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The map label for this gene is guaA [H]

Identifier: 148259910

GI number: 148259910

Start: 992345

End: 993907

Strand: Reverse

Name: guaA [H]

Synonym: Acry_0899

Alternate gene names: 148259910

Gene position: 993907-992345 (Counterclockwise)

Preceding gene: 148259911

Following gene: 148259909

Centisome position: 29.33

GC content: 68.65

Gene sequence:

>1563_bases
ATGTCCGACGCACCCTCCGCAGACCGCATCCTCATCCTCGATTTCGGCAGCCAGGTGACGCAGCTGATCGCGCGCCGCCT
GCGCGAGACCGGCGTCTATTGCGAAATCTGGCCATTCGACGCCGATCCGGCGCGCATGGCGGCTTTTGCGCCGAAGGGCA
TCATCCTTTCCGGCGGCCCGGCGAGCGTGATCGAGGAGGTCGCGCCGAAGCCCCCGGCCGACGTGTTCGGCGCCGGCGTG
CCGGTGCTCGGCATCTGCTACGGCGAGCAGGCGATCTGCGATGCGCTGGGCGGCGCGGTGGAAGGGTCGGACCATCGCGA
GTTCGGCCGCGCCTTCATCGACGTCACCGCGGACTGCGCGTTGTTCGAGGGCGTCTGGGCCAGGGGCCAGCGCGCCCAGG
TCTGGATGAGCCATGGCGACCGGGTGACCGCGCTGCCGCCCGGCTTCCGCGCGGTGGCGGTGAGCGAAGGCGCGCCCTTC
GCCGCCATCGCCGACGATGCGCGGCGCATCTACGGCGTGCAGTTCCATCCCGAGGTCGTCCACACGCCGGACGGCGCCCG
CCTGCTCGCGAATTTCGCGCACAAGGTCTGCGGCCTTGCGGGCGGCTGGACGATGGCGAATTTCCGCGAGACCGCGCGCG
ATGCGATCCGCGCCCAGGTCGGCACCGGGCGGGTGATCTGCGGCCTGTCCGGCGGCGTCGATTCCTCGGTCGCGGCGGCC
CTGATCCACGAGGCGATCGGCGACCAGCTCGTCTGCATCTTCGTCGATCACGGCCTGCTCCGCGCCGGCGAGGCGGACGA
GGTCGTGCGCGTCTTCCGCGACCGCTTCAACATACGACTGGTGCATCGAGACGCATCGGACCTGTTCTTCGCGGCTCTCG
AGGGCGTCACCGATCCGGAGGTGAAGCGCAAGACGATCGGCCGCCTGTTCATCGAGGTGTTCGAGGAAGAGGCGAAGAAT
CTCGGCGGCGCCGATTTCCTCGCCCAGGGCACGCTGTATCCGGACGTGATCGAAAGCGTCTCCGCTCGCGGCGGGCCCAG
CGCCGTCATCAAGTCGCACCACAATGTCGGCGGCCTGCCCGACCGGATGCGGATGAAACTGGTCGAGCCGCTGCGCGAAC
TCTTCAAGGACGAGGTGCGCGAACTCGGCCGCGAGCTGGGGCTGCCCGAGACCATCGTCGGCCGCCATCCCTTCCCCGGC
CCCGGCCTTGCCATCCGCATCCCCGGCCCGGTCGACCGCGAGAAGGTCCGCATCCTGCAGAAGGCAGATGCGATCTATCT
CGAGGAAATCCGCAATGCCGGCCTGTATGACGCGATCTGGCAGGCCTTCGTGGCCCTGCTACCGGTGCGCAGCGTCGGCG
TGATGGGCGACGGCCGCACCTACGACTTCGCCTGCGCCCTGCGCGCCGTCACCAGCACTGACGGAATGACAGCCGACGTC
TACCCGTTTGACATGAGCTTCCTGACGCGTGTCGCCGGGCGGATCGTCAACGAAGTGCGCGGCATCAACCGCGTCACCTA
TGACATCACCAGCAAGCCGCCCGGCACCATAGAGTGGGAATAG

Upstream 100 bases:

>100_bases
CGCCTTCTTCGCCGAACACGTCGTCTGACGGGCGGCAGCCGTGAGCGCCGCGCGGCCCGGAGGGATTGAACCCGGCCGCG
TGGCGTGCTGTTGAGGCGGC

Downstream 100 bases:

>100_bases
GGTCGAAGCGCAACCATCTGTTTCGATTTCGGAATTATAGTGTGTCGCACGATATGATCCGCATCATCAATGGCTCGGTT
CCTCGTATTCGAAGAGCGCG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSDAPSADRILILDFGSQVTQLIARRLRETGVYCEIWPFDADPARMAAFAPKGIILSGGPASVIEEVAPKPPADVFGAGV
PVLGICYGEQAICDALGGAVEGSDHREFGRAFIDVTADCALFEGVWARGQRAQVWMSHGDRVTALPPGFRAVAVSEGAPF
AAIADDARRIYGVQFHPEVVHTPDGARLLANFAHKVCGLAGGWTMANFRETARDAIRAQVGTGRVICGLSGGVDSSVAAA
LIHEAIGDQLVCIFVDHGLLRAGEADEVVRVFRDRFNIRLVHRDASDLFFAALEGVTDPEVKRKTIGRLFIEVFEEEAKN
LGGADFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLPDRMRMKLVEPLRELFKDEVRELGRELGLPETIVGRHPFPG
PGLAIRIPGPVDREKVRILQKADAIYLEEIRNAGLYDAIWQAFVALLPVRSVGVMGDGRTYDFACALRAVTSTDGMTADV
YPFDMSFLTRVAGRIVNEVRGINRVTYDITSKPPGTIEWE

Sequences:

>Translated_520_residues
MSDAPSADRILILDFGSQVTQLIARRLRETGVYCEIWPFDADPARMAAFAPKGIILSGGPASVIEEVAPKPPADVFGAGV
PVLGICYGEQAICDALGGAVEGSDHREFGRAFIDVTADCALFEGVWARGQRAQVWMSHGDRVTALPPGFRAVAVSEGAPF
AAIADDARRIYGVQFHPEVVHTPDGARLLANFAHKVCGLAGGWTMANFRETARDAIRAQVGTGRVICGLSGGVDSSVAAA
LIHEAIGDQLVCIFVDHGLLRAGEADEVVRVFRDRFNIRLVHRDASDLFFAALEGVTDPEVKRKTIGRLFIEVFEEEAKN
LGGADFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLPDRMRMKLVEPLRELFKDEVRELGRELGLPETIVGRHPFPG
PGLAIRIPGPVDREKVRILQKADAIYLEEIRNAGLYDAIWQAFVALLPVRSVGVMGDGRTYDFACALRAVTSTDGMTADV
YPFDMSFLTRVAGRIVNEVRGINRVTYDITSKPPGTIEWE
>Mature_519_residues
SDAPSADRILILDFGSQVTQLIARRLRETGVYCEIWPFDADPARMAAFAPKGIILSGGPASVIEEVAPKPPADVFGAGVP
VLGICYGEQAICDALGGAVEGSDHREFGRAFIDVTADCALFEGVWARGQRAQVWMSHGDRVTALPPGFRAVAVSEGAPFA
AIADDARRIYGVQFHPEVVHTPDGARLLANFAHKVCGLAGGWTMANFRETARDAIRAQVGTGRVICGLSGGVDSSVAAAL
IHEAIGDQLVCIFVDHGLLRAGEADEVVRVFRDRFNIRLVHRDASDLFFAALEGVTDPEVKRKTIGRLFIEVFEEEAKNL
GGADFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLPDRMRMKLVEPLRELFKDEVRELGRELGLPETIVGRHPFPGP
GLAIRIPGPVDREKVRILQKADAIYLEEIRNAGLYDAIWQAFVALLPVRSVGVMGDGRTYDFACALRAVTSTDGMTADVY
PFDMSFLTRVAGRIVNEVRGINRVTYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=36, Blast_Score=296, Evalue=2e-80,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=56.3809523809524, Blast_Score=591, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=37.5874125874126, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=37.5874125874126, Blast_Score=315, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI133901714, Length=572, Percent_Identity=37.5874125874126, Blast_Score=315, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=54.0384615384615, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=36.3636363636364, Blast_Score=301, Evalue=7e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56254; Mature: 56123

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAPSADRILILDFGSQVTQLIARRLRETGVYCEIWPFDADPARMAAFAPKGIILSGGP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCEEECCCH
ASVIEEVAPKPPADVFGAGVPVLGICYGEQAICDALGGAVEGSDHREFGRAFIDVTADCA
HHHHHHHCCCCCHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LFEGVWARGQRAQVWMSHGDRVTALPPGFRAVAVSEGAPFAAIADDARRIYGVQFHPEVV
HHHHHHCCCCCEEEEECCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHEEEEECCCEE
HTPDGARLLANFAHKVCGLAGGWTMANFRETARDAIRAQVGTGRVICGLSGGVDSSVAAA
ECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHEAIGDQLVCIFVDHGLLRAGEADEVVRVFRDRFNIRLVHRDASDLFFAALEGVTDPE
HHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCHH
VKRKTIGRLFIEVFEEEAKNLGGADFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCC
DRMRMKLVEPLRELFKDEVRELGRELGLPETIVGRHPFPGPGLAIRIPGPVDREKVRILQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
KADAIYLEEIRNAGLYDAIWQAFVALLPVRSVGVMGDGRTYDFACALRAVTSTDGMTADV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEE
YPFDMSFLTRVAGRIVNEVRGINRVTYDITSKPPGTIEWE
CCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SDAPSADRILILDFGSQVTQLIARRLRETGVYCEIWPFDADPARMAAFAPKGIILSGGP
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCEEECCCH
ASVIEEVAPKPPADVFGAGVPVLGICYGEQAICDALGGAVEGSDHREFGRAFIDVTADCA
HHHHHHHCCCCCHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LFEGVWARGQRAQVWMSHGDRVTALPPGFRAVAVSEGAPFAAIADDARRIYGVQFHPEVV
HHHHHHCCCCCEEEEECCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHEEEEECCCEE
HTPDGARLLANFAHKVCGLAGGWTMANFRETARDAIRAQVGTGRVICGLSGGVDSSVAAA
ECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHEAIGDQLVCIFVDHGLLRAGEADEVVRVFRDRFNIRLVHRDASDLFFAALEGVTDPE
HHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCHH
VKRKTIGRLFIEVFEEEAKNLGGADFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCC
DRMRMKLVEPLRELFKDEVRELGRELGLPETIVGRHPFPGPGLAIRIPGPVDREKVRILQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
KADAIYLEEIRNAGLYDAIWQAFVALLPVRSVGVMGDGRTYDFACALRAVTSTDGMTADV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEE
YPFDMSFLTRVAGRIVNEVRGINRVTYDITSKPPGTIEWE
CCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA