Click here to switch to the map view.

The map label for this gene is yuxL [H]

Identifier: 148259778

GI number: 148259778

Start: 857384

End: 859309

Strand: Reverse

Name: yuxL [H]

Synonym: Acry_0766

Alternate gene names: 148259778

Gene position: 859309-857384 (Counterclockwise)

Preceding gene: 148259779

Following gene: 148259777

Centisome position: 25.35

GC content: 70.61

Gene sequence:

>1926_bases
ATGGACCGCACGACAGACACCACCGCCCTGCCCCTCATTCCGCGCGCCGCCCTGTTCGGCAATCCGCGCCGGGCGGGCGC
GCAGATCAGCCCCGATGGCGGCACGATCGCCTTTCTCGCGCCGCGCAACGGGGTGATGAACCTCTTCGTCGCCCCGCGCG
GGCGGATCGACGCGGCGCGGCCGCTGACCGACGAGCGGCGGCGCGGCATTCCGGGCTATGCCTGGGCGCATGACGGGCGG
CATCTTCTCGTGGTCAAGGACAATGACGGGGACGAGAATTTCCATCTCCACGCCGTCGACCGCGAGACCGGGGCGATGCG
CGACCTGACGCCGCACGGCCCGATCCAGGCGAGCATCGTCAAGCTCTCCCCCCGCCATCCCGGCGAGGCGGTGGTCAGCC
ACAACGCGCGCGACCCGCAATGGCCGGATCTCTACCGGATCGAGATCGCGACCGGGCGGTCGACGATGATCGCGGAAAAT
CCCGGCCTCGCCGGCTTCGATGTGGACGAGGATTTCGCCCTGCGCCTCGCCGCGCGGCTGGAGGGCGACGGCAGCCAGAC
GGTGCTGCGCCCGGATGGCGCCGGCGGCTGGGCGCCGTTCATGCGTTTCGCGCCGGAAGACGCGATGACCTCGGGCGTGC
TTGGCCTGTTCACCGCCGATGGGCGGGCGACGCTGATGCTGAGCAGCGCCGGGCGCGATACCGCCGCGCTGTTCCGCCTC
GACCTCGAGACCGGCGAGGCCACCATGCTCGCCGAGGATGCGCGGGCGGATATCGGCGAGATCATCGTCCGGCTGCACGA
GAACACGCCGCTCGCCTATGGCGTGAATTACGAGCGCAACCGCTACGTGGCGCTCGATCCCGCGATCCAGCCGGATCTCG
ACGCGCTCGATGCCGCCGGGATCGGCGATTGGGGCATCCAGTCGCGCAGCGAGGACGACCGGTTCTGGATCGTCGGCGCC
GCCTCGGACACCGCCCCAGGCGTGGCCTGGCTGTATGACCGGAAGACGCGGGCGCTGGAGAAGCTCTACGACACAAGGCC
CGACCTTGCCGACGCCCCGCTCGCACCGATGCGCCCGGTGGTGATCGCCGCACGGGACGGGCTGTCCCTCGTGTCGTACC
TCACCCTGCCGGCGGATGGGGGATCGGCGCCGCGGCCGCTGGTGCTGCTGGTGCATGGCGGGCCGTGGGCGCGGGATTCC
TTCGGGTTCAACCCGTATCACCAGTGGCTGGCCAACCGGGGCTATGCCGTGCTGTCGGTCAATTTCCGGGCCTCGACCGG
GTTCGGCAAGGCGTTCCTCAATGCCGGCGACCGCGAATGGGGCCGGGCGATGGATGACGACCTGCTCGATGCGGTGGACT
GGGCGATCGGCCAGGGCATCGCCGATCCAAGCCGGATCGCCATCATGGGCGGGTCCTATGGCGGGTATGCGACGCTCGCC
GCGATGACCCGGAATCCGGAGCGCTATGCCTGCGGGGTGGACATCGTCGGTCCGTCCAATCTCGAAACCCTGCTCGCGAC
GATTCCGCCCTATTGGGAGGCGGGGCGCAGCATCTTCACCCGCGCGCTCGGCGACCCGGCGACGCCGGAGGGCGCGGCGC
TGCTGCGCGAGCGCTCGCCAGTGCACCAGGCCGCGCGCCTCGCCCGGCCGCTGCTGATCAGCCAGGGGGCGAACGACCCG
CGGGTGAAGCAGGCCGAGTCCGACCAGATGGTGGCGGCGCTGAAGGCGAAGGGGATCGCGGTGACCTACGTCCTGTTCCC
CGACGAGGGGCACGGTTTCGCGCGGCCGGAGAACAGCATCGCCTTCAACGCGATCACCGAGCATTTCCTCGCCGCCCATC
TCGGCGGGCGGGCGGAAGCGTTGGCGGCGGAAGAGATCGGCCGGTCGACGGCGCAACTCCTCGAAGGGGCGGAGATCCTG
CCATGA

Upstream 100 bases:

>100_bases
GGGCGCGGCAGTTTCGCCGCCCTGACGGGGCGCGGCGGTTTCGCCGCCCTGACGGGGCGCGGCGGTTTCGCCGCGACGCG
ATCTCCGATAGGAAGTCCGC

Downstream 100 bases:

>100_bases
AGGGCATCGTCACCCGCAAGCGCGTCATGATGGCGCTGGAAATCCTGTTCAATTTCCTGCTGCCCTGGACCGTCTATCAT
TTCAGCAAGCCGCATATCGG

Product: peptidase S9 prolyl oligopeptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MDRTTDTTALPLIPRAALFGNPRRAGAQISPDGGTIAFLAPRNGVMNLFVAPRGRIDAARPLTDERRRGIPGYAWAHDGR
HLLVVKDNDGDENFHLHAVDRETGAMRDLTPHGPIQASIVKLSPRHPGEAVVSHNARDPQWPDLYRIEIATGRSTMIAEN
PGLAGFDVDEDFALRLAARLEGDGSQTVLRPDGAGGWAPFMRFAPEDAMTSGVLGLFTADGRATLMLSSAGRDTAALFRL
DLETGEATMLAEDARADIGEIIVRLHENTPLAYGVNYERNRYVALDPAIQPDLDALDAAGIGDWGIQSRSEDDRFWIVGA
ASDTAPGVAWLYDRKTRALEKLYDTRPDLADAPLAPMRPVVIAARDGLSLVSYLTLPADGGSAPRPLVLLVHGGPWARDS
FGFNPYHQWLANRGYAVLSVNFRASTGFGKAFLNAGDREWGRAMDDDLLDAVDWAIGQGIADPSRIAIMGGSYGGYATLA
AMTRNPERYACGVDIVGPSNLETLLATIPPYWEAGRSIFTRALGDPATPEGAALLRERSPVHQAARLARPLLISQGANDP
RVKQAESDQMVAALKAKGIAVTYVLFPDEGHGFARPENSIAFNAITEHFLAAHLGGRAEALAAEEIGRSTAQLLEGAEIL
P

Sequences:

>Translated_641_residues
MDRTTDTTALPLIPRAALFGNPRRAGAQISPDGGTIAFLAPRNGVMNLFVAPRGRIDAARPLTDERRRGIPGYAWAHDGR
HLLVVKDNDGDENFHLHAVDRETGAMRDLTPHGPIQASIVKLSPRHPGEAVVSHNARDPQWPDLYRIEIATGRSTMIAEN
PGLAGFDVDEDFALRLAARLEGDGSQTVLRPDGAGGWAPFMRFAPEDAMTSGVLGLFTADGRATLMLSSAGRDTAALFRL
DLETGEATMLAEDARADIGEIIVRLHENTPLAYGVNYERNRYVALDPAIQPDLDALDAAGIGDWGIQSRSEDDRFWIVGA
ASDTAPGVAWLYDRKTRALEKLYDTRPDLADAPLAPMRPVVIAARDGLSLVSYLTLPADGGSAPRPLVLLVHGGPWARDS
FGFNPYHQWLANRGYAVLSVNFRASTGFGKAFLNAGDREWGRAMDDDLLDAVDWAIGQGIADPSRIAIMGGSYGGYATLA
AMTRNPERYACGVDIVGPSNLETLLATIPPYWEAGRSIFTRALGDPATPEGAALLRERSPVHQAARLARPLLISQGANDP
RVKQAESDQMVAALKAKGIAVTYVLFPDEGHGFARPENSIAFNAITEHFLAAHLGGRAEALAAEEIGRSTAQLLEGAEIL
P
>Mature_641_residues
MDRTTDTTALPLIPRAALFGNPRRAGAQISPDGGTIAFLAPRNGVMNLFVAPRGRIDAARPLTDERRRGIPGYAWAHDGR
HLLVVKDNDGDENFHLHAVDRETGAMRDLTPHGPIQASIVKLSPRHPGEAVVSHNARDPQWPDLYRIEIATGRSTMIAEN
PGLAGFDVDEDFALRLAARLEGDGSQTVLRPDGAGGWAPFMRFAPEDAMTSGVLGLFTADGRATLMLSSAGRDTAALFRL
DLETGEATMLAEDARADIGEIIVRLHENTPLAYGVNYERNRYVALDPAIQPDLDALDAAGIGDWGIQSRSEDDRFWIVGA
ASDTAPGVAWLYDRKTRALEKLYDTRPDLADAPLAPMRPVVIAARDGLSLVSYLTLPADGGSAPRPLVLLVHGGPWARDS
FGFNPYHQWLANRGYAVLSVNFRASTGFGKAFLNAGDREWGRAMDDDLLDAVDWAIGQGIADPSRIAIMGGSYGGYATLA
AMTRNPERYACGVDIVGPSNLETLLATIPPYWEAGRSIFTRALGDPATPEGAALLRERSPVHQAARLARPLLISQGANDP
RVKQAESDQMVAALKAKGIAVTYVLFPDEGHGFARPENSIAFNAITEHFLAAHLGGRAEALAAEEIGRSTAQLLEGAEIL
P

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=236, Percent_Identity=30.5084745762712, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI16933540, Length=284, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25144537, Length=654, Percent_Identity=36.085626911315, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI25144540, Length=423, Percent_Identity=42.080378250591, Blast_Score=318, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI25144543, Length=558, Percent_Identity=33.1541218637993, Blast_Score=291, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17552908, Length=235, Percent_Identity=30.6382978723404, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25149159, Length=244, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 68927; Mature: 68927

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00698 GLYCOSYL_HYDROL_F9_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRTTDTTALPLIPRAALFGNPRRAGAQISPDGGTIAFLAPRNGVMNLFVAPRGRIDAAR
CCCCCCCCCCCCCCHHHHCCCCCCCCCEECCCCCEEEEEECCCCEEEEEECCCCCCCCCC
PLTDERRRGIPGYAWAHDGRHLLVVKDNDGDENFHLHAVDRETGAMRDLTPHGPIQASIV
CCCHHHHCCCCCEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEE
KLSPRHPGEAVVSHNARDPQWPDLYRIEIATGRSTMIAENPGLAGFDVDEDFALRLAARL
EECCCCCCCHHHCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCHHHHHEEEEEE
EGDGSQTVLRPDGAGGWAPFMRFAPEDAMTSGVLGLFTADGRATLMLSSAGRDTAALFRL
CCCCCCEEECCCCCCCHHHHHHCCCCHHHHCCEEEEEECCCCEEEEEECCCCCEEEEEEE
DLETGEATMLAEDARADIGEIIVRLHENTPLAYGVNYERNRYVALDPAIQPDLDALDAAG
ECCCCCEEEEECHHHCCHHHHHEEEECCCCEEEECCCCCCEEEEECCCCCCCCHHHHCCC
IGDWGIQSRSEDDRFWIVGAASDTAPGVAWLYDRKTRALEKLYDTRPDLADAPLAPMRPV
CCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCE
VIAARDGLSLVSYLTLPADGGSAPRPLVLLVHGGPWARDSFGFNPYHQWLANRGYAVLSV
EEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEE
NFRASTGFGKAFLNAGDREWGRAMDDDLLDAVDWAIGQGIADPSRIAIMGGSYGGYATLA
EEEECCCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEE
AMTRNPERYACGVDIVGPSNLETLLATIPPYWEAGRSIFTRALGDPATPEGAALLRERSP
EECCCCCCEEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCH
VHQAARLARPLLISQGANDPRVKQAESDQMVAALKAKGIAVTYVLFPDEGHGFARPENSI
HHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCE
AFNAITEHFLAAHLGGRAEALAAEEIGRSTAQLLEGAEILP
EHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHCCCCCCC
>Mature Secondary Structure
MDRTTDTTALPLIPRAALFGNPRRAGAQISPDGGTIAFLAPRNGVMNLFVAPRGRIDAAR
CCCCCCCCCCCCCCHHHHCCCCCCCCCEECCCCCEEEEEECCCCEEEEEECCCCCCCCCC
PLTDERRRGIPGYAWAHDGRHLLVVKDNDGDENFHLHAVDRETGAMRDLTPHGPIQASIV
CCCHHHHCCCCCEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEE
KLSPRHPGEAVVSHNARDPQWPDLYRIEIATGRSTMIAENPGLAGFDVDEDFALRLAARL
EECCCCCCCHHHCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCHHHHHEEEEEE
EGDGSQTVLRPDGAGGWAPFMRFAPEDAMTSGVLGLFTADGRATLMLSSAGRDTAALFRL
CCCCCCEEECCCCCCCHHHHHHCCCCHHHHCCEEEEEECCCCEEEEEECCCCCEEEEEEE
DLETGEATMLAEDARADIGEIIVRLHENTPLAYGVNYERNRYVALDPAIQPDLDALDAAG
ECCCCCEEEEECHHHCCHHHHHEEEECCCCEEEECCCCCCEEEEECCCCCCCCHHHHCCC
IGDWGIQSRSEDDRFWIVGAASDTAPGVAWLYDRKTRALEKLYDTRPDLADAPLAPMRPV
CCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCE
VIAARDGLSLVSYLTLPADGGSAPRPLVLLVHGGPWARDSFGFNPYHQWLANRGYAVLSV
EEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEE
NFRASTGFGKAFLNAGDREWGRAMDDDLLDAVDWAIGQGIADPSRIAIMGGSYGGYATLA
EEEECCCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEE
AMTRNPERYACGVDIVGPSNLETLLATIPPYWEAGRSIFTRALGDPATPEGAALLRERSP
EECCCCCCEEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCH
VHQAARLARPLLISQGANDPRVKQAESDQMVAALKAKGIAVTYVLFPDEGHGFARPENSI
HHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCE
AFNAITEHFLAAHLGGRAEALAAEEIGRSTAQLLEGAEILP
EHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.47 {tosyl-Lys-methyl} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]