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The map label for this gene is nuoF2 [H]

Identifier: 148259851

GI number: 148259851

Start: 928548

End: 930098

Strand: Reverse

Name: nuoF2 [H]

Synonym: Acry_0840

Alternate gene names: 148259851

Gene position: 930098-928548 (Counterclockwise)

Preceding gene: 148259852

Following gene: 148259850

Centisome position: 27.44

GC content: 68.73

Gene sequence:

>1551_bases
ATGAAGATTTTCGTGCCGCAGGACATGGCCGCCGTGGCGGTCGGGGCGAACCGGGTGGCCGCGGCGATCGAGGCCGAGGC
GCGGGCGCGCAACATTCCGGTGACGATCGTGCGCAACGGCTCGCGCGGGCTGTTCTGGCTGGAGCCGCTGGTCGAGGTCG
CCACCGCGTCGGGGCGGATCGGCTACCGGAACATCGGGGACGCCGACGTGGCGGGGCTGTTCGAGGCCCGCTTCTTCGAC
GGCGCGCCGCATGAAAAATGTGTCGGCCATGTCGAGGAGATTCCCTTCCTCGCGAGGCAGACGCGCTTCACCTTCGGCCG
CGCCGGGATCATCGATCCGCTCTCGCTCGAGGATTACCGCCATCATGGCGGTTACAAGGGGCTGGAGGCGGCGCTCTCGA
TCGGGCCGGCGGCGACCGTCGCCGCGGTGAAGGAGAGCGGGCTGCGCGGGCGCGGCGGCGCGGGGTTCCCGACCGGGATC
AAATGGGAGACCGTGGCGCGCGCGCCGGCGGACCGCAAATATGTCGTCTGCAACGCCGACGAGGGCGATTCCGGCACCTT
CGCCGACCGGCTGATCATGGAAGCCGATCCGTTCATGCTGATCGAGGGCATGACGATCGCCGGCGTCGCGGTCGGCGCGA
CGAAGGGCTATGTCTATATCCGTTCGGAATATCCGCTGGCGATCCGAATGATGCGCCGGGCGATCGAGATCGCGGAGCGC
GCCGGCTATCTCGGCAAGGGGATCAACGGCAGCGCGCATGATTTCGACCTCGAGGTGCGGGTCGGCGCCGGGGCCTATGT
GTGCGGCGAGGAGACCTCGCTGCTGGAGAGCCTGGAGGGCAAGCGCGGGCAGGTGCGGCCGAAGCCGCCGCTGCCGGCGA
TCGAGGGGCTGTTCGGCCGGCCGACCATCATCAACAACACGATCAGCCTGGCGAGCGTGCCGTTCATCCTGGCCGAGGGG
GCGAAGCGCTATGCCGAGATGGGCTATGGCCGCTCGCGCGGGACGATGCCGGTGCAGCTCGCCGGCAACGTGAAGCATGG
CGGGCTGTTCGAATGCGCCTTCGGCGTGACGCTGGGCGAGCTGGTGAACGACATCGGCGGCGGCACCGCCTCGGGCCGGC
CGGTGAAGGCGGTGCAGGCGGGCGGGCCGCTCGGCGCCTATTTCCCGGTCTCGATGTTCGACACGCCCTATGATTACGAG
GCCTTCGCCAAGCGCGACGGGCTGATCGGCCATGGCGGGCTTGTGGTTTTCGACGACACTGCCGACATGGCCCAGATGGC
CCGGTTCGCGATGGAGTTCTGCGCCCTCGAATCCTGCGGCAAGTGCACGCCCTGCCGCATCGGCTCGACGCGCGGGGTGG
AGACATTCGACCGCATCCGCGCCGGGATCGAGCCGGAGACGAATCTCGCCCTCGTGCGTGACCTCTGCGAGACGATGAAG
TTCGGCTCGCTCTGCGCGCTGGGCGGCTTCACGCCGTATCCGGTGCTGTCCGCCATCAACCATTTCCCGGAAGAGTTTCG
CGCGCCGAAACTCCCCGCCGCGGCTGAGTGA

Upstream 100 bases:

>100_bases
TTGGCCTGTGCGCCACGGCGCCGAGCGCGCTGTTCGACGACGAGCCGGTGGGACGGGCGGATGCCGCCACCCTTGAAGCC
CTGGTCGCGGAGGCCGCGTG

Downstream 100 bases:

>100_bases
AGGAGAACCGCCATGGGTCTCGTCCATGAAATCGACTACGGCACCAAGGCCAGCAACGCCGCGGCGCTCGTTACCCTGAC
GATCGACGGGGTGAAGGTCA

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MKIFVPQDMAAVAVGANRVAAAIEAEARARNIPVTIVRNGSRGLFWLEPLVEVATASGRIGYRNIGDADVAGLFEARFFD
GAPHEKCVGHVEEIPFLARQTRFTFGRAGIIDPLSLEDYRHHGGYKGLEAALSIGPAATVAAVKESGLRGRGGAGFPTGI
KWETVARAPADRKYVVCNADEGDSGTFADRLIMEADPFMLIEGMTIAGVAVGATKGYVYIRSEYPLAIRMMRRAIEIAER
AGYLGKGINGSAHDFDLEVRVGAGAYVCGEETSLLESLEGKRGQVRPKPPLPAIEGLFGRPTIINNTISLASVPFILAEG
AKRYAEMGYGRSRGTMPVQLAGNVKHGGLFECAFGVTLGELVNDIGGGTASGRPVKAVQAGGPLGAYFPVSMFDTPYDYE
AFAKRDGLIGHGGLVVFDDTADMAQMARFAMEFCALESCGKCTPCRIGSTRGVETFDRIRAGIEPETNLALVRDLCETMK
FGSLCALGGFTPYPVLSAINHFPEEFRAPKLPAAAE

Sequences:

>Translated_516_residues
MKIFVPQDMAAVAVGANRVAAAIEAEARARNIPVTIVRNGSRGLFWLEPLVEVATASGRIGYRNIGDADVAGLFEARFFD
GAPHEKCVGHVEEIPFLARQTRFTFGRAGIIDPLSLEDYRHHGGYKGLEAALSIGPAATVAAVKESGLRGRGGAGFPTGI
KWETVARAPADRKYVVCNADEGDSGTFADRLIMEADPFMLIEGMTIAGVAVGATKGYVYIRSEYPLAIRMMRRAIEIAER
AGYLGKGINGSAHDFDLEVRVGAGAYVCGEETSLLESLEGKRGQVRPKPPLPAIEGLFGRPTIINNTISLASVPFILAEG
AKRYAEMGYGRSRGTMPVQLAGNVKHGGLFECAFGVTLGELVNDIGGGTASGRPVKAVQAGGPLGAYFPVSMFDTPYDYE
AFAKRDGLIGHGGLVVFDDTADMAQMARFAMEFCALESCGKCTPCRIGSTRGVETFDRIRAGIEPETNLALVRDLCETMK
FGSLCALGGFTPYPVLSAINHFPEEFRAPKLPAAAE
>Mature_516_residues
MKIFVPQDMAAVAVGANRVAAAIEAEARARNIPVTIVRNGSRGLFWLEPLVEVATASGRIGYRNIGDADVAGLFEARFFD
GAPHEKCVGHVEEIPFLARQTRFTFGRAGIIDPLSLEDYRHHGGYKGLEAALSIGPAATVAAVKESGLRGRGGAGFPTGI
KWETVARAPADRKYVVCNADEGDSGTFADRLIMEADPFMLIEGMTIAGVAVGATKGYVYIRSEYPLAIRMMRRAIEIAER
AGYLGKGINGSAHDFDLEVRVGAGAYVCGEETSLLESLEGKRGQVRPKPPLPAIEGLFGRPTIINNTISLASVPFILAEG
AKRYAEMGYGRSRGTMPVQLAGNVKHGGLFECAFGVTLGELVNDIGGGTASGRPVKAVQAGGPLGAYFPVSMFDTPYDYE
AFAKRDGLIGHGGLVVFDDTADMAQMARFAMEFCALESCGKCTPCRIGSTRGVETFDRIRAGIEPETNLALVRDLCETMK
FGSLCALGGFTPYPVLSAINHFPEEFRAPKLPAAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=399, Percent_Identity=38.3458646616541, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI20149568, Length=399, Percent_Identity=38.3458646616541, Blast_Score=248, Evalue=1e-65,
Organism=Escherichia coli, GI1788620, Length=400, Percent_Identity=40.5, Blast_Score=297, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17531727, Length=422, Percent_Identity=36.9668246445498, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI19920794, Length=399, Percent_Identity=37.34335839599, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI45550452, Length=385, Percent_Identity=37.4025974025974, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24653819, Length=383, Percent_Identity=31.0704960835509, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24653817, Length=306, Percent_Identity=29.7385620915033, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54987; Mature: 54987

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIFVPQDMAAVAVGANRVAAAIEAEARARNIPVTIVRNGSRGLFWLEPLVEVATASGRI
CEEECCCCHHHEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHCCCCC
GYRNIGDADVAGLFEARFFDGAPHEKCVGHVEEIPFLARQTRFTFGRAGIIDPLSLEDYR
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCHHHHH
HHGGYKGLEAALSIGPAATVAAVKESGLRGRGGAGFPTGIKWETVARAPADRKYVVCNAD
HCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEECC
EGDSGTFADRLIMEADPFMLIEGMTIAGVAVGATKGYVYIRSEYPLAIRMMRRAIEIAER
CCCCCCHHHHHHCCCCCEEEEECCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHH
AGYLGKGINGSAHDFDLEVRVGAGAYVCGEETSLLESLEGKRGQVRPKPPLPAIEGLFGR
CCCCCCCCCCCCCCEEEEEEECCCEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCC
PTIINNTISLASVPFILAEGAKRYAEMGYGRSRGTMPVQLAGNVKHGGLFECAFGVTLGE
CEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHH
LVNDIGGGTASGRPVKAVQAGGPLGAYFPVSMFDTPYDYEAFAKRDGLIGHGGLVVFDDT
HHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHCCCCCCHHHHHHCCCCEECCCEEEEECC
ADMAQMARFAMEFCALESCGKCTPCRIGSTRGVETFDRIRAGIEPETNLALVRDLCETMK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHC
FGSLCALGGFTPYPVLSAINHFPEEFRAPKLPAAAE
CCCEEECCCCCHHHHHHHHHHCHHHHCCCCCCCCCC
>Mature Secondary Structure
MKIFVPQDMAAVAVGANRVAAAIEAEARARNIPVTIVRNGSRGLFWLEPLVEVATASGRI
CEEECCCCHHHEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHCCCCC
GYRNIGDADVAGLFEARFFDGAPHEKCVGHVEEIPFLARQTRFTFGRAGIIDPLSLEDYR
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCHHHHH
HHGGYKGLEAALSIGPAATVAAVKESGLRGRGGAGFPTGIKWETVARAPADRKYVVCNAD
HCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEECC
EGDSGTFADRLIMEADPFMLIEGMTIAGVAVGATKGYVYIRSEYPLAIRMMRRAIEIAER
CCCCCCHHHHHHCCCCCEEEEECCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHH
AGYLGKGINGSAHDFDLEVRVGAGAYVCGEETSLLESLEGKRGQVRPKPPLPAIEGLFGR
CCCCCCCCCCCCCCEEEEEEECCCEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCC
PTIINNTISLASVPFILAEGAKRYAEMGYGRSRGTMPVQLAGNVKHGGLFECAFGVTLGE
CEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHH
LVNDIGGGTASGRPVKAVQAGGPLGAYFPVSMFDTPYDYEAFAKRDGLIGHGGLVVFDDT
HHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHCCCCCCHHHHHHCCCCEECCCEEEEECC
ADMAQMARFAMEFCALESCGKCTPCRIGSTRGVETFDRIRAGIEPETNLALVRDLCETMK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHC
FGSLCALGGFTPYPVLSAINHFPEEFRAPKLPAAAE
CCCEEECCCCCHHHHHHHHHHCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]