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The map label for this gene is purC

Identifier: 148259410

GI number: 148259410

Start: 450323

End: 451087

Strand: Reverse

Name: purC

Synonym: Acry_0393

Alternate gene names: 148259410

Gene position: 451087-450323 (Counterclockwise)

Preceding gene: 148259411

Following gene: 148259409

Centisome position: 13.31

GC content: 60.0

Gene sequence:

>765_bases
ATGGCGCGTCGCCGGCAACTTTATGAAGGCAAGGCAAAAATCCTGTTCGAAGGGCCGGAACCCGGCACCCTCGTGCAGTA
TTTCAAGGACGACGCCACCGCGTTCAACGCCCAGAAGAAGGGCGTGATCACGGGGAAGGGCGTGTTGAACAACCGCATCA
GCGAGTTCCTGATGCAGCGCCTCGGCGAAATCGGCATCCCGACCCATTTCGTCCGCCGCCTCAACATGCGCGAACAACTC
GTGCGCGAGGTCGAGATCATTCCGATCGAGGTCGTCATTCGCAACGTTGCCGCGGGCAGCATGAGCACGCGCCTCGGCAT
CCCTGAGGGTACGCGGCTCCCCCGATCGATCATCGAATATTATTACAAGAACGACGCCCTGAACGATCCGATGGTGTCCG
AGGACCACATCACCGCGTTCGGCTGGGCCAGCACCCAGGATATGGATGACATTGTCCATCTGAGCCTGCGCATCAACGAC
TTTCTCACTGGCCTGTTCCTCGGCGTCGGCATCGTGCTGGTGGACTTCAAGATCGAGTTCGGCCGGCTGTGGGAGAACGA
CGATATGCGCATCGTCCTCGCCGACGAAATCAGCCCGGACAATTGCCGTCTCTGGGATGCCAAGACCAACGAGAAGATGG
ACAAGGACCGCTTCCGCCGCGATCTCGGCCGGGTTGAGGAAGCATATCAGGAAGTCGCCAAGCGTCTCGGAATCCTGCCC
GAGGCCGGGACACGCGATATGAAGGGCCCGGAGACGATGCAATGA

Upstream 100 bases:

>100_bases
CGTCTGCCTCCGGGCATGGCGCAAACCGCTGCCGGTTGATATACCCGGTCGCGTGCGGCCTCACCGTTTCCCATCAGCCG
CCGAGATACGAGGTTCACCC

Downstream 100 bases:

>100_bases
AGGTTCTGGTCGCCGTGAAGCTGAAGGCCGGCGTGCTCGATCCGCAGGGCAAGGCCATCGGCCACGCGCTCGAAGGGCTT
GGATACAATGACGTGAACGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAFNAQKKGVITGKGVLNNRISEFLMQRLGEIGIPTHFVRRLNMREQL
VREVEIIPIEVVIRNVAAGSMSTRLGIPEGTRLPRSIIEYYYKNDALNDPMVSEDHITAFGWASTQDMDDIVHLSLRIND
FLTGLFLGVGIVLVDFKIEFGRLWENDDMRIVLADEISPDNCRLWDAKTNEKMDKDRFRRDLGRVEEAYQEVAKRLGILP
EAGTRDMKGPETMQ

Sequences:

>Translated_254_residues
MARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAFNAQKKGVITGKGVLNNRISEFLMQRLGEIGIPTHFVRRLNMREQL
VREVEIIPIEVVIRNVAAGSMSTRLGIPEGTRLPRSIIEYYYKNDALNDPMVSEDHITAFGWASTQDMDDIVHLSLRIND
FLTGLFLGVGIVLVDFKIEFGRLWENDDMRIVLADEISPDNCRLWDAKTNEKMDKDRFRRDLGRVEEAYQEVAKRLGILP
EAGTRDMKGPETMQ
>Mature_253_residues
ARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAFNAQKKGVITGKGVLNNRISEFLMQRLGEIGIPTHFVRRLNMREQLV
REVEIIPIEVVIRNVAAGSMSTRLGIPEGTRLPRSIIEYYYKNDALNDPMVSEDHITAFGWASTQDMDDIVHLSLRINDF
LTGLFLGVGIVLVDFKIEFGRLWENDDMRIVLADEISPDNCRLWDAKTNEKMDKDRFRRDLGRVEEAYQEVAKRLGILPE
AGTRDMKGPETMQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=251, Percent_Identity=34.2629482071713, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI5453539, Length=251, Percent_Identity=34.2629482071713, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI119220559, Length=258, Percent_Identity=32.9457364341085, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=44.5378151260504, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17531275, Length=234, Percent_Identity=32.4786324786325, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI18860083, Length=239, Percent_Identity=33.0543933054393, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24583917, Length=247, Percent_Identity=27.9352226720648, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_ACICJ (A5FVI6)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001233537.1
- ProteinModelPortal:   A5FVI6
- SMR:   A5FVI6
- STRING:   A5FVI6
- GeneID:   5159693
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_0393
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   ACRY349163:ACRY_0393-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 29078; Mature: 28947

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAFNAQKKGVITGKGVLNNRISEFLMQR
CCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHH
LGEIGIPTHFVRRLNMREQLVREVEIIPIEVVIRNVAAGSMSTRLGIPEGTRLPRSIIEY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHH
YYKNDALNDPMVSEDHITAFGWASTQDMDDIVHLSLRINDFLTGLFLGVGIVLVDFKIEF
HHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEE
GRLWENDDMRIVLADEISPDNCRLWDAKTNEKMDKDRFRRDLGRVEEAYQEVAKRLGILP
CCCCCCCCCEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EAGTRDMKGPETMQ
CCCCCCCCCCCCCC
>Mature Secondary Structure 
ARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAFNAQKKGVITGKGVLNNRISEFLMQR
CCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHH
LGEIGIPTHFVRRLNMREQLVREVEIIPIEVVIRNVAAGSMSTRLGIPEGTRLPRSIIEY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHH
YYKNDALNDPMVSEDHITAFGWASTQDMDDIVHLSLRINDFLTGLFLGVGIVLVDFKIEF
HHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEE
GRLWENDDMRIVLADEISPDNCRLWDAKTNEKMDKDRFRRDLGRVEEAYQEVAKRLGILP
CCCCCCCCCEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EAGTRDMKGPETMQ
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA