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCCC
GARFPLAIAQRMDILVDLPPSGAFPILARLEASRRRTGIVLATPGARIPTIAETGHDRTP
CCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHCCCCCCC
PLDNALEMRLAAAQPLRPRKPDLVHRIDLSGSMKPYRWALNGDYWPHVTPLMLEAGQRVE
CCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCHHHHCCCCEEE
IELVNRSSMAHPMHLHGHAFQVIGINGKTVNGAVRDTVLVTPRHGRVRIAFDADNPGRWA
EEEECCCCCCCCEEECCCEEEEEECCCCEECCCEEEEEEEECCCCEEEEEEECCCCCCEE
FHCHNLYHMATGMMTEFRYRGIAV
EEECCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]