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The map label for this gene is pepA [H]

Identifier: 148259436

GI number: 148259436

Start: 472090

End: 473325

Strand: Reverse

Name: pepA [H]

Synonym: Acry_0419

Alternate gene names: 148259436

Gene position: 473325-472090 (Counterclockwise)

Preceding gene: 148259439

Following gene: 148259435

Centisome position: 13.97

GC content: 65.05

Gene sequence:

>1236_bases
GTGGTTCTCCTACACGGCCCGAATGGCTGTTCGGGGGCATTGCTCGGGCTTGGCGACCGACCTACCCAGGCCACGTTCGG
CGATTTGCACACGAAGTTGCCGCCGGGCGCCGAATGGTCGCTGCTGCCAGGCGACTACGATCCTGGCCAGGCATGGCTTG
GAATTGCCTTGGGCACCTACCGATTCGAGCGGTTTCGTAGGCCGCGGCCTCCTCTGCCTCGGATTTCGGTCGACCACGCG
CCCGACCGGGCCCGGCACCTCGCGTCCGCGATCTGCTTCGCGCGCGACCTCATCAATACACCAGCCAATCATCTCGGCCC
TTCCGATCTAGCCGATGCGGGAACCACCCTGGCGGAACGCTACGGCGCCGCCGTCAGGCGAATCAGAGGCGCGGAACTTG
AAGACGGATATCCCGCGGTGCACGCGGTGGGCGCCGGTTCAGAGCGCCCACCGGAGGTCCTGCAGTTCAACTGGGGCAGC
GACAGTTCTCATCCGCTGATCTCGCTTTGCGGCAAGGGAGTTTGTTTTGATTCCGGCGGTTACGACCTCAAGCCGAGCGC
CGCAATGTTACGGATGAAGAAGGATATGGGCGGCGCCGCAATTACCCTCGGAGTCGCGCAGGCCGTGATGGCGCTGAATC
TTCCGGTTCGGCTCGATGTGCGGATCGGCTGCGTTGAGAACAGCGTGTCCGGACACGCGATGCGCCCCCTCGACATCATC
CGCACGCGCGCGGGCCTGAATGTGGAGGTAGGCAACACCGACGCCGAGGGCCGACTGGTCCTGGCCGACCTGCTAGCCGA
CGCAGCCGACGCAAAGCCCCATTGGCTGATCGATTTCGCGACGCTGACGGGGGCGGCCCGCGTTGCCCTCGGGCCGGATC
TGCCGGCACTTTTCTCGAATGATGATGCGCTCGCCAATGGGCTCTTAGCGGCGGGCACGGCCGCCGATGATCCGCTCTGG
CGCCTGCCGTTATGGCAAGGTTACGAATCCTGGCTGGACAGCCCAACCGCTGACCTGAATTCGGTCGCCTCGAAGCCGTT
CGCCGGGGCGATCATCGCAGCCCTGTTCCTGCGCCGCTTCGTCCCCTCCGGAACGCCCTGGGCACATATCGACACCTACG
CGTGGAACGACTCTACCAGAGCGGGAAAGCCTGAGGGCGGCGAGGCGCAGGCCCTTCATGCCACTTTTGGCGCCATCGAA
GCCCTTGCCAGCGTATCGACCACGAAACGGCCTTGA

Upstream 100 bases:

>100_bases
GGCGCTGCGTCCGGATGCCGTGGAACCGTTTCTCGCCACCACAGATACGCCGACCGCAGCATCTGTCCGCATGCAGGGAT
TTACGGGGCAGGCCTCTGCG

Downstream 100 bases:

>100_bases
TAATGACCTATGAATTAAGGCAAATATTCGGCAATGGAATTGCAATGTTTTCATGTTTCAATGTCTTGTGCGTAAGCTTC
AGGATTCATAATTGATCTCA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MVLLHGPNGCSGALLGLGDRPTQATFGDLHTKLPPGAEWSLLPGDYDPGQAWLGIALGTYRFERFRRPRPPLPRISVDHA
PDRARHLASAICFARDLINTPANHLGPSDLADAGTTLAERYGAAVRRIRGAELEDGYPAVHAVGAGSERPPEVLQFNWGS
DSSHPLISLCGKGVCFDSGGYDLKPSAAMLRMKKDMGGAAITLGVAQAVMALNLPVRLDVRIGCVENSVSGHAMRPLDII
RTRAGLNVEVGNTDAEGRLVLADLLADAADAKPHWLIDFATLTGAARVALGPDLPALFSNDDALANGLLAAGTAADDPLW
RLPLWQGYESWLDSPTADLNSVASKPFAGAIIAALFLRRFVPSGTPWAHIDTYAWNDSTRAGKPEGGEAQALHATFGAIE
ALASVSTTKRP

Sequences:

>Translated_411_residues
MVLLHGPNGCSGALLGLGDRPTQATFGDLHTKLPPGAEWSLLPGDYDPGQAWLGIALGTYRFERFRRPRPPLPRISVDHA
PDRARHLASAICFARDLINTPANHLGPSDLADAGTTLAERYGAAVRRIRGAELEDGYPAVHAVGAGSERPPEVLQFNWGS
DSSHPLISLCGKGVCFDSGGYDLKPSAAMLRMKKDMGGAAITLGVAQAVMALNLPVRLDVRIGCVENSVSGHAMRPLDII
RTRAGLNVEVGNTDAEGRLVLADLLADAADAKPHWLIDFATLTGAARVALGPDLPALFSNDDALANGLLAAGTAADDPLW
RLPLWQGYESWLDSPTADLNSVASKPFAGAIIAALFLRRFVPSGTPWAHIDTYAWNDSTRAGKPEGGEAQALHATFGAIE
ALASVSTTKRP
>Mature_411_residues
MVLLHGPNGCSGALLGLGDRPTQATFGDLHTKLPPGAEWSLLPGDYDPGQAWLGIALGTYRFERFRRPRPPLPRISVDHA
PDRARHLASAICFARDLINTPANHLGPSDLADAGTTLAERYGAAVRRIRGAELEDGYPAVHAVGAGSERPPEVLQFNWGS
DSSHPLISLCGKGVCFDSGGYDLKPSAAMLRMKKDMGGAAITLGVAQAVMALNLPVRLDVRIGCVENSVSGHAMRPLDII
RTRAGLNVEVGNTDAEGRLVLADLLADAADAKPHWLIDFATLTGAARVALGPDLPALFSNDDALANGLLAAGTAADDPLW
RLPLWQGYESWLDSPTADLNSVASKPFAGAIIAALFLRRFVPSGTPWAHIDTYAWNDSTRAGKPEGGEAQALHATFGAIE
ALASVSTTKRP

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=329, Percent_Identity=34.9544072948328, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI47155554, Length=290, Percent_Identity=32.4137931034483, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI87082123, Length=293, Percent_Identity=46.7576791808874, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1790710, Length=364, Percent_Identity=39.010989010989, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=288, Percent_Identity=35.7638888888889, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=166, Percent_Identity=33.1325301204819, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24661038, Length=332, Percent_Identity=31.3253012048193, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI21355725, Length=332, Percent_Identity=31.0240963855422, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24662227, Length=344, Percent_Identity=29.3604651162791, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI221379063, Length=290, Percent_Identity=33.448275862069, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI221379062, Length=290, Percent_Identity=33.448275862069, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21357381, Length=290, Percent_Identity=33.448275862069, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI21355645, Length=374, Percent_Identity=28.6096256684492, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24662223, Length=374, Percent_Identity=28.6096256684492, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20129969, Length=334, Percent_Identity=29.3413173652695, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI20129963, Length=337, Percent_Identity=31.7507418397626, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077148, Length=339, Percent_Identity=30.3834808259587, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI20130057, Length=339, Percent_Identity=30.3834808259587, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI19922386, Length=350, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646701, Length=165, Percent_Identity=35.7575757575758, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646703, Length=165, Percent_Identity=35.7575757575758, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358201, Length=165, Percent_Identity=35.7575757575758, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 43445; Mature: 43445

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00699 NITROGENASE_1_1 ; PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLLHGPNGCSGALLGLGDRPTQATFGDLHTKLPPGAEWSLLPGDYDPGQAWLGIALGTY
CEEEECCCCCCCCEEECCCCCCCCCHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHH
RFERFRRPRPPLPRISVDHAPDRARHLASAICFARDLINTPANHLGPSDLADAGTTLAER
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHH
YGAAVRRIRGAELEDGYPAVHAVGAGSERPPEVLQFNWGSDSSHPLISLCGKGVCFDSGG
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHCCCEEECCCC
YDLKPSAAMLRMKKDMGGAAITLGVAQAVMALNLPVRLDVRIGCVENSVSGHAMRPLDII
CCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCHHHH
RTRAGLNVEVGNTDAEGRLVLADLLADAADAKPHWLIDFATLTGAARVALGPDLPALFSN
HHCCCCEEEECCCCCCCCEEHHHHHHHHCCCCCCEEEEEHHHCCCEEEEECCCCCHHCCC
DDALANGLLAAGTAADDPLWRLPLWQGYESWLDSPTADLNSVASKPFAGAIIAALFLRRF
CHHHHCCEEECCCCCCCCEEECCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHH
VPSGTPWAHIDTYAWNDSTRAGKPEGGEAQALHATFGAIEALASVSTTKRP
CCCCCCCEEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLLHGPNGCSGALLGLGDRPTQATFGDLHTKLPPGAEWSLLPGDYDPGQAWLGIALGTY
CEEEECCCCCCCCEEECCCCCCCCCHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHH
RFERFRRPRPPLPRISVDHAPDRARHLASAICFARDLINTPANHLGPSDLADAGTTLAER
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHH
YGAAVRRIRGAELEDGYPAVHAVGAGSERPPEVLQFNWGSDSSHPLISLCGKGVCFDSGG
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHCCCEEECCCC
YDLKPSAAMLRMKKDMGGAAITLGVAQAVMALNLPVRLDVRIGCVENSVSGHAMRPLDII
CCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCHHHH
RTRAGLNVEVGNTDAEGRLVLADLLADAADAKPHWLIDFATLTGAARVALGPDLPALFSN
HHCCCCEEEECCCCCCCCEEHHHHHHHHCCCCCCEEEEEHHHCCCEEEEECCCCCHHCCC
DDALANGLLAAGTAADDPLWRLPLWQGYESWLDSPTADLNSVASKPFAGAIIAALFLRRF
CHHHHCCEEECCCCCCCCEEECCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHH
VPSGTPWAHIDTYAWNDSTRAGKPEGGEAQALHATFGAIEALASVSTTKRP
CCCCCCCEEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA