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The map label for this gene is truA [H]

Identifier: 148243240

GI number: 148243240

Start: 1845374

End: 1846249

Strand: Direct

Name: truA [H]

Synonym: SynRCC307_2141

Alternate gene names: 148243240

Gene position: 1845374-1846249 (Clockwise)

Preceding gene: 148243239

Following gene: 148243241

Centisome position: 82.94

GC content: 64.61

Gene sequence:

>876_bases
TTGACCGGCCAGCGCATCGCCCTCTGTCTGCAATACGACGGGGGGCCTTTTTGTGGCTGGCAGCGGCAGCCCCAGCACCG
CAGTGTTCAACAGAGCCTCGATGAAGCGATTGAGGCCCTCGACCCGCTCCCCGCTGGCATTGCAGCCAAACTGAGTCGCA
CCATTGCCGCCGGCCGCACCGACACCGGCGTCCATGCCGCTGCCCAGGTGGTGCACTTTGATTGCCATGGCCCCATCCCA
GCGGCCCGCTGGGCCCCAGCCCTCAATGGGCGACTGCCCGGCAGCATCCGGGTGAGGGCCAGTGCAGCCGTGGCAGCCAA
TTGGCATGCCTGCTTCAGCGCCACATATCGGCGGTACCGCTACTGCATCTACAACGCGCGGCGGCCGAATCTGTTTTTGT
CGCCCTTCAGCTGGCACCGCTACCAATGGCGCCTGCAAGACCACTTGATGCAGGAGCTGCTGCAGGAGCTACTCGGACAC
CACGACTTTTCGGCCTTTCAGCGGGCGGGCAGCCAGCGTGCCCACGCCCGCACCACCGTCCAGGAGGTGAGCCTGCAGCG
GGAAGGCGACATCCTCACGCTGGAGATCCAAGCGAGTGGATTTCTCTACGGCATGGTGCGATTGCTGGTGGGGCAACTGG
TGGCCGCTGGAGAGGGCCGCATCAGCCCTGAGCAATTCCGCCAACGCTGGCGTGAGCAACGCCGTGACGAGGTCAAAGAA
GCCGCTCCACCACAGGGACTTTGCCTGCTGCGTGTGGGCTACCCAGAGCCCGTGTTCCCAAGGGGTGCGTGGTACGATTG
CCAACCGCGGTATCGGCTGGAGACTTCCGATCCGCCCCCTGAGATCACCAGCAATCCGACAGGCGAAGTTCTCTGA

Upstream 100 bases:

>100_bases
GCGACCGCAACGGTGGCTACACCCGCATCATTCGCACAGTCCCCCGCCGCGGTGACAACGCCGAAATGGCCATCATCGAG
CTGGTCTGAGCTTCAGCCCA

Downstream 100 bases:

>100_bases
ACTAGCTTCGGAATTGGTGGAGATTTCAGACTTTTTGATCTGGATTCCAGCTCCAGCCAAGTCCAGTCCCTGCACACGCA
GGGCCCGTCCCGTGATTCCG

Product: tRNA pseudouridine synthase A

Products: NA

Alternate protein names: tRNA pseudouridylate synthase I; tRNA-uridine isomerase I [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTGQRIALCLQYDGGPFCGWQRQPQHRSVQQSLDEAIEALDPLPAGIAAKLSRTIAAGRTDTGVHAAAQVVHFDCHGPIP
AARWAPALNGRLPGSIRVRASAAVAANWHACFSATYRRYRYCIYNARRPNLFLSPFSWHRYQWRLQDHLMQELLQELLGH
HDFSAFQRAGSQRAHARTTVQEVSLQREGDILTLEIQASGFLYGMVRLLVGQLVAAGEGRISPEQFRQRWREQRRDEVKE
AAPPQGLCLLRVGYPEPVFPRGAWYDCQPRYRLETSDPPPEITSNPTGEVL

Sequences:

>Translated_291_residues
MTGQRIALCLQYDGGPFCGWQRQPQHRSVQQSLDEAIEALDPLPAGIAAKLSRTIAAGRTDTGVHAAAQVVHFDCHGPIP
AARWAPALNGRLPGSIRVRASAAVAANWHACFSATYRRYRYCIYNARRPNLFLSPFSWHRYQWRLQDHLMQELLQELLGH
HDFSAFQRAGSQRAHARTTVQEVSLQREGDILTLEIQASGFLYGMVRLLVGQLVAAGEGRISPEQFRQRWREQRRDEVKE
AAPPQGLCLLRVGYPEPVFPRGAWYDCQPRYRLETSDPPPEITSNPTGEVL
>Mature_290_residues
TGQRIALCLQYDGGPFCGWQRQPQHRSVQQSLDEAIEALDPLPAGIAAKLSRTIAAGRTDTGVHAAAQVVHFDCHGPIPA
ARWAPALNGRLPGSIRVRASAAVAANWHACFSATYRRYRYCIYNARRPNLFLSPFSWHRYQWRLQDHLMQELLQELLGHH
DFSAFQRAGSQRAHARTTVQEVSLQREGDILTLEIQASGFLYGMVRLLVGQLVAAGEGRISPEQFRQRWREQRRDEVKEA
APPQGLCLLRVGYPEPVFPRGAWYDCQPRYRLETSDPPPEITSNPTGEVL

Specific function: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs [H]

COG id: COG0101

COG function: function code J; Pseudouridylate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tRNA pseudouridine synthase truA family [H]

Homologues:

Organism=Homo sapiens, GI23503259, Length=278, Percent_Identity=33.0935251798561, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788657, Length=252, Percent_Identity=36.1111111111111, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001406
- InterPro:   IPR020097
- InterPro:   IPR020095
- InterPro:   IPR020094 [H]

Pfam domain/function: PF01416 PseudoU_synth_1 [H]

EC number: =5.4.99.12 [H]

Molecular weight: Translated: 32819; Mature: 32687

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGQRIALCLQYDGGPFCGWQRQPQHRSVQQSLDEAIEALDPLPAGIAAKLSRTIAAGRT
CCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
DTGVHAAAQVVHFDCHGPIPAARWAPALNGRLPGSIRVRASAAVAANWHACFSATYRRYR
CCCHHHHHHEEEEECCCCCCHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHH
YCIYNARRPNLFLSPFSWHRYQWRLQDHLMQELLQELLGHHDFSAFQRAGSQRAHARTTV
HHEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHH
QEVSLQREGDILTLEIQASGFLYGMVRLLVGQLVAAGEGRISPEQFRQRWREQRRDEVKE
HHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AAPPQGLCLLRVGYPEPVFPRGAWYDCQPRYRLETSDPPPEITSNPTGEVL
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGQRIALCLQYDGGPFCGWQRQPQHRSVQQSLDEAIEALDPLPAGIAAKLSRTIAAGRT
CCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
DTGVHAAAQVVHFDCHGPIPAARWAPALNGRLPGSIRVRASAAVAANWHACFSATYRRYR
CCCHHHHHHEEEEECCCCCCHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHH
YCIYNARRPNLFLSPFSWHRYQWRLQDHLMQELLQELLGHHDFSAFQRAGSQRAHARTTV
HHEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHH
QEVSLQREGDILTLEIQASGFLYGMVRLLVGQLVAAGEGRISPEQFRQRWREQRRDEVKE
HHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AAPPQGLCLLRVGYPEPVFPRGAWYDCQPRYRLETSDPPPEITSNPTGEVL
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA