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The map label for this gene is atpB

Identifier: 148259414

GI number: 148259414

Start: 452646

End: 453401

Strand: Reverse

Name: atpB

Synonym: Acry_0397

Alternate gene names: 148259414

Gene position: 453401-452646 (Counterclockwise)

Preceding gene: 148259416

Following gene: 148259413

Centisome position: 13.38

GC content: 60.98

Gene sequence:

>756_bases
ATGGCGCAAGAATCGGGGATCAACGCTCTCGGGCAGTTCCAGCTGACCACCGGATTCGGTGCGTTCGGCAAGGCGATCGA
ATTCACGAATTCGAACGAGATGATGCTGCTCGCCGCCGTGATCGTCACCTCGCTTTTCGTTGTCGCGCTGCGCCAGCGCG
CTCTGGTTCCCGGCCGCATGCAGGGCCTCGCCGAGATCAGCTATGAATTCGTCCACAACATGGTGCTCGACACGATCGGC
GAGGAAGGCAAGCGCTTCTTCCCCTTCGTCTTCACCCTGTTCGCCTTCATCCTGATCGGCAACATCCTTGGCCTGTTCCC
GTATTTCTTCGCCTTCACCAGCCACATCGCGATCACCGGCGCCCTGGCGCTTTTCGTCTTCGCCCTCTCGACGCTGGTAG
GTTTCTGGTATCACGGCATCGGCTTCCTGAAGTTCTTTTCCCCCCCGGGCGTGCCGGGCTGGCTGCTTCCGCTGCTGATT
CCGATCGAGATCGTTTCCTTCCTCTCGCGCCCGATCTCGCTTTCGGTTCGACTGTTCGCGAACATCACGGCCGGCCATGT
GATGTGGGAGGTGTTCGCGGGCTTCATGCTGATGCTGGTCTCCGGTCTCGGCGCAGTCGGCGTGGTGGCGGCGATCATAC
CGCTCGGCCTGAACATCGCGCTCACGGCGCTCGAATTCCTGGTCGCGTTCCTGCAGGCCTACGTGTTCGCGATCCTGACC
TGCCTTTACCTGCACGATGCGATCCACATGCACTGA

Upstream 100 bases:

>100_bases
TGGTTCATGATCGGCTTCGTGCCCATCGGCGCGGCTGCGGGGCTTCGAAACGTGTTCCGGGCCATGGGACCGGGCGACAA
GGACTGACCGGAGGATACGG

Downstream 100 bases:

>100_bases
TCGCCTCGCGCTCTCTTCAACCCGCCGGCCCGACCGGCCTCGCTACCGCTTGAACTGAAAGGAATCCAAGTTATGGCCAT
TGACACCCTCCTCCTCGCTC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MAQESGINALGQFQLTTGFGAFGKAIEFTNSNEMMLLAAVIVTSLFVVALRQRALVPGRMQGLAEISYEFVHNMVLDTIG
EEGKRFFPFVFTLFAFILIGNILGLFPYFFAFTSHIAITGALALFVFALSTLVGFWYHGIGFLKFFSPPGVPGWLLPLLI
PIEIVSFLSRPISLSVRLFANITAGHVMWEVFAGFMLMLVSGLGAVGVVAAIIPLGLNIALTALEFLVAFLQAYVFAILT
CLYLHDAIHMH

Sequences:

>Translated_251_residues
MAQESGINALGQFQLTTGFGAFGKAIEFTNSNEMMLLAAVIVTSLFVVALRQRALVPGRMQGLAEISYEFVHNMVLDTIG
EEGKRFFPFVFTLFAFILIGNILGLFPYFFAFTSHIAITGALALFVFALSTLVGFWYHGIGFLKFFSPPGVPGWLLPLLI
PIEIVSFLSRPISLSVRLFANITAGHVMWEVFAGFMLMLVSGLGAVGVVAAIIPLGLNIALTALEFLVAFLQAYVFAILT
CLYLHDAIHMH
>Mature_250_residues
AQESGINALGQFQLTTGFGAFGKAIEFTNSNEMMLLAAVIVTSLFVVALRQRALVPGRMQGLAEISYEFVHNMVLDTIGE
EGKRFFPFVFTLFAFILIGNILGLFPYFFAFTSHIAITGALALFVFALSTLVGFWYHGIGFLKFFSPPGVPGWLLPLLIP
IEIVSFLSRPISLSVRLFANITAGHVMWEVFAGFMLMLVSGLGAVGVVAAIIPLGLNIALTALEFLVAFLQAYVFAILTC
LYLHDAIHMH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=195, Percent_Identity=31.7948717948718, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1790176, Length=222, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6226527, Length=250, Percent_Identity=34, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ACICJ (A5FVJ0)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001233541.1
- ProteinModelPortal:   A5FVJ0
- SMR:   A5FVJ0
- STRING:   A5FVJ0
- GeneID:   5160211
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_0397
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   RFANTVE
- ProtClustDB:   PRK05815
- BioCyc:   ACRY349163:ACRY_0397-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 27421; Mature: 27290

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1142c854)-; HASH(0x134bc090)-; HASH(0x1334917c)-; HASH(0x134b6058)-; HASH(0x13062c80)-; HASH(0x12e10374)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCH
>Mature Secondary Structure 
AQESGINALGQFQLTTGFGAFGKAIEFTNSNEMMLLAAVIVTSLFVVALRQRALVPGRM
CCCCCCCHHHHEEEECCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
QGLAEISYEFVHNMVLDTIGEEGKRFFPFVFTLFAFILIGNILGLFPYFFAFTSHIAITG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALALFVFALSTLVGFWYHGIGFLKFFSPPGVPGWLLPLLIPIEIVSFLSRPISLSVRLFA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NITAGHVMWEVFAGFMLMLVSGLGAVGVVAAIIPLGLNIALTALEFLVAFLQAYVFAILT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
CLYLHDAIHMH
HHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA