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The map label for this gene is purH [H]

Identifier: 148243415

GI number: 148243415

Start: 2014031

End: 2015593

Strand: Direct

Name: purH [H]

Synonym: SynRCC307_2316

Alternate gene names: 148243415

Gene position: 2014031-2015593 (Clockwise)

Preceding gene: 148243413

Following gene: 148243416

Centisome position: 90.52

GC content: 65.26

Gene sequence:

>1563_bases
TTGGCTGTCCCTGCGATCTCCATGGCCCGTCTGGCTCTGCTGAGTGTGTCGAACAAAGAGGGGATTGAACCTCTGGCCCG
GGCCCTGGTGGAACGCCATGGTTTCCAGCTGCTCTCCAGCGGCGGCACCGCGAAATGTCTGGCGGATGCAGGGCTGCCTG
TCACCAAGGTGGCAGAGCACACCGGTGCCCCAGAAATCCTGGGGGGTCGCGTCAAAACCCTGCACCCGCGCATCCATGGC
GGCATCTTGGGCCGCCCCAGCGACGCGGCCGACCAGGCCGACATGGAGGCCCAGAACATCCCCGCGATCGAGCTGGTGGT
GGTGAATCTTTACCCGTTTGAAGCCACCATCGCCAAGGCCGATGTGAGCTGGGATGAGGCCATCGAGAAGATCGACATCG
GCGGACCGGCCATGGTGCGGGCTGCCGCCAAAAACCATGCCCACGTCAGCGTTTTAACCAGCCCGACCCAATACGAGCGA
CTGCTTGGTGCTCTCGACGCCGGGCCCATCCCTGCCGAGCTGCGGCGTCAGCTCGCACTGGAAGCCTTCCAGCACACCGC
CGCCTACGACAGCGCCATCAGCACTTGGCTGGGCACCCAGTTGGAAGCCAATGCCCCAAGCCCCCACACCTTGGCGGTGA
CGCTGCCGCAGCGGCAAACCTTGCGCTACGGAGAAAACCCCCATCAAGCGGCGGCTTGGTACAGCAGCTCAGCGGGATGG
GGCGGTGCCCAGCAACTGCAGGGCAAAGAGCTCAGCTACAACAACCTGCTCGATCTCGATGCGGCCCAAGCCACGGTGGA
GCGCTTCCCCGCCAGCGAAGGGGCAGCCGCTGTGGTGATCAAACACACCAACCCCTGCGGCGTCGCCACAGGGCGCGATG
CCAGCGATGCCCTGGCCAGGGCCATTGCCGCTGATCCCGTCTCAGCCTTCGGCGGCATCGTGGCCCTCAATCAACCCCTC
GACGGGGCGGCCTGCGCCAGCCTGCAGGGCCTCTTCCTCGAATGCATCGTGGCGCCGGAGATCAGCGCCGAAGCACGCGA
GATCCTCTCCAGCAAAAGCAATCTGCGGCTGCTGGAACTGCCAGCAGCGGCCTCAGCAGCAGCCACCCGGCAGCAATTGC
GCTCGGTCTTAGGCGGCGTGCTGCTGCAAGAACGCGATCAGATCAGCGACGACGACAGCGCCTGGCAGGTGGTGAGCCAA
CGCCAACCCGATGCCGAAGAGATGGCTGATCTGCGCTTTGCTTGGCGTGTGGTGCGCCATGTGCGCTCCAACGCGATCGT
GGTGGCCAAAGCCGGGCAAAGCCTGGGCGTTGGCGCCGGTCAAATGAATCGTGTGGGTTCAGCAGGCATTGCCCTCGATG
CCGCCGGTGATCAAGCCCGTGGCGCCGTTCTCGCCAGCGATGGCTTCTTCCCCTTCGATGACACCGTCAAGCTGGCCGCT
GAGCGGGGCATCCGCGCGGTGATCCAACCCGGAGGCAGCAAGCGCGACAGCGACTCGATTGCCGCCTGTGATGCCGCTGG
GCTGGTGATGGTGACCACGGGCCGTCGCCATTTCCTGCACTGA

Upstream 100 bases:

>100_bases
CCTAAGGGCAGCAGGTCAGCGGCATTGGCCCCCCAGCCGTGCAGAAAGATCAAGCGCATCAACCAGCAACAGCGTCAGGA
CCACCCCATACCATCAGAGA

Downstream 100 bases:

>100_bases
AGCGGAATCAGGCGACCCAGTAGCGTCGCTCCCATCGCACGCTGAGCCGATGCCCGAGGCCCTGCTTTTCAATCTGAACT
TCCTGCATCCTCTGCTGATG

Product: bifunctional phospho ribosylaminoimidazole carboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MAVPAISMARLALLSVSNKEGIEPLARALVERHGFQLLSSGGTAKCLADAGLPVTKVAEHTGAPEILGGRVKTLHPRIHG
GILGRPSDAADQADMEAQNIPAIELVVVNLYPFEATIAKADVSWDEAIEKIDIGGPAMVRAAAKNHAHVSVLTSPTQYER
LLGALDAGPIPAELRRQLALEAFQHTAAYDSAISTWLGTQLEANAPSPHTLAVTLPQRQTLRYGENPHQAAAWYSSSAGW
GGAQQLQGKELSYNNLLDLDAAQATVERFPASEGAAAVVIKHTNPCGVATGRDASDALARAIAADPVSAFGGIVALNQPL
DGAACASLQGLFLECIVAPEISAEAREILSSKSNLRLLELPAAASAAATRQQLRSVLGGVLLQERDQISDDDSAWQVVSQ
RQPDAEEMADLRFAWRVVRHVRSNAIVVAKAGQSLGVGAGQMNRVGSAGIALDAAGDQARGAVLASDGFFPFDDTVKLAA
ERGIRAVIQPGGSKRDSDSIAACDAAGLVMVTTGRRHFLH

Sequences:

>Translated_520_residues
MAVPAISMARLALLSVSNKEGIEPLARALVERHGFQLLSSGGTAKCLADAGLPVTKVAEHTGAPEILGGRVKTLHPRIHG
GILGRPSDAADQADMEAQNIPAIELVVVNLYPFEATIAKADVSWDEAIEKIDIGGPAMVRAAAKNHAHVSVLTSPTQYER
LLGALDAGPIPAELRRQLALEAFQHTAAYDSAISTWLGTQLEANAPSPHTLAVTLPQRQTLRYGENPHQAAAWYSSSAGW
GGAQQLQGKELSYNNLLDLDAAQATVERFPASEGAAAVVIKHTNPCGVATGRDASDALARAIAADPVSAFGGIVALNQPL
DGAACASLQGLFLECIVAPEISAEAREILSSKSNLRLLELPAAASAAATRQQLRSVLGGVLLQERDQISDDDSAWQVVSQ
RQPDAEEMADLRFAWRVVRHVRSNAIVVAKAGQSLGVGAGQMNRVGSAGIALDAAGDQARGAVLASDGFFPFDDTVKLAA
ERGIRAVIQPGGSKRDSDSIAACDAAGLVMVTTGRRHFLH
>Mature_519_residues
AVPAISMARLALLSVSNKEGIEPLARALVERHGFQLLSSGGTAKCLADAGLPVTKVAEHTGAPEILGGRVKTLHPRIHGG
ILGRPSDAADQADMEAQNIPAIELVVVNLYPFEATIAKADVSWDEAIEKIDIGGPAMVRAAAKNHAHVSVLTSPTQYERL
LGALDAGPIPAELRRQLALEAFQHTAAYDSAISTWLGTQLEANAPSPHTLAVTLPQRQTLRYGENPHQAAAWYSSSAGWG
GAQQLQGKELSYNNLLDLDAAQATVERFPASEGAAAVVIKHTNPCGVATGRDASDALARAIAADPVSAFGGIVALNQPLD
GAACASLQGLFLECIVAPEISAEAREILSSKSNLRLLELPAAASAAATRQQLRSVLGGVLLQERDQISDDDSAWQVVSQR
QPDAEEMADLRFAWRVVRHVRSNAIVVAKAGQSLGVGAGQMNRVGSAGIALDAAGDQARGAVLASDGFFPFDDTVKLAAE
RGIRAVIQPGGSKRDSDSIAACDAAGLVMVTTGRRHFLH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=473, Percent_Identity=38.2663847780127, Blast_Score=248, Evalue=7e-66,
Organism=Escherichia coli, GI1790439, Length=529, Percent_Identity=46.3137996219282, Blast_Score=437, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71985564, Length=474, Percent_Identity=34.5991561181435, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71985574, Length=304, Percent_Identity=25.6578947368421, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323768, Length=476, Percent_Identity=38.0252100840336, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6323056, Length=479, Percent_Identity=37.3695198329854, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24649832, Length=470, Percent_Identity=38.7234042553192, Blast_Score=256, Evalue=3e-68,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 54439; Mature: 54308

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVPAISMARLALLSVSNKEGIEPLARALVERHGFQLLSSGGTAKCLADAGLPVTKVAEH
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHEECCCCCEEEHHCCCCCHHHHHHH
TGAPEILGGRVKTLHPRIHGGILGRPSDAADQADMEAQNIPAIELVVVNLYPFEATIAKA
CCCCHHHCCCCEEECCHHCCCCCCCCCCCCCHHCCHHCCCCEEEEEEEEEECCCEEEEEC
DVSWDEAIEKIDIGGPAMVRAAAKNHAHVSVLTSPTQYERLLGALDAGPIPAELRRQLAL
CCCHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHH
EAFQHTAAYDSAISTWLGTQLEANAPSPHTLAVTLPQRQTLRYGENPHQAAAWYSSSAGW
HHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCHHHHHCCCCCCHHHHEECCCCCC
GGAQQLQGKELSYNNLLDLDAAQATVERFPASEGAAAVVIKHTNPCGVATGRDASDALAR
CCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHH
AIAADPVSAFGGIVALNQPLDGAACASLQGLFLECIVAPEISAEAREILSSKSNLRLLEL
HHHCCCHHHHCCEEEECCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCCCEEEEC
PAAASAAATRQQLRSVLGGVLLQERDQISDDDSAWQVVSQRQPDAEEMADLRFAWRVVRH
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VRSNAIVVAKAGQSLGVGAGQMNRVGSAGIALDAAGDQARGAVLASDGFFPFDDTVKLAA
HCCCEEEEEECCCCCCCCCCHHHCCCCCCEEEECCCCCCCCEEEECCCCCCCCHHHHHHH
ERGIRAVIQPGGSKRDSDSIAACDAAGLVMVTTGRRHFLH
HCCCEEEECCCCCCCCCCCEEEECCCCEEEEECCCHHCCC
>Mature Secondary Structure 
AVPAISMARLALLSVSNKEGIEPLARALVERHGFQLLSSGGTAKCLADAGLPVTKVAEH
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHEECCCCCEEEHHCCCCCHHHHHHH
TGAPEILGGRVKTLHPRIHGGILGRPSDAADQADMEAQNIPAIELVVVNLYPFEATIAKA
CCCCHHHCCCCEEECCHHCCCCCCCCCCCCCHHCCHHCCCCEEEEEEEEEECCCEEEEEC
DVSWDEAIEKIDIGGPAMVRAAAKNHAHVSVLTSPTQYERLLGALDAGPIPAELRRQLAL
CCCHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHH
EAFQHTAAYDSAISTWLGTQLEANAPSPHTLAVTLPQRQTLRYGENPHQAAAWYSSSAGW
HHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCHHHHHCCCCCCHHHHEECCCCCC
GGAQQLQGKELSYNNLLDLDAAQATVERFPASEGAAAVVIKHTNPCGVATGRDASDALAR
CCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHH
AIAADPVSAFGGIVALNQPLDGAACASLQGLFLECIVAPEISAEAREILSSKSNLRLLEL
HHHCCCHHHHCCEEEECCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCCCEEEEC
PAAASAAATRQQLRSVLGGVLLQERDQISDDDSAWQVVSQRQPDAEEMADLRFAWRVVRH
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VRSNAIVVAKAGQSLGVGAGQMNRVGSAGIALDAAGDQARGAVLASDGFFPFDDTVKLAA
HCCCEEEEEECCCCCCCCCCHHHCCCCCCEEEECCCCCCCCEEEECCCCCCCCHHHHHHH
ERGIRAVIQPGGSKRDSDSIAACDAAGLVMVTTGRRHFLH
HCCCEEEECCCCCCCCCCCEEEECCCCEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA