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The map label for this gene is hemC [H]

Identifier: 148259148

GI number: 148259148

Start: 140056

End: 141057

Strand: Reverse

Name: hemC [H]

Synonym: Acry_0128

Alternate gene names: 148259148

Gene position: 141057-140056 (Counterclockwise)

Preceding gene: 148259153

Following gene: 148259147

Centisome position: 4.16

GC content: 68.76

Gene sequence:

>1002_bases
ATGCACCAGGAAAGCTCGTCGGGCAGCAAAGTCGCCCCCCATTCCGGCCGCCGGCTGCCGCTACGAGTCGGCACCCGCGG
GTCGCCGCTAGCCCTCCGGCAGACCGACATGTTCCTCGCGGCGCTGCGCGAGATCTGCCCGGCCCTCGGTTTCGCGCCGG
ATGCCTTCGCGCCCGAGATCATCAGCACGACCGGTGACCGGGTGACCGACCGCCCCCTCGCCGAAATCGGCGGCAAGGGG
CTGTTCGCCAAGGAAATCCATGAGGCGCTGCTCGACGGGCGGATCGACTTCGCAGTGCACAGCCTCAAGGATCTCGAGAC
CGCATTGCCGGACGGCATCATCCTCGCCTGCACGATGAAGCGCGAGGACGCCCGCGACGCGCTGATCCTTGCCGACGGGC
TCGGGCCGGTGAACGACGGCGATATCTGGTCGAGCCTGCCGAAGGGCGCGCGGGTCGGCACCTCGTCGGTGCGGCGGCAG
GCGCAACTGCTGCATGCCCGGCCCGACCTACAGATCGGCCTGCTGCGCGGCAATGTCCGCACCAGGCTGGATGCGGCACG
CATTGGCACGTTCGATGCAACCTTGCTCGCTCTCGCCGGGCTGCGGCGGCTTGGATTCGAGGAGGAGGTGGCCGCAGCCA
TCGACCCGGAAGCGATGGTGCCAGCCGCCTGCCAGGGGATTGTCGGGATTACCGTGCGGGCGGCAGACAGCCGGCTCGCC
GAACTGCTCGCGGCGATCGAGAATCACGAGGCGAAGGCAGTCTCCAAGGCAGAGCGGGCATTGCTCGCTGCGCTTGACGG
TTCCTGCCGCACGCCGATCGGCGGACATGCACGGCTGCTGCCGGATGGCAATCTGCACCTGACAGGGCTCACAGCGCGTC
CGGATGGCAGTTTCCTGCTGAAGCGCAGCGAGGTGGCGAACGCCGCCGATGCGGTGCGACTGGGGGCGGAACTCGGTGCC
TCGCTGCGGCGCGACAGCCCGGCCGACATCTTTCTTGACTGA

Upstream 100 bases:

>100_bases
TCGTCGCACGAACTCTCGATACCGAGGATCAGCGAGTCGTGGCCCAACGCGTCGCCGCTTGCGGCTTTTCTTTCCATCGC
GATCCTTTTAAGCAGTGAAG

Downstream 100 bases:

>100_bases
CCCCGGTGCGACAGAGCCGCTCACCGTCCTGGTGACGCGCCCCGAACCGGGCGGCAGCGCCACCGCCGCCGCCCTCCGCG
CGGCAGGATATGTGCCGGTT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MHQESSSGSKVAPHSGRRLPLRVGTRGSPLALRQTDMFLAALREICPALGFAPDAFAPEIISTTGDRVTDRPLAEIGGKG
LFAKEIHEALLDGRIDFAVHSLKDLETALPDGIILACTMKREDARDALILADGLGPVNDGDIWSSLPKGARVGTSSVRRQ
AQLLHARPDLQIGLLRGNVRTRLDAARIGTFDATLLALAGLRRLGFEEEVAAAIDPEAMVPAACQGIVGITVRAADSRLA
ELLAAIENHEAKAVSKAERALLAALDGSCRTPIGGHARLLPDGNLHLTGLTARPDGSFLLKRSEVANAADAVRLGAELGA
SLRRDSPADIFLD

Sequences:

>Translated_333_residues
MHQESSSGSKVAPHSGRRLPLRVGTRGSPLALRQTDMFLAALREICPALGFAPDAFAPEIISTTGDRVTDRPLAEIGGKG
LFAKEIHEALLDGRIDFAVHSLKDLETALPDGIILACTMKREDARDALILADGLGPVNDGDIWSSLPKGARVGTSSVRRQ
AQLLHARPDLQIGLLRGNVRTRLDAARIGTFDATLLALAGLRRLGFEEEVAAAIDPEAMVPAACQGIVGITVRAADSRLA
ELLAAIENHEAKAVSKAERALLAALDGSCRTPIGGHARLLPDGNLHLTGLTARPDGSFLLKRSEVANAADAVRLGAELGA
SLRRDSPADIFLD
>Mature_333_residues
MHQESSSGSKVAPHSGRRLPLRVGTRGSPLALRQTDMFLAALREICPALGFAPDAFAPEIISTTGDRVTDRPLAEIGGKG
LFAKEIHEALLDGRIDFAVHSLKDLETALPDGIILACTMKREDARDALILADGLGPVNDGDIWSSLPKGARVGTSSVRRQ
AQLLHARPDLQIGLLRGNVRTRLDAARIGTFDATLLALAGLRRLGFEEEVAAAIDPEAMVPAACQGIVGITVRAADSRLA
ELLAAIENHEAKAVSKAERALLAALDGSCRTPIGGHARLLPDGNLHLTGLTARPDGSFLLKRSEVANAADAVRLGAELGA
SLRRDSPADIFLD

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=280, Percent_Identity=41.0714285714286, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI66933009, Length=280, Percent_Identity=41.0714285714286, Blast_Score=181, Evalue=7e-46,
Organism=Escherichia coli, GI48994974, Length=311, Percent_Identity=44.0514469453376, Blast_Score=223, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319996, Length=266, Percent_Identity=34.5864661654135, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI20130425, Length=305, Percent_Identity=37.0491803278689, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35158; Mature: 35158

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQESSSGSKVAPHSGRRLPLRVGTRGSPLALRQTDMFLAALREICPALGFAPDAFAPEI
CCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ISTTGDRVTDRPLAEIGGKGLFAKEIHEALLDGRIDFAVHSLKDLETALPDGIILACTMK
HHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
REDARDALILADGLGPVNDGDIWSSLPKGARVGTSSVRRQAQLLHARPDLQIGLLRGNVR
CCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHH
TRLDAARIGTFDATLLALAGLRRLGFEEEVAAAIDPEAMVPAACQGIVGITVRAADSRLA
HHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCEEEEEEECHHHHHH
ELLAAIENHEAKAVSKAERALLAALDGSCRTPIGGHARLLPDGNLHLTGLTARPDGSFLL
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCEEE
KRSEVANAADAVRLGAELGASLRRDSPADIFLD
EHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MHQESSSGSKVAPHSGRRLPLRVGTRGSPLALRQTDMFLAALREICPALGFAPDAFAPEI
CCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ISTTGDRVTDRPLAEIGGKGLFAKEIHEALLDGRIDFAVHSLKDLETALPDGIILACTMK
HHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
REDARDALILADGLGPVNDGDIWSSLPKGARVGTSSVRRQAQLLHARPDLQIGLLRGNVR
CCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHH
TRLDAARIGTFDATLLALAGLRRLGFEEEVAAAIDPEAMVPAACQGIVGITVRAADSRLA
HHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCEEEEEEECHHHHHH
ELLAAIENHEAKAVSKAERALLAALDGSCRTPIGGHARLLPDGNLHLTGLTARPDGSFLL
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCEEE
KRSEVANAADAVRLGAELGASLRRDSPADIFLD
EHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA