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The map label for this gene is hisN [H]

Identifier: 148259990

GI number: 148259990

Start: 1084420

End: 1085208

Strand: Reverse

Name: hisN [H]

Synonym: Acry_0980

Alternate gene names: 148259990

Gene position: 1085208-1084420 (Counterclockwise)

Preceding gene: 148259991

Following gene: 148259989

Centisome position: 32.02

GC content: 74.4

Gene sequence:

>789_bases
ATGATCCCCGAGGGCGCGATCGAGGCGGCGAAGGCCGCGGCGGAGGCCGCGCGGGCGGCGATCCGCCCGTATTTCCGCGC
CGGCGTGGGTGCCGACGACAAGGCGGATGCGAGCCCGGTGACGGCGGCGGACCGGGCGGCGGAGACGGCGATGCGCGCGG
CGCTGGCGCGGCACACGCCGGGGTTCGGGGTGATCGGCGAGGAATTCGGCGACGACCGGCGCGGGCGGTTCAACTGGGTG
ATCGACCCGATCGACGGGACGCGGGAATTCATCACCGGGCGGGCGAGTTTCGTGACGCTGATCGGCCTGGTCGAGGACGG
CGTGCCGGTGCTCGGGCTGATCGATCAGCCGATGACCGGCGAGCGGTGGCTGGCGGCTGGCGGGCAGATCGAGTTCCACG
GCCCGTTCGGCGGGGTGCCGGGCTGCCGGCGGCGCGCGGCGCTGGGCGAGGCGGAACTCTCCTGCACCGGGCCGGAATGG
TTCGCGCCGGCGCAGCGCGTGGCGTTCGACCGGCTCGGCCGGGCCTGCCGCCGGGTGTCGTGGGGCGACAATGCCTATGC
CGCGGGACTGCTGGCGCTCGGCGCGATCGACATCATCGCCGAGGCCGGGCACAAGCCGTGGGACTGGGCGGCGTCGGTGC
CGATCGTCGAGGCGGCGGGCGGGACGATGTGCGACTGGTCGGGCCGGGCGCTGCGGCTCGACGCCGAGACCGACGGGACC
GTGCTGATCCTGGGCGACCCGTCGCTGCGCGACGAGGCCCTTGCCATTCTTCGAGGTGACTCTTGCTGA

Upstream 100 bases:

>100_bases
TCGCGGCGGCGATGCCGAGTGCGGAGGCTGGCGCTGTGGCACAGGGCAGCCGGGTTTCGATCTGGTGGGACGGGGAGGCG
CCGCGGGTGCTGGCCGCCGG

Downstream 100 bases:

>100_bases
TTGCCCATATTTCCGACCTGCATGTCCGCCCGGTCGGCCGGCCGGCCAACCGCGTGGTCGAGACCAACATGATGGCCGAG
CGCGTGCTGCGCCGGGTGGC

Product: inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIPEGAIEAAKAAAEAARAAIRPYFRAGVGADDKADASPVTAADRAAETAMRAALARHTPGFGVIGEEFGDDRRGRFNWV
IDPIDGTREFITGRASFVTLIGLVEDGVPVLGLIDQPMTGERWLAAGGQIEFHGPFGGVPGCRRRAALGEAELSCTGPEW
FAPAQRVAFDRLGRACRRVSWGDNAYAAGLLALGAIDIIAEAGHKPWDWAASVPIVEAAGGTMCDWSGRALRLDAETDGT
VLILGDPSLRDEALAILRGDSC

Sequences:

>Translated_262_residues
MIPEGAIEAAKAAAEAARAAIRPYFRAGVGADDKADASPVTAADRAAETAMRAALARHTPGFGVIGEEFGDDRRGRFNWV
IDPIDGTREFITGRASFVTLIGLVEDGVPVLGLIDQPMTGERWLAAGGQIEFHGPFGGVPGCRRRAALGEAELSCTGPEW
FAPAQRVAFDRLGRACRRVSWGDNAYAAGLLALGAIDIIAEAGHKPWDWAASVPIVEAAGGTMCDWSGRALRLDAETDGT
VLILGDPSLRDEALAILRGDSC
>Mature_262_residues
MIPEGAIEAAKAAAEAARAAIRPYFRAGVGADDKADASPVTAADRAAETAMRAALARHTPGFGVIGEEFGDDRRGRFNWV
IDPIDGTREFITGRASFVTLIGLVEDGVPVLGLIDQPMTGERWLAAGGQIEFHGPFGGVPGCRRRAALGEAELSCTGPEW
FAPAQRVAFDRLGRACRRVSWGDNAYAAGLLALGAIDIIAEAGHKPWDWAASVPIVEAAGGTMCDWSGRALRLDAETDGT
VLILGDPSLRDEALAILRGDSC

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Localized On The Inner Face Of The Cytoplasm Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1790659, Length=100, Percent_Identity=41, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788882, Length=212, Percent_Identity=28.7735849056604, Blast_Score=65, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320493, Length=238, Percent_Identity=26.890756302521, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357329, Length=234, Percent_Identity=29.0598290598291, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27554; Mature: 27554

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPEGAIEAAKAAAEAARAAIRPYFRAGVGADDKADASPVTAADRAAETAMRAALARHTP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
GFGVIGEEFGDDRRGRFNWVIDPIDGTREFITGRASFVTLIGLVEDGVPVLGLIDQPMTG
CCCCCCHHCCCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCC
ERWLAAGGQIEFHGPFGGVPGCRRRAALGEAELSCTGPEWFAPAQRVAFDRLGRACRRVS
CCEEECCCEEEECCCCCCCCCHHHHHHCCCCCEEECCCHHHCHHHHHHHHHHHHHHHHCC
WGDNAYAAGLLALGAIDIIAEAGHKPWDWAASVPIVEAAGGTMCDWSGRALRLDAETDGT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCEECCCCCEEEEECCCCCE
VLILGDPSLRDEALAILRGDSC
EEEECCCCCCCHHEEEEECCCC
>Mature Secondary Structure
MIPEGAIEAAKAAAEAARAAIRPYFRAGVGADDKADASPVTAADRAAETAMRAALARHTP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
GFGVIGEEFGDDRRGRFNWVIDPIDGTREFITGRASFVTLIGLVEDGVPVLGLIDQPMTG
CCCCCCHHCCCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCC
ERWLAAGGQIEFHGPFGGVPGCRRRAALGEAELSCTGPEWFAPAQRVAFDRLGRACRRVS
CCEEECCCEEEECCCCCCCCCHHHHHHCCCCCEEECCCHHHCHHHHHHHHHHHHHHHHCC
WGDNAYAAGLLALGAIDIIAEAGHKPWDWAASVPIVEAAGGTMCDWSGRALRLDAETDGT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCEECCCCCEEEEECCCCCE
VLILGDPSLRDEALAILRGDSC
EEEECCCCCCCHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]