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The map label for this gene is lpd [H]

Identifier: 148259213

GI number: 148259213

Start: 220749

End: 222866

Strand: Reverse

Name: lpd [H]

Synonym: Acry_0193

Alternate gene names: 148259213

Gene position: 222866-220749 (Counterclockwise)

Preceding gene: 148259214

Following gene: 148259212

Centisome position: 6.58

GC content: 71.91

Gene sequence:

>2118_bases
ATGAGCACGACGACGGTCGGCCGCGCGGGGCGGCGGGGCACTGCGCGGGCGCTCGGCTTCGCAGCACTGGCGCTGGCGCT
GGTCGCATTGGTGGTGGCGTTGCAGCGCCAGGGGCTGGGCATCGCGCGGCTGGAGGGCGATCTCGCCGGGCTGCGCGGCA
TGGTGGCGGCGCATCCGCTCGCCGGGTTCCTCCTCTATTTCGGGCTCTACGTGGCGGCGACTTCGCTCTCGGTGCCGGGG
GCGGCGGTGCTGACGCTCGGCGCCGGCGCGTTGTTCGGCGTGGCGGAGGGGGCGGTGCTGGTCTCCTTCGCCTCGTCGAT
CGGCGCGAGTCTTGCGTTTCTCGCCGCCCGCTTCCTGCTGCGGGATTTCGCCCTCGCCCGCTTCCCCGCGCTGTTCGAGC
GGATCGAGCGGGGCATCGCCCGCGACGGGGCATTCTATCTCGTCTCGCTCAGGCTGGCGCCGGTGGTGCCGTTCTTCGCG
GTCAACCTGCTGGCGGGGCTGACAAGCCTGCGGCTGCGCAGCTTCTACCTCGCGAGCCAGATCGGCATGCTGCCGGCGAC
ATTGATCTATGTGAATGCCGGCGCCTCGCTCGCGACACTCGGCGGGCACGGTCCGATCCTCACGCAGCGCCTCGTCATCG
GCCTGCTGCTGCTCGCCGCCCTGCCGCTCGCGGCCCCGCGCCTGCGCGACGCGCTAGCCACCCGCAGGCTTTATGCGCGG
TTTCGCCGGCCGAAGCGGTTCGACCGCAACCTCGTGGTGATCGGCGCCGGCGCCGGCGGGCTCGTCGCCGCCTATGTCGC
CAGCGCGGTGAAGGCAAAGGTGACGCTGGTCGAGGCCGGCGAGATGGGCGGGGACTGCCTCAATTCCGGCTGCGTGCCGT
CCAAGGCGCTGCTCCACGCCGCGCGCGCGGGCAAGGATTTTCGCGCCGCGATCGCCGATGTCCGCGCCGCGATCGCGGGG
ATCGCGCCGCATGATTCGGTCGCCCGCTACGAGGGGCTCGGCGTCGAGGTCAGGCGGGGACGGGCCGTGATCGAATCGCC
CTGGTGCGTCGCCGTCGACGGGGTGCCGATCACGACACGCGCCATCGTGATTGCGGCCGGAGCAGAACCCTTCGTGCCGC
CCATTCCCGGCCTTGCCGAGGCGCCCCATGCCACTTCGGAGACGCTGTGGGATATCGAGGACCTGCCGCGGCGGCTCGTC
ATTCTCGGCGGCGGGCCGATCGGCTGCGAGATGGCGCAGGCCTTTGCCCGCCTCGGCAGCGCGGTGACGCTGGTGGAGAT
GTCGGAGCGGCTGCTGGTGCGCGAGGACGACGAGGTTTCGGCGGCAATGGCGGCGGCGCTGGCGCGCGATGGCGTCGCGA
TCCGCACCGGCCACAGGGCCGAGGCGGTGACGCGCACGGAGGCGGGGTTCGCGCTCGTCGCGGCCAGCGGGGTCCAGACC
ATCGAGCTGCCGTTCGACCGGCTGCTGGTTGCCATCGGTCGCCGCCCGCGGGTGAGCGGCTACGGGCTGGAGGCGCTCGG
CATTCCGCTCACCCCGGCGAGGACGATCGAGACCGATGACGGGCTGCGCACGCTCTATCCCAACATCTTTGCCTGCGGCG
ACGTCGCCGGGCCCTACCAGTTCACCCATATGGCCGGGTATCAGGGCGGATATGCCGCGCTGGGCGCGCTGTTCGCCCCG
TTCTGGCGGTTTCGCCCGAGCTACCGGGCGGTGCCGGCGGTGACCTATACCAGCCCGGAGATCGCCCGCGTCGGGCTGAA
CGCGCGCGAGGCGGCGGCGCGGGGCATCGAAGCCGAGATCACCCGCTACGATTTCGCGGAGCTCGACCGCGCCATCGCCG
AGGGCGATACCGAAGGCTTCGTCACCGTGCTGACAAGGAAGGGCAGCGACCGCATCCTCGGCGCGACCATCGTCGGCCCC
CAGGCCGGCGAGTTGCTCACGGGCTTCACCCTCGCGATGCAGCACGGGCTCGGGCTGAAGAAGCTGATGGGCACGATCTT
CCCCTATCCGACCCGTTCGGAGGCGATCCGCGCCGTCGCCGGGCAGTGGCGGCAGGCGCATGCCTCGGCGCGCGGGCTTG
CGATCCTCGAGCGGTTCCACCGATGGCGACGCGGGTGA

Upstream 100 bases:

>100_bases
CTGGAGGACGCATCGCGGGCGGTCACGCTCGATCATCCGCATTGCGCGCGGTTCTGCGTGTTTGGCGCATCCTCCTGCAT
GAGTGCGAGGTAAGACGGAC

Downstream 100 bases:

>100_bases
GCCTCCCCGTCATCGTCGTCTTCAGCCGCATCCCCCGCCTCGGCGTCGGCAAGCGGCGGCTCGCCCGCACGGTGGGGGAC
CGCGCGGCTTGGCGCCTGTC

Product: pyridine nucleotide-disulfide oxidoreductase dimerisation region

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 705; Mature: 704

Protein sequence:

>705_residues
MSTTTVGRAGRRGTARALGFAALALALVALVVALQRQGLGIARLEGDLAGLRGMVAAHPLAGFLLYFGLYVAATSLSVPG
AAVLTLGAGALFGVAEGAVLVSFASSIGASLAFLAARFLLRDFALARFPALFERIERGIARDGAFYLVSLRLAPVVPFFA
VNLLAGLTSLRLRSFYLASQIGMLPATLIYVNAGASLATLGGHGPILTQRLVIGLLLLAALPLAAPRLRDALATRRLYAR
FRRPKRFDRNLVVIGAGAGGLVAAYVASAVKAKVTLVEAGEMGGDCLNSGCVPSKALLHAARAGKDFRAAIADVRAAIAG
IAPHDSVARYEGLGVEVRRGRAVIESPWCVAVDGVPITTRAIVIAAGAEPFVPPIPGLAEAPHATSETLWDIEDLPRRLV
ILGGGPIGCEMAQAFARLGSAVTLVEMSERLLVREDDEVSAAMAAALARDGVAIRTGHRAEAVTRTEAGFALVAASGVQT
IELPFDRLLVAIGRRPRVSGYGLEALGIPLTPARTIETDDGLRTLYPNIFACGDVAGPYQFTHMAGYQGGYAALGALFAP
FWRFRPSYRAVPAVTYTSPEIARVGLNAREAAARGIEAEITRYDFAELDRAIAEGDTEGFVTVLTRKGSDRILGATIVGP
QAGELLTGFTLAMQHGLGLKKLMGTIFPYPTRSEAIRAVAGQWRQAHASARGLAILERFHRWRRG

Sequences:

>Translated_705_residues
MSTTTVGRAGRRGTARALGFAALALALVALVVALQRQGLGIARLEGDLAGLRGMVAAHPLAGFLLYFGLYVAATSLSVPG
AAVLTLGAGALFGVAEGAVLVSFASSIGASLAFLAARFLLRDFALARFPALFERIERGIARDGAFYLVSLRLAPVVPFFA
VNLLAGLTSLRLRSFYLASQIGMLPATLIYVNAGASLATLGGHGPILTQRLVIGLLLLAALPLAAPRLRDALATRRLYAR
FRRPKRFDRNLVVIGAGAGGLVAAYVASAVKAKVTLVEAGEMGGDCLNSGCVPSKALLHAARAGKDFRAAIADVRAAIAG
IAPHDSVARYEGLGVEVRRGRAVIESPWCVAVDGVPITTRAIVIAAGAEPFVPPIPGLAEAPHATSETLWDIEDLPRRLV
ILGGGPIGCEMAQAFARLGSAVTLVEMSERLLVREDDEVSAAMAAALARDGVAIRTGHRAEAVTRTEAGFALVAASGVQT
IELPFDRLLVAIGRRPRVSGYGLEALGIPLTPARTIETDDGLRTLYPNIFACGDVAGPYQFTHMAGYQGGYAALGALFAP
FWRFRPSYRAVPAVTYTSPEIARVGLNAREAAARGIEAEITRYDFAELDRAIAEGDTEGFVTVLTRKGSDRILGATIVGP
QAGELLTGFTLAMQHGLGLKKLMGTIFPYPTRSEAIRAVAGQWRQAHASARGLAILERFHRWRRG
>Mature_704_residues
STTTVGRAGRRGTARALGFAALALALVALVVALQRQGLGIARLEGDLAGLRGMVAAHPLAGFLLYFGLYVAATSLSVPGA
AVLTLGAGALFGVAEGAVLVSFASSIGASLAFLAARFLLRDFALARFPALFERIERGIARDGAFYLVSLRLAPVVPFFAV
NLLAGLTSLRLRSFYLASQIGMLPATLIYVNAGASLATLGGHGPILTQRLVIGLLLLAALPLAAPRLRDALATRRLYARF
RRPKRFDRNLVVIGAGAGGLVAAYVASAVKAKVTLVEAGEMGGDCLNSGCVPSKALLHAARAGKDFRAAIADVRAAIAGI
APHDSVARYEGLGVEVRRGRAVIESPWCVAVDGVPITTRAIVIAAGAEPFVPPIPGLAEAPHATSETLWDIEDLPRRLVI
LGGGPIGCEMAQAFARLGSAVTLVEMSERLLVREDDEVSAAMAAALARDGVAIRTGHRAEAVTRTEAGFALVAASGVQTI
ELPFDRLLVAIGRRPRVSGYGLEALGIPLTPARTIETDDGLRTLYPNIFACGDVAGPYQFTHMAGYQGGYAALGALFAPF
WRFRPSYRAVPAVTYTSPEIARVGLNAREAAARGIEAEITRYDFAELDRAIAEGDTEGFVTVLTRKGSDRILGATIVGPQ
AGELLTGFTLAMQHGLGLKKLMGTIFPYPTRSEAIRAVAGQWRQAHASARGLAILERFHRWRRG

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=505, Percent_Identity=32.6732673267327, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI50301238, Length=456, Percent_Identity=28.0701754385965, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI22035672, Length=428, Percent_Identity=26.4018691588785, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI33519430, Length=438, Percent_Identity=25.3424657534247, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI33519428, Length=438, Percent_Identity=25.3424657534247, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI33519426, Length=438, Percent_Identity=25.3424657534247, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI148277065, Length=438, Percent_Identity=25.3424657534247, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI148277071, Length=438, Percent_Identity=25.3424657534247, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI291045266, Length=428, Percent_Identity=25.7009345794392, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI18087813, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786307, Length=472, Percent_Identity=30.2966101694915, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI87081717, Length=433, Percent_Identity=29.3302540415704, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=29.004329004329, Blast_Score=152, Evalue=8e-38,
Organism=Escherichia coli, GI1789915, Length=432, Percent_Identity=27.5462962962963, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87081964, Length=230, Percent_Identity=31.7391304347826, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1788049, Length=143, Percent_Identity=35.6643356643357, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1789065, Length=183, Percent_Identity=31.1475409836066, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=486, Percent_Identity=33.5390946502058, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71983419, Length=431, Percent_Identity=27.6102088167053, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=431, Percent_Identity=27.6102088167053, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17557007, Length=493, Percent_Identity=27.1805273833671, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17532687, Length=169, Percent_Identity=26.6272189349112, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=493, Percent_Identity=30.6288032454361, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=471, Percent_Identity=26.5392781316348, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6325240, Length=487, Percent_Identity=26.4887063655031, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21358499, Length=480, Percent_Identity=32.0833333333333, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI17737741, Length=492, Percent_Identity=28.4552845528455, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640549, Length=480, Percent_Identity=27.0833333333333, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640553, Length=480, Percent_Identity=27.0833333333333, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=26.7782426778243, Blast_Score=108, Evalue=2e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 74178; Mature: 74047

