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The map label for this gene is nuoI1 [H]

Identifier: 148260117

GI number: 148260117

Start: 1239405

End: 1239917

Strand: Reverse

Name: nuoI1 [H]

Synonym: Acry_1113

Alternate gene names: 148260117

Gene position: 1239917-1239405 (Counterclockwise)

Preceding gene: 148260118

Following gene: 148260116

Centisome position: 36.58

GC content: 62.57

Gene sequence:

>513_bases
ATGCTGAGTTCGCTGGTCACGCTCTGGTACACGTTCCTCCACCTGTTCCAGCGCAACGTGACGGTATCCTATCCCGACGA
GATGCCCTATCTCGCGCCGCGCTATCGCGGCCGGATCGTGCTCACCCGTGACCCGGACGGCGAGGAACGCTGCGTCTCCT
GCTATCTCTGCGCGGTCGCCTGCCCGGTCGACTGCATCAGCCTGCAGAAGACCGAAGCCGAGGGAAGGTGGTATCCCGAA
TTCTTCCGCATCAATTTCTCCCGCTGCATCTTCTGCGGCTTCTGCGAGGAAGCCTGCCCGACCTACGCGATCCAGCTCAC
CCCGGATTTCGAGATGAGCGAATACGACCGGCAGAACCTCGTCTACGAGAAGGAACACCTGCTGATCAGCGGCACCGGCA
AGTATCCCGACTACAATTTCTACCGCGTCTCCGGCCTCTCGATCCCGGGCAAGGACAAGGGCGAGGCCGCGCGCGAGCGC
AAGCCGATCGACACGCGCAGCCTGCTGCCATGA

Upstream 100 bases:

>100_bases
GCGTTCGGCTGGAAGATCCTGCTGCCGCTCACCTTGCTGAACATTCTCGTCACCGGCGCGCTCATGCTCGCCGGGCCGGC
CATATGAAGGGGAGGGGATC

Downstream 100 bases:

>100_bases
ACGCGGACGGGAAGGGGAGGCATAGCGGAACATGAACGCCACCTTCGTCATCTCCGCGATCATCGCGGTCGTCGCGACGG
CGATGATGATCACCCGCCCC

Product: NADH-quinone oxidoreductase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 1; NDH-1 subunit I 1 [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MLSSLVTLWYTFLHLFQRNVTVSYPDEMPYLAPRYRGRIVLTRDPDGEERCVSCYLCAVACPVDCISLQKTEAEGRWYPE
FFRINFSRCIFCGFCEEACPTYAIQLTPDFEMSEYDRQNLVYEKEHLLISGTGKYPDYNFYRVSGLSIPGKDKGEAARER
KPIDTRSLLP

Sequences:

>Translated_170_residues
MLSSLVTLWYTFLHLFQRNVTVSYPDEMPYLAPRYRGRIVLTRDPDGEERCVSCYLCAVACPVDCISLQKTEAEGRWYPE
FFRINFSRCIFCGFCEEACPTYAIQLTPDFEMSEYDRQNLVYEKEHLLISGTGKYPDYNFYRVSGLSIPGKDKGEAARER
KPIDTRSLLP
>Mature_170_residues
MLSSLVTLWYTFLHLFQRNVTVSYPDEMPYLAPRYRGRIVLTRDPDGEERCVSCYLCAVACPVDCISLQKTEAEGRWYPE
FFRINFSRCIFCGFCEEACPTYAIQLTPDFEMSEYDRQNLVYEKEHLLISGTGKYPDYNFYRVSGLSIPGKDKGEAARER
KPIDTRSLLP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=125, Percent_Identity=42.4, Blast_Score=107, Evalue=4e-24,
Organism=Escherichia coli, GI1788617, Length=169, Percent_Identity=73.3727810650888, Blast_Score=260, Evalue=4e-71,
Organism=Escherichia coli, GI1789075, Length=148, Percent_Identity=28.3783783783784, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555194, Length=119, Percent_Identity=41.1764705882353, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17864306, Length=122, Percent_Identity=43.4426229508197, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19761; Mature: 19761

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSLVTLWYTFLHLFQRNVTVSYPDEMPYLAPRYRGRIVLTRDPDGEERCVSCYLCAVA
CHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
CPVDCISLQKTEAEGRWYPEFFRINFSRCIFCGFCEEACPTYAIQLTPDFEMSEYDRQNL
CCHHHEEEEECCCCCCCCCHHEEECHHHEEEEECHHHCCCEEEEEECCCCCCCHHCHHCC
VYEKEHLLISGTGKYPDYNFYRVSGLSIPGKDKGEAARERKPIDTRSLLP
EEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLSSLVTLWYTFLHLFQRNVTVSYPDEMPYLAPRYRGRIVLTRDPDGEERCVSCYLCAVA
CHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
CPVDCISLQKTEAEGRWYPEFFRINFSRCIFCGFCEEACPTYAIQLTPDFEMSEYDRQNL
CCHHHEEEEECCCCCCCCCHHEEECHHHEEEEECHHHCCCEEEEEECCCCCCCHHCHHCC
VYEKEHLLISGTGKYPDYNFYRVSGLSIPGKDKGEAARERKPIDTRSLLP
EEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA