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The map label for this gene is nuoF [H]

Identifier: 148260120

GI number: 148260120

Start: 1243604

End: 1244908

Strand: Reverse

Name: nuoF [H]

Synonym: Acry_1116

Alternate gene names: 148260120

Gene position: 1244908-1243604 (Counterclockwise)

Preceding gene: 148260121

Following gene: 148260119

Centisome position: 36.73

GC content: 70.11

Gene sequence:

>1305_bases
ATGGCGATGGCGGACCGACCCCTCACTTCATACATCCAGCCCGGCCGCCAGCCGCTCGACATCGCCGGCTACGAGCGCGC
CGGCGGCTACGCGGCGATGCGCAAGGCCTTCGGCATGTCGCCGGAAAGCGTCGTCGAGGAGGTCAAGCGCGCGAAGGTGC
GCGGCCGCGGCGGCGCCGGCTTTCCCGCCGGCCGCAAATGGGAAGGCGCGCCCCGCGGCGCGGACGCGCCGCGCCACCGC
TACCTCGTGATCAACGCCGACGAGATGGAACCCGGCAGCTTCAAGGACCGCCTCCTGCTCGAAGCCGCGCCGCATCTGAT
GATCGAGGGGATCATCATCGGCGCCTTCGCGGTCCAGGCCGAAACCGCCTACATCTTCGTCCGCGGCGAATACGTGCTGG
CGATGGAGCGGCTCTCCCGCGCCGTGGCCGAGGCCGAGGCGCGCGGCTATCTCGGCGCCGACATCCTGGGCTCCGGCTTC
TCGCTCACCATCCACGTCCACGGCAGCGGCGGGCGCTACATCTGCGGCGAGGCCAGCGCCCTGTTCTCCGCGCTGGAGGG
CAAGCGCGCCGTGCCGCGCACCCGTCCGCCGCGCTCGACGACCAGCGGCCTGTGGGGCAAGCCCACCGTCGTCAACAACG
TCGAAACGCTGTGCTGCGTGCCGTCCATCATCGAGCGCGGCGCGGACTGGTTTCTCGGCCTGAGCCGCAGCGCGACCGAA
GGCGGCACCAAGCTCTACGGCGTCAGCGGCCGGGTCAACCGCCCCGGTCTGTGGGAACTGCCGGTGGGCACGCCGCTCAA
CGAAATCATCGAGGAGCATGCCGGCGGCATGCGCGAGGGCTACGAGGCGCGCGCGGTGCTGCCCGGCGGCGCGTCGACCG
CGTTCATCATGCGCGAGAATTTCGACGTCCCGATGGATTTCGACTCCGTCGGCAAGATCGGCAGCTGGCTCGGCACCGCC
AACATCCTGGTGCTGGACCAGAAGCGCTGCCCGGTCGGCCTGCTGCGCAACATCGAGCATTTCTTCGCCCAGGAATCCTG
CGGCTGGTGCACCCCCTGCCGCGACGGCCTGCCCTGGGTCGAGCGCATCCTCACGGCGCTGGAAGCCGGCGAGGGCGAGC
CGGATGACATCGAGCTGCTCGCCCATCACGTCGACTTCCTCGGTCCCGGCCGCACCTTCTGCGATCTCGCCCCCGGTGCC
ATGGCGCCGCTGCGCAGCGGCCTGAAATTCTTCCGTGAGGAATTCGAACGTCATGTCAGCGAGCGGCATTGCCCCTGGCA
CGACACGGCGGAGGGCTGGGCATGA

Upstream 100 bases:

>100_bases
TCGGCTGCTGCGACCGCGCCCCGGCCATGATGATCGGCGACGACCTGCACGGCAACCTCACCCCCGAGCGGATCGACGCG
ATCCTGGAGCAGTACAGGTG

Downstream 100 bases:

>100_bases
CGACCTTCGAGGTGGACGGCAAGACCCTGACCGCGAAGCCCGACGAAAACCTGCTCCAGGCCTGCCTCGGCGCCGGGCTC
GACCTGCCGTATTTCTGCTG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F; NUO6 [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MAMADRPLTSYIQPGRQPLDIAGYERAGGYAAMRKAFGMSPESVVEEVKRAKVRGRGGAGFPAGRKWEGAPRGADAPRHR
YLVINADEMEPGSFKDRLLLEAAPHLMIEGIIIGAFAVQAETAYIFVRGEYVLAMERLSRAVAEAEARGYLGADILGSGF
SLTIHVHGSGGRYICGEASALFSALEGKRAVPRTRPPRSTTSGLWGKPTVVNNVETLCCVPSIIERGADWFLGLSRSATE
GGTKLYGVSGRVNRPGLWELPVGTPLNEIIEEHAGGMREGYEARAVLPGGASTAFIMRENFDVPMDFDSVGKIGSWLGTA
NILVLDQKRCPVGLLRNIEHFFAQESCGWCTPCRDGLPWVERILTALEAGEGEPDDIELLAHHVDFLGPGRTFCDLAPGA
MAPLRSGLKFFREEFERHVSERHCPWHDTAEGWA

Sequences:

>Translated_434_residues
MAMADRPLTSYIQPGRQPLDIAGYERAGGYAAMRKAFGMSPESVVEEVKRAKVRGRGGAGFPAGRKWEGAPRGADAPRHR
YLVINADEMEPGSFKDRLLLEAAPHLMIEGIIIGAFAVQAETAYIFVRGEYVLAMERLSRAVAEAEARGYLGADILGSGF
SLTIHVHGSGGRYICGEASALFSALEGKRAVPRTRPPRSTTSGLWGKPTVVNNVETLCCVPSIIERGADWFLGLSRSATE
GGTKLYGVSGRVNRPGLWELPVGTPLNEIIEEHAGGMREGYEARAVLPGGASTAFIMRENFDVPMDFDSVGKIGSWLGTA
NILVLDQKRCPVGLLRNIEHFFAQESCGWCTPCRDGLPWVERILTALEAGEGEPDDIELLAHHVDFLGPGRTFCDLAPGA
MAPLRSGLKFFREEFERHVSERHCPWHDTAEGWA
>Mature_433_residues
AMADRPLTSYIQPGRQPLDIAGYERAGGYAAMRKAFGMSPESVVEEVKRAKVRGRGGAGFPAGRKWEGAPRGADAPRHRY
LVINADEMEPGSFKDRLLLEAAPHLMIEGIIIGAFAVQAETAYIFVRGEYVLAMERLSRAVAEAEARGYLGADILGSGFS
LTIHVHGSGGRYICGEASALFSALEGKRAVPRTRPPRSTTSGLWGKPTVVNNVETLCCVPSIIERGADWFLGLSRSATEG
GTKLYGVSGRVNRPGLWELPVGTPLNEIIEEHAGGMREGYEARAVLPGGASTAFIMRENFDVPMDFDSVGKIGSWLGTAN
ILVLDQKRCPVGLLRNIEHFFAQESCGWCTPCRDGLPWVERILTALEAGEGEPDDIELLAHHVDFLGPGRTFCDLAPGAM
APLRSGLKFFREEFERHVSERHCPWHDTAEGWA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=418, Percent_Identity=38.2775119617225, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI260656005, Length=418, Percent_Identity=38.2775119617225, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI1788620, Length=422, Percent_Identity=53.7914691943128, Blast_Score=463, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17531727, Length=425, Percent_Identity=38.5882352941176, Blast_Score=297, Evalue=7e-81,
Organism=Drosophila melanogaster, GI19920794, Length=422, Percent_Identity=38.1516587677725, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI45550452, Length=424, Percent_Identity=36.3207547169811, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24653819, Length=407, Percent_Identity=33.9066339066339, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24653817, Length=357, Percent_Identity=33.6134453781513, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47222; Mature: 47091

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMADRPLTSYIQPGRQPLDIAGYERAGGYAAMRKAFGMSPESVVEEVKRAKVRGRGGAG
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
FPAGRKWEGAPRGADAPRHRYLVINADEMEPGSFKDRLLLEAAPHLMIEGIIIGAFAVQA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHEEEHEEEEE
ETAYIFVRGEYVLAMERLSRAVAEAEARGYLGADILGSGFSLTIHVHGSGGRYICGEASA
CEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEECCCCCEEECCHHH
LFSALEGKRAVPRTRPPRSTTSGLWGKPTVVNNVETLCCVPSIIERGADWFLGLSRSATE
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCEEEECCCCCCC
GGTKLYGVSGRVNRPGLWELPVGTPLNEIIEEHAGGMREGYEARAVLPGGASTAFIMREN
CCCEEEEECCCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECC
FDVPMDFDSVGKIGSWLGTANILVLDQKRCPVGLLRNIEHFFAQESCGWCTPCRDGLPWV
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
ERILTALEAGEGEPDDIELLAHHVDFLGPGRTFCDLAPGAMAPLRSGLKFFREEFERHVS
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ERHCPWHDTAEGWA
HCCCCCCCCCCCCC
>Mature Secondary Structure 
AMADRPLTSYIQPGRQPLDIAGYERAGGYAAMRKAFGMSPESVVEEVKRAKVRGRGGAG
CCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
FPAGRKWEGAPRGADAPRHRYLVINADEMEPGSFKDRLLLEAAPHLMIEGIIIGAFAVQA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHEEEHEEEEE
ETAYIFVRGEYVLAMERLSRAVAEAEARGYLGADILGSGFSLTIHVHGSGGRYICGEASA
CEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEECCCCCEEECCHHH
LFSALEGKRAVPRTRPPRSTTSGLWGKPTVVNNVETLCCVPSIIERGADWFLGLSRSATE
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCEEEECCCCCCC
GGTKLYGVSGRVNRPGLWELPVGTPLNEIIEEHAGGMREGYEARAVLPGGASTAFIMREN
CCCEEEEECCCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECC
FDVPMDFDSVGKIGSWLGTANILVLDQKRCPVGLLRNIEHFFAQESCGWCTPCRDGLPWV
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
ERILTALEAGEGEPDDIELLAHHVDFLGPGRTFCDLAPGAMAPLRSGLKFFREEFERHVS
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ERHCPWHDTAEGWA
HCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7690854; 8157582; 9205837; 9278503; 8366049 [H]