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTTVGRAGRRGTARALGFAALALALVALVVALQRQGLGIARLEGDLAGLRGMVAAHPL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
AGFLLYFGLYVAATSLSVPGAAVLTLGAGALFGVAEGAVLVSFASSIGASLAFLAARFLL
HHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RDFALARFPALFERIERGIARDGAFYLVSLRLAPVVPFFAVNLLAGLTSLRLRSFYLASQ
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGMLPATLIYVNAGASLATLGGHGPILTQRLVIGLLLLAALPLAAPRLRDALATRRLYAR
HCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FRRPKRFDRNLVVIGAGAGGLVAAYVASAVKAKVTLVEAGEMGGDCLNSGCVPSKALLHA
HCCCHHCCCCEEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHCCCCCCHHHHHHH
ARAGKDFRAAIADVRAAIAGIAPHDSVARYEGLGVEVRRGRAVIESPWCVAVDGVPITTR
HHCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCEEECCCCEEEECCCCEEEE
AIVIAAGAEPFVPPIPGLAEAPHATSETLWDIEDLPRRLVILGGGPIGCEMAQAFARLGS
EEEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHCCCEEEEECCCCCCHHHHHHHHHHCC
AVTLVEMSERLLVREDDEVSAAMAAALARDGVAIRTGHRAEAVTRTEAGFALVAASGVQT
CEEEHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHCCCCEEEEEECCCEE
IELPFDRLLVAIGRRPRVSGYGLEALGIPLTPARTIETDDGLRTLYPNIFACGDVAGPYQ
EECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCH
FTHMAGYQGGYAALGALFAPFWRFRPSYRAVPAVTYTSPEIARVGLNAREAAARGIEAEI
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHCCCCHHHHHHCCCCHHH
TRYDFAELDRAIAEGDTEGFVTVLTRKGSDRILGATIVGPQAGELLTGFTLAMQHGLGLK
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHH
KLMGTIFPYPTRSEAIRAVAGQWRQAHASARGLAILERFHRWRRG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STTTVGRAGRRGTARALGFAALALALVALVVALQRQGLGIARLEGDLAGLRGMVAAHPL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
AGFLLYFGLYVAATSLSVPGAAVLTLGAGALFGVAEGAVLVSFASSIGASLAFLAARFLL
HHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RDFALARFPALFERIERGIARDGAFYLVSLRLAPVVPFFAVNLLAGLTSLRLRSFYLASQ
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGMLPATLIYVNAGASLATLGGHGPILTQRLVIGLLLLAALPLAAPRLRDALATRRLYAR
HCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FRRPKRFDRNLVVIGAGAGGLVAAYVASAVKAKVTLVEAGEMGGDCLNSGCVPSKALLHA
HCCCHHCCCCEEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHCCCCCCHHHHHHH
ARAGKDFRAAIADVRAAIAGIAPHDSVARYEGLGVEVRRGRAVIESPWCVAVDGVPITTR
HHCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCEEECCCCEEEECCCCEEEE
AIVIAAGAEPFVPPIPGLAEAPHATSETLWDIEDLPRRLVILGGGPIGCEMAQAFARLGS
EEEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHCCCEEEEECCCCCCHHHHHHHHHHCC
AVTLVEMSERLLVREDDEVSAAMAAALARDGVAIRTGHRAEAVTRTEAGFALVAASGVQT
CEEEHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHCCCCEEEEEECCCEE
IELPFDRLLVAIGRRPRVSGYGLEALGIPLTPARTIETDDGLRTLYPNIFACGDVAGPYQ
EECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCH
FTHMAGYQGGYAALGALFAPFWRFRPSYRAVPAVTYTSPEIARVGLNAREAAARGIEAEI
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHCCCCHHHHHHCCCCHHH
TRYDFAELDRAIAEGDTEGFVTVLTRKGSDRILGATIVGPQAGELLTGFTLAMQHGLGLK
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHH
KLMGTIFPYPTRSEAIRAVAGQWRQAHASARGLAILERFHRWRRG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA